992
Views
46
CrossRef citations to date
0
Altmetric
Reviews

Direct AMP-activated protein kinase activators: a review of evidence from the patent literature

&
Pages 1467-1477 | Published online: 08 Nov 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Abdul Hameed, Mariya Al-Rashida, Rima D. Alharthy, Maliha Uroos, Ehsan Ullah Mughal, Syed Abid Ali & Khalid Mohammed Khan. (2017) Small molecules as activators in medicinal chemistry (2000–2016). Expert Opinion on Therapeutic Patents 27:10, pages 1089-1110.
Read now
Nathalie Esser, Nicolas Paquot & André J Scheen. (2015) Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opinion on Investigational Drugs 24:3, pages 283-307.
Read now
Joungmok Kim, Joonsoo Shin & Joohun Ha. (2015) Screening methods for AMP-activated protein kinase modulators: a patent review. Expert Opinion on Therapeutic Patents 25:3, pages 261-277.
Read now

Articles from other publishers (43)

Mingxing Teng, Damian W. Young & Zhi Tan. (2022) The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. Journal of Medicinal Chemistry 65:21, pages 14289-14304.
Crossref
Marta Sanz-Gómez, Elnaz Aledavood, Marina Beroiz-Salaverri, Laura Lagartera, Elena Vega-Martín, Marta Gil-Ortega, Jose Cumella, Concepción Pérez, Francisco Javier Luque, Carolina Estarellas, María S. Fernández-Alfonso & Ana Castro. (2022) Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway. Scientific Reports 12:1.
Crossref
Manjula Ramu, Sonali S. Vishal & Neha Gogia. 2022. Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging. Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging 241 278 .
Peirong Cai, Zhiheng Feng, Nannan Feng, Hui Zou, Jianhong Gu, Xuezhong Liu, Zongping Liu, Yan Yuan & Jianchun Bian. (2021) Activated AMPK promoted the decrease of lactate production in rat Sertoli cells exposed to Zearalenone. Ecotoxicology and Environmental Safety 220, pages 112367.
Crossref
Yong Liu, Shengnan Cui, Jiayi Sun, Xiaoning Yan & Dongran Han. (2021) Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression Datasets. Frontiers in Genetics 12.
Crossref
Jianlu Lv, Wei Wang, Xialin Zhu, Xiaoju Xu, Qiuying Yan, Jian Lu, Xiaofan Shi, Zhengyu Wang, Jinpei Zhou, Xi Huang, Jiaying Wang, Wenhu Duan & Xu Shen. (2020) DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation. Brain, Behavior, and Immunity 90, pages 55-69.
Crossref
Xu Xu, Wei Wang, Zhengyu Wang, Jianlu Lv, Xiaoju Xu, Jiawen Xu, Juanzhen Yang, Xialin Zhu, Yin Lu, Wenhu Duan, Xi Huang, Jiaying Wang, Jinpei Zhou & Xu Shen. (2020) DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice. Diabetes 69:9, pages 1974-1988.
Crossref
Stephen L. Pinkosky, John W. Scott, Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Rebecca J. Ford, Christopher G. Langendorf, Naomi X. Y. Ling, Tracy L. Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J. Smiles, Kevin R. W. Ngoei, Michael W. Parker, Yan Yan, Karsten Melcher, Bruce E. Kemp, Jonathan S. Oakhill & Gregory R. Steinberg. (2020) Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms. Nature Metabolism 2:9, pages 873-881.
Crossref
Bing-Huei Chen, Chia-Hung Hsieh, Su-Yun Tsai, Chian-Yu Wang & Chi-Chung Wang. (2020) Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway. Scientific Reports 10:1.
Crossref
Sandip Mukherjee, Jake Haubner & Anutosh Chakraborty. (2020) Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases. Molecules 25:6, pages 1403.
Crossref
Juan Manuel Germán-Acacio, David Eduardo Meza-Sánchez & David Morales-Morales. 2020. Bioactive Natural Products. Bioactive Natural Products 57 90 .
Gregory R. Steinberg & David Carling. (2019) AMP-activated protein kinase: the current landscape for drug development. Nature Reviews Drug Discovery 18:7, pages 527-551.
Crossref
Simon W. F. Mok, Wu Zeng, Yuzhen Niu, Paolo Coghi, Yujun Wu, Wai Man Sin, Sio Ian Ng, Flora Gordillo-Martínez, Jia Yin Gao, Betty Y. K. Law, Liang Liu, Xiaojun Yao & Vincent K. W. Wong. (2018) A Method for Rapid Screening of Anilide-Containing AMPK Modulators Based on Computational Docking and Biological Validation. Frontiers in Pharmacology 9.
Crossref
Naomi Rozentul, Yosef Avrahami, Moran Shubely, Laura Levy, Anna Munder, Guy Cohen, Erol Cerasi, Shlomo Sasson & Arie Gruzman. (2017) A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK. Pharmaceutical Research 34:12, pages 2873-2890.
Crossref
Li-Xue Su, Xing-Xing Shi, Peng Yang, Hao Chen, Xin Li, Hong-Gang Fan & Hong-Bin Wang. (2017) Effects of tiletamine on the adenosine monophosphate-activated protein kinase signaling pathway in the rat central nervous system. Research in Veterinary Science 114, pages 101-108.
Crossref
A. A. Spasov, O. N. Zhukovskaya, A. A. Brigadirova, H. S. A. Abbas, V. A. Anisimova, V. A. Sysoeva, A. I. Rashchenko, R. A. Litvinov, O. Yu. Mayka, D. A. Babkov & A. S. Morkovnik. (2018) Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles. Russian Chemical Bulletin 66:10, pages 1905-1912.
Crossref
Tonghui Huang, Jie Sun, Shanshan Zhou, Jian Gao & Yi Liu. (2017) Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach. International Journal of Molecular Sciences 18:7, pages 1408.
Crossref
Betty Yuen Kwan Law, Flora Gordillo-Martínez, Yuan Qing Qu, Ni Zhang, Su Wei Xu, Paolo Saul Coghi, Simon Wing Fai Mok, Jianru Guo, Wei Zhang, Elaine Lai Han Leung, Xing Xing Fan, An Guo Wu, Wai Kit Chan, Xiao Jun Yao, Jing Rong Wang, Liang Liu & Vincent Kam Wai Wong. (2017) Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death. Oncotarget 8:18, pages 30077-30091.
Crossref
David Carling. (2017) AMPK signalling in health and disease. Current Opinion in Cell Biology 45, pages 31-37.
Crossref
Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar, Ravi G. Kurumbail, Russell Miller, Christopher T. Salatto, Jessica Ward, Jane M. Withka, Samit K. Bhattacharya, Markus Boehm, Kris A. Borzilleri, Janice A. Brown, Matthew Calabrese, Nicole L. Caspers, Emily Cokorinos, Edward L. Conn, Matthew S. Dowling, David J. Edmonds, Heather Eng, Dilinie P. Fernando, Richard Frisbie, David Hepworth, James Landro, Yuxia Mao, Francis Rajamohan, Allan R. Reyes, Colin R. Rose, Tim Ryder, Andre Shavnya, Aaron C. Smith, Meihua Tu, Angela C. Wolford & Jun Xiao. (2016) Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H -indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy . Journal of Medicinal Chemistry 59:17, pages 8068-8081.
Crossref
Marie Miglianico, Gerry A. F. Nicolaes & Dietbert Neumann. (2015) Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design. Journal of Medicinal Chemistry 59:7, pages 2879-2893.
Crossref
Yan Ouyang, Li Zhu, Yifang Li, Miaomiao Guo, Yang Liu, Jin Cheng, Jing Zhao & Yi Wu. (2016) Architectural plasticity of AMPK revealed by electron microscopy and X-ray crystallography. Scientific Reports 6:1.
Crossref
Joungmok Kim, Goowon Yang, Yeji Kim, Jin Kim & Joohun Ha. (2016) AMPK activators: mechanisms of action and physiological activities. Experimental & Molecular Medicine 48:4, pages e224-e224.
Crossref
Christopher G. Langendorf, Kevin R. W. Ngoei, John W. Scott, Naomi X. Y. Ling, Sam M. A. Issa, Michael A. Gorman, Michael W. Parker, Kei Sakamoto, Jonathan S. Oakhill & Bruce E. Kemp. (2016) Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nature Communications 7:1.
Crossref
Betty Yuen Kwan Law, Simon Wing Fai Mok, Wai Kit Chan, Su Wei Xu, An Guo Wu, Xiao Jun Yao, Jing Rong Wang, Liang Liu & Vincent Kam Wai Wong. (2016) Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers. Oncotarget 7:7, pages 8090-8104.
Crossref
Evangelos P. Daskalopoulos, Cécile Dufeys, Luc Bertrand, Christophe Beauloye & Sandrine Horman. (2016) AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation. Journal of Molecular and Cellular Cardiology 91, pages 188-200.
Crossref
Bruno Guigas & Benoit Viollet. 2016. AMP-activated Protein Kinase. AMP-activated Protein Kinase 327 350 .
Marina N Asiedu, Gregory Dussor & Theodore J Price. 2016. AMP-activated Protein Kinase. AMP-activated Protein Kinase 257 285 .
Stephen B. Helliwell. 2016. Mitochondrial Dysfunction in Neurodegenerative Disorders. Mitochondrial Dysfunction in Neurodegenerative Disorders 349 371 .
Eman M. E. Dokla, Chun-Sheng Fang, Po-Ting Lai, Samuel K. Kulp, Rabah A. T. Serya, Nasser S. M. Ismail, Khaled A. M. Abouzid & Ching-Shih Chen. (2015) Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators. ChemMedChem 10:11, pages 1915-1923.
Crossref
Benoit Viollet & Marc Foretz. 2015. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases 326 338 .
Brandon Faubert, Emma E. Vincent, Maya C. Poffenberger & Russell G. Jones. (2015) The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator. Cancer Letters 356:2, pages 165-170.
Crossref
Martin Pelosse, Malgorzata Tokarska-Schlattner & Uwe Schlattner. 2015. Cardiac Cytoarchitecture. Cardiac Cytoarchitecture 187 225 .
Therese Admyre, Lena Amrot-Fors, Maria Andersson, Martin Bauer, Mikael Bjursell, Tomas Drmota, Stefan Hallén, Judith Hartleib-Geschwindner, Bo Lindmark, Jianming Liu, Lars Löfgren, Mattias Rohman, Nidhal Selmi & Kristina Wallenius. (2014) Inhibition of AMP Deaminase Activity Does Not Improve Glucose Control in Rodent Models of Insulin Resistance or Diabetes. Chemistry & Biology 21:11, pages 1486-1496.
Crossref
Christos E. Zois, Elena Favaro & Adrian L. Harris. (2014) Glycogen metabolism in cancer. Biochemical Pharmacology 92:1, pages 3-11.
Crossref
Xiaomei ZhouYongjun CaoGuizhen AoLifang HuHui LiuJian WuXiaoyu WangMengmeng JinShuli ZhengXuechu ZhenNabil J. AlkayedJia JiaJian Cheng. (2014) CaMKKβ-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation. Antioxidants & Redox Signaling 21:12, pages 1741-1758.
Crossref
Yu-Chiang Lai, Samanta Kviklyte, Didier Vertommen, Louise Lantier, Marc Foretz, Benoît Viollet, Stefan Hallén & Mark H. Rider. (2014) A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators. Biochemical Journal 460:3, pages 363-375.
Crossref
John W. Scott, Naomi Ling, Samah M.A. Issa, Toby A. Dite, Matthew T. O’Brien, Zhi-Ping Chen, Sandra Galic, Christopher G. Langendorf, Gregory R. Steinberg, Bruce E. Kemp & Jonathan S. Oakhill. (2014) Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling. Chemistry & Biology 21:5, pages 619-627.
Crossref
Sandra W Cowan-JacobWolfgang Jahnke & Stefan Knapp. (2014) Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases. Future Medicinal Chemistry 6:5, pages 541-561.
Crossref
Bing Xiao, Matthew J. Sanders, David Carmena, Nicola J. Bright, Lesley F. Haire, Elizabeth Underwood, Bhakti R. Patel, Richard B. Heath, Philip A. Walker, Stefan Hallen, Fabrizio Giordanetto, Stephen R. Martin, David Carling & Steven J. Gamblin. (2013) Structural basis of AMPK regulation by small molecule activators. Nature Communications 4:1.
Crossref
Theodore J. Price & Gregory Dussor. (2013) AMPK: An emerging target for modification of injury-induced pain plasticity. Neuroscience Letters 557, pages 9-18.
Crossref
Rachelle R. Landgraf, Devrishi Goswami, Francis Rajamohan, Melissa S. Harris, Matthew F. Calabrese, Lise R. Hoth, Rachelle Magyar, Bruce D. Pascal, Michael J. Chalmers, Scott A. Busby, Ravi G. Kurumbail & Patrick R. Griffin. (2013) Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry. Structure 21:11, pages 1942-1953.
Crossref
Pascual Sanz, Teresa Rubio & Maria Adelaida Garcia-Gimeno. (2013) AMPKbeta subunits: more than just a scaffold in the formation of AMPK complex. FEBS Journal 280:16, pages 3723-3733.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.