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H+/K+-ATPase inhibitors: a patent review

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Pages 99-111 | Published online: 04 Dec 2012

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Eda Eken, David S Estores, Emily J Cicali, Kristin K Wiisanen & Julie A Johnson. (2023) A Pharmacogenetics-Based Approach to Managing Gastroesophageal Reflux Disease: Current Perspectives and Future Steps. Pharmacogenomics and Personalized Medicine 16, pages 645-664.
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Xiao-Yu Zhang, Tao Li, Haibing Wu, Yun Ling, Zhi-Ping Qian & Liang Chen. (2021) Analysis of the Effect of Proton-Pump Inhibitors on the Course of COVID-19. Journal of Inflammation Research 14, pages 287-298.
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Yawei Shen, Lingyuan Song, Tiantian Chen, Hewei Jiang, Guokun Yang, Yanmin Zhang, Xindang Zhang, Kah Kheng Lim, Xiaolin Meng, Jinliang Zhao & Xiaowu Chen. (2023) Identification of hub genes in digestive system of mandarin fish (Siniperca chuatsi) fed with artificial diet by weighted gene co-expression network analysis. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 47, pages 101112.
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Hichem Alimi, Faten Haj Mabrouk, Nacim Zouari, Mohsen Sakly & Khémais Ben Rhouma. (2023) LC–ESI–MS phenolic contents assessment, antioxidant, and protective ability of Punica granatum root bark extract against ethanol-induced gastric ulcer in rats: in silico H+, K+-ATPase inhibitory pathway study . Toxicology Research 12:2, pages 189-200.
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Thien-Kim Le, Young Jin Park, Gun Su Cha, Fikri A. R. Hardiyanti Oktavia, Dong Hyun Kim & Chul-Ho Yun. (2022) Roles of Human Liver Cytochrome P450 Enzymes in Tenatoprazole Metabolism. Pharmaceutics 15:1, pages 23.
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Shilin Gong, Xiaolan Hu, Shengshuang Chen, Baoqing Sun, Jian‐Lin Wu & Na Li. (2022) Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics. Medicinal Research Reviews 42:4, pages 1704-1734.
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Pallavi H M, Fares Hezam Al-Ostoot, Hamse Kameshwar Vivek & Shaukath Ara Khanum. (2022) Synthesis, characterization, DFT, docking studies and molecular dynamics of some 3-phenyl-5-furan isoxazole derivatives as anti-inflammatory and anti-ulcer agents. Journal of Molecular Structure 1250, pages 131812.
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Muhammad T. Khan, Humaira Nadeem, Arif‐ullah Khan, Muzaffar Abbas, Muazzam Arif, Nadia Shamshad Malik, Zulkifal Malik & Ibrahim Javed. (2020) Amino acid conjugates of 2‐mercaptobenzimidazole provide better anti‐inflammatory pharmacology and improved toxicity profile. Drug Development Research 81:8, pages 1057-1072.
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Doha Abou Baker. (2020) Plants against Helicobacter pylori to combat resistance: An ethnopharmacological review. Biotechnology Reports 26, pages e00470.
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He-Jian Zhang, Xue-Hui Zhang, Jie Liu, Lu-Ning Sun, Yi-Wen Shen, Chen Zhou, Hong-Wen Zhang, Li-Jun Xie, Juan Chen, Yun Liu & Yong-Qing Wang. (2020) Effects of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of proton pump inhibitors. Pharmacological Research 152, pages 104606.
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Thien-Kim Le, Gun-Su Cha, Hyun-Hee Jang, Thi Huong Ha Nguyen, Tiep Thi My Doan, Young Ju Lee, Ki Deok Park, Yumi Shin, Dong-Hyun Kim & Chul-Ho Yun. (2019) Regioselective hydroxylation pathway of tenatoprazole to produce human metabolites by Bacillus megaterium CYP102A1. Process Biochemistry 87, pages 95-104.
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Hui-Wen Jiao, Lu-Ning Sun, Yue-Qi Li, Lei Yu, Hong-Wen Zhang, Mei-Feng Wang, Li-Yuan Yu, Zi-Qing-Yun Yuan, Li-Jun Xie, Juan Chen, Ling Meng, Xue-Hui Zhang & Yong-Qing Wang. (2017) Safety, pharmacokinetics, and pharmacodynamics of S-(−)-pantoprazole sodium injections after single and multiple intravenous doses in healthy Chinese subjects. European Journal of Clinical Pharmacology 74:3, pages 257-265.
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Xin-Xin She, Qing Dong, Hua-Jun Luo, Jun-Zhi Wang, Nian-Yu Huang, Wei-Qiao Deng & Kun Zou. (2017) Molecular docking, binding free energy analysis, and biological evaluation of bisabolonalone hydrazone carboxamides as H+,K+-ATPase reversible inhibitors. Medicinal Chemistry Research 27:1, pages 332-340.
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Lu-Ning Sun, Yang Cao, Yue-Qi Li, Yun-Qian Fang, Hong-Wen Zhang, Mei-Feng Wang, Li-Jun Xie, Juan Chen, Zhi-Cheng Yang, Ming-Liang Bian, Hao Li, Pei-Pei Zhang, Ji-Fu Wei, Ling Meng, Xue-Hui Zhang, Ping Zhao & Yong-Qing Wang. (2017) Impact of Gastric H+/K+-ATPase rs2733743 on the Intragastric pH-Values of Dexlansoprazole Injection in Chinese Subjects. Frontiers in Pharmacology 8.
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Cheng-yuan Li, Mei Su, Yun-yi Yan, Lin Zhou, Lu-yao Ao, Wei-rong Fang & Yun-man Li. (2017) KFP-H008 blocks gastric acid secretion through inhibiting H+-K+-ATPase. European Journal of Pharmacology 810, pages 112-119.
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Artem Minalyan, Lilit Gabrielyan, David Scott, Jonathan Jacobs & Joseph R. Pisegna. (2017) The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors. Current Gastroenterology Reports 19:8.
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Li-Yuan Yu, Lu-Ning Sun, Xue-Hui Zhang, Yue-Qi Li, Lei Yu, Zi-Qing-Yun Yuan, Ling Meng, Hong-Wen Zhang & Yong-Qing Wang. (2017) A Review of the Novel Application and Potential Adverse Effects of Proton Pump Inhibitors. Advances in Therapy 34:5, pages 1070-1086.
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Yue-Qi Li, Zheng-Yu Yan, Hong-Wen Zhang, Lu-Ning Sun, Hui-Wen Jiao, Mei-Feng Wang, Li-Yuan Yu, Lei Yu, Zi-Qing-Yun Yuan, Ling Meng & Yong-Qing Wang. (2017) Safety, tolerability, pharmacokinetics and pharmacodynamics of dexlansoprazole injection in healthy Chinese subjects. European Journal of Clinical Pharmacology 73:5, pages 547-554.
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Evence DaureLinda RossCynthia R. L. Webster. (2017) Gastroduodenal Ulceration in Small Animals: Part 2. Proton Pump Inhibitors and Histamine-2 Receptor Antagonists. Journal of the American Animal Hospital Association 53:1, pages 11-23.
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Young Kwang ShimNayoung Kim. (2017) The Effect of H 2 Receptor Antagonist in Acid Inhibition and Its Clinical Efficacy . The Korean Journal of Gastroenterology 70:1, pages 4.
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Nian-Yu Huang, Wen-Bin Wang, Lei Chen, Hua-Jun Luo, Jun-Zhi Wang, Wei-Qiao Deng & Kun Zou. (2016) Design, synthesis and biological evaluation of bisabolangelone oxime derivatives as potassium-competitive acid blockers (P-CABs). Bioorganic & Medicinal Chemistry Letters 26:9, pages 2268-2272.
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Rocío Retamales-Ortega, Carlos P. Vio & Nibaldo C. Inestrosa. (2015) P2C-Type ATPases and Their Regulation. Molecular Neurobiology 53:2, pages 1343-1354.
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Fernando Pereira Beserra, Ariane Leite Rozza, Ana Júlia Vieira, Lucas Fernando Sérgio Gushiken & Cláudia Helena Pellizzon. 2016. 215 234 .
Hua-Jun Luo, Jun-Zhi Wang, Nian-Yu Huang, Wei-Qiao Deng & Kun Zou. (2015) Computational insights into the interaction mechanism of triazolyl substituted tetrahydrobenzofuran derivatives with H+,K+-ATPase at different pH. Journal of Computer-Aided Molecular Design 30:1, pages 27-37.
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Quan Li Yang, Chun Xue Chen, Wu Li, Wan Liu, Hu Biao Fang & Nian Yu Huang. (2014) Synthesis and Characterization of Triazole-Linked Bistetrahydrobenzofuran Derivatives as Anti-Ulcer Agents. Advanced Materials Research 997, pages 128-131.
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Hua-Jun Luo, Wei-Qiao Deng & Kun Zou. (2014) Protonated Form: The Potent Form of Potassium-Competitive Acid Blockers. PLoS ONE 9:5, pages e97688.
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Chao-Hung Kuo, Chien-Yu Lu, Hsiang-Yao Shih, Chung-Jung Liu, Meng-Chieh Wu, Huang-Ming Hu, Wen-Hung Hsu, Fang-Jung Yu, Deng-Chyang Wu & Fu-Chen Kuo. (2014) CYP2C19 polymorphism influences Helicobacter pylori eradication . World Journal of Gastroenterology 20:43, pages 16029.
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Eugene B. Chang & Po Sing Leung. 2014. The Gastrointestinal System. The Gastrointestinal System 63 85 .
C.F. Dick, A.L.A. Dos-Santos, D. Majerowicz, L.S. Paes, N.L. Giarola, K.C. Gondim, A. Vieyra & J.R. Meyer-Fernandes. (2013) Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K+ cycling and to active Na+ extrusion. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:8, pages 4265-4273.
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