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Dopamine D3 receptor antagonists: a patent review (2007 – 2012)

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Pages 363-381 | Published online: 03 Jan 2013

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Antoni Cortés, Estefanía Moreno, Mar Rodríguez-Ruiz, Enric I. Canela & Vicent Casadó. (2016) Targeting the dopamine D3 receptor: an overview of drug design strategies. Expert Opinion on Drug Discovery 11:7, pages 641-664.
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Alberto Leoni, Alessandra Locatelli, Rita Morigi & Mirella Rambaldi. (2014) Novel thiazole derivatives: a patent review (2008 – 2012. Part 2). Expert Opinion on Therapeutic Patents 24:7, pages 759-777.
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Articles from other publishers (38)

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K. Y. Kalitin, A. A. Spasov, O. Y. Mukha, G. V. Pridvorov & V. A. Lipatov. (2022) Pharmacological Targets and Mechanisms of Action of Antipsychotic Substances in the Context of the Neurochemical Theory of the Pathogenesis of Schizophrenia. Neuroscience and Behavioral Physiology 52:1, pages 108-123.
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Francisco O. Battiti, Saheem A. Zaidi, Vsevolod Katritch, Amy Hauck Newman & Alessandro Bonifazi. (2021) Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D 2 or D 3 Receptor Agonists . Journal of Medicinal Chemistry 64:21, pages 16088-16105.
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Jin Cai, Mingqi Huang, Yuhong Wang, Xixi Chen & Min Ji. (2021) Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents. Bioorganic & Medicinal Chemistry Letters 48, pages 128269.
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Akihiro Shiina, Tadashi Hasegawa & Masaomi Iyo. (2021) Possible effect of blonanserin on gambling disorder: A clinical study protocol and a case report. World Journal of Clinical Cases 9:11, pages 2469-2477.
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Amy Hauck Newman, Francisco O. Battiti & Alessandro Bonifazi. (2019) 2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts. Journal of Medicinal Chemistry 63:5, pages 1779-1797.
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Anver Basha Shaik, Vivek Kumar, Alessandro Bonifazi, Adrian M. Guerrero, Sophie L. Cemaj, Alexandra Gadiano, Jenny Lam, Zheng-Xiong Xi, Rana Rais, Barbara S. Slusher & Amy Hauck Newman. (2019) Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D 3 Receptor Antagonists and Partial Agonists . Journal of Medicinal Chemistry 62:20, pages 9061-9077.
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Benhua Zhou, Kwon Ho Hong, Min Ji & Jin Cai. (2018) Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands. Chemical Biology & Drug Design 92:3, pages 1597-1609.
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Benhua Zhou, Min Ji & Jin Cai. (2018) Design, synthesis and biological evaluation of bitopic arylpiperazine-hexahydro-pyrazinoquinolines as preferential dopamine D3 receptor ligands. Bioorganic Chemistry 77, pages 125-135.
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Sean W. Reilly, Suzy Griffin, Michelle Taylor, Kristoffer Sahlholm, Chi-Chang Weng, Kuiying Xu, Daniel A. Jacome, Robert R. Luedtke & Robert H. Mach. (2017) Highly Selective Dopamine D 3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores . Journal of Medicinal Chemistry 60:23, pages 9905-9910.
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Zhi-Bing You, Jun-Tao Gao, Guo-Hua Bi, Yi He, Comfort Boateng, Jianjing Cao, Eliot L. Gardner, Amy Hauck Newman & Zheng-Xiong Xi. (2017) The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats. Neuropharmacology 126, pages 190-199.
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Fabrizio Micheli. (2017) Novel, Selective, and Developable Dopamine D 3 Antagonists with a Modified “Amino” Region . ChemMedChem 12:16, pages 1254-1260.
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Pınar Öz, F. Duygu Kaya Yertutanol, Tayfun Gözler, Ayşe Özçetin & İ. Tayfun Uzbay. (2017) Lesions of the paraventricular thalamic nucleus attenuates prepulse inhibition of the acoustic startle reflex. Neuroscience Letters 642, pages 31-36.
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Vivek Kumar, Amy E. Moritz, Thomas M. Keck, Alessandro Bonifazi, Michael P. Ellenberger, Christopher D. Sibley, R. Benjamin Free, Lei Shi, J. Robert Lane, David R. Sibley & Amy Hauck Newman. (2017) Synthesis and Pharmacological Characterization of Novel trans -Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D 3 Receptor (D 3 R) . Journal of Medicinal Chemistry 60:4, pages 1478-1494.
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Geancarlo Zanatta, Gustavo Della Flora Nunes, Eveline M. Bezerra, Roner F. da Costa, Alice Martins, Ewerton W. S. Caetano, Valder N. Freire & Carmem Gottfried. (2016) Two Binding Geometries for Risperidone in Dopamine D3 Receptors: Insights on the Fast-Off Mechanism through Docking, Quantum Biochemistry, and Molecular Dynamics Simulations. ACS Chemical Neuroscience 7:10, pages 1331-1347.
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Fabrizio Micheli, Alessia Bacchi, Simone Braggio, Laura Castelletti, Palmina Cavallini, Paolo Cavanni, Susanna Cremonesi, Michele Dal Cin, Aldo Feriani, Sylvie Gehanne, Mahmud Kajbaf, Luciano Marchió, Selena Nola, Beatrice Oliosi, Annalisa Pellacani, Elisabetta Perdonà, Anna Sava, Teresa Semeraro, Luca Tarsi, Silvia Tomelleri, Andrea Wong, Filippo Visentini, Laura Zonzini & Christian Heidbreder. (2016) 1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists. Journal of Medicinal Chemistry 59:18, pages 8549-8576.
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Vivek Kumar, Alessandro Bonifazi, Michael P. Ellenberger, Thomas M. Keck, Elie Pommier, Rana Rais, Barbara S. Slusher, Eliot Gardner, Zhi-Bing You, Zheng-Xiong Xi & Amy Hauck Newman. (2016) Highly Selective Dopamine D 3 Receptor (D 3 R) Antagonists and Partial Agonists Based on Eticlopride and the D 3 R Crystal Structure: New Leads for Opioid Dependence Treatment . Journal of Medicinal Chemistry 59:16, pages 7634-7650.
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Valerio Mammoli, Alessandro Bonifazi, Diego Dal Ben, Mario Giannella, Gianfabio Giorgioni, Alessandro Piergentili, Maria Pigini, Wilma Quaglia, Ajiroghene Thomas, Amy H. Newman, Sergi Ferré, Marta Sanchez-Soto, Thomas M. Keck & Fabio Del Bello. (2016) A Novel Class of Dopamine D 4 Receptor Ligands Bearing an Imidazoline Nucleus . ChemMedChem 11:16, pages 1819-1828.
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Satishkumar Gadhiya, Sudharshan Madapa, Thomas Kurtzman, Ian L. Alberts, Steven Ramsey, Nagavara-Kishore Pillarsetty, Teja Kalidindi & Wayne W. Harding. (2016) Tetrahydroprotoberberine alkaloids with dopamine and σ receptor affinity. Bioorganic & Medicinal Chemistry 24:9, pages 2060-2071.
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Fabrizio Micheli, Andrea Bernardelli, Federica Bianchi, Simone Braggio, Laura Castelletti, Palmina Cavallini, Paolo Cavanni, Susanna Cremonesi, Michele Dal Cin, Aldo Feriani, Beatrice Oliosi, Teresa Semeraro, Luca Tarsi, Silvia Tomelleri, Andrea Wong, Filippo Visentini, Laura Zonzini & Christian Heidbreder. (2016) 1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists. Bioorganic & Medicinal Chemistry 24:8, pages 1619-1636.
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Fabrizio Micheli, Susanna Cremonesi, Teresa Semeraro, Luca Tarsi, Silvia Tomelleri, Paolo Cavanni, Beatrice Oliosi, Elisabetta Perdonà, Anna Sava, Laura Zonzini, Aldo Feriani, Simone Braggio & Christian Heidbreder. (2016) Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 26:4, pages 1329-1332.
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Yongkai Cao, Chengchun Min, Srijan Acharya, Kyeong-Man Kim & Seung Hoon Cheon. (2016) Design, synthesis and evaluation of bitopic arylpiperazinephenyl-1,2,4-oxadiazoles as preferential dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry 24:2, pages 191-200.
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Emilio Merlo Pich & Ginetta Collo. (2015) Pharmacological targeting of dopamine D3 receptors: Possible clinical applications of selective drugs. European Neuropsychopharmacology 25:9, pages 1437-1447.
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Cheryse A. Furman, Rebecca A. Roof, Amy E. Moritz, Brittney N. Miller, Trevor B. Doyle, R. Benjamin Free, Ashwini K. Banala, Noel M. Paul, Vivek Kumar, Christopher D. Sibley, Amy Hauck Newman & David R. Sibley. (2015) Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists. European Neuropsychopharmacology 25:9, pages 1448-1461.
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Mattia Stucchi, Peter Gmeiner, Harald Huebner, Giulia Rainoldi, Alessandro Sacchetti, Alessandra Silvani & Giordano Lesma. (2015) Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library. ACS Medicinal Chemistry Letters 6:8, pages 882-887.
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Comfort A. Boateng, Oluyomi M. Bakare, Jia Zhan, Ashwini K. Banala, Caitlin Burzynski, Elie Pommier, Thomas M. Keck, Prashant Donthamsetti, Jonathan A. Javitch, Rana Rais, Barbara S. Slusher, Zheng-Xiong Xi & Amy Hauck Newman. (2015) High Affinity Dopamine D 3 Receptor (D 3 R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D 3 R Knockout Mice . Journal of Medicinal Chemistry 58:15, pages 6195-6213.
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Thomas M. Keck, William S. John, Paul W. Czoty, Michael A. Nader & Amy Hauck Newman. (2015) Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis. Journal of Medicinal Chemistry 58:14, pages 5361-5380.
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Thomas M. Keck, Ashwini K. Banala, Rachel D. Slack, Caitlin Burzynski, Alessandro Bonifazi, Oluyomi M. Okunola-Bakare, Martin Moore, Jeffrey R. Deschamps, Rana Rais, Barbara S. Slusher & Amy Hauck Newman. (2015) Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry 23:14, pages 4000-4012.
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Sa Li, Yuxiu Shi & Gilbert J. Kirouac. (2014) The hypothalamus and periaqueductal gray are the sources of dopamine fibers in the paraventricular nucleus of the thalamus in the rat. Frontiers in Neuroanatomy 8.
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Subramaniam Ananthan, Surendra K. Saini, Guangyan Zhou, Judith V. Hobrath, Indira Padmalayam, Ling Zhai, J. Robert Bostwick, Tamara Antonio, Maarten E. A. Reith, Shea McDowell, Eunie Cho, Leah McAleer, Michelle Taylor & Robert R. Luedtke. (2014) Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity. Journal of Medicinal Chemistry 57:16, pages 7042-7060.
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Fei Liu, Xiaomei Zhuang, Cuiping Yang, Zheng Li, Shan Xiong, Zhiwei Zhang, Jin Li, Chuang Lu & Zhenqing Zhang. (2014) Characterization of preclinical in vitro and in vivo ADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA-14, a new dopamine D 3 receptor antagonist candidate for treatment of drug addiction . Biopharmaceutics & Drug Disposition 35:5, pages 296-307.
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Vivek Kumar, Ashwini K. Banala, Erick G. Garcia, Jianjing Cao, Thomas M. Keck, Alessandro Bonifazi, Jeffery R. Deschamps & Amy Hauck Newman. (2014) Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66. ACS Medicinal Chemistry Letters 5:6, pages 647-651.
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Jianyong Chen, Beth Levant, Cheng Jiang, Thomas M. Keck, Amy Hauck Newman & Shaomeng Wang. (2014) Tranylcypromine Substituted cis -Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D 3 Receptor Antagonists . Journal of Medicinal Chemistry 57:11, pages 4962-4968.
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Ralf Brisch, Arthur Saniotis, Rainer Wolf, Hendrik Bielau, Hans-Gert Bernstein, Johann Steiner, Bernhard Bogerts, Anna Katharina Braun, Zbigniew Jankowski, Jaliya Kumaritlake, Maciej Henneberg & Tomasz Gos. (2014) The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue. Frontiers in Psychiatry 5.
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Bernard Le Foll, Ginetta Collo, Eugenii A. Rabiner, Isabelle Boileau, Emilio Merlo Pich & Pierre Sokoloff. 2014. Dopamine. Dopamine 255 275 .
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C.A. Boateng, C.A. Schweppe & A.H. Newman. 2014. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Peng Du, Lili Xu, Jiye Huang, Kunqian Yu, Rui Zhao, Bo Gao, Hualiang Jiang, Weili Zhao, Xuechu Zhen & Wei Fu. (2013) Design, Synthesis, and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands. Chemical Biology & Drug Design 82:3, pages 326-335.
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