Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 23, 2013 - Issue 4
Submit an article Journal homepage
727
Views
55
CrossRef citations to date
0
Altmetric
Reviews

mGlu5 negative allosteric modulators: a patent review (2010 – 2012)

Kyle A EmmitteVanderbilt University Medical Center, Vanderbilt Center for Neuroscience Drug Discovery, Department of Chemistry and Department of Pharmacology, Nashville, TN 37232, [email protected]
Pages 393-408 | Published online: 22 Jan 2013

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Kyle A. Emmitte. (2017) mGlu5 negative allosteric modulators: a patent review (2013 - 2016). Expert Opinion on Therapeutic Patents 27:6, pages 691-706.
Read now
Dmitry Petrov, Ignacio Pedros, Maria Luisa de Lemos, Mercè Pallàs, Anna Maria Canudas, Alberto Lazarowski, Carlos Beas-Zarate, Carme Auladell, Jaume Folch & Antoni Camins. (2014) Mavoglurant as a treatment for Parkinson’s disease. Expert Opinion on Investigational Drugs 23:8, pages 1165-1179.
Read now

Articles from other publishers (53)

James Robert Brašić, Jack Alexander Goodman, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, Keith Slifer, Thomas Sedlak, Anil Kumar Mathur, John P. Seibyl, Elizabeth M. Berry-Kravis, Dean F. Wong & Dejan B. Budimirovic. (2022) Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study. Brain Sciences 12:3, pages 314.
Crossref
Ting-ting Fu, Gao Tu, Meng Ping, Guo-xun Zheng, Feng-yuan Yang, Jing-yi Yang, Yang Zhang, Xiao-jun Yao, Wei-wei Xue & Feng Zhu. (2020) Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors. Acta Pharmacologica Sinica 42:8, pages 1354-1367.
Crossref
Kirstie A. Bennett, Eugenia Sergeev, Cliona P. MacSweeney, Geor Bakker & Anne E. Cooper. (2021) Understanding Exposure-Receptor Occupancy Relationships for Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators across a Range of Preclinical and Clinical Studies. Journal of Pharmacology and Experimental Therapeutics 377:1, pages 157-168.
Crossref
Katarina Varnäs, Zsolt Cselényi, Ryosuke Arakawa, Sangram Nag, Vladimir Stepanov, Mohammad Mahdi Moein, Peter Johnström, Lee Kingston, Charles S. Elmore, Christer Halldin & Lars Farde. (2020) The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans. Neuropharmacology 162, pages 107809.
Crossref
Shaoyong Lu & Jian Zhang. (2018) Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug–Target Interactions. Journal of Medicinal Chemistry 62:1, pages 24-45.
Crossref
Andrew S. Felts, Katrina A. Bollinger, Christopher J. Brassard, Alice L. Rodriguez, Ryan D. Morrison, J. Scott Daniels, Anna L. Blobaum, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Kyle A. Emmitte & Craig W. Lindsley. (2019) Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters 29:1, pages 47-50.
Crossref
Phuc N.H. Trinh, Lauren T. May, Katie Leach & Karen J. Gregory. (2018) Biased agonism and allosteric modulation of metabotropic glutamate receptor 5. Clinical Science 132:21, pages 2323-2338.
Crossref
Tingting Fu, Guoxun Zheng, Gao Tu, Fengyuan Yang, Yuzong Chen, Xiaojun Yao, Xiaofeng Li, Weiwei Xue & Feng Zhu. (2018) Exploring the Binding Mechanism of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators in Clinical Trials by Molecular Dynamics Simulations. ACS Chemical Neuroscience 9:6, pages 1492-1502.
Crossref
Katarina Varnäs, Anders Juréus, Sjoerd J. Finnema, Peter Johnström, Patrick Raboisson, Nahid Amini, Akihiro Takano, Vladimir Stepanov, Christer Halldin & Lars Farde. (2018) The metabotropic glutamate receptor 5 radioligand [11C]AZD9272 identifies unique binding sites in primate brain. Neuropharmacology 135, pages 455-463.
Crossref
Samuel A. Barnes, Douglas J. Sheffler, Svetlana Semenova, Nicholas D.P. Cosford & Anton Bespalov. (2018) Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy. Biological Psychiatry 83:11, pages 955-962.
Crossref
Khaled S. Abd-Elrahman, Alison Hamilton, Shaunessy R. Hutchinson, Fang LiuRyan C. RussellStephen S. G. Ferguson. (2017) mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease . Science Signaling 10:510.
Crossref
Wataru Hirose, Yoshihiro Kato, Itaru Natsutani, Makoto Takata, Maiko Kitaichi, Satoki Imai, Shun Hayashi, Yukiyo Arai, Kohei Hoshino & Kohzo Yoshida. (2017) Synthesis and optimization of 4,5,6,7-tetrahydrooxazolo[4,5-c]pyridines as potent and orally-active metabotropic glutamate receptor 5 negative allosteric modulators. Bioorganic & Medicinal Chemistry Letters 27:18, pages 4331-4335.
Crossref
Cristiano Chiamulera, Laura Padovani & Mauro Corsi. (2017) Drug discovery for the treatment of substance use disorders: novel targets, repurposing, and the need for new paradigms. Current Opinion in Pharmacology 35, pages 120-124.
Crossref
Falgun Shah, Antonia F. Stepan, Alison O'Mahony, Sharlene Velichko, Alexandra E. Folias, Christopher Houle, Christopher L. Shaffer, John Marcek, Jessica Whritenour, Robert Stanton & Ellen L. Berg. (2017) Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Cell Chemical Biology 24:7, pages 858-869.e5.
Crossref
János Galambos, Attila Bielik, Gábor Wágner, György Domány, János Kóti, Zoltán Béni, Áron Szigetvári, Zsuzsanna Sánta, Zoltán Orgován, Amrita Bobok, Béla Kiss, Mónika L. Mikó-Bakk, Mónika Vastag, Katalin Sághy, Mikhail Krasavin, Krisztina Gál, István Greiner, Zsolt Szombathelyi & György M. Keserű. (2017) Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu 5 ) receptor negative allosteric modulators. European Journal of Medicinal Chemistry 133, pages 240-254.
Crossref
Senthilkumar Sivanesan, Aaron Tan, Rebecca Jeyaraj, James Lam, Monica Gole, Antonio Hardan, Keyoumars Ashkan & Jayakumar Rajadas. (2017) Pharmaceuticals and Stem Cells in Autism Spectrum Disorders: Wishful Thinking?. World Neurosurgery 98, pages 659-672.
Crossref
Katie Leach & Karen J. Gregory. (2017) Molecular insights into allosteric modulation of Class C G protein-coupled receptors. Pharmacological Research 116, pages 105-118.
Crossref
Xavier Gómez-Santacana, Silvia Pittolo, Xavier Rovira, Marc Lopez, Charleine Zussy, James A. R. Dalton, Adèle Faucherre, Chris Jopling, Jean-Philippe Pin, Francisco Ciruela, Cyril Goudet, Jesús Giraldo, Pau Gorostiza & Amadeu Llebaria. (2016) Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals. ACS Central Science 3:1, pages 81-91.
Crossref
Kazuto Yamazaki, Kazuyuki Fukushima, Michiko Sugawara, Yoshikuni Tabata, Yoichi Imaizumi, Yasuharu Ishihara, Masashi Ito, Kappei Tsukahara, Jun Kohyama & Hideyuki Okano. (2016) Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell–Derived Neural Stem Cells under Different Oxygen and Medium Conditions. SLAS Discovery 21:10, pages 1054-1064.
Crossref
Wataru Hirose, Yoshihiro Kato, Takayoshi Yamamoto, Momoe Kassai, Makoto Takata, Shun Hayashi, Yukiyo Arai, Satoki Imai & Kohzo Yoshida. (2016) Synthesis, structure–activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators. Bioorganic & Medicinal Chemistry Letters 26:16, pages 3866-3869.
Crossref
Valerio D'Amore, Renée H.L. Raaijmakers, Ines Santolini, Clementina M. van Rijn, Richard Teke Ngomba, Ferdinando Nicoletti & Gilles van Luijtelaar. (2016) The anti-absence effect of mGlu5 receptor amplification with VU0360172 is maintained during and after antiepileptogenesis. Pharmacology Biochemistry and Behavior 146-147, pages 50-59.
Crossref
Craig W. Lindsley, Kyle A. Emmitte, Corey R. Hopkins, Thomas M. Bridges, Karen J. Gregory, Colleen M. Niswender & P. Jeffrey Conn. (2016) Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. Chemical Reviews 116:11, pages 6707-6741.
Crossref
Rajapillai L. I. Pillai & Dnyanesh N. Tipre. (2016) Metabotropic glutamate receptor 5 ? a promising target in drug development and neuroimaging. European Journal of Nuclear Medicine and Molecular Imaging 43:6, pages 1151-1170.
Crossref
Andrew S. Felts, Alice L. Rodriguez, Ryan D. Morrison, Daryl F. Venable, Anna L. Blobaum, Frank W. Byers, J. Scott Daniels, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley & Kyle A. Emmitte. (2016) N-Alkylpyrido[1?,2?:1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents. Bioorganic & Medicinal Chemistry Letters 26:8, pages 1894-1900.
Crossref
Fukang Yang, Lawrence B. Snyder, Anand Balakrishnan, Jeffrey M. Brown, Digavalli V. Sivarao, Amy Easton, Alda Fernandes, Michael Gulianello, Umesh M. Hanumegowda, Hong Huang, Yanling Huang, Kelli M. Jones, Yu-Wen Li, Michele Matchett, Gail Mattson, Regina Miller, Kenneth S. Santone, Arun Senapati, Eric E. Shields, Frank J. Simutis, Ryan Westphal, Valerie J. Whiterock, Joanne J. Bronson, John E. Macor & Andrew P. Degnan. (2016) Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5. ACS Medicinal Chemistry Letters 7:3, pages 289-293.
Crossref
János Galambos, György Domány, Katalin Nógrádi, Gábor Wágner, György M. Keserű, Amrita Bobok, Sándor Kolok, Mónika L. Mikó-Bakk, Mónika Vastag, Katalin Sághy, János Kóti, Zoltán Szakács, Zoltán Béni, Krisztina Gál, Zsolt Szombathelyi & István Greiner. (2016) 4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate. Bioorganic & Medicinal Chemistry Letters 26:4, pages 1249-1252.
Crossref
Hoang Nam Vu, Ji Young Kim, Ahmed H.E. Hassan, Kihang Choi, Jong-Hyun Park, Ki Duk Park, Jae Kyun Lee, Ae Nim Pae, Hyunah Choo, Sun-Joon Min & Yong Seo Cho. (2016) Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists. Bioorganic & Medicinal Chemistry Letters 26:1, pages 140-144.
Crossref
E.B. Warren, S.E. Sillivan & C. Konradi. 2016. Handbook of Basal Ganglia Structure and Function, Second Edition. Handbook of Basal Ganglia Structure and Function, Second Edition 555 581 .
Christina J. Perry & Andrew J. Lawrence. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse 86 96 .
Elliot H. Sherr. 2016. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry 587 599 .
Ludi JiangYong LiLiansheng QiaoXi ChenYusu HeYanling ZhangGongyu Li. (2015) Discovery of potential negative allosteric modulators of mGluR5 from natural products using pharmacophore modeling, molecular docking, and molecular dynamics simulation studies. Canadian Journal of Chemistry 93:11, pages 1199-1206.
Crossref
Gopinath S. Palanisamy, John M. Marcek, Gregg D. Cappon, Jessica Whritenour, Christopher L. Shaffer, Joseph T. Brady & Christopher Houle. (2015) Drug-induced Skin Lesions in Cynomolgus Macaques Treated with Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators. Toxicologic Pathology 43:7, pages 995-1003.
Crossref
Kasper Harpsøe, Vignir Isberg, Benjamin G. Tehan, Dahlia Weiss, Angela Arsova, Fiona H. Marshall, Hans Bräuner-Osborne & David E. Gloriam. (2015) Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants. Scientific Reports 5:1.
Crossref
John A. ChristopherSarah J. AvesKirstie A. BennettAndrew S. DoréJames C. ErreyAli JazayeriFiona H. MarshallKrzysztof OkrasaMaria J. Serrano-VegaBenjamin G. TehanGiselle R. WigginMiles Congreve. (2015) Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu 5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile) . Journal of Medicinal Chemistry 58:16, pages 6653-6664.
Crossref
Zhiwei Feng, Shifan Ma, Guanxing Hu & Xiang-Qun Xie. (2015) Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family. The AAPS Journal 17:3, pages 737-753.
Crossref
Katalin Nógrádi, Gábor Wágner, György Domány, Amrita Bobok, Ildikó Magdó, Sándor Kolok, Mónika L. Mikó-Bakk, Mónika Vastag, Katalin Sághy, István Gyertyán, János Kóti, Krisztina Gál, Sándor Farkas, György M. Keserű, István Greiner & Zsolt Szombathelyi. (2015) Thieno[2,3- b ]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization. Bioorganic & Medicinal Chemistry Letters 25:8, pages 1724-1729.
Crossref
Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Patrick Boissin, Edilio Borroni, Bernd Büttelmann, Simona Ceccarelli, Nicole Clemann, Beatrice David, Christoph Funk, Wolfgang Guba, Anthony Harrison, Thomas Hartung, Michael Honer, Jörg Huwyler, Martin Kuratli, Urs Niederhauser, Axel Pähler, Jens-Uwe Peters, Ann Petersen, Eric Prinssen, Antonio Ricci, Daniel Rueher, Marianne Rueher, Manfred Schneider, Paul Spurr, Theodor Stoll, Daniel Tännler, Jürgen Wichmann, Richard H. Porter, Joseph G. Wettstein & Lothar Lindemann. (2015) Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1 H -imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases . Journal of Medicinal Chemistry 58:3, pages 1358-1371.
Crossref
Jerri M Rook, Mohammed N Tantawy, Mohammad S Ansari, Andrew S Felts, Shaun R Stauffer, Kyle A Emmitte, Robert M Kessler, Colleen M Niswender, J Scott Daniels, Carrie K Jones, Craig W Lindsley & P Jeffrey Conn. (2014) Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles. Neuropsychopharmacology 40:3, pages 755-765.
Crossref
Sebastian H Scharf, Georg Jaeschke, Joseph G Wettstein & Lothar Lindemann. (2015) Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome. Current Opinion in Pharmacology 20, pages 124-134.
Crossref
Kirstie A Bennett, Andrew S Doré, John A Christopher, Dahlia R Weiss & Fiona H Marshall. (2015) Structures of mGluRs shed light on the challenges of drug development of allosteric modulators. Current Opinion in Pharmacology 20, pages 1-7.
Crossref
Kelly A Newell & Natalie Matosin. (2014) Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics. BMC Psychiatry 14:1.
Crossref
Christina Mølck, Kasper Harpsøe, David E. Gloriam, Jesper M. Mathiesen, Søren M. Nielsen & Hans Bräuner-Osborne. (2014) mGluR5: Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery. Neurochemical Research 39:10, pages 1862-1875.
Crossref
P. Jeffrey Conn, Craig W. Lindsley, Jens Meiler & Colleen M. Niswender. (2014) Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. Nature Reviews Drug Discovery 13:9, pages 692-708.
Crossref
Olivier Rascol, Susan Fox, Fabrizio Gasparini, Christopher Kenney, Thérèse Di Paolo & Baltazar Gomez-Mancilla. (2014) Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias. Parkinsonism & Related Disorders 20:9, pages 947-956.
Crossref
Katalin Nógrádi, Gábor Wágner, György Domány, Amrita Bobok, Ildikó Magdó, Béla Kiss, Sándor Kolok, Katalin Fónagy, István Gyertyán, Viktor Háda, János Kóti, Krisztina Gál, Sándor Farkas, György M. Keserű, István Greiner & Zsolt Szombathelyi. (2014) Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Hit-to-lead optimization. Bioorganic & Medicinal Chemistry Letters 24:16, pages 3845-3849.
Crossref
Brittney S. Bates, Alice L. Rodriguez, Andrew S. Felts, Ryan D. Morrison, Daryl F. Venable, Anna L. Blobaum, Frank W. Byers, Kera P. Lawson, J. Scott Daniels, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley & Kyle A. Emmitte. (2014) Discovery of VU0431316: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorganic & Medicinal Chemistry Letters 24:15, pages 3307-3314.
Crossref
Lei Zhang, Gayatri Balan, Gabriela Barreiro, Brian P. Boscoe, Lois K. Chenard, Julie Cianfrogna, Michelle M. Claffey, Laigao Chen, Karen J. Coffman, Susan E. Drozda, Joshua R. Dunetz, Kari R. Fonseca, Paul Galatsis, Sarah Grimwood, John T. Lazzaro, Jessica Y. Mancuso, Emily L. Miller, Matthew R. Reese, Bruce N. Rogers, Isao Sakurada, Marc Skaddan, Deborah L. Smith, Antonia F. Stepan, Patrick Trapa, Jamison B. Tuttle, Patrick R. Verhoest, Daniel P. Walker, Ann S. Wright, Margaret M. Zaleska, Kenneth Zasadny & Christopher L. Shaffer. (2014) Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 H -pyrazolo-[3,4- b ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator . Journal of Medicinal Chemistry 57:3, pages 861-877.
Crossref
X. G?mez-Santacana, X. Rovira, J. A. Dalton, C. Goudet, J. P. Pin, P. Gorostiza, J. Giraldo & A. Llebaria. (2014) A double effect molecular switch leads to a novel potent negative allosteric modulator of metabotropic glutamate receptor 5. Med. Chem. Commun. 5:10, pages 1548-1554.
Crossref
Hilary Highfield Nickols & P. Jeffrey Conn. (2014) Development of allosteric modulators of GPCRs for treatment of CNS disorders. Neurobiology of Disease 61, pages 55-71.
Crossref
Guiying LiMorten Jørgensen & Brian M Campbell. (2013) Metabotropic glutamate receptor 5-negative allosteric modulators for the treatment of psychiatric and neurological disorders (2009–July 2013). Pharmaceutical Patent Analyst 2:6, pages 767-802.
Crossref
Andrew S. Felts, Alice L. Rodriguez, Ryan D. Morrison, Daryl F. Venable, Jason T. Manka, Brittney S. Bates, Anna L. Blobaum, Frank W. Byers, J. Scott Daniels, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley & Kyle A. Emmitte. (2013) Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorganic & Medicinal Chemistry Letters 23:21, pages 5779-5785.
Crossref
Russell J. Amato, Andrew S. Felts, Alice L. Rodriguez, Daryl F. Venable, Ryan D. Morrison, Frank W. Byers, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Carrie K. Jones & Kyle A. Emmitte. (2013) Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu 5 : Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction . ACS Chemical Neuroscience 4:8, pages 1217-1228.
Crossref
Ashok Kumar Grover. (2013) Use of Allosteric Targets in the Discovery of Safer Drugs. Medical Principles and Practice 22:5, pages 418-426.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.