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PTEN modulators: a patent review

, PhD & , PhD MBA
Pages 569-580 | Published online: 05 Feb 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Chandra S. Boosani, Palanikumar Gunasekar & Devendra K. Agrawal. (2019) An update on PTEN modulators – a patent review. Expert Opinion on Therapeutic Patents 29:11, pages 881-889.
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Kun-Chun Chiang, Huang-Yang Chen, Shu-Yuan Hsu, Jong-Hwei S Pang, Shang-Yu Wang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Chi-Chin Sun, Jim-Ming Lee, Chun-Nan Yeh & Horng-Heng Juang. (2015) PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. Drug Design, Development and Therapy 9, pages 4631-4638.
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Articles from other publishers (46)

Ting Wang, Longci Sun, Chengkun Chen, Yingchao Zhang, Baoyu He, Yanhua Zhang, Zhenghe Wang, Hanbing Xue & Yujun Hao. (2023) Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesis. Cell & Bioscience 13:1.
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Sagarika Majhi, Sokindra Kumar & Lubhan Singh. (2023) A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions. CNS & Neurological Disorders - Drug Targets 22:5, pages 659-677.
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Mingyuan Fan, Jing Zhang, Lei Zeng, Danpeng Wang, Jiao Chen, Xiaorong Xi, Jing Long, Jinzhu Huang & Xueping Li. (2023) Non-coding RNA mediates endoplasmic reticulum stress-induced apoptosis in heart disease. Heliyon 9:5, pages e16246.
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Tim Hohmann, Urszula Hohmann & Faramarz Dehghani. (2023) MACC1-induced migration in tumors: Current state and perspective. Frontiers in Oncology 13.
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Jue Zheng, Guiheng Chen, Tieqiu Li, Xiang He, Yuanman Luo & Ke Yang. (2022) Isoflurane Promotes Cell Proliferation, Invasion, and Migration by Regulating BACH1 and miR-375 in Prostate Cancer Cells In Vitro. International Journal of Toxicology 41:3, pages 212-224.
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Laura TorrenteGina M. DeNicola. (2022) Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges. Annual Review of Pharmacology and Toxicology 62:1, pages 279-300.
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Hyunsung Kim & Young Hyeh Ko. (2022) The Pathologic and Genetic Characteristics of Extranodal NK/T-Cell Lymphoma. Life 12:1, pages 73.
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Xiao-Qing Wang, Lei Zhang, Zhong-Yuan Xia, Jia-Yin Chen, Yiru Fang & Yu-Qiang Ding. (2021) PTEN in prefrontal cortex is essential in regulating depression-like behaviors in mice. Translational Psychiatry 11:1.
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Huachao Shen, Jie Wang, Lihua Shen, Huamei Wang, Wenlei Li & Xinsheng Ding. (2020) Phosphatase and tensin homolog deletion enhances neurite outgrowth during neural stem cell differentiation. Neuropathology 40:3, pages 224-231.
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Nahal Haddadi, Glena Travis, Najah T. Nassif, Ann M. Simpson & Deborah J. Marsh. (2020) Toward Systems Pathology for PTEN Diagnostics. Cold Spring Harbor Perspectives in Medicine 10:5, pages a037127.
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Jing Li, Xia Qi, Xiaochuan Wang, Weina Li, Ya Li & Qingjun Zhou. (2020) PTEN Inhibition Facilitates Diabetic Corneal Epithelial Regeneration by Reactivating Akt Signaling Pathway. Translational Vision Science & Technology 9:3, pages 5.
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Scott Gross, Pranava Mallu, Hinal Joshi, Bryant Schultz, Christina Go & Jonathan Soboloff. 2020. 233 317 .
Rafael Pulido, Janire Mingo, Ayman Gaafar, Caroline E. Nunes-Xavier, Sandra Luna, Leire Torices, Javier C. Angulo & José I. López. (2019) Precise Immunodetection of PTEN Protein in Human Neoplasia. Cold Spring Harbor Perspectives in Medicine 9:12, pages a036293.
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Tsui, Lin, Chang, Hou, Chen, Feng & Juang. (2019) Transgelin, a p53 and PTEN-Upregulated Gene, Inhibits the Cell Proliferation and Invasion of Human Bladder Carcinoma Cells in Vitro and in Vivo. International Journal of Molecular Sciences 20:19, pages 4946.
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Liang Li, Qiang Chen, Chao Feng, Yongping Jin & Shudong Xia. (2019) Aberrant expression of TNRC6a and miR-21 during myocardial infarction. 3 Biotech 9:7.
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Arduino Mangoni, Jean Eynde, Josef Jampilek, Dimitra Hadjipavlou-Litina, Hong Liu, Jóhannes Reynisson, Maria Sousa, Paula Gomes, Katalin Prokai-Tatrai, Tiziano Tuccinardi, Jean-Marc Sabatier, F. Luque, Jarkko Rautio, Rafik Karaman, M. Vasconcelos, Sandra Gemma, Stefania Galdiero, Christopher Hulme, Simona Collina, Michael Gütschow, George Kokotos, Carlo Siciliano, Raffaele Capasso, Luigi Agrofoglio, Rino Ragno & Diego Muñoz-Torrero. (2019) Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5. Molecules 24:13, pages 2415.
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Nahal Haddadi, Yiguang Lin, Glena Travis, Ann M. Simpson, Najah T. Nassif & Eileen M. McGowan. (2018) PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy. Molecular Cancer 17:1.
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Qiuliang Liu, Peishuo Geng, Longyan Shi, Qi Wang & Pengliang Wang. (2018) miR-29 promotes osteosarcoma cell proliferation and migration by targeting PTEN. Oncology Letters.
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Rui Liu, Jun-Chun Tang, Meng-Xian Pan, Yang Zhuang, Ya Zhang, Hua-Bao Liao, Dan Zhao, Yang Lei, Rui-Xue Lei, Shu Wang, An-Chun Liu, Xing-Ping Qin, Juan Chen, Zhi-Feng Zhang & Qi Wan. (2018) ERK 1/2 Activation Mediates the Neuroprotective Effect of BpV(pic) in Focal Cerebral Ischemia–Reperfusion Injury. Neurochemical Research 43:7, pages 1424-1438.
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Mingliang Wang, Min Liu, Ting Ni & Qiliang Liu. (2018) miR‑214 mediates vascular inflammation and apoptosis via PTEN expression. Molecular Medicine Reports.
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Zhiwen Song, Xiu Han, Liming Shen, Hongjun Zou, Bin Zhang, Jinbo Liu & Aihua Gong. (2018) PTEN silencing enhances neuronal proliferation and differentiation by activating PI3K/Akt/GSK3β pathway in vitro. Experimental Cell Research 363:2, pages 179-187.
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Rafael Pulido. (2018) PTEN Inhibition in Human Disease Therapy. Molecules 23:2, pages 285.
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Ke-Hung Tsui, Kun-Chun Chiang, Yu-Hsiang Lin, Kang-Shuo Chang, Tsui-Hsia Feng & Horng-Heng Juang. (2018) BTG2 is a tumor suppressor gene upregulated by p53 and PTEN in human bladder carcinoma cells. Cancer Medicine 7:1, pages 184-195.
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Yan-Hong Guo, Feng-Yan Tang, Yong Wang, Wen-Jun Huang, Jing Tian, Hui-Ling Lu, Min Xin & Jian Chen. (2017) Low concentration of formononetin promotes proliferation of estrogen receptor-positive cells through an ERα-miR-375-PTEN-ERK1/2-bcl-2 pathway. Oncotarget 8:59, pages 100045-100055.
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Xiaorui Fu, Xudong Zhang, Jinli Gao, Xin Li, Lei Zhang, Ling Li, Xinhua Wang, Zhenchang Sun, Zhaoming Li, Yu Chang, Qingjiang Chen & Mingzhi Zhang. (2017) Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes. Medicine 96:29, pages e7111.
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Pauline Delannoy, François Guillaume Debray, Alain Verloes, Albert Beckers & Hernan Valdes-Socin. (2017) How to recognize Cowden syndrome: A novel PTEN mutation description. Annales d'Endocrinologie 78:3, pages 188-190.
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Nikoleta Tellios, Jillian C. Belrose, Alexander C. Tokarewicz, Cindy Hutnik, Hong Liu, Andrew Leask, Michael Motolko, Miho Iijima & Sunil K. Parapuram. (2017) TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma. Scientific Reports 7:1.
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Yuan-Ming An, Han Feng, Xing-Zhong Zhang, Xin Cong, Qian Zhao, Li-Ling Wu & Dou Dou. (2017) Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of phosphatidylinositol 3-kinase/Akt pathway in porcine coronary arteries. Biochemical and Biophysical Research Communications 486:1, pages 178-183.
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Hongyu Shen, Dandan Wang, Liangpeng Li, Sujin Yang, Xiu Chen, Siying Zhou, Shanliang Zhong, Jianhua Zhao & Jinhai Tang. (2017) MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway. Gene 596, pages 110-118.
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M. Perluigi, E. Barone, F. Di Domenico & D.A. Butterfield. (2016) Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1862:10, pages 1871-1882.
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Zdenka Navratilova, Vitezslav Kolek & Martin Petrek. (2015) Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease. Archivum Immunologiae et Therapiae Experimentalis 64:3, pages 177-193.
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S-J Kim, H-W Lee, J-H Baek, Y-H Cho, H G Kang, J S Jeong, J Song, H-S Park & K-H Chun. (2015) Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer. Oncogene 35:2, pages 251-260.
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Feng YangWenwei LiuXiaojuan YanHanyun ZhouHongshen ZhangJianfei LiuMing YuXiaoshan ZhuKezhong Ma. (2016) Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)/Vascular Endothelial Growth Factor (VEGF) Signal Pathway. Medical Science Monitor 22, pages 3562-3575.
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Andrés Alonso, Caroline E. Nunes-Xavier, Yolanda Bayón & Rafael Pulido. 2016. Protein Tyrosine Phosphatases. Protein Tyrosine Phosphatases 1 23 .
Eun Mi Chang, Eunjin Lim, Sookyoung Yoon, Kyungah Jeong, Sijeong Bae, Dong Ryul Lee, Tae Ki Yoon, Youngsok Choi & Woo Sik Lee. (2015) Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice. PLOS ONE 10:12, pages e0144245.
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Iván Roa, Gonzalo de Toro, Fernanda Fernández, Anakaren Game, Sergio Muñoz, Xabier de Aretxabala & Milind Javle. (2015) Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer. Diagnostic Pathology 10:1.
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Antonio PalumboJrJr, Nathalia de Oliveira Meireles Da Costa, Martin Hernan Bonamino, Luis Felipe Ribeiro Pinto & Luiz Eurico Nasciutti. (2015) Genetic instability in the tumor microenvironment: a new look at an old neighbor. Molecular Cancer 14:1.
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Maira Zorzan, Enrico Giordan, Marco Redaelli, Antonio Caretta & Carla Mucignat-Caretta. (2015) Molecular targets in glioblastoma. Future Oncology 11:9, pages 1407-1420.
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Rafael Pulido. (2015) PTEN: A yin-yang master regulator protein in health and disease. Methods 77-78, pages 3-10.
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Jun Liu & Ian D. Chin-Sang. (2015) C. elegans as a model to study PTEN’s regulation and function. Methods 77-78, pages 180-190.
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Natalia S. Sotelo, Jan T.G. Schepens, Miguel Valiente, Wiljan J.A.J. Hendriks & Rafael Pulido. (2015) PTEN–PDZ domain interactions: Binding of PTEN to PDZ domains of PTPN13. Methods 77-78, pages 147-156.
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Michele Milella, Italia Falcone, Fabiana Conciatori, Ursula Cesta Incani, Anais Del Curatolo, Nicola Inzerilli, Carmen M. A. Nuzzo, Vanja Vaccaro, Sabrina Vari, Francesco Cognetti & Ludovica Ciuffreda. (2015) PTEN: Multiple Functions in Human Malignant Tumors. Frontiers in Oncology 5.
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Kai Zhang, Jing Chen, Dongqin Chen, Jiayuan Huang, Bing Feng, Siqi Han, Yitian Chen, Haizhu Song, Wei De, Ziman Zhu, Rui Wang & Longbang Chen. (2014) Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway. Oncotarget 5:24, pages 12916-12935.
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Evelyne Lima-Fernandes, Stanislas Misticone, Cédric Boularan, Justine S. Paradis, Hervé Enslen, Philippe P. Roux, Michel Bouvier, George S. Baillie, Stefano Marullo & Mark G.H. Scott. (2014) A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells. Nature Communications 5:1.
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Yeon Jung Lee, Soo Hyun Oh, Chanmin Park, Minha Hong, Ah Rah Lee, Hee Jeong Yoo, Chan Young Shin, Keun-Ah Cheon & Geon Ho Bahn. (2014) Advanced Pharmacotherapy Evidenced by Pathogenesis of Autism Spectrum Disorder. Clinical Psychopharmacology and Neuroscience 12:1, pages 19-30.
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