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Expert Opinion on Therapeutic Patents Volume 23, 2013 - Issue 5
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BACE2 as a new diabetes target: a patent review (2010 – 2012)

Christopher SouthanTW2Informatics Ltd,, Göteborg, 42166, Sweden+0046 0702 530710; [email protected]
, BSc MSc PhD
Pages 649-663 | Published online: 18 Mar 2013

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JungIn Um, Ji-Hyung Lee, Da-Woon Jung & Darren R. Williams. (2018) Re-education begins at home: an overview of the discovery of in vivo-active small molecule modulators of endogenous stem cells. Expert Opinion on Drug Discovery 13:4, pages 307-326.
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H. M. Kumalo & Mahmoud E. Soliman. (2016) A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility. Journal of Receptors and Signal Transduction 36:5, pages 505-514.
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Eric J Gilbert. (2013) 1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284). Expert Opinion on Therapeutic Patents 23:8, pages 1069-1073.
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Articles from other publishers (13)

Yee Jie Yeap, Nagaendran Kandiah, Dean Nizetic & Kah-Leong Lim. (2023) BACE2: A Promising Neuroprotective Candidate for Alzheimer’s Disease. Journal of Alzheimer's Disease 94:s1, pages S159-S171.
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Pinky Gehlot, Sunil Kumar, Vivek Kumar Vyas, Bhanwar Singh Choudhary, Manish Sharma & Ruchi Malik. (2022) Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review. Bioorganic & Medicinal Chemistry 74, pages 117047.
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Susrutha Puthanmadhom NarayananJeong-Heon LeeAditya BhagwateSaatchi KuwelkerHuihuang YanTamas OrdogAdil E. Bharucha. (2020) Epigenetic Alterations Are Associated With Gastric Emptying Disturbances in Diabetes Mellitus. Clinical and Translational Gastroenterology 11:3, pages e00136.
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Arun K. Ghosh, Margherita Brindisi, Yu‐Chen Yen, Emma K. Lendy, Satish Kovela, Emilio Leal Cárdenas, Bhavanam Sekhara Reddy, Kalapala Venketeswara Rao, Deborah Downs, Xiangping Huang, Jordan Tang & Andrew D. Mesecar. (2019) Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies. ChemMedChem.
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Joshua A Kulas, Kendra L Puig & Colin K Combs. (2017) Amyloid precursor protein in pancreatic islets. Journal of Endocrinology 235:1, pages 49-67.
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Gema Alcarraz-Vizán, Carlos Castaño, Montse Visa, Joel Montane, Joan-Marc Servitja & Anna Novials. (2017) BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression. Cellular and Molecular Life Sciences 74:15, pages 2827-2838.
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C. Southan. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 464 487 .
Christopher Southan, Joanna L. Sharman, Helen E. Benson, Elena Faccenda, Adam J. Pawson, Stephen P. H. Alexander, O. Peter Buneman, Anthony P. Davenport, John C. McGrath, John A. Peters, Michael Spedding, William A. Catterall, Doriano Fabbro & Jamie A. Davies. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Research 44:D1, pages D1054-D1068.
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Arun K. Ghosh, Bhavanam Sekhara Reddy, Yu-Chen Yen, Emilio L. Cárdenas, Kalapala Venkateswara Rao, Deborah Downs, Xiangping Huang, Jordan Tang & Andrew D. Mesecar. (2016) Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes. Chemical Science 7:5, pages 3117-3122.
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Christopher Southan. (2015) Expanding opportunities for mining bioactive chemistry from patents. Drug Discovery Today: Technologies 14, pages 3-9.
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Gema Alcarraz‐Vizán, Paola Casini, Lisa Cadavez, Montse Visa, Joel Montane, Joan‐Marc Servitja & Anna Novials. (2014) Inhibition of BACE2 counteracts hIAPP‐induced insulin secretory defects in pancreatic β‐cells. The FASEB Journal 29:1, pages 95-104.
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Daniel Längle, Jonas Halver, Bernd Rathmer, Erik Willems & Dennis Schade. (2014) Small Molecules Targeting in Vivo Tissue Regeneration . ACS Chemical Biology 9:1, pages 57-71.
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Christopher Southan, Peter Varkonyi, Kiran Boppana, Sarma A.R.P. Jagarlapudi & Sorel Muresan. (2013) Tracking 20 Years of Compound-to-Target Output from Literature and Patents. PLoS ONE 8:10, pages e77142.
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