Citations (40)
Keep up to date with the latest research on this topic with citation updates for this article.
Articles from other publishers (40)
Zhihai Ke & Ying-Yeung Yeung. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV
412
449
.
Preeti Kumari Chaudhary & Soochong Kim. (2021) An Insight into GPCR and G-Proteins as Cancer Drivers. Cells 10:12, pages 3288.
Crossref
Crossref
John L. Gilmore, Hai-Yun Xiao, T. G. Murali Dhar, Michael Yang, Zili Xiao, Xiaoxia Yang, Tracy L. Taylor, Kim W. McIntyre, Bethanne M. Warrack, Hong Shi, Paul C. Levesque, Anthony M. Marino, Georgia Cornelius, Arvind Mathur, Ding Ren Shen, Jian Pang, Mary Ellen Cvijic, Lois D. Lehman-McKeeman, Huadong Sun, Jenny Xie, Luisa Salter-Cid, Percy H. Carter & Alaric J. Dyckman. (2021)
Bicyclic Ligand-Biased Agonists of S1P
1
: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles
. Journal of Medicinal Chemistry 64:3, pages 1454-1480.
Crossref
Crossref
James D. Grayson & Alexander J. Cresswell. (2021) γ-Amino phosphonates via the photocatalytic α-C–H alkylation of primary amines. Tetrahedron 81, pages 131896.
Crossref
Crossref
Hui Liu, Zonghua Luo, Jiwei Gu, Hao Jiang, Sumit Joshi, Kooresh I. Shoghi, Yun Zhou, Robert J. Gropler, Tammie L. S. Benzinger & Zhude Tu. (2020) In vivo Characterization of Four 18F-Labeled S1PR1 Tracers for Neuroinflammation. Molecular Imaging and Biology 22:5, pages 1362-1369.
Crossref
Crossref
Qiong Xiao, Minwan Hu, Si Chen, Jing Jin, Li Li, Jinping Hu, Ping Xie & Dali Yin. (2020) S1P1-selective agonist prodrug IMMH002 is phosphorylated in rats to form an S-configured enantiomer: Synthesis, verification, and biological activity of the in vivo active metabolite. Bioorganic & Medicinal Chemistry Letters 30:11, pages 127141.
Crossref
Crossref
Daan van Kruining, Qian Luo, Gerhild van Echten-Deckert, Michelle M. Mielke, Andrew Bowman, Shane Ellis, Tiago Gil Oliveira & Pilar Martinez-Martinez. (2020) Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods. Advanced Drug Delivery Reviews 159, pages 232-244.
Crossref
Crossref
Yonghui Chen, Tianqi Liu, Qiumu Xi, Wenqiang Jia, Dali Yin & Xiaojian Wang. (2019)
A Computational Approach to the Study of the Binding Mode of S1P
1
R Agonists Based on the Active-Like Receptor Model
. Journal of Chemical Information and Modeling 59:4, pages 1624-1633.
Crossref
Crossref
John L. Gilmore, Hai-Yun Xiao, T. G. Murali Dhar, Michael G. Yang, Zili Xiao, Jenny Xie, Lois D. Lehman-McKeeman, Lei Gong, Huadong Sun, Lloyd Lecureux, Cliff Chen, Dauh-Rurng Wu, Marta Dabros, Xiaoxia Yang, Tracy L. Taylor, Xia D. Zhou, Elizabeth M. Heimrich, Rochelle Thomas, Kim W. McIntyre, Virna Borowski, Bethanne M. Warrack, Yuwen Li, Hong Shi, Paul C. Levesque, Zheng Yang, Anthony M. Marino, Georgia Cornelius, Celia J. D’Arienzo, Arvind Mathur, Richard Rampulla, Anuradha Gupta, Bala Pragalathan, Ding Ren Shen, Mary Ellen Cvijic, Luisa M. Salter-Cid, Percy H. Carter & Alaric J. Dyckman. (2019)
Identification and Preclinical Pharmacology of ((1
R
,3
S
)-1-Amino-3-((
S
)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P
1
) Modulator Advanced into Clinical Trials
. Journal of Medicinal Chemistry 62:5, pages 2265-2285.
Crossref
Crossref
Simon Taylor. 2018. Early Drug Development. Early Drug Development
603
630
.
Nahal Haddadi, Yiguang Lin, Ann Simpson, Najah Nassif & Eileen McGowan. (2017) “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer. International Journal of Molecular Sciences 18:9, pages 1891.
Crossref
Crossref
Sathya Narayanan Patmanathan, Wei Wang, Lee Fah Yap, Deron R. Herr & Ian C. Paterson. (2017) Mechanisms of sphingosine 1-phosphate receptor signalling in cancer. Cellular Signalling 34, pages 66-75.
Crossref
Crossref
Frédéric St-Cyr Giguère, Suzanne Attiori Essis, Laure Chagniel, Marc Germain, Michel Cyr & Guy Massicotte. (2017) The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain Research 1658, pages 51-59.
Crossref
Crossref
C. Roger White, Samantha Giordano & G.M. Anantharamaiah. (2016) High-density lipoprotein, mitochondrial dysfunction and cell survival mechanisms. Chemistry and Physics of Lipids 199, pages 161-169.
Crossref
Crossref
John L. Gilmore, James E. SheppeckIIII, Scott H. Watterson, Lauren Haque, Parag Mukhopadhyay, Andrew J. Tebben, Michael A. Galella, Ding Ren Shen, Melissa Yarde, Mary Ellen Cvijic, Virna Borowski, Kathleen Gillooly, Tracy Taylor, Kim W. McIntyre, Bethanne Warrack, Paul C. Levesque, Julia P. Li, Georgia Cornelius, Celia D’Arienzo, Anthony Marino, Praveen Balimane, Luisa Salter-Cid, Joel C. Barrish, William J. Pitts, Percy H. Carter, Jenny Xie & Alaric J. Dyckman. (2016)
Discovery and Structure–Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P
1
)
. Journal of Medicinal Chemistry 59:13, pages 6248-6264.
Crossref
Crossref
Ying Liu, Su An, Richard Ward, Yang Yang, Xiao-Xi Guo, Wei Li & Tian-Rui Xu. (2016) G protein-coupled receptors as promising cancer targets. Cancer Letters 376:2, pages 226-239.
Crossref
Crossref
Kira V. Blankenbach, Stephanie Schwalm, Josef Pfeilschifter & Dagmar Meyer zu Heringdorf. (2016) Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks. Frontiers in Pharmacology 7.
Crossref
Crossref
Cyrille Lescop, Claus Müller, Boris Mathys, Magdalena Birker, Ruben de Kanter, Christopher Kohl, Patrick Hess, Oliver Nayler, Markus Rey, Patrick Sieber, Beat Steiner, Thomas Weller & Martin H. Bolli. (2016) Novel S1P 1 receptor agonists – Part 4: Alkylaminomethyl substituted aryl head groups. European Journal of Medicinal Chemistry 116, pages 222-238.
Crossref
Crossref
Martin H. Bolli, Cyrille Lescop, Magdalena Birker, Ruben de Kanter, Patrick Hess, Christopher Kohl, Oliver Nayler, Markus Rey, Patrick Sieber, Jörg Velker, Thomas Weller & Beat Steiner. (2016) Novel S1P1 receptor agonists – Part 5: From amino-to alkoxy-pyridines. European Journal of Medicinal Chemistry 115, pages 326-341.
Crossref
Crossref
Monica Guma, Stefano Tiziani & Gary S. Firestein. (2016) Metabolomics in rheumatic diseases: desperately seeking biomarkers. Nature Reviews Rheumatology 12:5, pages 269-281.
Crossref
Crossref
Hung-Jen Shih, Jiin-Cherng Yen, Allen W. Chiu, Yung-Chiong Chow, Wynn H.T. Pan & Chun-Jen Huang. (2016) FTY720 inhibits germ cell apoptosis in testicular torsion/detorsion. Journal of Surgical Research 202:1, pages 155-164.
Crossref
Crossref
Pol Sanllehí, José-Luis Abad, Josefina Casas & Antonio Delgado. (2016) Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase). Chemistry and Physics of Lipids 197, pages 69-81.
Crossref
Crossref
Junqing Guo, Scott H. Watterson, Steven H. Spergel, James Kempson, Charles M. Langevine, Ding Ren Shen, Melissa Yarde, Mary Ellen Cvijic, Dana Banas, Richard Liu, Suzanne J. Suchard, Kathleen Gillooly, Tracy Taylor, Sandra Rex-Rabe, David J. Shuster, Kim W. McIntyre, Georgia Cornelius, Celia D’Arienzo, Anthony Marino, Praveen Balimane, Luisa Salter-Cid, Murray McKinnon, Joel C. Barrish, Percy H. Carter, William J. Pitts, Jenny Xie & Alaric J. Dyckman. (2016) Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). Bioorganic & Medicinal Chemistry Letters 26:10, pages 2470-2474.
Crossref
Crossref
Qiong Xiao, Jing Jin, Xiaojian Wang, Jinping Hu, Meiyang Xi, Yulin Tian & Dali Yin. (2016) Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists. Bioorganic & Medicinal Chemistry 24:10, pages 2273-2279.
Crossref
Crossref
Emmanuel H. DemontJames M. BaileyRino A. BitJack A. BrownColin A. CampbellNigel DeeksSimon J. DowellColin EldredPam GaskinJames R. J. GrayAndrea HaynesDavid J. HirstDuncan S. HolmesUmesh KumarMary A. MorseGreg J. OsborneJessica F. RenauxGail A. L. SealChris A. SmethurstSimon TaylorRobert WatsonRobert WillisJason Witherington. (2016)
Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P
3
)-Sparing S1P
1
Agonists Active at Low Oral Doses
. Journal of Medicinal Chemistry 59:3, pages 1003-1020.
Crossref
Crossref
Martin Braddock. 2016. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays
2091
2203
.
Margherita Russo, Claudio Guarneri, Emanuela Mazzon, Edoardo Sessa, Placido Bramanti & Rocco Salvatore Calabrò. (2015) Fingolimod-Associated Peripheral Vascular Adverse Effects. Mayo Clinic Proceedings 90:10, pages 1424-1427.
Crossref
Crossref
Hung-Jen Shih, Jiin-Cherng Yen, Allen W. Chiu, Yung-Chiong Chow, Wynn H.T. Pan, Tao-Yeuan Wang & Chun-Jen Huang. (2015) FTY720 mitigates torsion/detorsion-induced testicular injury in rats. Journal of Surgical Research 196:2, pages 325-331.
Crossref
Crossref
Anna Quattropani, Wolfgang H. B. Sauer, Stefano Crosignani, Jerome Dorbais, Patrick Gerber, Jerome Gonzalez, Delphine Marin, Mathilde Muzerelle, Fanny Beltran, Anthony Nichols, Katrin Georgi, Manfred Schneider, Pierre-Alain Vitte, Valerie Eligert, Laurence Novo-Perez, Jennifer Hantson, Sebastien Nock, Susanna Carboni, Adriano Luis Soares de Souza, Jean-François Arrighi, Ursula Boschert & Agnes Bombrun. (2015) Pharmacophore-Based Design of Novel Oxadiazoles as Selective Sphingosine-1-phosphate (S1P) Receptor Agonists with in vivo Efficacy. ChemMedChem 10:4, pages 688-714.
Crossref
Crossref
Xuyi Yue, Hongjun Jin, Hui Liu, Adam J. Rosenberg, Robyn S. Klein & Zhude Tu. (2015) A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression. Organic & Biomolecular Chemistry 13:29, pages 7928-7939.
Crossref
Crossref
Martin Braddock. 2014. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays
1
131
.
Yulin Tian, Jing Jin, Xiaojian Wang, Jinping Hu, Qiong Xiao, Wanqi Zhou, Xiaoguang Chen & Dali Yin. (2014) Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design. European Journal of Medicinal Chemistry 85, pages 1-15.
Crossref
Crossref
Lucie Aliouane, Sovy Chao, Leyre Brizuela, Emmanuel Pfund, Olivier Cuvillier, Ludovic Jean, Pierre-Yves Renard & Thierry Lequeux. (2014) Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1. Bioorganic & Medicinal Chemistry 22:17, pages 4955-4960.
Crossref
Crossref
Guangwei Liu, Yujing Bi, Ruoning Wang, Hui Yang, Yan Zhang, Xiao Wang, Huanrong Liu, Yun Lu, Zhengguo Zhang, Wanna Chen, Yiwei Chu & Ruifu Yang. (2014) Targeting S1P1 Receptor Protects against Murine Immunological Hepatic Injury through Myeloid-Derived Suppressor Cells. The Journal of Immunology 192:7, pages 3068-3079.
Crossref
Crossref
Martin H. Bolli, Stefan Abele, Magdalena Birker, Roberto Bravo, Daniel Bur, Ruben de Kanter, Christopher Kohl, Julien Grimont, Patrick Hess, Cyrille Lescop, Boris Mathys, Claus Müller, Oliver Nayler, Markus Rey, Michael Scherz, Gunther Schmidt, Jürgen Seifert, Beat Steiner, Jörg Velker & Thomas Weller. (2013)
Novel S1P
1
Receptor Agonists − Part 3: From Thiophenes to Pyridines
. Journal of Medicinal Chemistry 57:1, pages 110-130.
Crossref
Crossref
Martin H. Bolli, Jörg Velker, Claus Müller, Boris Mathys, Magdalena Birker, Roberto Bravo, Daniel Bur, Ruben de Kanter, Patrick Hess, Christopher Kohl, David Lehmann, Solange Meyer, Oliver Nayler, Markus Rey, Michael Scherz & Beat Steiner. (2013)
Novel S1P
1
Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes
. Journal of Medicinal Chemistry 57:1, pages 78-97.
Crossref
Crossref
Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera & Edward Roberts. 2014. Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases. Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
1
21
.
Mariangela Urbano, Miguel Guerrero, Hugh Rosen & Edward Roberts. (2013) Modulators of the Sphingosine 1-phosphate receptor 1. Bioorganic & Medicinal Chemistry Letters 23:23, pages 6377-6389.
Crossref
Crossref
Shunji Shiohira, Takumi Yoshida, Hidekazu Sugiura, Miki Nishida, Kosaku Nitta & Ken Tsuchiya. (2013) Sphingosine-1-phosphate acts as a key molecule in the direct mediation of renal fibrosis. Physiological Reports 1:7, pages e00172.
Crossref
Crossref
Catherine O'Sullivan & Kumlesh K. Dev. (2013) The structure and function of the S1P1 receptor. Trends in Pharmacological Sciences 34:7, pages 401-412.
Crossref
Crossref