Citations (42)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Zhihao Liu, Mingjian Liu, Zhenqing Cao, Pengsen Qiu & Gaopeng Song. (2022) Phosphodiesterase‑4 inhibitors: a review of current developments (2013–2021). Expert Opinion on Therapeutic Patents 32:3, pages 261-278.
Read now
Read now
Fuminori Ohba, Shunji Matsuki, Shuhei Imayama, Kyoko Matsuguma, Seiichiro Hojo, Maiko Nomoto & Hideto Akama. (2016) Efficacy of a novel phosphodiesterase inhibitor, E6005, in patients with atopic dermatitis: An investigator-blinded, vehicle-controlled study. Journal of Dermatological Treatment 27:5, pages 467-472.
Read now
Read now
Fuminori Ohba, Maiko Nomoto, Seiichiro Hojo & Hideto Akama. (2016) Safety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis. Journal of Dermatological Treatment 27:3, pages 241-246.
Read now
Read now
Ana Martinez & Carmen Gil. (2014) cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opinion on Therapeutic Patents 24:12, pages 1311-1321.
Read now
Read now
Maria Gabriella Matera, Clive Page & Mario Cazzola. (2014) PDE inhibitors currently in early clinical trials for the treatment of asthma. Expert Opinion on Investigational Drugs 23:9, pages 1267-1275.
Read now
Read now
Articles from other publishers (37)
Dhritiman Roy, Shivaramakrishnan Balasubramanian, Praveen Thaggikuppe Krishnamurthy, Piyong Sola & Emdormi Rymbai. (2023) Phosphodiesterase-4 Inhibition in Parkinson’s Disease: Molecular Insights and Therapeutic Potential. Cellular and Molecular Neurobiology 43:6, pages 2713-2741.
Crossref
Crossref
Gang Li, Dengqin He, Xiaojia Cai, Wen Guan, Yali Zhang, Jia-Qiang Wu & Hongliang Yao. (2023) Advances in the development of phosphodiesterase-4 inhibitors. European Journal of Medicinal Chemistry 250, pages 115195.
Crossref
Crossref
Aurélie Moniot, Julien Braux, Camille Bour, Christine Guillaume, Fabien Lamret, Ingrid Allart-Simon, Sandra Audonnet, Sarah Renault, Francoise Rédini, Marie Laronze-Cochard, Janos Sapi, Sophie C. Gangloff, Stéphane Gérard & Frédéric Velard. (2021) Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo. Cancers 13:23, pages 5992.
Crossref
Crossref
Xiao-Liu Dong, Yan-Hui Wang, Jing Xu & Nan Zhang. (2021) The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway. Scientific Reports 11:1.
Crossref
Crossref
Hualing Peng, Jingyi Zhang, Amanda Ya, Winston Ma, Sammy Villa, Shahar Sukenik & Xuecai Ge. (2021) Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome. Molecular Biology of the Cell 32:19, pages 1807-1817.
Crossref
Crossref
Sung-Jun Park, Faiyaz Ahmad, Robert J. Bahde, Andrew Philp, Jeonghan Kim, Tianjiao Huang, Myung K. Kim, William C. Trenkle & Jay H. Chung. (2021) Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis. PLOS ONE 16:6, pages e0253269.
Crossref
Crossref
Ingrid Allart-Simon, Aurélie Moniot, Nicolo Bisi, Miguel Ponce-Vargas, Sandra Audonnet, Marie Laronze-Cochard, Janos Sapi, Eric Hénon, Frédéric Velard & Stéphane Gérard. (2021) Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors. RSC Medicinal Chemistry 12:4, pages 584-592.
Crossref
Crossref
Rui Zhang, Heng Li, Xianglei Zhang, Jian Li, Haixia Su, Qiukai Lu, Guangyu Dong, Huixia Dou, Chen Fan, Zhanni Gu, Qianwen Mu, Wei Tang, Yechun Xu & Hong Liu. (2021) Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment. European Journal of Medicinal Chemistry 211, pages 113004.
Crossref
Crossref
Heng Li, Jianping Zuo & Wei Tang. (2018) Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Pharmacology 9.
Crossref
Crossref
Richard S. Roberts, Sara Sevilla, Manel Ferrer, Joan Taltavull, Begoña Hernández, Victor Segarra, Jordi Gràcia, Martin D. Lehner, Amadeu Gavaldà, Miriam Andrés, Judit Cabedo, Dolors Vilella, Peter Eichhorn, Elena Calama, Carla Carcasona & Montserrat Miralpeix. (2018)
4-Amino-7,8-dihydro-1,6-naphthyridin-5(6
H
)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure–Activity Relationships
. Journal of Medicinal Chemistry 61:6, pages 2472-2489.
Crossref
Crossref
V. Cenacchi, M. Salvadori, B. Riccardi, G. Brogin, A. Ghiglieri, M. Messina, G. Imre & P. Puccini. (2018) Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001. European Journal of Pharmaceutical Sciences 115, pages 100-108.
Crossref
Crossref
Chantal Barberot, Aurélie Moniot, Ingrid Allart-Simon, Laurette Malleret, Tatiana Yegorova, Marie Laronze-Cochard, Abderrazzaq Bentaher, Maurice Médebielle, Jean-Philippe Bouillon, Eric Hénon, Janos Sapi, Frédéric Velard & Stéphane Gérard. (2018) Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents. European Journal of Medicinal Chemistry 146, pages 139-146.
Crossref
Crossref
Valentin S. Dorokhov, Ivan S. Golovanov, Vladimir A. Tartakovsky, Alexey Yu. Sukhorukov & Sema L. Ioffe. (2018) Diastereoselective synthesis and profiling of bicyclic imidazolidinone derivatives bearing a difluoromethylated catechol unit as potent phosphodiesterase 4 inhibitors. Organic & Biomolecular Chemistry 16:38, pages 6900-6908.
Crossref
Crossref
Ana Santos de Medeiros, Arlene R. Wyman, Manal A. Alaamery, Christina Allain, F. Douglas Ivey, Lili Wang, Hai Le, James P. Morken, Alawi Habara, Cuong Le, Shuaiying Cui, Adam Lerner & Charles S. Hoffman. (2017) Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays. Cellular Signalling 40, pages 73-80.
Crossref
Crossref
Faraat Ali, Robin Kumar, Puran Lal Sahu & Gyanendra Nath Singh. (2017) Physicochemical characterization and compatibility study of roflumilast with various pharmaceutical excipients. Journal of Thermal Analysis and Calorimetry 130:3, pages 1627-1641.
Crossref
Crossref
Lennart M. Roesner, Petra Kienlin, Gabriele Begemann, Oliver Dittrich-Breiholz & Thomas Werfel. (2017) Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment. Journal of Allergy and Clinical Immunology 140:4, pages 1184-1187.e8.
Crossref
Crossref
Futoshi Hasegawa, Kazushi Kawamura, Hiroshi Tsuchikawa & Michio Murata. (2017) Stable C–N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor. Bioorganic & Medicinal Chemistry 25:16, pages 4506-4511.
Crossref
Crossref
Sara Guariento, Anna Karawajczyk, James A. Bull, Gessica Marchini, Martyna Bielska, Xenia Iwanowa, Olga Bruno, Paola Fossa & Fabrizio Giordanetto. (2017) Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors. Bioorganic & Medicinal Chemistry Letters 27:1, pages 24-29.
Crossref
Crossref
Graeme B. Bolger. 2017. Phosphodiesterases: CNS Functions and Diseases. Phosphodiesterases: CNS Functions and Diseases
63
102
.
Jan-Philip Schülke & Nicholas J. Brandon. 2017. Phosphodiesterases: CNS Functions and Diseases. Phosphodiesterases: CNS Functions and Diseases
15
43
.
Jordi Gràcia, Maria Antonia Buil, Jordi Castro, Peter Eichhorn, Manel Ferrer, Amadeu Gavaldà, Begoña Hernández, Victor Segarra, Martin D. Lehner, Imma Moreno, Lluís Pagès, Richard S. Roberts, Jordi Serrat, Sara Sevilla, Joan Taltavull, Miriam Andrés, Judit Cabedo, Dolors Vilella, Elena Calama, Carla Carcasona & Montserrat Miralpeix. (2016) Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure–Activity Relationships. Journal of Medicinal Chemistry 59:23, pages 10479-10497.
Crossref
Crossref
Zhong-Zhen Zhou, Bing-Chen Ge, Qiu-Ping Zhong, Chang Huang, Yu-Fang Cheng, Xue-Mei Yang, Hai-Tao Wang & Jiang-Ping Xu. (2016) Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. European Journal of Medicinal Chemistry 124, pages 372-379.
Crossref
Crossref
Ying-Hong Cai, Yanqiong Guo, Zhe Li, Deyang Wu, Xiruo Li, Heng Zhang, Junjie Yang, Heng Lu, Zhaowei Sun, Hai-Bin Luo, Sheng Yin & Yinuo Wu. (2016) Discovery and modelling studies of natural ingredients from Gaultheria yunnanensi s (FRANCH.) against phosphodiesterase-4. European Journal of Medicinal Chemistry 114, pages 134-140.
Crossref
Crossref
Zhong-Zhen Zhou, Bing-Chen Ge, Yu-Fang Chen, Xiu-Dong Shi, Xue-Mei Yang & Jiang-Ping Xu. (2015) Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure–activity relationships. Bioorganic & Medicinal Chemistry 23:22, pages 7332-7339.
Crossref
Crossref
Xuecai Ge, Ljiljana Milenkovic, Kaye Suyama, Tom Hartl, Teresa Purzner, Amy Winans, Tobias Meyer & Matthew P Scott. (2015) Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma. eLife 4.
Crossref
Crossref
Yuji Mano, Takuho Ishii, Koichiro Hotta & Kazutomi Kusano. (2015) Validation of a UPLC–MS/MS method for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human plasma. Journal of Chromatography B 998-999, pages 31-39.
Crossref
Crossref
Tonny Studsgaard Petersen, Martin Stahlhut & Claus Yding Andersen. (2015) Phosphodiesterases in the rat ovary: effect of cAMP in primordial follicles. REPRODUCTION 150:1, pages 11-20.
Crossref
Crossref
Ya. D. Boyko, A. Yu. Sukhorukov, S. L. Ioffe & V. A. Tartakovsky. (2016) Advances in the synthesis of 7-(3-cyclopentyloxy-4-methoxyphenyl)-hexahydro-3H-pyrrolizin-3-one (Pyrromilast)–a promising agent for treatment of chronic obstructive pulmonary disease. Russian Chemical Bulletin 64:6, pages 1240-1248.
Crossref
Crossref
Sanghapal D. Sawant, G. Lakshma Reddy, Mohd Ishaq Dar, M. Srinivas, Gourav Gupta, Promod Kumar Sahu, Priya Mahajan, Amit Nargotra, Surjeet Singh, Subhash C. Sharma, Manoj Tikoo, Gurdarshan Singh, Ram A. Vishwakarma & Sajad Hussain Syed. (2015) Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5. Bioorganic & Medicinal Chemistry 23:9, pages 2121-2128.
Crossref
Crossref
JINGWU LIAO, JINGMING XIE, DAQIANG LIN, NING LU, LIMIN GUO, WEIQIANG LI, BO PU, YANG YANG, ZHENLONG YANG, YING ZHANG & YUEMING SONG. (2014) Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats. Molecular Medicine Reports 10:3, pages 1225-1230.
Crossref
Crossref
Sandro Boland, Jo Alen, Arnaud Bourin, Karolien Castermans, Nicki Boumans, Laura Panitti, Jessica Vanormelingen, Dirk Leysen & Olivier Defert. (2014) Novel Roflumilast analogs as soft PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters 24:18, pages 4594-4597.
Crossref
Crossref
Zhong-Bin Cheng, Ya-Lin Deng, Cheng-Qi Fan, Qing-Hua Han, Shu-Ling Lin, Gui-Hua Tang, Hai-Bin Luo & Sheng Yin. (2014)
Prostaglandin Derivatives: Nonaromatic Phosphodiesterase-4 Inhibitors from the Soft Coral
Sarcophyton ehrenbergi
. Journal of Natural Products 77:8, pages 1928-1936.
Crossref
Crossref
Henry Insuasty, Edinson Castro, Juan C Escobar, Vanesa Murillo, Jeanette Rodriguez, Luis Cuca, Martin Estrada, Braulio Insuasty & Mario Guerrero. (2014) Assessment of the anticonvulsant activity of pyrazolo[1,5-a][1,3,5]triazines obtained by synthesis. Revista Colombiana de Ciencias Químico-Farmacéuticas 43:1, pages 22-38.
Crossref
Crossref
Tarek S. Belal, Hytham M. Ahmed, Mohamed S. Mahrous, Hoda G. Daabees & Mostafa M. Baker. (2014) Validated stability-indicating HPLC-DAD method for determination of the phosphodiesterase (PDE-4) inhibitor roflumilast. Bulletin of Faculty of Pharmacy, Cairo University 52:1, pages 79-89.
Crossref
Crossref
Susanne C. Feil, Jessica K. Holien, Craig J. Morton, Nancy C. Hancock, Philip E. Thompson & Michael W. Parker. (2014) Discovery of Phosphodiesterase-4 Inhibitors: Serendipity and Rational Drug Design. Australian Journal of Chemistry 67:12, pages 1780.
Crossref
Crossref
Manel Ferrer, Richard S. Roberts & Sara Sevilla. (2013) A modular synthesis of novel 4-amino-7,8-dihydro-1,6-naphthyridin-5(6H)-ones as PDE4 inhibitors. Tetrahedron Letters 54:36, pages 4821-4825.
Crossref
Crossref
Petr A. Zhmurov, Alexey Yu. Sukhorukov, Vladimir I. Chupakhin, Yulia V. Khomutova, Sema L. Ioffe & Vladimir A. Tartakovsky. (2013) Synthesis of PDE IV inhibitors. First asymmetric synthesis of two of GlaxoSmithKline's highly potent Rolipram analogues. Organic & Biomolecular Chemistry 11:46, pages 8082.
Crossref
Crossref