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Therapeutic uses of furin and its inhibitors: a patent review

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Dhiman Chandra Paul, Minakshi Bhattacharjee, Dhani Ram Mahato & Manash Pratim Sarma. (2023) Natural furin inhibitor(s) as potent therapeutic molecule to mitigate SARS-CoV-2 infection. Journal of Biomolecular Structure and Dynamics 41:15, pages 7365-7371.
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Articles from other publishers (63)

Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz & Gisa Gerold. (2023) Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses. Journal of Medical Virology 95:11.
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Shanping Ji & Steven H. L. Verhelst. (2023) Furin-targeting activity-based probes with phosphonate and phosphinate esters as warheads. Organic & Biomolecular Chemistry 21:32, pages 6498-6502.
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Lisa E.J. Douglas, James A. Reihill, Bethany M. Montgomery & S. Lorraine Martin. (2023) Furin as a therapeutic target in cystic fibrosis airways disease. European Respiratory Review 32:168, pages 220256.
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Wei Yang, Junjun Cao, David G. McVey & Shu Ye. (2023) Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus. Cells 12:13, pages 1681.
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Agata Gitlin-Domagalska, Dawid Dębowski, Aleksandra Maciejewska, Sergey Samsonov, Martyna Maszota-Zieleniak, Natalia Ptaszyńska, Anna Łęgowska & Krzysztof Rolka. (2023) Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry. ACS Medicinal Chemistry Letters 14:4, pages 458-465.
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Dongyan Feng, Le Ren, Jiaqi Wu, Lingling Guo, Zhitao Han, Jingjing Yang, Wei Xie, Yanbing Wang, Fanxing Xu, Xin Su, Dahong Li & Hao Cao. (2023) Permethrin as a Potential Furin Inhibitor through a Novel Non-Competitive Allosteric Inhibition. Molecules 28:4, pages 1883.
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Li Ni, Pin Li, Mingming Li, Shuhong Huang & Ningning Dang. (2022) SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells . Experimental Dermatology 32:1, pages 24-29.
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Laila Rahmah, Sunny O. Abarikwu, Amanuel Godana Arero, Mickael Essouma, Aliyu Tijani Jibril, Andrzej Fal, Robert Flisiak, Rangarirai Makuku, Leander Marquez, Kawthar Mohamed, Lamin Ndow, Dorota Zarębska-Michaluk, Nima Rezaei & Piotr Rzymski. (2022) Oral antiviral treatments for COVID-19: opportunities and challenges. Pharmacological Reports 74:6, pages 1255-1278.
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Zhanfeng Liang, Zhaoqi Zhang, Qian Zhang, Xue Dong, Xiaofeng Yang, Jiayu Zhang, Tong Lei, John W.M. Creemers, Baojun Zhang & Yong Zhao. (2022) The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance. iScience 25:10, pages 105233.
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Shailendra Pratap Singh, Aayushi Bhatnagar, Sujeet Kumar Singh, Sanjib K. Patra, Navjot Kanwar, Abhinav Kanwal, Salomon Amar & Ranata Manna. (2022) SARS-CoV-2 Infections, Impaired Tissue, and Metabolic Health: Pathophysiology and Potential Therapeutics. Mini-Reviews in Medicinal Chemistry 22:16, pages 2102-2123.
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Ahmed M. Abu El‐Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mohammad M. Siddiquei, Eef Allegaert, Priscilla W. Gikandi, Gert De Hertogh & Ghislain Opdenakker. (2022) Proprotein convertase furin is a driver and potential therapeutic target in proliferative diabetic retinopathy. Clinical & Experimental Ophthalmology 50:6, pages 632-652.
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Arijit Ghosh, Paritosh K. Kar, Anupam Gautam, Rahul Gupta, Rajveer Singh, Rudra Chakravarti, Velayutham Ravichandiran, Shubhra Ghosh Dastidar, Dipanjan Ghosh & Syamal Roy. (2022) An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives. RSC Medicinal Chemistry 13:6, pages 647-675.
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Digant Nayak, Elizabeth V. Wasmuth & Shaun K. Olsen. (2022) Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy. Cell Chemical Biology 29:6, pages 927-929.
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Lisa E.J. Douglas, James A. Reihill, Melisa W.Y. Ho, Jeffrey M. Axten, Nino Campobasso, Jessica L. Schneck, Alan R. Rendina, Keith M. Wilcoxen & S. Lorraine Martin. (2022) A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease. Cell Chemical Biology 29:6, pages 947-957.e8.
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Maryam Kianpour, Mohsen Akbarian & Vladimir N. Uversky. (2022) Nanoparticles for Coronavirus Control. Nanomaterials 12:9, pages 1602.
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Gary Thomas, Frédéric Couture & Anna Kwiatkowska. (2022) The Path to Therapeutic Furin Inhibitors: From Yeast Pheromones to SARS-CoV-2. International Journal of Molecular Sciences 23:7, pages 3435.
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Zongsheng He, Abdel-Majid Khatib & John W. M. Creemers. (2022) The proprotein convertase furin in cancer: more than an oncogene. Oncogene 41:9, pages 1252-1262.
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Essam Eldin A. Osman, Alnawaz Rehemtulla & Nouri Neamati. (2021) Why All the Fury over Furin?. Journal of Medicinal Chemistry 65:4, pages 2747-2784.
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Manica Negahdaripour, Mohammad Reza Rahbar, Zahra Mosalanejad & Ahmad Gholami. (2022) Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design. Computational and Mathematical Methods in Medicine 2022, pages 1-15.
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Yuka Kiba, Rio Oyama, Sae Misawa, Takashi Tanikawa, Masashi Kitamura & Ryuichiro Suzuki. (2021) Screening for inhibitory effects of crude drugs on furin-like enzymatic activities. Journal of Natural Medicines 75:4, pages 1080-1085.
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Adam W. Akerman, Elizabeth N. Collins, Andrew R. Peterson, Lauren B. Collins, Jessica K. Harrison, Amari DeVaughn, Jaleel M. Townsend, Rebecca L. Vanbuskirk, Jessica Riopedre‐Maqueira, Ailet Reyes, Joyce E. Oh, Charles M. Raybuck, Jeffrey A. Jones & John S. Ikonomidis. (2021) miR‐133a Replacement Attenuates Thoracic Aortic Aneurysm in Mice. Journal of the American Heart Association 10:16.
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Zahra Sheybani, Maryam Heydari Dokoohaki, Manica Negahdaripour, Mehdi Dehdashti, Hassan Zolghadr, Mohsen Moghadami, Seyed Masoom Masoompour & Amin Reza Zolghadr. (2021) The interactions of folate with the enzyme furin: a computational study. RSC Advances 11:38, pages 23815-23824.
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Yidi Wu, Youliang Huang, Wenwu Zhang & Susan J. Gunst. (2021) The proprotein convertase furin inhibits IL-13-induced inflammation in airway smooth muscle by regulating integrin-associated signaling complexes. American Journal of Physiology-Lung Cellular and Molecular Physiology 321:1, pages L102-L115.
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N.R. Jena. (2021) Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2. Chemical Physics Impact 2, pages 100011.
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Manita Shakya & Iris Lindberg. (2021) Mouse Models of Human Proprotein Convertase Insufficiency. Endocrine Reviews 42:3, pages 259-294.
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Dengke Tian, Yuzhi Liu, Chengyuan Liang, Liang Xin, Xiaolin Xie, Dezhu Zhang, Minge Wan, Han Li, Xueqi Fu, Hong Liu & Wenqiang Cao. (2021) An update review of emerging small-molecule therapeutic options for COVID-19. Biomedicine & Pharmacotherapy 137, pages 111313.
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Areej M. AssafRanda N. HaddadinAmal A. Akour. (2021) COVID-19: Between Past and Present. Viral Immunology 34:3, pages 145-157.
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Monika A. Lewandowska-Goch, Anna Kwiatkowska, Teresa Łepek, Kévin Ly, Pauline Navals, Hugo Gagnon, Yves L. Dory, Adam Prahl & Robert Day. (2021) Design and Structure–Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin. ACS Medicinal Chemistry Letters 12:3, pages 365-372.
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Zsuzsanna Ortutay, Anna Grönholm, Melina Laitinen, Melinda Keresztes-Andrei, Ismail Hermelo & Marko Pesu. (2021) Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells. Frontiers in Immunology 12.
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Mahamudul Haque, Ruby J Siegel, David A Fox & Salahuddin Ahmed. (2021) Interferon-stimulated GTPases in autoimmune and inflammatory diseases: promising role for the guanylate-binding protein (GBP) family. Rheumatology 60:2, pages 494-506.
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Rhea Conchita Gonsalves, Himavani Pacharla, Sai Manohar, Siva Kumar Belliraj, Ekta Tripathi, Prashanthi Karyala & Suresh B. Pakala. 2021. Pandemic Outbreaks in the 21st Century. Pandemic Outbreaks in the 21st Century 185 210 .
Marcel Alexander Heinrich, Byron Martina & Jai Prakash. (2020) Nanomedicine strategies to target coronavirus. Nano Today 35, pages 100961.
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Magda Gioia, Chiara Ciaccio, Paolo Calligari, Giovanna De Simone, Diego Sbardella, Grazia Tundo, Giovanni Francesco Fasciglione, Alessandra Di Masi, Donato Di Pierro, Alessio Bocedi, Paolo Ascenzi & Massimo Coletta. (2020) Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches. Biochemical Pharmacology 182, pages 114225.
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Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E. Campillo & Ana Martinez. (2020) COVID-19: Drug Targets and Potential Treatments. Journal of Medicinal Chemistry 63:21, pages 12359-12386.
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Qiongqiong Angela Zhou, Junko Kato-Weinstein, Yingzhu Li, Yi Deng, Roger Granet, Linda Garner, Cynthia Liu, Dmitrii Polshakov, Chris Gessner & Steven Watkins. (2020) Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections. ACS Pharmacology & Translational Science 3:5, pages 813-834.
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Prasenjit Mitra. (2020) Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection. American Journal of Physiology-Cell Physiology 319:3, pages C500-C509.
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Naveen Vankadari. (2020) Structure of Furin Protease Binding to SARS-CoV-2 Spike Glycoprotein and Implications for Potential Targets and Virulence. The Journal of Physical Chemistry Letters 11:16, pages 6655-6663.
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Zongsheng He, Abdel-Majid Khatib & John W.M. Creemers. (2020) Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer. Cancer Letters 484, pages 40-49.
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Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin & Maurizio Pellecchia. (2020) Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming. Molecules 25:10, pages 2424.
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Zongsheng He, Lieven Thorrez, Geraldine Siegfried, Sandra Meulemans, Serge Evrard, Sabine Tejpar, Abdel-Majid Khatib & John W. M. Creemers. (2020) The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer. Oncogene 39:17, pages 3571-3587.
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Diana Farhat, Sophie Léon, Sandra E. Ghayad, Nicolas Gadot, Philippe Icard, Muriel Le Romancer, Nader Hussein & Hubert Lincet. (2020) Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation. British Journal of Cancer 122:6, pages 885-894.
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Geraldine Siegfried, Jean Descarpentrie, Serge Evrard & Abdel-Majid Khatib. (2020) Proprotein convertases: Key players in inflammation-related malignancies and metastasis. Cancer Letters 473, pages 50-61.
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Karin Löw, Kornelia Hardes, Chiara Fedeli, Nabil G. Seidah, Daniel B. Constam, Antonella Pasquato, Torsten Steinmetzer, Alexandre Roulin & Stefan Kunz. (2019) A novel cell‐based sensor detecting the activity of individual basic proprotein convertases. The FEBS Journal 286:22, pages 4597-4620.
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Imran, Saleemi, Chen, Wang, Zhou, Li, Zhao, Zheng, Li, Cao & Ye. (2019) Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses 11:11, pages 1011.
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T. V. Osadchuk, V. K. Kibirev & O. V. Shybyryn. (2019) 1,3-Oxazol-4-ylphosphonium salts as new non-peptide inhibitors of furin. The Ukrainian Biochemical Journal 91:4, pages 5-16.
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Kenneth H. Pearce, Laurie K. Overton, Robert T. Gampe, George B. Barrett, J. David Taylor, David D. McKee, Nino Campobasso, Robert T. Nolte & Robert A. Reid. (2019) BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution. Acta Crystallographica Section F Structural Biology Communications 75:4, pages 239-245.
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Elisabeth Braun & Daniel Sauter. (2019) Furin‐mediated protein processing in infectious diseases and cancer. Clinical & Translational Immunology 8:8.
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