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Expert Opinion on Therapeutic Patents Volume 24, 2014 - Issue 1
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An update on recent patents on thrombin inhibitors (2010 – 2013)

Akul Y MehtaVirginia Commonwealth University, Institute for Structural Biology and Drug Discovery, Department of Medicinal Chemistry, 800 East Leigh Street, Suite 212, PO Box 980133, Richmond, VA 23219, USA+1 804 828 7328; +1 804 827 3664; [email protected]
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Yingzi JinVirginia Commonwealth University, Institute for Structural Biology and Drug Discovery, Department of Medicinal Chemistry, 800 East Leigh Street, Suite 212, PO Box 980133, Richmond, VA 23219, USA+1 804 828 7328; +1 804 827 3664; [email protected]
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Umesh R DesaiVirginia Commonwealth University, Institute for Structural Biology and Drug Discovery, Department of Medicinal Chemistry, 800 East Leigh Street, Suite 212, PO Box 980133, Richmond, VA 23219, USA+1 804 828 7328; +1 804 827 3664; [email protected]
Pages 47-67 | Published online: 08 Oct 2013

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Zhi-Hao Shi, Nian-Guang Li, Yu-Ping Tang & Jin-Ao Duan. (2014) Prolinamide derivatives as thrombin inhibitors for the treatment of thrombin-mediated diseases: a patent evaluation of US2013296245. Expert Opinion on Therapeutic Patents 24:10, pages 1139-1148.
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Articles from other publishers (13)

Jiangming Wang, Xiaojing Sun, Na Li, Ruilong Sheng & Ruihua Guo. (2023) An Overview of Thrombin Inhibitors in the Perspective of Structureactivity Relationships. Current Medicinal Chemistry 30:25, pages 2864-2930.
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Uttam Ghosh, Vikash Kumar, Gajendra Singh & Tushar Kanti Chakraborty. (2023) Conformation Based in silico Studies of Cyclic Tetrapeptides with βγ Fused Turns as Thrombin Inhibitors. ChemistrySelect 8:11.
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Andréa Patrícia da Silva Pomposo Bastos, Patrícia Gomes Cardoso, Ítalo Augusto Férrer Melo Santos, Marcus Vinicius Cardoso Trento, Laura Cristina Jardim Porto & Silvana Marcussi. (2020) Enzymatic Modulators from Induratia spp.. Current Microbiology 77:11, pages 3603-3611.
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Anabella Origone, Grisel Bersi, Andrés Illanes, Héctor Sturniolo, Constanza Liggieri, Fanny Guzmán & Sonia Barberis. (2018) Enzymatic and chemical synthesis of new anticoagulant peptides. Biotechnology Progress 34:5, pages 1093-1101.
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Emmanuel Pérez-Escalante, Judith Jaimez-Ordaz, Araceli Castañeda-Ovando, Elizabeth Contreras-López, Javier Añorve-Morga & Luis Guillermo González-Olivares. (2018) Antithrombotic Activity of Milk Protein Hydrolysates by Lactic Acid Bacteria Isolated from Commercial Fermented Milks. Brazilian Archives of Biology and Technology 61.
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Pei-Xin Lai, Ju-Yi Mao, Binesh Unnikrishnan, Han-Wei Chu, Chien-Wei Wu, Huan-Tsung Chang & Chih-Ching Huang. (2018) Self-assembled, bivalent aptamers on graphene oxide as an efficient anticoagulant. Biomaterials Science 6:7, pages 1882-1891.
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Rupamoni Thakur & Ashis K. Mukherjee. (2017) Pathophysiological significance and therapeutic applications of snake venom protease inhibitors. Toxicon 131, pages 37-47.
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Nader N. Nasief, Ahmed M. Said & David Hangauer. (2017) Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation. European Journal of Medicinal Chemistry 125, pages 975-991.
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Yi Tao, Yanhui Jiang, Weidong Li & Baochang Cai. (2016) Rapid magnetic solid-phase extraction combined with ultra-high performance liquid chromatography and quadrupole-time-of-flight mass spectrometry for analysis of thrombin binders from a crude extract and injection of Erigeron breviscapus. RSC Advances 6:41, pages 34782-34790.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 383 412 .
Li-Wei He, Wei-Chen Dai & Nian-Guang Li. (2015) Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder Diseases. Molecules 20:6, pages 11046-11062.
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Rupamoni Thakur, Ashok Kumar, Biplab Bose, Dulal Panda, Debashree Saikia, Pronobesh Chattopadhyay & Ashis K. Mukherjee. (2014) A new peptide (Ruviprase) purified from the venom of Daboia russelii russelii shows potent anticoagulant activity via non-enzymatic inhibition of thrombin and factor Xa. Biochimie 105, pages 149-158.
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Yi-Heng So, Huan-Tsung Chang, Wei-Jane Chiu & Chih-Ching Huang. (2014) Graphene oxide modified with aptamer-conjugated gold nanoparticles and heparin: a potent targeted anticoagulant. Biomater. Sci. 2:10, pages 1332-1337.
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