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Nitric oxide synthase inhibitors: a review of patents from 2011 to the present

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Ricardo A. M. Serafim, Filipe G. Pernichelle & Elizabeth I. Ferreira. (2017) The latest advances in the discovery of nitric oxide hybrid drug compounds. Expert Opinion on Drug Discovery 12:9, pages 941-953.
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Binxiang Tang, Junhao Tu, Meiping Zhang, Zhiqiang Zhang, Jieqing Yu, Li Shen, Qing Luo & Jing Ye. (2023) Diagnostic value and underlying mechanism of nasal nitric oxide in eosinophilic chronic rhinosinusitis with nasal polyps. Molecular Immunology 159, pages 1-14.
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M. M. Galagudza, Yu. P. Belsky & N. N. Belsky. (2023) Inducible NO synthase as a pharmacological target of anti-inflammatory therapy: hope is not lost?. The Siberian Journal of Clinical and Experimental Medicine 38:1, pages 13-20.
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Roghayeh Heiran, Aliasghar Jarrahpour, Elham Riazimontazer, Ahmad Gholami, Azza Troudi, Carole Digiorgio, Jean Michel Brunel & Edward Turos. (2021) Sulfonamide‐β‐lactam Hybrids Incorporating the Piperazine Moiety as Potential Antiinflammatory Agent with Promising Antibacterial Activity. ChemistrySelect 6:21, pages 5313-5319.
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Han-Yan Zhu, Fen-Fang Hong & Shu-Long Yang. (2021) The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches. International Journal of Molecular Sciences 22:9, pages 4540.
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Daniele Santi, Giorgia Spaggiari, Carla Greco, Clara Lazzaretti, Elia Paradiso, Livio Casarini, Francesco Potì, Giulia Brigante & Manuela Simoni. (2021) The “Hitchhiker’s Guide to the Galaxy” of Endothelial Dysfunction Markers in Human Fertility. International Journal of Molecular Sciences 22:5, pages 2584.
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Ying Dong, Xiao-Rong Li, Jia Li, Yi Zang & Xin Li. (2020) Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system. Journal of Pharmaceutical Analysis 10:5, pages 466-472.
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Roghayeh Heiran, Saghi Sepehri, Aliasghar Jarrahpour, Carole Digiorgio, Hana Douafer, Jean Michel Brunel, Ahmad Gholami, Elham Riazimontazer & Edward Turos. (2020) Synthesis, docking and evaluation of in vitro anti-inflammatory activity of novel morpholine capped β-lactam derivatives. Bioorganic Chemistry 102, pages 104091.
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Richa Minhas, Yogita Bansal & Gulshan Bansal. (2019) Inducible nitric oxide synthase inhibitors: A comprehensive update. Medicinal Research Reviews 40:3, pages 823-855.
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Maris A. Cinelli, Ha T. Do, Galen P. Miley & Richard B. Silverman. (2019) Inducible nitric oxide synthase: Regulation, structure, and inhibition. Medicinal Research Reviews 40:1, pages 158-189.
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Yujie Guo, Renjie Fu, Yin Qian, Zhenzhen Zhou, Haichun Liu, Jin Qi, Boli Zhang & Boyang Yu. (2019) Comprehensive screening and identification of natural inducible nitric oxide synthase inhibitors from Radix Ophiopogonis by off-line multi-hyphenated analyses. Journal of Chromatography A 1592, pages 55-63.
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Maryam Hezavehei, Homa Mohseni Kouchesfahani, Abdolhossein Shahverdi, Mohsen Sharafi, Ghasem Hosseini Salekdeh & Poopak Eftekhari-Yazdi. (2019) Preconditioning of sperm with sublethal nitrosative stress: a novel approach to improve frozen–thawed sperm function. Reproductive BioMedicine Online 38:3, pages 413-425.
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Yanfeng Gao, Shuang Zhou, Yi Xu, Sen Sheng, Steven Y. Qian & Xiongwei Huo. (2019) Nitric oxide synthase inhibitors 1400W and L-NIO inhibit angiogenesis pathway of colorectal cancer. Nitric Oxide 83, pages 33-39.
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Arramshetti Venkanna, Kyo Hee Cho, Lama Prema Dhorma, Duddukuri Nandan Kumar, Jung Mi Hah, Hyeung-geun Park, Sun Yeou Kim & Mi-hyun Kim. (2019) Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone. European Journal of Medicinal Chemistry 163, pages 453-480.
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Daniel Perez Vieira, Andrés Jimenez Galisteo Jr.Heitor Franco De Andrade Jr.. (2019) Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation. Brazilian Journal of Radiation Sciences 7:1.
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Qing-Qing Wu, Yang Xiao, Ming-Xia Duan, Yuan Yuan, Xiao-Han Jiang, Zheng Yang, Hai-Han Liao, Wei Deng & Qi-Zhu Tang. (2018) Aucubin protects against pressure overload-induced cardiac remodelling via the β 3 -adrenoceptor-neuronal NOS cascades . British Journal of Pharmacology 175:9, pages 1548-1566.
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Cristina Maccallini, Mauro Di Matteo, Marialucia Gallorini, Monica Montagnani, Valentina Graziani, Alessandra Ammazzalorso, Pasquale Amoia, Barbara De Filippis, Sara Di Silvestre, Marialuigia Fantacuzzi, Letizia Giampietro, Maria A. Potenza, Nazzareno Re, Assunta Pandolfi, Amelia Cataldi & Rosa Amoroso. (2018) Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma. European Journal of Medicinal Chemistry 152, pages 53-64.
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Sang Yun Han, Young-Su Yi, Seong-Gu Jeong, Yo Han Hong, Kang Jun Choi, Mohammad Amjad Hossain, Hyunsik Hwang, Ho Sik Rho, Jongsung Lee, Jong-Hoon Kim & Jae Youl Cho. (2018) Ethanol Extract of Lilium Bulbs Plays an Anti-Inflammatory Role by Targeting the IKKα/β-Mediated NF-κB Pathway in Macrophages . The American Journal of Chinese Medicine 46:06, pages 1281-1296.
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Ji-Young An, Hwi-Ho Lee, Ji-Sun Shin, Hyung-Seok Yoo, Jong Seon Park, Seung Hwan Son, Sang Won Kim, Jihyun Yu, Jun Lee, Kyung-Tae Lee & Nam-Jung Kim. (2017) Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE 2 in LPS-induced RAW 264.7 cells. Bioorganic & Medicinal Chemistry Letters 27:11, pages 2613-2616.
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J. Chang, F. Pan, Q. Tang, W. Wu, M. Chen, C. Lu, H. Ding, L. Hu, D. Chen, Y. Xia & X. Wang. (2017) eNOS gene T786C , G894T and 4a4b polymorphisms and male infertility susceptibility: a meta-analysis . Andrologia 49:4, pages e12646.
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Christian Drerup, Johannes Ermert & Heinz Coenen. (2016) Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added 18F-Labelling Methods. Molecules 21:9, pages 1160.
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Eunji Kim, Young-Jin Son, Yanyan Yang, Ting Shen, Ikyon Kim, Adithan Aravinthan, Jong-Hoon Kim & Jae Cho. (2016) 1-(2,3-Dibenzimidazol-2-ylpropyl)-2-methoxybenzene Is a Syk Inhibitor with Anti-Inflammatory Properties. Molecules 21:4, pages 508.
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Michel Félétou. (2016) Discovery of Nitric Oxide and Translation to Clinical Application. Physiology 31:2, pages 76-77.
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Puebla Cassini-Vieira, Fernanda Assis Araújo, Filipi Leles da Costa Dias, Remo Castro Russo, Silvia Passos Andrade, Mauro Martins Teixeira & Luciola Silva Barcelos. (2015) iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants. Mediators of Inflammation 2015, pages 1-9.
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