795
Views
35
CrossRef citations to date
0
Altmetric
Review

An updated patent review of calpain inhibitors (2012 – 2014)

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Isaac O. Donkor. (2020) An update on the therapeutic potential of calpain inhibitors: a patent review. Expert Opinion on Therapeutic Patents 30:9, pages 659-675.
Read now
Levente Endre Dókus, Mo’ath Yousef & Zoltán Bánóczi. (2020) Modulators of calpain activity: inhibitors and activators as potential drugs. Expert Opinion on Drug Discovery 15:4, pages 471-486.
Read now

Articles from other publishers (33)

Michel Baudry, Yun Lyna Luo & Xiaoning Bi. (2023) Calpain-2 Inhibitors as Therapy for Traumatic Brain Injury. Neurotherapeutics 20:6, pages 1592-1602.
Crossref
Jameel Inal, Ainura Paizuldaeva & Esmeralda Terziu. (2022) Therapeutic use of calpeptin in COVID-19 infection. Clinical Science 136:20, pages 1439-1447.
Crossref
Reetu Reetu, Raghuram Gujjarappa & Chandi C. Malakar. (2022) Recent Advances in Synthesis and Medicinal Evaluation of 1,2‐Benzothiazine Analogues. Asian Journal of Organic Chemistry 11:8.
Crossref
Marta H. Branquinha, Pedro S. S. Araújo, Simone S. C. Oliveira, Leandro S. Sangenito, Diego S. Gonçalves, Sérgio H. Seabra, Claudia M. d’Avila-Levy & André L. S. Santos. (2022) Antileishmanial Efficacy of the Calpain Inhibitor MDL28170 in Combination with Amphotericin B. Tropical Medicine and Infectious Disease 7:2, pages 29.
Crossref
Sashidar Bandaru, Chandu Ala, Alex-Xianghua Zhou & Levent M. Akyürek. (2021) Filamin A Regulates Cardiovascular Remodeling. International Journal of Molecular Sciences 22:12, pages 6555.
Crossref
Simone Spinozzi, Sonia Albini, Heather Best & Isabelle Richard. (2021) Calpains for dummies: What you need to know about the calpain family. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1869:5, pages 140616.
Crossref
Elena Britti, Fabien Delaspre, Jordi Tamarit & Joaquim Ros. (2020) Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis. Neurochemical Research 46:1, pages 108-119.
Crossref
Isaac O. Donkor, Jin Xu, Jiuyu Liu & Keyuna Cameron. (2020) Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors. Bioorganic & Medicinal Chemistry 28:9, pages 115433.
Crossref
Marcos André Vannier-Santos, Giselle V. Brunoro, Maria de Nazaré C. Soeiro, Solange L. DeCastro & Rubem F.S. Menna-Barreto. 2019. Biology of Trypanosoma cruzi . Biology of Trypanosoma cruzi .
Ana M. Matos, Francisco R. Pinto, Patrícia Barros, Margarida D. Amaral, Rainer Pepperkok & Paulo Matos. (2019) Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant. Journal of Biological Chemistry 294:36, pages 13396-13410.
Crossref
Katja Jantos, Andreas Kling, Helmut Mack, Wilfried Hornberger, Achim Moeller, Volker Nimmrich, Yanbin Lao & Marjoleen Nijsen. (2019) Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability. Bioorganic & Medicinal Chemistry Letters 29:15, pages 1968-1973.
Crossref
Keriann M. Backus, Jian Cao & Sean M. Maddox. (2019) Opportunities and challenges for the development of covalent chemical immunomodulators. Bioorganic & Medicinal Chemistry 27:15, pages 3421-3439.
Crossref
Ronald A.M. Buijsen, Lodewijk J.A. Toonen, Sarah L. Gardiner & Willeke M.C. van Roon-Mom. (2019) Genetics, Mechanisms, and Therapeutic Progress in Polyglutamine Spinocerebellar Ataxias. Neurotherapeutics 16:2, pages 263-286.
Crossref
Christian-Scott E. McCartney & Peter L. Davies. 2019. Calpain. Calpain 39 55 .
Qiangdong Guan, Benyu Su, Xiaomin Wei, Shue Wang, Miaomiao Wang, Ning Liu, Wenchong Jiang, Mengmeng Xu & Sufang Yu. (2018) Protective effect of calpeptin on acrylamide-induced microtubule injury in sciatic nerve. Toxicology 409, pages 103-111.
Crossref
Zhujin Song, Hui Chen, Wen Xu, Shengbing Wu & Guoqi Zhu. (2018) Basolateral amygdala calpain is required for extinction of contextual fear-memory. Neurobiology of Learning and Memory 155, pages 180-188.
Crossref
Michal Alon, Rand Arafeh, Joo Sang Lee, Sanna Madan, Shelly Kalaora, Adi Nagler, Tereza Abgarian, Polina Greenberg, Eytan Ruppin & Yardena Samuels. (2018) CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma. Oncotarget 9:58, pages 31264-31277.
Crossref
Pedro Soares de Sousa Araújo, Simone Santiago Carvalho de Oliveira, Claudia Masini d’Avila-Levy, André Luis Souza dos Santos & Marta Helena Branquinha. (2018) Susceptibility of promastigotes and intracellular amastigotes from distinct Leishmania species to the calpain inhibitor MDL28170. Parasitology Research 117:7, pages 2085-2094.
Crossref
Bruno Popik, Ana Paula Crestani, Mateus Oliveira Silva, Jorge Alberto Quillfeldt & Lucas de Oliveira Alvares. (2018) Calpain modulates fear memory consolidation, retrieval and reconsolidation in the hippocampus. Neurobiology of Learning and Memory 151, pages 53-58.
Crossref
Andreas Kling, Katja Jantos, Helmut Mack, Wilfried Hornberger, Gisela Backfisch, Yanbin Lao, Marjoleen Nijsen, Beatrice Rendenbach-Mueller & Achim Moeller. (2018) Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1′ Extension. ACS Medicinal Chemistry Letters 9:3, pages 221-226.
Crossref
SIMONE S. C. OLIVEIRA, INÊS C. GONÇALVES, VITOR ENNES-VIDAL, ANGELA H. C. S. LOPES, RUBEM F. S. MENNA-BARRETO, CLAUDIA M. D’ÁVILA-LEVY, ANDRÉ L. S. SANTOS & MARTA H. BRANQUINHA. (2017) In vitro selection of Phytomonas serpens cells resistant to the calpain inhibitor MDL28170: alterations in fitness and expression of the major peptidases and efflux pumps . Parasitology 145:3, pages 355-370.
Crossref
Kareem C. Clark, Brooke A. Sword & Jeffrey L. Dupree. (2017) Oxidative Stress Induces Disruption of the Axon Initial Segment. ASN Neuro 9:6, pages 175909141774542.
Crossref
Fernanda A. Marinho, Leandro S. Sangenito, Simone S.C. Oliveira, Luciana B. De Arruda, Claudia M. D'Ávila-levy, André L.S. Santos & Marta H. Branquinha. (2017) The potent cell permeable calpain inhibitor MDL28170 affects the interaction of Leishmania amazonensis with macrophages and shows anti-amastigote activity. Parasitology International 66:5, pages 579-583.
Crossref
Andreas Kling, Katja Jantos, Helmut Mack, Wilfried Hornberger, Karla Drescher, Volker Nimmrich, Ana Relo, Karsten Wicke, Charles W. Hutchins, Yanbin Lao, Kennan Marsh & Achim Moeller. (2017) Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2-(3-Phenyl-1 H -pyrazol-1-yl)-nicotinamides . Journal of Medicinal Chemistry 60:16, pages 7123-7138.
Crossref
Xing-Yu Lin & Si-Zeng Chen. (2017) Calpain inhibitors ameliorate muscle wasting in a cachectic mouse model bearing CT26 colorectal adenocarcinoma. Oncology Reports 37:3, pages 1601-1610.
Crossref
VITOR ENNES-VIDAL, RUBEM FIGUEIREDO SADOCK MENNA-BARRETO, MARTA HELENA BRANQUINHA, ANDRÉ LUIS SOUZA DOS SANTOS & CLAUDIA MASINI D'AVILA-LEVY. (2016) Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?. Parasitology 144:2, pages 117-123.
Crossref
Simone Santiago Carvalho de Oliveira, Diego de Souza Gonçalves, Aline dos Santos Garcia-Gomes, Inês Correa Gonçalves, Sergio Henrique Seabra, Rubem Figueiredo Menna-Barreto, Angela Hampshire de Carvalho Santos Lopes, Claudia Masini D’Avila-Levy, André Luis Souza dos Santos & Marta Helena Branquinha. (2016) Susceptibility of Phytomonas serpens to calpain inhibitors in vitro: interference on the proliferation, ultrastructure, cysteine peptidase expression and interaction with the invertebrate host. Memórias do Instituto Oswaldo Cruz 112:1, pages 31-43.
Crossref
Yasuko Ono, Takaomi C. Saido & Hiroyuki Sorimachi. (2016) Calpain research for drug discovery: challenges and potential. Nature Reviews Drug Discovery 15:12, pages 854-876.
Crossref
Katarzyna Starska, Ewa Forma, Paweł Jóźwiak, Iwona Lewy-Trenda, Marian Danilewicz, Olga Stasikowska-Kanicka, Michał Skóra, Katarzyna Kolary, Jakub Miazga, Anna Krześlak & Magdalena Bryś. (2016) Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer. Tumor Biology 37:10, pages 13185-13203.
Crossref
Kristin E. Low, Spencer Ler, Kevin J. Chen, Robert L. Campbell, Jennifer L. Hickey, Joanne Tan, Conor C. G. Scully, Peter L. Davies, Andrei K. Yudin & Serge Zaretsky. (2016) Rational Design of Calpain Inhibitors Based on Calpastatin Peptidomimetics. Journal of Medicinal Chemistry 59:11, pages 5403-5415.
Crossref
Simone Santiago Carvalho de Oliveira, Aline dos Santos Garcia-Gomes, Claudia Masini d’Avila-Levy, André Luis Souza dos Santos & Marta Helena Branquinha. (2015) Expression of calpain-like proteins and effects of calpain inhibitors on the growth rate of Angomonas deanei wild type and aposymbiotic strains. BMC Microbiology 15:1.
Crossref
Laura E. Clemens, Jonasz J. Weber, Tanja T. Wlodkowski, Libo Yu-Taeger, Magali Michaud, Carsten Calaminus, Schamim H. Eckert, Janett Gaca, Andreas Weiss, Janine C. D. Magg, Erik K. H. Jansson, Gunter P. Eckert, Bernd J. Pichler, Thierry Bordet, Rebecca M. Pruss, Olaf Riess & Huu P. Nguyen. (2015) Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat. Brain 138:12, pages 3632-3653.
Crossref
Marton Siklos, Manel BenAissa & Gregory R.J. Thatcher. (2015) Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. Acta Pharmaceutica Sinica B 5:6, pages 506-519.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.