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Expert Opinion on Therapeutic Patents Volume 25, 2015 - Issue 5
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Review

Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer’s disease

Katarina JovanovicUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
, PhD (Post-Doctoral Fellow) ,
Carryn J ChettyUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
, BSc Hons (MSc Candidate) ,
Thandokuhle KhumaloUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
, BSc Hons (MSc Candidate) ,
Bianca Da Costa DiasUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
, PhD (Post Doctoral Fellow) ,
Eloise FerreiraUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
, PhD (Post Doctoral Fellow) ,
Sibusiso T MalindisaUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
, BSc Hons (MSc Candidate) ,
Robert CaveneyUniversity of the Witwatersrand, Wits Enterprise, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
(Intellectual Property Consultant) ,
Boitelo T LetsoloUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa
, PhD (Lecturer of Genetics and Development Biology) &
Stefan FT WeissUniversity of the Witwatersrand, School of Molecular and Cell Biology, Private Bag 3, Wits 2050, Johannesburg, Republic of South Africa+27 11 717 6346; +27 11 717 6351; [email protected]
, PhD (Professor of Biochemistry) show all
Pages 567-582 | Published online: 08 Mar 2015

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Leila Vania, Gavin Morris, Tyrone C Otgaar, Monique J Bignoux, Martin Bernert, Jessica Burns, Anne Gabathuse, Elvira Singh, Eloise Ferreira & Stefan F T Weiss. (2019) Patented therapeutic approaches targeting LRP/LR for cancer treatment. Expert Opinion on Therapeutic Patents 29:12, pages 987-1009.
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Xiao Chen, Ye Sun, Haiyan Huang, Wei Liu, Panpan Hu, Xinfeng Huang, Fei Zou & Jianjun Liu. (2018) Uncovering the proteome response of murine neuroblastoma cells against low-dose exposure to saxitoxin. Toxicology Mechanisms and Methods 28:5, pages 335-344.
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Articles from other publishers (31)

Adriana Limone, Valentina Maggisano, Daniela Sarnataro & Stefania Bulotta. (2023) Emerging roles of the cellular prion protein (PrPC) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biology. Cellular and Molecular Life Sciences 80:8.
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Kaiying Yang, Yu Sun, Jie Zhao, Chang He, Xudong Pan & Xiaoyan Zhu. (2023) Biogenesis, function, and landscape of tsRNAs in central nervous system diseases. Clinical and Translational Discovery 3:4.
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Isobel C Jones & Crispin R Dass. (2023) Roles of pigment epithelium-derived factor in cardiomyocytes: implications for use as a cardioprotective therapeutic. Journal of Pharmacy and Pharmacology 75:6, pages 746-757.
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Ji-Eun Kim, Duk-Shin Lee & Tae-Cheon Kang. (2023) Epigallocatechin-3-Gallate Attenuates Leukocyte Infiltration in 67-kDa Laminin Receptor-Dependent and -Independent Pathways in the Rat Frontoparietal Cortex following Status Epilepticus. Antioxidants 12:4, pages 969.
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Matthew Vassey, Rininta Firdaus, Akhmed Aslam, Lee M. Wheldon, Neil J. Oldfield, Dlawer A. A. Ala’Aldeen & Karl G. Wooldridge. (2023) G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells. Cellular Microbiology 2023, pages 1-15.
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Blessy Aksa Mathew, Madhumitha Katta, Abhilash Ludhiadch, Paramdeep Singh & Anjana Munshi. (2022) Role of tRNA-Derived Fragments in Neurological Disorders: a Review. Molecular Neurobiology 60:2, pages 655-671.
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Monique J. Bignoux, Tyrone C. Otgaar, Martin Bernert, Stefan F. T. Weiss & Eloise Ferreira. (2023) Downregulation of LRP / LR with siRNA inhibits several cancer hallmarks in lung cancer cells . FEBS Open Bio 13:2, pages 323-340.
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Fan Chen, Na Wang & Xiaping He. (2022) Identification of Differential Genes of DNA Methylation Associated With Alzheimer’s Disease Based on Integrated Bioinformatics and Its Diagnostic Significance. Frontiers in Aging Neuroscience 14.
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Romi Gupta. (2022) Epigenetic regulation and targeting of ECM for cancer therapy. American Journal of Physiology-Cell Physiology 322:4, pages C762-C768.
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Leila Vania, Gavin Morris, Eloise Ferreira & Stefan F. T. Weiss. (2021) Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells. BMC Cancer 21:1.
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Agnieszka Zabłocka, Wioletta Kazana, Marta Sochocka, Bartłomiej Stańczykiewicz, Maria Janusz, Jerzy Leszek & Beata Orzechowska. (2021) Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview. Molecular Neurobiology 58:12, pages 6335-6349.
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Eun-Jung Park, Seung-Woo Jin, Hyun-Ji Lim, Hyeon-Young Kim, Min-Sung Kang & Siyoung Yang. (2021) Whole Cigarette Smoke Condensates Induce Accumulation of Amyloid Beta Precursor Protein with Oxidative Stress in Murine Astrocytes. Toxics 9:7, pages 150.
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Antaripa Bhattacharya, Antonella Izzo, Nunzia Mollo, Filomena Napolitano, Adriana Limone, Francesca Margheri, Alessandra Mocali, Giuseppina Minopoli, Alessandra Lo Bianco, Federica Di Maggio, Valeria D’Argenio, Nunzia Montuori, Antonio Lavecchia & Daniela Sarnataro. (2020) Inhibition of 37/67kDa Laminin-1 Receptor Restores APP Maturation and Reduces Amyloid-β in Human Skin Fibroblasts from Familial Alzheimer’s Disease. Journal of Personalized Medicine 10:4, pages 232.
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Ming Fu, Amanda J. Barlow‐Anacker, Korah P. Kuruvilla, Gary L. Bowlin, Christopher W. Seidel, Paul A. Trainor & Ankush Gosain. (2020) 37/67‐laminin receptor facilitates neural crest cell migration during enteric nervous system development. The FASEB Journal 34:8, pages 10931-10947.
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Katelyn Cuttler, Monique J. Bignoux, Tyrone C. Otgaar, Stephanie Chigumba, Eloise Ferreira & Stefan F.T. Weiss. (2020) LRP::FLAG Reduces Phosphorylated Tau Levels in Alzheimer’s Disease Cell Culture Models. Journal of Alzheimer's Disease 76:2, pages 753-768.
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Antaripa Bhattacharya, Adriana Limone, Filomena Napolitano, Carmen Cerchia, Silvia Parisi, Giuseppina Minopoli, Nunzia Montuori, Antonio Lavecchia & Daniela Sarnataro. (2020) APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells. International Journal of Molecular Sciences 21:5, pages 1738.
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Hana Park & Tae-Cheon Kang. (2019) The Regional Specific Alterations in BBB Permeability are Relevant to the Differential Responses of 67-kDa LR Expression in Endothelial Cells and Astrocytes Following Status Epilepticus. International Journal of Molecular Sciences 20:23, pages 6025.
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Shuai Zhang, Hejian Li, Ling Zheng, Hong Li, Chengqiang Feng & Wensheng Zhang. (2019) Identification of functional tRNA-derived fragments in senescence-accelerated mouse prone 8 brain. Aging 11:22, pages 10485-10498.
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Monique J. Bignoux, Katelyn Cuttler, Tyrone C. Otgaar, Eloise Ferreira, Boitelo T. Letsolo & Stefan F.T. Weiss. (2019) LRP::FLAG Rescues Cells from Amyloid-β-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity. Journal of Alzheimer's Disease 69:3, pages 729-741.
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Thalia M. Rebelo, Leila Vania, Eloise Ferreira & Stefan F.T. Weiss. (2018) siRNA - Mediated LRP/LR knock-down reduces cellular viability of malignant melanoma cells through the activation of apoptotic caspases. Experimental Cell Research 368:1, pages 1-12.
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Eloise Ferreira, Monique J. Bignoux, Tyrone C. Otgaar, Nicolas Tagliatti, Katarina Jovanovic, Boitelo T. Letsolo & Stefan F.T. Weiss. (2018) LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice. Oncotarget 9:43, pages 27059-27073.
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Li Zhou, Fan Yang, Guobing Li, Jingbin Huang, Yali Liu, Qian Zhang, Qin Tang, Changpeng Hu & Rong Zhang. (2018) Coptisine Induces Apoptosis in Human Hepatoma Cells Through Activating 67-kDa Laminin Receptor/cGMP Signaling. Frontiers in Pharmacology 9.
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Carryn J. Chetty, Eloise Ferreira, Katarina Jovanovic & Stefan F.T. Weiss. (2017) Knockdown of LRP/LR induces apoptosis in pancreatic cancer and neuroblastoma cells through activation of caspases. Experimental Cell Research 360:2, pages 264-272.
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Tyrone C. Otgaar, Eloise Ferreira, Sibusiso Malindisa, Martin Bernert, Boitelo T. Letsolo & Stefan F.T. Weiss. (2017) 37 kDa LRP::FLAG enhances telomerase activity and reduces senescent markers in vitro . Oncotarget 8:49, pages 86646-86656.
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Carmelle Munien, Thalia M. Rebelo, Eloise Ferreira & Stefan F.T. Weiss. (2017) IgG1-iS18 impedes the adhesive and invasive potential of early and late stage malignant melanoma cells. Experimental Cell Research 351:2, pages 135-141.
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Thalia M. Rebelo, Carryn J. Chetty, Eloise Ferreira & Stefan F. T. Weiss. (2016) Anti-LRP/LR-specific antibody IgG1-iS18 impedes adhesion and invasion of pancreatic cancer and neuroblastoma cells. BMC Cancer 16:1.
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Daniela Sarnataro, Anna Pepe, Gennaro Altamura, Imma De Simone, Ada Pesapane, Lucio Nitsch, Nunzia Montuori, Antonio Lavecchia & Chiara Zurzolo. (2016) The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein. Scientific Reports 6:1.
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Leila Vania, Carryn J Chetty, Eloise Ferreira & Stefan F T Weiss. (2016) Anti-LRP/LR-Specific Antibody IgG1-iS18 Significantly Impedes Adhesion and Invasion in Early- and Late-Stage Colorectal Carcinoma Cells. Molecular Medicine 22:1, pages 664-673.
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Emma C. PinnockKatarina JovanovicMaxine G. PintoEloise FerreiraBianca Da Costa DiasClement PennyStefan Knackmuss, Uwe Reusch, Melvyn Little, Hermann M. Schatzl & Stefan F.T. Weiss. (2015) LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer’s Disease. Journal of Alzheimer's Disease 49:3, pages 645-657.
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Shijie Liu. (2015) A review on protein oligomerization process. International Journal of Precision Engineering and Manufacturing 16:13, pages 2731-2760.
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Thandokuhle Khumalo, Eloise Ferreira, Katarina Jovanovic, Rob B. Veale & Stefan F. T. Weiss. (2015) Knockdown of LRP/LR Induces Apoptosis in Breast and Oesophageal Cancer Cells. PLOS ONE 10:10, pages e0139584.
Crossref

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