882
Views
46
CrossRef citations to date
0
Altmetric
Review

c-Jun N-terminal kinase inhibitors: a patent review (2010 – 2014)

, , &

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Valentin R Wydra, Raphael B Ditzinger, Nico J Seidler, Frederik W Hacker & Stefan A Laufer. (2023) A patent review of MAPK inhibitors (2018 – present). Expert Opinion on Therapeutic Patents 33:6, pages 421-444.
Read now
Xiaoxia Jiang, Mengjie Wu, Zhenzhen Xu, Haohao Wang, Haiyong Wang, Xiongfei Yu, Zhongqi Li & Lisong Teng. (2018) HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer. Cancer Management and Research 10, pages 6857-6867.
Read now

Articles from other publishers (44)

Karim I. Mersal, Mohammed S. Abdel-Maksoud, Eslam M.H. Ali, Usama M. Ammar, Seyed-Omar Zaraei, Md Mamunul Haque, Tanuza Das, Noha F. Hassan, Eunice EunKyeong Kim, Jun-Seok Lee, HaJeung Park, Kwan Hyi Lee, Mohammed I. El-Gamal, Hee-Kwon Kim, Tamer M. Ibrahim & Chang-Hyun Oh. (2023) Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells. European Journal of Medicinal Chemistry 261, pages 115779.
Crossref
Mark B. Plotnikov, Galina A. Chernysheva, Vera I. Smol’yakova, Oleg I. Aliev, Anna M. Anishchenko, Olga A. Ulyakhina, Eugene S. Trofimova, Anastasia A. Ligacheva, Nina D. Anfinogenova, Anton N. Osipenko, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Igor A. Schepetkin, Anastasia G. Drozd, Evgenii V. Plotnikov, Dmitriy N. Atochin & Mark T. Quinn. (2023) Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia. Pharmaceuticals 16:8, pages 1057.
Crossref
Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska & Mark T. Quinn. (2023) Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors. Molecules 28:12, pages 4806.
Crossref
Wenchao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B. Ficarro, Cynthia J. Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, Jianwei Che, Audrey Y. Kim, Tengteng Yu, Kenneth Wen, Kenneth C. Anderson, Jarrod A. Marto, Kenneth D. Westover, Tinghu Zhang & Nathanael S. Gray. (2023) Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. Journal of Medicinal Chemistry 66:5, pages 3356-3371.
Crossref
Mark B. Plotnikov, Galina A. Chernysheva, Vera I. Smol’yakova, Oleg I. Aliev, Tatyana I. Fomina, Lyubov A. Sandrikina, Irina V. Sukhodolo, Vera V. Ivanova, Anton N. Osipenko, Nina D. Anfinogenova, Andrei I. Khlebnikov, Dmitriy N. Atochin, Igor A. Schepetkin & Mark T. Quinn. (2023) Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction. Biomedicines 11:3, pages 714.
Crossref
Anna A. Zhdankina, Dmitry I. Tikhonov, Sergey V. Logvinov, Mark B. Plotnikov, Andrei I. Khlebnikov & Nataliya G. Kolosova. (2023) Suppression of Age-Related Macular Degeneration-like Pathology by c-Jun N-Terminal Kinase Inhibitor IQ-1S. Biomedicines 11:2, pages 395.
Crossref
Ngoc Minh Nguyen, Men Thi Hoai Duong, Bich Phuong Bui, Phuong Linh Nguyen, Xiaozhen Chen, Jungsook Cho & Hee-Chul Ahn. (2022) Sonidegib Suppresses Production of Inflammatory Mediators and Cell Migration in BV2 Microglial Cells and Mice Treated with Lipopolysaccharide via JNK and NF-κB Inhibition. International Journal of Molecular Sciences 23:18, pages 10590.
Crossref
Igor A. Schepetkin, Anastasia R. Kovrizhina, Ksenia S. Stankevich, Andrei I. Khlebnikov, Liliya N. Kirpotina, Mark T. Quinn & Matthew J. Cook. (2022) Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors. Frontiers in Pharmacology 13.
Crossref
Igor A. Schepetkin, Galina A. Chernysheva, Oleg I. Aliev, Liliya N. Kirpotina, Vera I. Smol’yakova, Anton N. Osipenko, Mark B. Plotnikov, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Evgenii V. Plotnikov & Mark T. Quinn. (2022) Neuroprotective Effects of the Lithium Salt of a Novel JNK Inhibitor in an Animal Model of Cerebral Ischemia–Reperfusion. Biomedicines 10:9, pages 2119.
Crossref
Chongyun Cheng, Miaomiao Liu, Xiaoqin Gao, Dong Wu, Mengchen Pu, Jun Ma, Ronald J. Quinn, Zhicheng Xiao & Zhijie Liu. (2022) Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Assays and Native Mass Spectrometry. ACS Omega 7:16, pages 13925-13931.
Crossref
Nadiya Byts, Subodh Sharma, Tarja Malm, Mika Kaakinen, Paula Korhonen, Laura Jaakkonen, Meike Keuters, Mikko Huuskonen, Ilkka Pietilä, Jari Koistinaho, Peppi Koivunen & Johanna Myllyharju. (2022) Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation. Journal of Biological Chemistry 298:3, pages 101721.
Crossref
Biswadeep Das, Chayna Sarkar, Vikram Singh Rawat, Deepjyoti Kalita, Sangeeta Deka & Akash Agnihotri. (2021) Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease Models. Molecules 26:16, pages 4996.
Crossref
Ying Shi, Jin Bai, Yuhui Dang, Qingli Bai, Rong Zheng, Jia Chen & Zhilan Li. (2021) Protection of apigenin against acrylonitrile-induced sperm and testis injury in rats: involvement of activation of ASK1-JNK/p38 signaling pathway. Toxicology Research 10:2, pages 159-168.
Crossref
Mark B. Plotnikov, Galina A. Chernysheva, Vera I. Smolyakova, Oleg I. Aliev, Eugene S. Trofimova, Eugene Y. Sherstoboev, Anton N. Osipenko, Andrei I. Khlebnikov, Yana J. Anfinogenova, Igor A. Schepetkin & Dmitriy N. Atochin. (2020) Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia. Cells 9:8, pages 1860.
Crossref
Mei Han, Yuxia Pan, Mengying Gao, Junli Zhang & Fan Wang. (2020) JNK Signaling Pathway Suppresses LPS-Mediated Apoptosis of HK-2 Cells by Upregulating NGAL. International Journal of Inflammation 2020, pages 1-5.
Crossref
Pierre Koch. 2021. Proteinkinase Inhibitors. Proteinkinase Inhibitors 203 224 .
Matthias Gehringer. 2021. Proteinkinase Inhibitors. Proteinkinase Inhibitors 43 94 .
Renzo Rossi & Maurizio Ciofalo. (2019) Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives. Current Organic Chemistry 23:19, pages 2016-2101.
Crossref
Shu-Chen Chu, Pei-Ni Chen, Ching-Han Yu, Yih-Shou Hsieh & Dong-Yih Kuo. (2019) Double immunofluorescent evidence that oxidative stress-associated activation of JNK/AP-1 signaling participates in neuropeptide-mediated appetite control. European Neuropsychopharmacology 29:11, pages 1235-1249.
Crossref
Celeste M Pilato, Jae Hong Park, Lingling Kong, Constantin d’Ydewalle, David Valdivia, Karen S Chen, Irene Griswold-Prenner & Charlotte J Sumner. (2019) Motor neuron loss in SMA is not associated with somal stress-activated JNK/c-Jun signaling. Human Molecular Genetics 28:19, pages 3282-3292.
Crossref
Antonio Di Zazzo, Alessandra Micera, Maria De Piano, Magdalena Cortes & Stefano Bonini. (2018) Tears and ocular surface disorders: Usefulness of biomarkers. Journal of Cellular Physiology 234:7, pages 9982-9993.
Crossref
Mark B. Plotnikov, Galina A. Chernysheva, Oleg I. Aliev, Vera I. Smol’iakova, Tatiana I. Fomina, Anton N. Osipenko, Victoria S. Rydchenko, Yana J. Anfinogenova, Andrei I. Khlebnikov, Igor A. Schepetkin & Dmitriy N. Atochin. (2019) Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats. Molecules 24:9, pages 1722.
Crossref
Wei Hu, Wanjin Fu, Xin Wei, Yang Yang, Chao Lu & Zeyuan Liu. (2019) A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-15.
Crossref
Igor A. Schepetkin, Andrei I. Khlebnikov, Andrei S. Potapov, Anastasia R. Kovrizhina, Vladislava V. Matveevskaya, Maxim L. Belyanin, Dmitriy N. Atochin, Svitlana O. Zanoza, Nadiya M. Gaidarzhy, Sergiy A. Lyakhov, Liliya N. Kirpotina & Mark T. Quinn. (2019) Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors. European Journal of Medicinal Chemistry 161, pages 179-191.
Crossref
Tokiko Suzuki, Kimimasa Sakata, Natsumi Mizuno, Sailesh Palikhe, Shigeyuki Yamashita, Kohshi Hattori, Naoyuki Matsuda & Yuichi Hattori. (2018) Different involvement of the MAPK family in inflammatory regulation in human pulmonary microvascular endothelial cells stimulated with LPS and IFN-γ. Immunobiology 223:12, pages 777-785.
Crossref
Guo-Dong Yao, Meng-Yao Ge, Dan-Qi Li, Ling Chen, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Chun Guo, Shao-Jiang Song & Takashi Ikejima. (2018) L-A03, a dihydroartemisinin derivative, promotes apoptotic cell death of human breast cancer MCF-7 cells by targeting c-Jun N-terminal kinase. Biomedicine & Pharmacotherapy 105, pages 320-325.
Crossref
Patrik Hollos, Francesca Marchisella & Eleanor T. Coffey. (2018) JNK Regulation of Depression and Anxiety. Brain Plasticity 3:2, pages 145-155.
Crossref
Francesco Ansideri, Joana T. Macedo, Michael Eitel, Ahmed El-Gokha, Dhafer S. Zinad, Camilla Scarpellini, Mark Kudolo, Dieter Schollmeyer, Frank M. Boeckler, Bärbel S. Blaum, Stefan A. Laufer & Pierre Koch. (2018) Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. ACS Omega 3:7, pages 7809-7831.
Crossref
Maria Shvedova, Yana Anfinogenova, Elena N. Atochina-Vasserman, Igor A. Schepetkin & Dmitriy N. Atochin. (2018) c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury. Frontiers in Pharmacology 9.
Crossref
M. V. Shvedova, Ya. D. Anfinogenova, I. A. Shchepetkin & D. N. Atochin. (2018) c-Jun N-Terminal Kinases and Their Pharmacological Modulation in Ischemic and Reperfusion Brain Injury. Neuroscience and Behavioral Physiology 48:6, pages 721-728.
Crossref
Jin Zheng, Jianguo Qi, Quan Zou & Zhenzhong Zhang. (2018) Construction of PLGA/JNK3-shRNA nanoparticles and their protective role in hippocampal neuron apoptosis induced by oxygen and glucose deprivation. RSC Advances 8:36, pages 20108-20116.
Crossref
Avril A. B. Robertson. 2018. Inflammasomes: Clinical and Therapeutic Implications. Inflammasomes: Clinical and Therapeutic Implications 343 400 .
Francesco Ansideri, Marcel Dammann, Frank M. Boeckler & Pierre Koch. (2017) Fluorescence polarization-based competition binding assay for c-Jun N-terminal kinases 1 and 2. Analytical Biochemistry 532, pages 26-28.
Crossref
Claire E. Le Pichon, William J. Meilandt, Sara DominguezHilda SolanoyHan Lin, Hai NguAlvin Gogineni, Arundhati Sengupta GhoshZhiyu JiangSeung-Hye Lee, Janice Maloney, Vineela D. Gandham, Christine D. Pozniak, Bei WangSebum Lee, Michael Siu, Snahel Patel, Zora ModrusanXingrong LiuYork RudhardMiriam Baca, Amy Gustafson, Josh Kaminker, Richard A. D. Carano, Eric J. Huang, Oded ForemanRobby WeimerKimberly Scearce-LevieJoseph W. Lewcock. (2017) Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Science Translational Medicine 9:403.
Crossref
Yu-Ping Yang, Yu-Mei Jin & Zhi-Yuan Zhu. (2017) Statistical molecular identification of kinase inhibitors to disrupt c-Jun N-terminal protein kinase involved in paraquat-mediated toxicological effects. Journal of Chemometrics 31:8, pages e2905.
Crossref
Y Wang, G Zhang, J Jin, S Degan, Y Tameze & J Y Zhang. (2017) MALT1 promotes melanoma progression through JNK/c-Jun signaling. Oncogenesis 6:7, pages e365-e365.
Crossref
Giovanni Solinas & Barbara Becattini. (2017) JNK at the crossroad of obesity, insulin resistance, and cell stress response. Molecular Metabolism 6:2, pages 174-184.
Crossref
Felix Muth, Ahmed El-Gokha, Francesco Ansideri, Michael Eitel, Eva Döring, Adrian Sievers-Engler, Andreas Lange, Frank M. Boeckler, Michael Lämmerhofer, Pierre Koch & Stefan A. Laufer. (2017) Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3. Journal of Medicinal Chemistry 60:2, pages 594-607.
Crossref
Francesco Ansideri, Andreas Lange, Ahmed El-Gokha, Frank M. Boeckler & Pierre Koch. (2016) Fluorescence polarization-based assays for detecting compounds binding to inactive c-Jun N-terminal kinase 3 and p38α mitogen-activated protein kinase. Analytical Biochemistry 503, pages 28-40.
Crossref
Yabin Wu, Daisy W.J. van der Schaft, Frank P. Baaijens & Cees W.J. Oomens. (2016) Cell death induced by mechanical compression on engineered muscle results from a gradual physiological mechanism. Journal of Biomechanics 49:7, pages 1071-1077.
Crossref
Qiuzhen Zhu, Yuefan Zhang, Yulan Liu, Hao Cheng, Jing Wang, Yue Zhang, Yaocheng Rui & Tiejun Li. (2016) MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2. PLOS ONE 11:2, pages e0149965.
Crossref
Ramon Yarza, Silvia Vela, Maite Solas & Maria J. Ramirez. (2016) c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease. Frontiers in Pharmacology 6.
Crossref
Andreas Lange, Marcel Günther, Felix Michael Büttner, Markus O. Zimmermann, Johannes Heidrich, Susanne Hennig, Stefan Zahn, Christoph Schall, Adrian Sievers-Engler, Francesco Ansideri, Pierre Koch, Michael Laemmerhofer, Thilo Stehle, Stefan A. Laufer & Frank M. Boeckler. (2015) Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond. Journal of the American Chemical Society 137:46, pages 14640-14652.
Crossref
Guillaume Bastin, Jin Ye Yang & Scott P. Heximer. (2015) Gαi3-Dependent Inhibition of JNK Activity on Intracellular Membranes. Frontiers in Bioengineering and Biotechnology 3.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.