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Patent Review

Inhibitors of melanogenesis: a patent review (2009 – 2014)

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Ewa Markiewicz & Olusola Clement Idowu. (2020) Melanogenic Difference Consideration in Ethnic Skin Type: A Balance Approach Between Skin Brightening Applications and Beneficial Sun Exposure. Clinical, Cosmetic and Investigational Dermatology 13, pages 215-232.
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Thanigaimalai Pillaiyar, Manoj Manickam & Vigneshwaran Namasivayam. (2017) Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 403-425.
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Halleh Hamedifar, Somaye Karimian, Maryam Kabiri, Azam Bagheri, Mina Zarei, Ali Moazzam, Mohammad Mahdavi, Nima Sepehri & Mehdi Khoshneviszadeh. (2023) Benzylidine‐ N ‐phenylhydrazine‐1‐carboxamide Derivatives as Tyrosinase Inhibitors: Design, Preparation, Molecular Docking, and Biological Activity . ChemistrySelect 8:39.
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Yu-Tung Ho, I-Hsuan Liu, Shang-Tzen Chang, Sheng-Yang Wang & Hui-Ting Chang. (2023) In Vitro and In Vivo Antimelanogenesis Effects of Leaf Essential Oil from Agathis dammara. Pharmaceutics 15:9, pages 2269.
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Panupong Mahalapbutr, Sahachai Sabuakham, Sutita Nasoontorn, Thanyada Rungrotmongkol, Atit Silsirivanit & Utid Suriya. (2023) Discovery of amphotericin B, an antifungal drug as tyrosinase inhibitor with potent anti-melanogenic activity. International Journal of Biological Macromolecules 246, pages 125587.
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Sifan Wang, Yuanbo Kang, Fei Qi & Hongzhong Jin. (2023) Genetics of hair graying with age. Ageing Research Reviews 89, pages 101977.
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Ting Gao, Xiaoyu Wang, Yixuan Li & Fazheng Ren. (2023) The Role of Probiotics in Skin Health and Related Gut–Skin Axis: A Review. Nutrients 15:14, pages 3123.
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Yuanyuan Wang, Baichen Xiong, Shuaishuai Xing, Ying Chen, Qinghong Liao, Jun Mo, Yao Chen, Qi Li & Haopeng Sun. (2023) Medicinal Prospects of Targeting Tyrosinase: A Feature Review. Current Medicinal Chemistry 30:23, pages 2638-2671.
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Min Chang Oh, Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari lakmini Herath & Jin Won Hyun. (2023) Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells. Journal of Cancer Prevention 28:2, pages 40-46.
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Meysam Talebi, Kiarash Majidi, Kiana Bassam, Movahed Abdi, Maryam Daneshvar, Seyedeh Sara Moayedi, Saba Pourhesabi, Mahshid Attarroshan, Shahin Boumi, Maryam Kabiri, Faezeh Sadat Hosseini, Mehdi Khoshneviszadeh & Massoud Amanlou. (2022) Synthesis, biological evaluation, and molecular docking analysis of novel 1, 3, 4-thiadiazole -based kojic acid derivatives as tyrosinase inhibitors. Journal of Molecular Structure 1268, pages 133707.
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Samaneh Noroozi, Fatemeh Fadaei, Mohammadreza Rahbar, Malihe Tabarrai, Parvin Mansouri & Laila Shirbeigi. (2022) Novel Preventive and Therapeutic Strategies for Ephelides (Freckles) from a Persian Medicine Perspective: A Narrative Review. Journal of Skin and Stem Cell 9:3.
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Hogwuan Jung, JaeWook Oh, Younghae Kwon, Woongshin Kang, Minsuk Seo, Yurin Seol & Je Won Park. (2022) Enzymatic Biosynthesis of Simple Phenolic Glycosides as Potential Anti-Melanogenic Antioxidants. Antioxidants 11:7, pages 1396.
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Li Ting Kee, Chiew Yong Ng, Maimonah Eissa Al-Masawa, Jhi Biau Foo, Chee Wun How, Min Hwei Ng & Jia Xian Law. (2022) Extracellular Vesicles in Facial Aesthetics: A Review. International Journal of Molecular Sciences 23:12, pages 6742.
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Ayse Kose & Suphi S. Oncel. (2022) Design of melanogenesis regulatory peptides derived from phycocyanin of the microalgae Spirulina platensis. Peptides 152, pages 170783.
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Pablo Garcia-Molina, Francisco Garcia-Molina, Jose Antonio Teruel-Puche, Jose Neptuno Rodriguez-Lopez, Francisco Garcia-Canovas & Jose Luis Muñoz-Muñoz. (2022) The Relationship between the IC50 Values and the Apparent Inhibition Constant in the Study of Inhibitors of Tyrosinase Diphenolase Activity Helps Confirm the Mechanism of Inhibition. Molecules 27:10, pages 3141.
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Jinyan Yu, Xumin Ma, Xiaoyu Wang, Xuetao Cui, Kai Ding, Shiyuan Wang & Chunchao Han. (2022) Application and mechanism of probiotics in skin care: A review. Journal of Cosmetic Dermatology 21:3, pages 886-894.
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Qi Li, Jun Mo, Baichen Xiong, Qinghong Liao, Ying Chen, Yuanyuan Wang, Shuaishuai Xing, Siyu He, Weiping Lyu, Ning Zhang & Haopeng Sun. (2021) Discovery of Resorcinol-Based Polycyclic Structures as Tyrosinase Inhibitors for Treatment of Parkinson’s Disease. ACS Chemical Neuroscience 13:1, pages 81-96.
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Ayse Kose. 2022. Sustainable Global Resources of Seaweeds Volume 2. Sustainable Global Resources of Seaweeds Volume 2 495 517 .
Jin Li, Lu Feng, Li Liu, Fang Wang, Liang Ouyang, Lan Zhang, Xiuying Hu & Guan Wang. (2021) Recent advances in the design and discovery of synthetic tyrosinase inhibitors. European Journal of Medicinal Chemistry 224, pages 113744.
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Ashraf S.A. El-Sayed, Hanaa Salah Maamoun, Gamal H. Rabie, Ibrahim Shaker, Bothaina A. Alaidaroos, Mostafa G. Ali & Amgad M. Rady. (2021) Microbial Tyrosinase: Biochemical, Molecular Properties and Pharmaceutical Applications. Biomedical and Pharmacology Journal 14:3, pages 1281-1295.
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Majid Saeedi, Khadijeh Khezri, Abbas Seyed Zakaryaei & Hassan Mohammadamini. (2021) A comprehensive review of the therapeutic potential of α‐arbutin. Phytotherapy Research 35:8, pages 4136-4154.
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Chi-Ya Huang, I-Hsuan Liu, Xiang-Zhe Huang, Hui-Jen Chen, Shang-Tzen Chang, Mei-Ling Chang, Yu-Tung Ho & Hui-Ting Chang. (2021) Antimelanogenesis Effects of Leaf Extract and Phytochemicals from Ceylon Olive (Elaeocarpus serratus) in Zebrafish Model. Pharmaceutics 13:7, pages 1059.
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Ziyin Chai, Jizhen Shang, Wen Shi, Xiaohua Li & Huimin Ma. (2021) Increase of tyrosinase activity at the wound site in zebrafish imaged by a new fluorescent probe. Chemical Communications 57:22, pages 2764-2767.
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Z. T. Yang, D. X. Lu, E.-K. Hong, B. Y. Zhang, M. C. Jiang, Y. J. Yang & D. J. Zhang. (2021) Extraction and Separation of Sinapine from Rapeseed Cake and the Mode of Action of Melanin Production Inhibition. Molecular Biology 54:6, pages 911-918.
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Thanigaimalai Pillaiyar, Sangeetha Meenakshisundaram, Manoj Manickam & Murugesan Sankaranarayanan. (2020) A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery. European Journal of Medicinal Chemistry 195, pages 112275.
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Wenhui Qian, Wenya Liu, Dong Zhu, Yanli Cao, Anfu Tang, Guangming Gong & Hua Su. (2020) Natural skin‑whitening compounds for the treatment of melanogenesis (Review). Experimental and Therapeutic Medicine 20:1, pages 173-185.
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Seung-Hyun Moon, You Chul Chung & Chang-Gu Hyun. (2019) Tobramycin Promotes Melanogenesis by Upregulating p38 MAPK Protein Phosphorylation in B16F10 Melanoma Cells. Antibiotics 8:3, pages 140.
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Sateesh Kumar Arepalli, Chaerim Lee, Jae-Kyung Jung, Youngsoo Kim, Kiho Lee & Heesoon Lee. (2019) Synthesis of N-arylindazole-3-carboxamide and N-benzoylindazole derivatives and their evaluation against α-MSH-stimulated melanogenesis. Bioorganic & Medicinal Chemistry Letters 29:18, pages 2604-2608.
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Fang Miao, Meng-Yun Su, Shan Jiang, Long-Fei Luo, Ying Shi & Tie-Chi Lei. (2019) Intramelanocytic Acidification Plays a Role in the Antimelanogenic and Antioxidative Properties of Vitamin C and Its Derivatives. Oxidative Medicine and Cellular Longevity 2019, pages 1-14.
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Katarzyna Hałdys & Rafał Latajka. (2019) Thiosemicarbazones with tyrosinase inhibitory activity. MedChemComm 10:3, pages 378-389.
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Jihyun Lim, Sorim Nam, Ji Hye Jeong, Min Jung Kim, Young Yang, Myeong‐Sok Lee, Hee Gu Lee, Jae‐Ha Ryu & Jong‐Seok Lim. (2019) Kazinol U inhibits melanogenesis through the inhibition of tyrosinase‐related proteins via AMP kinase activation . British Journal of Pharmacology 176:5, pages 737-750.
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Sung Min Woo, Woo Rin Choi, Dong-Ryung Lee, Hong-Suk Kim, Chunsik Yi, Kyung-Hyeon Kim, Hae-Lim Kim, Jinhua Cheng, Bao Le, Seung Hwan Yang & Joo-Won Suh. (2019) Leukodin isolated from Artemisia capillaris inhibits alpha-melanocyte stimulating hormone induced melanogenesis in B16F10 melanoma cells. European Journal of Integrative Medicine 25, pages 85-91.
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Thuany Alencar-Silva, Mariana Carolina Braga, Gustavo Oliveira Silva Santana, Felipe Saldanha-Araujo, Robert Pogue, Simoni Campos Dias, Octavio Luiz Franco & Juliana Lott Carvalho. (2018) Breaking the frontiers of cosmetology with antimicrobial peptides. Biotechnology Advances 36:8, pages 2019-2031.
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Shuai Hao, Shuang Li, Jing Wang, Lei Zhao, Chan Zhang, Weiwei Huang & Chengtao Wang. (2018) Phycocyanin Reduces Proliferation of Melanoma Cells through Downregulating GRB2/ERK Signaling. Journal of Agricultural and Food Chemistry 66:41, pages 10921-10929.
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Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Manoj Manickam & Sang-Hun Jung. (2018) Inhibitors of Melanogenesis: An Updated Review. Journal of Medicinal Chemistry 61:17, pages 7395-7418.
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Gyeong-A. Ko & Somi Kim Cho. (2018) Phytol suppresses melanogenesis through proteasomal degradation of MITF via the ROS-ERK signaling pathway. Chemico-Biological Interactions 286, pages 132-140.
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Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Pedro Antonio Garcia-Ruiz, Adrian Saura-Sanmartin, Jose Berna, Jose Neptuno Rodríguez-López & Francisco Garcia-Canovas. (2018) Action of tyrosinase on caffeic acid and its n-nonyl ester. Catalysis and suicide inactivation. International Journal of Biological Macromolecules 107, pages 2650-2659.
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Qi Li, Hongyu Yang, Jun Mo, Yao Chen, Yue Wu, Chen Kang, Yuan Sun & Haopeng Sun. (2018) Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors. PeerJ 6, pages e4206.
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Thanigaimalai Pillaiyar, Manoj Manickam & Sang-Hun Jung. (2017) Recent development of signaling pathways inhibitors of melanogenesis. Cellular Signalling 40, pages 99-115.
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Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Pedro Antonio Garcia-Ruiz, Adrian Saura-Sanmartin, Jose Berna, Francisco Garcia-Canovas & José Neptuno Rodriguez-Lopez. (2017) Structural and kinetic considerations on the catalysis of deoxyarbutin by tyrosinase. PLOS ONE 12:11, pages e0187845.
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Raffaella Micillo, Valeria Pistorio, Elio Pizzo, Lucia Panzella, Alessandra Napolitano & Marco d’Ischia. (2017) 2-S-Lipoylcaffeic Acid, a Natural Product-Based Entry to Tyrosinase Inhibition via Catechol Manipulation. Biomimetics 2:4, pages 15.
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Chao Niu & Haji A. Aisa. (2017) Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo. Molecules 22:8, pages 1303.
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Hyeju Jo, Minho Choi, Jaeuk Sim, Mayavan Viji, Siyuan Li, Young Hee Lee, Youngsoo Kim, Seung-Yong Seo, Yuanyuan Zhou, Kiho Lee, Wun-Jae Kim, Jin Tae Hong, Heesoon Lee & Jae-Kyung Jung. (2017) Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis. Bioorganic & Medicinal Chemistry Letters 27:15, pages 3374-3377.
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Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Jose Berna, José Neptuno Rodriguez-Lopez, Jose Tudela & Francisco Garcia-Canovas. (2017) Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLOS ONE 12:5, pages e0177330.
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Yuan-Yuan Liu, Xiu-Rong Su, Shou-Sheng Liu, Shuang-Shuang Yang, Cheng-Yan Jiang, Yu Zhang & Shicui Zhang. (2017) Zebrafish phosvitin-derived peptide Pt5 inhibits melanogenesis via cAMP pathway. Fish Physiology and Biochemistry 43:2, pages 517-525.
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Francesca Pintus, Maria J. Matos, Santiago Vilar, George Hripcsak, Carla Varela, Eugenio Uriarte, Lourdes Santana, Fernanda Borges, Rosaria Medda, Amalia Di Petrillo, Benedetta Era & Antonella Fais. (2017) New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies. Bioorganic & Medicinal Chemistry 25:5, pages 1687-1695.
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Thanigaimalai Pillaiyar, Manoj Manickam & Sang-Hun Jung. (2017) Downregulation of melanogenesis: drug discovery and therapeutic options. Drug Discovery Today 22:2, pages 282-298.
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Pauline Burger, Anne Landreau, Stéphane Azoulay, Thomas Michel & Xavier Fernandez. (2016) Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners. Cosmetics 3:4, pages 36.
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Lijun Sun, Shengjun Pan, Yuejin Yang, Jingying Sun, Daoyan Liang, Xin Wang, Xin Xie & Jun Hu. (2016) Toll-like receptor 9 regulates melanogenesis through NF-κB activation. Experimental Biology and Medicine 241:14, pages 1497-1504.
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Carmen Vanessa Ortiz-Ruiz, Jose Berna, Jose Neptuno Rodriguez-Lopez, Virginia Tomas & Francisco Garcia-Canovas. (2015) Tyrosinase-Catalyzed Hydroxylation of 4-Hexylresorcinol, an Antibrowning and Depigmenting Agent: A Kinetic Study. Journal of Agricultural and Food Chemistry 63:31, pages 7032-7040.
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M. J. Matos, C. Varela, S. Vilar, G. Hripcsak, F. Borges, L. Santana, E. Uriarte, A. Fais, A. Di Petrillo, F. Pintus & B. Era. (2015) Design and discovery of tyrosinase inhibitors based on a coumarin scaffold. RSC Advances 5:114, pages 94227-94235.
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Ayse Kose & Suphi S. Oncel. (2022) <i>In Silico</i> Design of Melanogenesis Regulatory Peptides from Phycocyanin of <i>Spirulina Platensis</i>. SSRN Electronic Journal.
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