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Expert Opinion on Therapeutic Patents Volume 25, 2015 - Issue 7
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Patent Review

Small molecule inhibitor of apoptosis proteins antagonists: a patent review

Alexander W HirdAstraZeneca, Medicinal Chemistry, Oncology iMed, 35 Gatehouse Drive, Waltham, MA 02451, USA+1 781 839 4145; [email protected]
, PhD (Team Leader) ,
Brian M AquilaAstraZeneca, Medicinal Chemistry, Oncology iMed, 35 Gatehouse Drive, Waltham, MA 02451, USA
, PhD (Associate Director) ,
Edward J HennessyAstraZeneca, Medicinal Chemistry, Oncology iMed, 35 Gatehouse Drive, Waltham, MA 02451, USA
, PhD (Senior Medicinal Chemist) ,
Melissa M VasbinderAstraZeneca, Medicinal Chemistry, Oncology iMed, 35 Gatehouse Drive, Waltham, MA 02451, USA+1 781 839 4145; [email protected]
, PhD (Team Leader) &
Bin YangAstraZeneca, Medicinal Chemistry, Oncology iMed, 35 Gatehouse Drive, Waltham, MA 02451, USA
, PhD (Medicinal Chemist)
Pages 755-774 | Published online: 18 May 2015

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Qingsheng Huang, Yin Peng, Yuefeng Peng, Dan Wei, Yanjie Wei & Shengzhong Feng. (2019) The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP. Drug Design, Development and Therapy 13, pages 1373-1388.
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Articles from other publishers (12)

Yun Li, Yunhong Song & Yulian Liang. (2023) AREL1 resists the apoptosis induced by TGF‐β by inhibiting SMAC in vascular endothelial cells. Journal of Biochemical and Molecular Toxicology.
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Agnieszka Łupicka-Słowik, Mateusz Psurski, Renata Grzywa, Monika Cuprych, Jarosław Ciekot, Waldemar Goldeman, Elżbieta Wojaczyńska, Jacek Wojaczyński, Józef Oleksyszyn & Marcin Sieńczyk. (2020) Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists. Investigational New Drugs 38:5, pages 1350-1364.
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Nicole Blaquiere, Elisia Villemure & Steven T. Staben. (2020) Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases. Journal of Medicinal Chemistry 63:15, pages 7957-7985.
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Jiafei Zhan, Hongyu Song, Ning Wang, Cheng Guo, Nengxing Shen, Ruiqi Hua, Yuan Shi, Christiana Angel, Xiaobin Gu, Yue Xie, Weimin Lai, Xuerong Peng & Guangyou Yang. (2020) Molecular and Functional Characterization of Inhibitor of Apoptosis Proteins (IAP, BIRP) in Echinococcus granulosus. Frontiers in Microbiology 11.
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Emma Morrish, Gabriela Brumatti & John Silke. (2020) Future Therapeutic Directions for Smac-Mimetics. Cells 9:2, pages 406.
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Maja T. Tomicic, Christian Steigerwald, Birgit Rasenberger, Anamaria Brozovic & Markus Christmann. (2019) Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Archives of Toxicology.
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Hui Cong, Lijuan Xu, Yougen Wu, Zhuo Qu, Tengfei Bian, Wannian Zhang, Chengguo Xing & Chunlin Zhuang. (2019) Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. Journal of Medicinal Chemistry 62:12, pages 5750-5772.
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Xianbo Huang, Feng Xiao, Yuan Li, Wenbin Qian, Wei Ding & Xiujin Ye. (2018) Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia. Journal of Experimental & Clinical Cancer Research 37:1.
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Tiane C. Finimundy, Rui M.V. Abreu, Natalia Bonetto, Fernando J. Scariot, Aldo J.P. Dillon, Sergio Echeverrigaray, Lillian Barros, Isabel C.F.R. Ferreira, João A.P. Henriques & Mariana Roesch-Ely. (2018) Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines. Food and Chemical Toxicology 112, pages 383-392.
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Rama Rathore, Jennifer E. McCallum, Elizabeth Varghese, Ana-Maria Florea & Dietrich Büsselberg. (2017) Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs). Apoptosis 22:7, pages 898-919.
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Mary Iconomou & Darren N. Saunders. (2016) Systematic approaches to identify E3 ligase substrates. Biochemical Journal 473:22, pages 4083-4101.
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Huizhong Gan, Hua Liu, Hui Zhang, Yueyue Li, Xiaorong Xu, Xuanfu Xu & Jianming Xu. (2016) SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral IAP repeat-containing 3 (BIRC3) gene in pancreatic cancer cells. Tumor Biology 37:7, pages 9943-9950.
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