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Lessons from black pepper: piperine and derivatives thereof

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Pages 245-264 | Received 10 Jun 2015, Accepted 05 Nov 2015, Published online: 05 Dec 2015

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Diaaeldin M. Elimam, Abdullah A. Elgazar, Fardous F. El-Senduny, Ramadan A. El-Domany, Farid A Badria & Wagdy M. Eldehna. (2022) Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 39-50.
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Sayan Biswas, Amit Kar, Nanaocha Sharma, Pallab K. Haldar & Pulok K. Mukherjee. (2021) Synergistic effect of ursolic acid and piperine in CCl4 induced hepatotoxicity. Annals of Medicine 53:1, pages 2009-2017.
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Anita Trajkovska-Broach & Anka Trajkovska Petkoska. 2023. Herbs and Spices - New Advances. Herbs and Spices - New Advances.
Shofiul Azam, Ju-Young Park, In-Su Kim & Dong-Kug Choi. (2022) Piperine and Its Metabolite’s Pharmacology in Neurodegenerative and Neurological Diseases. Biomedicines 10:1, pages 154.
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Araceli Rivera-Pérez, Roberto Romero-González & Antonia Garrido Frenich. (2022) A metabolomics approach based on 1H NMR fingerprinting and chemometrics for quality control and geographical discrimination of black pepper. Journal of Food Composition and Analysis 105, pages 104235.
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Nihong Lu, Yongrui Yang, Xiaofei Li, Jie Li, Jie Cheng, Zhengxuan Lv & Yingrong Du. (2021) The protective action of piperlongumine against mycobacterial pulmonary tuberculosis in its mitigation of inflammation and macrophage infiltration in male BALB/c mice. Journal of Veterinary Research 65:4, pages 431-440.
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Dongdong Wang, Lu Zhang, Jiansheng Huang, K. Himabindu, Devesh Tewari, Jarosław O. Horbańczuk, Suowen Xu, Zhu Chen & Atanas G. Atanasov. (2021) Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine. Trends in Food Science & Technology 117, pages 34-45.
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Rainer Ziegenhagen, Katharina Heimberg, Alfonso Lampen & Karen Ildico Hirsch-Ernst. (2021) Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus. Foods 10:9, pages 2121.
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Helin Li, Xiaoyu Wu, Xin Li, Xiaobing Cao, Yanjun Li, Huaru Cao & Yongzhi Men. (2021) Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity. Frontiers in Chemistry 9.
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Karolina Wojtowicz, Karolina Sterzyńska, Monika Świerczewska, Michał Nowicki, Maciej Zabel & Radosław Januchowski. (2021) Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs. International Journal of Molecular Sciences 22:8, pages 4243.
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Sagar Joshi, Salahuddin, Rajnish Kumar & Divya Sharma. (2021) An Overview of Bioactive Alkaloid, Semi-Synthetic Analogs, Mechanism of Action and Structure-Activity Relationship of Piperine as Antioxidant. Asian Journal of Chemistry 33:9, pages 2244-2250.
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Neetu Sachan, Dilipkumar Pal & Phool Chandra. 2021. Bioactive Natural Products for Pharmaceutical Applications. Bioactive Natural Products for Pharmaceutical Applications 759 791 .
Eleonora Turrini, Piero Sestili & Carmela Fimognari. (2020) Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine. Toxins 12:12, pages 747.
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Elwira Sieniawska, Magdalena Maciejewska‐Turska, Łukasz Świątek & Jianbo Xiao. (2020) Plant‐based Food Products for Antimycobacterial Therapy. eFood 1:3, pages 199-216.
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Chuchu Qiao, Shiling Hu, Delu Che, Jue Wang, Jiapan Gao, Ruiping Ma, Wenjun Jiang, Tao Zhang & Rui Liu. (2020) The anti‐anaphylactoid effects of Piperine through regulating MAS‐related G protein‐coupled receptor X2 activation. Phytotherapy Research 34:6, pages 1409-1420.
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Arumugam Priya & Shunmugiah Karutha Pandian. (2020) Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans. Frontiers in Microbiology 11.
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Yan-Ni Mi, Na-Na Ping & Yong-Xiao Cao. 2021. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 139 188 .
Megan M. Niedzwiecki, Douglas I. Walker, Jennifer Christina Howell, Kelly D. Watts, Dean P. Jones, Gary W. Miller & William T. Hu. (2019) High‐resolution metabolomic profiling of Alzheimer’s disease in plasma. Annals of Clinical and Translational Neurology 7:1, pages 36-45.
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Jose F. Garcia-Bustos, Brad E. Sleebs & Robin B. Gasser. (2019) An appraisal of natural products active against parasitic nematodes of animals. Parasites & Vectors 12:1.
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Katarina Smilkov, Darinka G. Ackova, Aleksandar Cvetkovski, Tatjana Ruskovska, Bojana Vidovic & Mustafa Atalay. (2019) Piperine: Old Spice and New Nutraceutical?. Current Pharmaceutical Design 25:15, pages 1729-1739.
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Sergey Shityakov, Ehsan Bigdelian, Aqeel A. Hussein, Muhammad Bilal Hussain, Yogesh Chandra Tripathi, Muhammad Usman Khan & Mohammad Ali Shariati. (2019) Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper. European Journal of Medicinal Chemistry 176, pages 149-161.
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Eunice Ego Mgbeahuruike, Milla Stålnacke, Heikki Vuorela & Yvonne Holm. (2019) Antimicrobial and Synergistic Effects of Commercial Piperine and Piperlongumine in Combination with Conventional Antimicrobials. Antibiotics 8:2, pages 55.
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Daniel Chavarria, Fernando Cagide, Miguel Pinto, Lígia R. Gomes, John N. Low & Fernanda Borges. (2019) Development of piperic acid-based monoamine oxidase inhibitors: Synthesis, structural characterization and biological evaluation. Journal of Molecular Structure 1182, pages 298-307.
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Karen Jesus Oliveira, Maria Isabel Chiamolera, Gisele Giannocco, Carmen Cabanelas Pazos-Moura & Tania Maria Ortiga-Carvalho. (2019) Thyroid function disruptors: from nature to chemicals. Journal of Molecular Endocrinology 62:1, pages R1-R19.
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Eunice Mgbeahuruike, Pia Fyhrquist, Heikki Vuorela, Riitta Julkunen-Tiitto & Yvonne Holm. (2018) Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects. Antibiotics 7:4, pages 98.
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Irena Philipova, Violeta Valcheva, Rositsa Mihaylova, Mina Mateeva, Irini Doytchinova & Georgi Stavrakov. (2018) Synthetic piperine amide analogs with antimycobacterial activity. Chemical Biology & Drug Design 91:3, pages 763-768.
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Florence Lefranc, Nurhayat Tabanca & Robert Kiss. (2017) Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests. Seminars in Cancer Biology 46, pages 14-32.
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Nami Kim, Miso Nam, Mi Sun Kang, Jung Ok Lee, Yong Woo Lee, Geum-Sook Hwang & Hyeon Soo Kim. (2017) Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells. Scientific Reports 7:1.
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