307
Views
36
CrossRef citations to date
0
Altmetric
Reviews

2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008–2014)

, , &
Pages 149-173 | Received 06 Jul 2015, Accepted 05 Nov 2015, Published online: 04 Dec 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Jamelah S. Al-Otaibi, Y. Sheena Mary, Y. Shyma Mary & S. Aayisha. (2023) DFT Conformational, Wavefunction Based Reactivity Analysis, Docking and MD Simulations of a Carboxamide Derivative with Potential Anticancer Activity. Polycyclic Aromatic Compounds 43:2, pages 1590-1601.
Read now
Veerareddy Arava & Surendrareddy Gogireddy. (2017) An improved process for the synthesis of nintedanib esylate. Synthetic Communications 47:10, pages 975-981.
Read now

Articles from other publishers (34)

Johannes Großkopf, Alexandra A. Heidecker & Thorsten Bach. (2023) Photochemical Deracemization of 3‐Substituted Oxindoles. Angewandte Chemie International Edition 62:30.
Crossref
Johannes Großkopf, Alexandra A. Heidecker & Thorsten Bach. (2023) Photochemical Deracemization of 3‐Substituted Oxindoles. Angewandte Chemie 135:30.
Crossref
Dawon Bae, Prakash Chaudhary, Jae-Hui Been, Jaya Gautam, Jisu Lee, Sajita Shah, Euijung Kim, Hyunji Lee, Tae-gyu Nam, Byeong-Seon Jeong & Jung-Ae Kim. (2023) Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis. European Journal of Medicinal Chemistry 251, pages 115274.
Crossref
Silvia Salerno, Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Federico Da Settimo & Sabrina Taliani. (2023) Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents. Molecules 28:6, pages 2587.
Crossref
Sameer A. Karpe & Dhananjoy Mondal. (2022) Synthesis of 3‐Hydroxy‐2‐oxindole and 2,5‐Diketopiperazine Cores as Privileged Scaffolds of Indole Alkaloids. ChemistrySelect 7:36.
Crossref
Rita Morigi, Elena Catanzaro, Alessandra Locatelli, Cinzia Calcabrini, Valentina Pellicioni, Alberto Leoni & Carmela Fimognari. (2021) Synthesis and Biological Evaluation of New Bis-Indolinone Derivatives Endowed with Cytotoxic Activity. Molecules 26:20, pages 6277.
Crossref
Munmee Goswami, Arup Dutta, Pooja Paul & Rishanlang Nongkhlaw. (2021) Recent Developments on Catalyst‐Free, Visible‐Light‐Triggered Synthesis of Heterocyclic Scaffolds and Their Mechanistic Study. ChemistrySelect 6:36, pages 9684-9700.
Crossref
Humberto Ortega, Daniel Torres-Mendoza, Zuleima Caballero E.Luis Cubilla-Rios. (2021) Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi. Journal of Fungi 7:7, pages 570.
Crossref
Vartika Bisht, Katrina Nash, Yuanwei Xu, Prasoon Agarwal, Sofie Bosch, Georgios V. Gkoutos & Animesh Acharjee. (2021) Integration of the Microbiome, Metabolome and Transcriptomics Data Identified Novel Metabolic Pathway Regulation in Colorectal Cancer. International Journal of Molecular Sciences 22:11, pages 5763.
Crossref
Yue Liu, Ying Zhang, Qian‐Wei Huang, Chuan Gou, Qing‐Zhu Li, Qing‐Song Dai, Hai‐Jun Leng & Jun‐Long Li. (2021) Organocatalytic Enantioselective Synthesis of Tetrahydro‐Furanyl Spirooxindoles via [3+2] Annulations of 3‐Hydroxyoxindoles and Cyclic Ketolactams. Advanced Synthesis & Catalysis 363:8, pages 2177-2182.
Crossref
Youpeng Zuo, Xinwei He, Qiang Tang, Wangcheng Hu, Tongtong Zhou, Wenbo Hu & Yongjia Shang. (2020) Palladium‐Catalyzed 5‐ exo‐dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3‐Methyleneindolinones . Advanced Synthesis & Catalysis 363:8, pages 2117-2123.
Crossref
Xuan Wang, Jiaxiang Liu, Ziqin Yan, Xiaohong Liu, Sixiu Liu, Yanrui Suo, Weiwei Lu, Jinfeng Yue, Kaixian Chen, Hualiang Jiang, Yujun Zhao, Mingyue Zheng, Dongcheng Dai & Xiaojie Lu. (2021) Diversified strategy for the synthesis of DNA-encoded oxindole libraries. Chemical Science 12:8, pages 2841-2847.
Crossref
Hye Suk Baek, Victor Sukbong Hong, Sang Hyon Kim, Jinho Lee & Shin Kim. (2021) KMU-1170, a Novel Multi-Protein Kinase Inhibitor, Suppresses Inflammatory Signal Transduction in THP-1 Cells and Human Osteoarthritic Fibroblast-Like Synoviocytes by Suppressing Activation of NF-κB and NLRP3 Inflammasome Signaling Pathway. International Journal of Molecular Sciences 22:3, pages 1194.
Crossref
Huda K. Mahmoud, Thoraya A. Farghaly, Hanan G. Abdulwahab, Nadia T. Al-Qurashi & Mohamed R. Shaaban. (2020) Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity. European Journal of Medicinal Chemistry 208, pages 112752.
Crossref
Sami A. Al-Hussain, Thoraya A. Farghaly, Magdi E.A. Zaki, Hanan G. Abdulwahab, Nadia T. Al-Qurashi & Zeinab A. Muhammad. (2020) Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity. Bioorganic Chemistry 105, pages 104330.
Crossref
N. P. Novichikhina, A. A. Skoptsova, A. S. Shestakov, A. Yu. Potapov, E. A. Kosheleva, O. A. Kozaderov, I. V. Ledenyova, N. A. Podoplelova, M. A. Panteleev & Kh. S. Shikhaliev. (2020) Synthesis and Anticoagulant Activity of New Ethylidene and Spiro Derivatives of Pyrrolo[3,2,1-ij]quinolin-2-ones. Russian Journal of Organic Chemistry 56:9, pages 1550-1556.
Crossref
Hye Suk Baek, Hyeon Ji Min, Victor Sukbong Hong, Taeg Kyu Kwon, Jong Wook Park, Jinho Lee & Shin Kim. (2020) Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU-470 in RAW 264.7 Cells through the TLR4-NF-κB-NLRP3 Pathway. International Journal of Molecular Sciences 21:14, pages 5138.
Crossref
Kobra Nikoofar & Seyedeh S. Peyrovebaghi. (2020) Ultrasound‐assisted synthesis of 3‐(1‐(2‐(1 H ‐indol‐3‐yl)ethyl)‐2‐aryl‐6,6‐dimethyl‐4‐oxo‐4,5,6,7‐tetrahydro‐1 H ‐indol‐3‐yl)indolin‐2‐ones by novel core‐shell bio‐based nanocatalyst anchoring sulfonated L ‐histidine on magnetized silica (SO 3 H‐ L ‐His@SiO 2 ‐nano Fe 3 O 4 ) . Journal of the Chinese Chemical Society 67:7, pages 1303-1313.
Crossref
Jyothi Dhuguru & Rachid Skouta. (2020) Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents. Molecules 25:7, pages 1615.
Crossref
Assem Barakat, Mohammad Shahidul Islam, Hussien Mansur Ghawas, Abdullah Mohammed Al-Majid, Fardous F. El-Senduny, Farid A. Badria, Yaseen A.M.M. Elshaier & Hazem A. Ghabbour. (2019) Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction. Bioorganic Chemistry 86, pages 598-608.
Crossref
Alpana K. Gupta, Mausumi Bharadwaj & Ravi Mehrotra. (2019) Eco-friendly Polyethylene Glycol-400 as a Rapid and Efficient Recyclable Reaction Medium for the Synthesis of Anticancer Isatin-linked Chalcones and Their 3-Hydroxy Precursor. Journal of Heterocyclic Chemistry 56:2, pages 703-709.
Crossref
Lucas Milanez Benicio, Ane Stefano Simionato, Cláudio Roberto Novello, Jeconias Rocha Guimarães, Ingrid Felicidade, Admilton Gonçalves de Oliveira, João Carlos Palazzo de Mello, Mário Sérgio Mantovani, Andreas Lazaros Chryssafidis, Galdino Andrade, Ilce Mara de Syllos Colus & Marcelo Tempesta de Oliveira. (2018) RNAm expression profile of cancer marker genes in HepG2 cells treated with different concentrations of a new indolin-3-one from Pseudomonas aeruginosa. Scientific Reports 8:1.
Crossref
Geoffrey Schwertz, Matthias C. Witschel, Matthias Rottmann, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Watcharee Amornwatcharapong, Wanwipa Ittarat, Anja Schäfer, Raphael A. Aponte, Nils Trapp, Pimchai Chaiyen & François Diederich. (2018) Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold . ChemMedChem 13:9, pages 931-943.
Crossref
Anna Pratima G. Nikalje, Shailee V. Tiwari, Jaiprakash N. Sangshetti & Manoj D. Damale. (2018) Ultrasound-mediated synthesis, biological evaluation, docking and in vivo acute oral toxicity study of novel indolin-2-one coupled pyrimidine derivatives. Research on Chemical Intermediates 44:5, pages 3031-3059.
Crossref
Alexei Medvedev, Olga Buneeva, Oksana Gnedenko, Pavel Ershov & Alexis Ivanov. (2018) Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications. BioFactors 44:2, pages 95-108.
Crossref
Riham F George. (2018) Facile synthesis of simple 2-oxindole-based compounds with promising antiproliferative activity. Future Medicinal Chemistry 10:3, pages 269-282.
Crossref
Assem Barakat, Mohammad Shahidul Islam, Hussien Mansur Ghawas, Abdullah Mohammed Al-Majid, Fardous F. El-Senduny, Farid A. Badria, Yaseen A. M. M. Elshaier & Hazem A. Ghabbour. (2018) Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1. RSC Advances 8:26, pages 14335-14346.
Crossref
Carlos J.A. Ribeiro, Rute C. Nunes, Joana D. Amaral, Lídia M. Gonçalves, Cecília M.P. Rodrigues, Rui Moreira & Maria M.M. Santos. (2017) Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry 140, pages 494-509.
Crossref
Duc Nghia Ong, Sebastian Dittrich, Sören Swyter, Manfred Jung & Franz Bracher. (2017) Synthesis of highly substituted 3-arylideneindolin-2-ones. Tetrahedron.
Crossref
E. Vessally, R. Hosseinzadeh-Khanmiri, E. Ghorbani-Kalhor, M. Es'haghi & A. Bekhradnia. (2017) Domino carbometalation/coupling reactions of N-arylpropiolamides: a novel and promising synthetic strategy toward stereocontrolled preparation of highly substituted 3-methyleneindolinones. RSC Advances 7:31, pages 19061-19072.
Crossref
Atulya Nagarsenkar, Lalita Guntuku, Sravanthi Devi Guggilapu, Danthi Bai K., Srinivasulu Gannoju, V.G.M. Naidu & Nagendra Babu Bathini. (2016) Synthesis and apoptosis inducing studies of triazole linked 3-benzylidene isatin derivatives. European Journal of Medicinal Chemistry 124, pages 782-793.
Crossref
Hua Sun, Yazhou Zhang, Weina Ding, Xue Zhao, Xiaotong Song, Dong Wang, Yashan Li, Kailin Han, Yang Yang, Ying Ma, Runling Wang, Dong Wang & Peng Yu. (2016) Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry 123, pages 365-378.
Crossref
Kishna Ram Senwar, T. Srinivasa Reddy, Dinesh Thummuri, Pankaj Sharma, V.G.M. Naidu, Gannoju Srinivasulu & Nagula Shankaraiah. (2016) Design, synthesis and apoptosis inducing effect of novel (Z)-3-(3′-methoxy-4′-(2-amino-2-oxoethoxy)-benzylidene)indolin-2-ones as potential antitumour agents. European Journal of Medicinal Chemistry 118, pages 34-46.
Crossref
Kishna Ram Senwar, T. Srinivasa Reddy, Dinesh Thummuri, Pankaj Sharma, Suresh K. Bharghava, V.G.M. Naidu & Nagula Shankaraiah. (2016) Design and synthesis of 4′-O-alkylamino-tethered-benzylideneindolin-2-ones as potent cytotoxic and apoptosis inducing agents. Bioorganic & Medicinal Chemistry Letters 26:16, pages 4061-4069.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.