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Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn’s disease

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Pages 175-197 | Received 17 Jul 2015, Accepted 09 Dec 2015, Published online: 22 Jan 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Vishnu C. Damalanka, Amarendar Reddy Maddirala & James W. Janetka. (2021) Novel approaches to glycomimetic design: development of small molecular weight lectin antagonists. Expert Opinion on Drug Discovery 16:5, pages 513-536.
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Wael Elhenawy, Alexander Oberc & Brian K. Coombes. (2018) A polymicrobial view of disease potential in Crohn's-associated adherent-invasive E. coli. Gut Microbes 9:2, pages 166-174.
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Adeline Sivignon, Julie Bouckaert, Julien Bernard, Sebastien G. Gouin & Nicolas Barnich. (2017) The potential of FimH as a novel therapeutic target for the treatment of Crohn’s disease. Expert Opinion on Therapeutic Targets 21:9, pages 837-847.
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Laurel K. Mydock-McGrane, Thomas J. Hannan & James W. Janetka. (2017) Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn’s disease. Expert Opinion on Drug Discovery 12:7, pages 711-731.
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Francesco Scaglione, Paola Minghetti, Francesco Ambrosio, Beat Ernst, Vincenzo Ficarra, Marco Gobbi, Kurt Naber & Huub Schellekens. (2023) Nature of the Interaction of Alpha-D-Mannose and Escherichia coli Bacteria, and Implications for its Regulatory Classification. A Delphi Panel European Consensus Based on Chemistry and Legal Evidence. Therapeutic Innovation & Regulatory Science 57:6, pages 1153-1166.
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Priyanka Samanta & Robert J. Doerksen. (2023) Identifying FmlH lectin-binding small molecules for the prevention of Escherichia coli-induced urinary tract infections using hybrid fragment-based design and molecular docking. Computers in Biology and Medicine 163, pages 107072.
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