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Research

Patent Update Central & Peripheral Nervous Systems: Glycine-site NMDA receptor antagonists: an update

Pages 1069-1079 | Published online: 29 Feb 2008

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Trevor W Stone. (2001) Kynurenic acid antagonists and kynurenine pathway inhibitors. Expert Opinion on Investigational Drugs 10:4, pages 633-645.
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Articles from other publishers (33)

Nadeem Siddiqui, Md. Shamsher Alam, Ruhi Ali, M. Shahar Yar & Ozair Alam. (2016) Synthesis of new benzimidazole and phenylhydrazinecarbothiomide hybrids and their anticonvulsant activity. Medicinal Chemistry Research 25:7, pages 1390-1402.
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Shailesh V. Jain, Kamlendra S. Bhadoriya, Sanjaykumar B. Bari, Nitendra K. Sahu & Manjunath Ghate. (2011) Discovery of potent anticonvulsant ligands as dual NMDA and AMPA receptors antagonists by molecular modelling studies. Medicinal Chemistry Research 21:11, pages 3465-3484.
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Zhengjun Cheng, Yuntao Zhang & Weizhong Fu. (2010) Predictive QSAR models of 3-acylamino-2-aminopropionic acid derivatives as partial agonists of the glycine site on the NMDA receptor. Medicinal Chemistry Research 20:8, pages 1235-1246.
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Flavia Varano, Daniela Catarzi, Vittoria Colotta, Daniela Poli, Guido Filacchioni, Alessandro Galli & Chiara Costagli. (2009) Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazolines as Glycine/N-Methyl-D-aspartic Acid Receptor Antagonists. Chemical and Pharmaceutical Bulletin 57:8, pages 826-829.
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Flavia Varano, Daniela Catarzi, Vittoria Colotta, Francesca Romana Calabri, Ombretta Lenzi, Guido Filacchioni, Alessandro Galli, Chiara Costagli, Francesca Deflorian & Stefano Moro. (2005) 1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: Synthesis, biological evaluation, and molecular modeling study. Bioorganic & Medicinal Chemistry 13:19, pages 5536-5549.
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Daniela Catarzi, Vittoria Colotta, Flavia Varano, Francesca Romana Calabri, Guido Filacchioni, Alessandro Galli, Chiara Costagli & Vincenzo Carlà. (2003) Synthesis and Biological Evaluation of Analogues of 7-Chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5- a ]quinoxaline-2-carboxylic Acid (TQX-173) as Novel Selective AMPA Receptor Antagonists . Journal of Medicinal Chemistry 47:1, pages 262-272.
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Boris Chizh & P Max Headley. 2003. Pain. Pain.
Trevor W. Stone & L. Gail Darlington. (2002) Endogenous kynurenines as targets for drug discovery and development. Nature Reviews Drug Discovery 1:8, pages 609-620.
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Flavia Varano, Daniela Catarzi, Vittoria Colotta, Guido Filacchioni, Alessandro Galli, Chiara Costagli & Vincenzo Carlà. (2002) Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5- c ]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists . Journal of Medicinal Chemistry 45:5, pages 1035-1044.
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Daniela Catarzi, Vittoria Colotta, Flavia Varano, Guido Filacchioni, Alessandro Galli, Chiara Costagli & Vincenzo Carlà. (2001) Synthesis, Ionotropic Glutamate Receptor Binding Affinity, and Structure−Activity Relationships of a New Set of 4,5-Dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5- a ]quinoxaline-2-carboxylates Analogues of TQX-173 . Journal of Medicinal Chemistry 44:19, pages 3157-3165.
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Ki-Jun Hwang, Tae-Suk Lee, Ki-Won Kim, Beom-Tae Kim, Chul-Min Lee, Eun-Young Park & Ran-Sook Woo. (2001) 4-Hydroxy-6-Oxo-6,7-Dihydro-Thieno[2,3-b] pyrimidine derivatives: Synthesis and their biological evaluation for the glycine site acting on theN-Methyl-D-aspartate (NMDA) receptor. Archives of Pharmacal Research 24:4, pages 270-275.
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M. Jonathan FrayDavid J. BullChristopher L. CarrElisabeth C. L. GautierCharles E. MowbrayAlan Stobie. (2001) Structure−Activity Relationships of 1,4-Dihydro-(1H,4H)-quinoxaline-2,3-diones as N -Methyl- d -aspartate (Glycine Site) Receptor Antagonists. 1. Heterocyclic Substituted 5-Alkyl Derivatives . Journal of Medicinal Chemistry 44:12, pages 1951-1962.
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Trevor W Stone. (2001) Kynurenines in the CNS: from endogenous obscurity to therapeutic importance. Progress in Neurobiology 64:2, pages 185-218.
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Flavia Varano, Daniela Catarzi, Vittoria Colotta, Lucia Cecchi, Guido Filacchioni, Alessandro Galli & Chiara Costagli. (2001) Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and of their constrained analogue imidazo[1,5-a]quinoxaline-1,3,4-triones as glycine/NMDA receptor antagonists. European Journal of Medicinal Chemistry 36:2, pages 203-209.
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Terushi HARADAHIRA, Ming-Rong ZHANG, Jun MAEDA, Takashi OKAUCHI, Takayo KIDA, Kouichi KAWABE, Sigeki SASAKI, Tetsuya SUHARA & Kazutoshi SUZUKI. (2001) A Prodrug of NMDA/Glycine Site Antagonist, L-703,717, with Improved BBB Permeability. 4-Acetoxy Derivative and Its Positron-Emitter Labeled Analog.. Chemical and Pharmaceutical Bulletin 49:2, pages 147-150.
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Daniela Catarzi, Vittoria Colotta, Flavia Varano, Lucia Cecchi, Guido Filacchioni, Alessandro Galli, Chiara Costagli & Vincenzo Carlà. (2000) 7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)- 4-oxo-1,2,4-triazolo[1,5- a ]quinoxaline-2- carboxylates as Novel Highly Selective AMPA Receptor Antagonists . Journal of Medicinal Chemistry 43:21, pages 3824-3826.
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Patrick Jimonet, Yves Ribeill, Georg Andrees Bohme, Alain Boireau, Michel Chevé,, Dominique Damour, Adam Doble, Arielle Genevois-Borella, Frédéric Herman, Assunta Imperato, Sylvain Le Guern, Franco Manfré, Jeremy Pratt, John C. R. Randle, Jean-Marie Stutzmann & Serge Mignani. (2000) Indeno[1,2- b ]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity . Journal of Medicinal Chemistry 43:12, pages 2371-2381.
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Ki-Jun Hwang & Tae-suk Lee. (2000) Synthesis of 4,6-dichloro-3-[(1-N-arylaminocarbonyl)-hydrazono]-1,3-dihydro-indole-2-one as a potential NMDA receptor glycine site antagonist. Archives of Pharmacal Research 23:2.
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Manolo Mugnaini, Giovanna Dal Forno, Mauro Corsi & Bernd Bunnemann. (2000) Receptor binding characteristics of the novel NMDA receptor glycine site antagonist [3H]GV150526A in rat cerebral cortical membranes. European Journal of Pharmacology 391:3, pages 233-241.
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Trevor W Stone. (2000) Inhibitors of the kynurenine pathway. European Journal of Medicinal Chemistry 35:2, pages 179-186.
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Éva Csikós, György G. Ferenczy, János G. Ángyán, Zsolt Böcskei, Kálmán Simon, Csaba Gönczi, István Hermecz & István Hermecz. (1999) Colour Polymorphism of a Bis(quinoxaline) Compound. European Journal of Organic Chemistry 1999:9, pages 2119-2125.
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Daniela Catarzi, Vittoria Colotta, Flavia Varano, Lucia Cecchi, Guido Filacchioni, Alessandro Galli & Chiara Costagli. (1999) 4,5-Dihydro-1,2,4-triazolo[1,5- a ]quinoxalin-4-ones:  Excitatory Amino Acid Antagonists with Combined Glycine/NMDA and AMPA Receptor Affinity . Journal of Medicinal Chemistry 42:13, pages 2478-2484.
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Takayoshi Yoshikawa, Toshiyuki Sakaeda (nee Kakutani)Tamio Sugawara, Koichiro Hirano & Valentino J Stella. (1999) A novel chemical delivery system for brain targeting. Advanced Drug Delivery Reviews 36:2-3, pages 255-275.
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Terushi Haradahira & Kazutoshi Suzuki. (1999) An improved synthesis of [11C]L-703,717 as a radioligand for the glycine site of the NMDA receptor. Nuclear Medicine and Biology 26:2, pages 245-247.
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Cesarino Balsamini, Annalida Bedini, Giuseppe Diamantini, Gilberto Spadoni, Giorgio Tarzia, Andrea Tontini, Romano Di Fabio & Daniele Donati. (1999) 3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification. Il Farmaco 54:1-2, pages 101-111.
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Flavia Varano, Daniela Catarzi, Vittoria Colotta, Guido Filacchioni, Lucia Cecchi, Alessandro Galli & Chiara Costagli. (1998) Synthesis of 2-substituted-6,8-dichloro-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-1,1-dioxides and -1-oxides as glycine-NMDA receptor antagonists. Il Farmaco 53:12, pages 752-757.
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P Popik, J Mamczarz, M Frączek, M Widła, M Hesselink & W Danysz. (1998) Inhibition of reinforcing effects of morphine and naloxone: precipitated opioid withdrawal by novel glycine site and uncompetitive NMDA receptor antagonists. Neuropharmacology 37:8, pages 1033-1042.
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Cesarino Balsamini, Annalida Bedini, Giuseppe Diamantini, Gilberto Spadoni, Andrea Tontini, Giorgio Tarzia, Romano Di Fabio, Aldo Feriani, Angelo Reggiani, Giovanna Tedesco & Roberta Valigi. (1998) ( E )-3-(2-( N -Phenylcarbamoyl)vinyl)pyrrole-2-carboxylic Acid Derivatives. A Novel Class of Glycine Site Antagonists . Journal of Medicinal Chemistry 41:6, pages 808-820.
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Pierre Acklin, Hans Allgeier, Yves P. Auberson, Serge Bischoff, Silvio Ofner, Dirk Sauer & Markus Schmutz. (1998) 5-aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists. Bioorganic & Medicinal Chemistry Letters 8:5, pages 493-498.
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