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Expert Opinion on Therapeutic Patents Volume 8, 1998 - Issue 1
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Miscellaneous

Recently reported inhibitors of cyclooxygenase-2

Jeffery S Carter Department of Discovery Medicinal Chemistry, GD Searle, Monsanto Life Sciences, MZ BB-41, 700 Chesterfield Parkway North, St Louis, Missouri 63198, USA
Pages 21-29 | Published online: 25 Feb 2005

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Jeffery S Carter. (2000) Inhibitors of cyclooxygenase-2: November 1999 - April 2000. Expert Opinion on Therapeutic Patents 10:7, pages 1011-1020.
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Amit S Kalgutkar. (1999) Selective cyclooxygenase-2 inhibitors as non-ulcerogenic anti-inflammatory agents. Expert Opinion on Therapeutic Patents 9:7, pages 831-849.
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Articles from other publishers (27)

Amany Belal & Mohamed A. Abdelgawad. (2017) New benzothiazole/benzoxazole-pyrazole hybrids with potential as COX inhibitors: design, synthesis and anticancer activity evaluation. Research on Chemical Intermediates 43:7, pages 3859-3872.
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Chen-Ming Tan, Grace Shiahuy Chen, Chien-Shu Chen, Pei-Teh Chang & Ji-Wang Chern. (2011) Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors. Bioorganic & Medicinal Chemistry 19:21, pages 6316-6328.
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Rossella Fioravanti, Adriana Bolasco, Fedele Manna, Francesca Rossi, Francisco Orallo, Francesco Ortuso, Stefano Alcaro & Roberto Cirilli. (2010) Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors. European Journal of Medicinal Chemistry 45:12, pages 6135-6138.
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Gökçen Eren, Serdar Ünlü, Maria-Teresa Nuñez, Luis Labeaga, Francisco Ledo, Antonio Entrena, Erden Banoğlu, Gabriele Costantino & M. Fethi Şahin. (2010) Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry 18:17, pages 6367-6376.
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Zhiqiang Feng, Fengming Chu, Zongru Guo & Piaoyang Sun. (2009) Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib. Bioorganic & Medicinal Chemistry Letters 19:8, pages 2270-2272.
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Afshin Zarghi, Samaneh Kakhgi, Atefeh Hadipoor, Bahram Daraee, Orkideh G. Dadrass & Mehdi Hedayati. (2008) Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorganic & Medicinal Chemistry Letters 18:4, pages 1336-1339.
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Subas M. Sakya, Andrei Shavnya, Hengmiao Cheng, Chao Li, Bryson Rast, Jin Li, David A. Koss, Burton H. Jaynes, Donald W. Mann, Carol F. Petras, Scott B. Seibel, Michelle L. Haven & Michael P. Lynch. (2008) Comparative structure–activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition. Bioorganic & Medicinal Chemistry Letters 18:3, pages 1042-1045.
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Andrew Smellie. (2007) General Purpose Interactive Physico-Chemical Property Exploration. Journal of Chemical Information and Modeling 47:3, pages 1182-1187.
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Subas M. Sakya, Xinjun Hou, Martha L. Minich, Bryson Rast, Andrei Shavnya, Kristin M.L. DeMello, Hengmiao Cheng, Jin Li, Burton H. Jaynes, Donald W. Mann, Carol F. Petras, Scott B. Seibel & Michelle L. Haven. (2007) 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile. Bioorganic & Medicinal Chemistry Letters 17:4, pages 1067-1072.
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Jörg Degen & Matthias Rarey. (2006) FlexNovo: Structure-Based Searching in Large Fragment Spaces. ChemMedChem 1:8, pages 854-868.
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Hengmiao Cheng, Kristin M. Lundy DeMello, Jin Li, Subas M. Sakya, Kazuo Ando, K. Kawamura, Tomoki Kato, Robert J. Rafka, Burton H. Jaynes, Carl B. Ziegler, Rod Stevens, Lisa A. Lund, Donald W. Mann, Carolyn Kilroy, Michelle L. Haven, Erik L. Nimz, Jason K. Dutra, Chao Li, Martha L. Minich, Nicole L. Kolosko, Carol Petras, Annette M. Silvia & Scott B. Seibel. (2006) Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 16:8, pages 2076-2080.
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Subas M. Sakya, Hengmiao Cheng, Kristin M. Lundy DeMello, Andrei Shavnya, Martha L. Minich, Bryson Rast, Jason Dutra, Chao Li, Robert J. Rafka, David A. Koss, Jin Li, Burton H. Jaynes, Carl B. Ziegler, Donald W. Mann, Carol F. Petras, Scott B. Seibel, Annette M. Silvia, David M. George, Anne Hickman, Michelle L. Haven & Michael P. Lynch. (2006) 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers. Bioorganic & Medicinal Chemistry Letters 16:5, pages 1202-1206.
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Subas M. Sakya, Kristin M. Lundy DeMello, Martha L. Minich, Bryson Rast, Andrei Shavnya, Robert J. Rafka, David A. Koss, Hengmiao Cheng, Jin Li, Burton H. Jaynes, Carl B. Ziegler, Donald W. Mann, Carol F. Petras, Scott B. Seibel, Annette M. Silvia, David M. George, Lisa A. Lund, Suzanne St. Denis, Anne Hickman, Michelle L. Haven & Michael P. Lynch. (2006) 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog. Bioorganic & Medicinal Chemistry Letters 16:2, pages 288-292.
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Manojit Pal, Nalivela Kumara Swamy, P.Shahul Hameed, Srinivas Padakanti & Koteswar Rao Yeleswarapu. (2004) A rapid and direct access to symmetrical/unsymmetrical 3,4-diarylmaleimides and pyrrolin-2-ones. Tetrahedron 60:18, pages 3987-3997.
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Jin Li, Kristin M.Lundy DeMello, Henry Cheng, Subas M. Sakya, Brian S. Bronk, Robert J. Rafka, Burton H. Jaynes, Carl B. Ziegler, Carolyn Kilroy, Donald W. Mann, Eric L. Nimz, Michael P. Lynch, Michelle L. Haven, Nicole L. Kolosko, Martha L. Minich, Chao Li, Jason K. Dutra, Bryson Rast, Rhonda M. Crosson, Barry J. Morton, Glen W. Kirk, Kathleen M. Callaghan, David A. Koss, Andrei Shavnya, Lisa A. Lund, Scott B. Seibel, Carol F. Petras & Annette Silvia. (2004) Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine. Bioorganic & Medicinal Chemistry Letters 14:1, pages 95-98.
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H.X. Liu, R.S. Zhang, X.J. Yao, M.C. Liu, Z.D. Hu & B.T. Fan. (2004) QSAR and classification models of a novel series of COX-2 selective inhibitors: 1, 5-diarylimidazoles based on support vector machines. Journal of Computer-Aided Molecular Design 18:6, pages 389-399.
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Tanja Schulz-Gasch & Martin Stahl. (2003) Binding site characteristics in structure-based virtual screening: evaluation of current docking tools. Journal of Molecular Modeling 9:1, pages 47-57.
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Sabine Barbey, Laurence Goossens, Thierry Taverne, Joséphine Cornet, Valérie Choesmel, Céline Rouaud, Gilles Gimeno, Sylvie Yannic-Arnoult, Catherine Michaux, Caroline Charlier, Raymond Houssin & Jean-Pierre Hénichart. (2002) Synthesis and Activity of a New Methoxytetrahydropyran Derivative as Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitor. Bioorganic & Medicinal Chemistry Letters 12:5, pages 779-782.
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Hiromasa Hashimoto, Kimiya Maeda, Koichi Ozawa, Jun-ichi Haruta & Korekiyo Wakitani. (2002) 4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 12:1, pages 65-68.
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Dimitra Kovala-Demertzi. (2000) Transition metal complexes of diclofenac with potentially interesting anti-inflammatory activity. Journal of Inorganic Biochemistry 79:1-4, pages 153-157.
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Zhihua Sui, Jihua Guan, Michael P. Ferro, Kathy McCoy, Michael P. Wachter, William V. Murray, Monica Singer, Michele Steber, Dave M. Ritchie & Dennis C. Argentieri. (2000) 1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2. Bioorganic & Medicinal Chemistry Letters 10:6, pages 601-604.
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Sharon M. Dankwardt. 2000. High Throughput Screening for Novel Anti-Inflammatories. High Throughput Screening for Novel Anti-Inflammatories 1 17 .
Jeffery S. Carter, D.J. Rogier, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Yan Zhang & John J. Talley. (1999) Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 9:8, pages 1167-1170.
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Jeffery S. Carter, Steven Kramer, John J. Talley, Thomas Penning, Paul Collins, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Jaime Masferrer & Ben Zweifel. (1999) Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 9:8, pages 1171-1174.
Crossref
Martin Beuck. (1999) Nichtsteroidale Antirheumatika: Generationswechsel bei den Cyclooxygenase-Inhibitoren. Angewandte Chemie 111:5, pages 663-666.
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John J. Talley. 1999. 201 234 .
Alison M. Badger & Jerry L. Adams. 1998. 203 212 .

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