Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 8, 1998 - Issue 10
Submit an article Journal homepage
16
Views
13
CrossRef citations to date
0
Altmetric
Review

The 5-hydroxytryptamine 6 receptor: localisation and function

Andrew J Sleight Pharma Division, Preclinical Research, F Hoffmann-La Roche, 4070 Basel, Switzerland. [email protected]
,
Frank G Boess Pharma Division, Preclinical Research, F Hoffmann-La Roche, 4070 Basel, Switzerland. [email protected]
,
Michael Bös Pharma Division, Preclinical Research, F Hoffmann-La Roche, 4070 Basel, Switzerland. [email protected]
,
Bernard Levet-Trafit Pharma Division, Preclinical Research, F Hoffmann-La Roche, 4070 Basel, Switzerland. [email protected]
&
Anne Bourson Pharma Division, Preclinical Research, F Hoffmann-La Roche, 4070 Basel, Switzerland. [email protected]
Pages 1217-1224 | Published online: 25 Feb 2005

Citations (13)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Abdelmalik Slassi, Methvin Isaac & Anne O’Brien. (2002) Recent progress in 5-HT6 receptor antagonists for the treatment of CNS diseases. Expert Opinion on Therapeutic Patents 12:4, pages 513-527.
Read now

Articles from other publishers (12)

Faisal Hayat, Euna Yoo, Hyewhon Rhim & Hea-Young ParkChoo. (2013) Synthesis and Inhibition Effects on 5-HT 6 Receptor of Benzothiazole Derivatives . Bulletin of the Korean Chemical Society 34:2, pages 495-499.
Crossref
Matthew L. Isherwood, Peter R. Guzzo, Alan J. Henderson, Ming Min Hsia, Jagjit Kaur, Kassoum Nacro, Venkateswara R. Narreddula, Shailaja Panduga, Rashmi Pathak, Bharat Shimpukade, Valentina Tan, Kai Xiang, Zhu Qiang & Animesh Ghosh. (2012) An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist. Tetrahedron: Asymmetry 23:22-23, pages 1522-1527.
Crossref
Ramakrishna V.S. Nirogi, Rajeshkumar Badange, Ramasastri Kambhampati, Anil Chindhe, Amol D. Deshpande, Vinaykumar Tiriveedhi, Vishwottam Kandikere, Nageswararao Muddana, Renny Abraham & Mukkanti Khagga. (2012) Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands. Bioorganic & Medicinal Chemistry Letters 22:24, pages 7431-7435.
Crossref
Kevin G. Liu, Albert J. Robichaud, Alexander A. Greenfield, Jennifer R. Lo, Cristina Grosanu, James F. Mattes, Yanxuan Cai, Guo Ming Zhang, Jean Y. Zhang, Dianne M. Kowal, Deborah L. Smith, Li Di, Edward H. Kerns, Lee E. Schechter & Thomas A. Comery. (2011) Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists. Bioorganic & Medicinal Chemistry 19:1, pages 650-662.
Crossref
Tania de la Fuente, Mar Martín-Fontecha, Jessica Sallander, Bellinda Benhamú, Mercedes Campillo, Rocío A. Medina, Lucie P. Pellissier, Sylvie Claeysen, Aline Dumuis, Leonardo Pardo & María L. López-Rodríguez. (2010) Benzimidazole Derivatives as New Serotonin 5-HT 6 Receptor Antagonists. Molecular Mechanisms of Receptor Inactivation . Journal of Medicinal Chemistry 53:3, pages 1357-1369.
Crossref
Kevin G. Liu & Albert J. Robichaud. 2010. Pharmacology of 5-HT6 receptors - Part 1. Pharmacology of 5-HT6 receptors - Part 1 1 34 .
Munikumar Reddy Doddareddy, Yeon Joo Lee, Yong Seo Cho, Kyung Il Choi, Hun Yeong Koh & Ae Nim Pae. (2004) Hologram quantitative structure activity relationship studies on 5-HT6 antagonists. Bioorganic & Medicinal Chemistry 12:14, pages 3815-3824.
Crossref
Hans C. Dringenberg, Kristopher E.B. Dennis, Summer Tomaszek & Jody Martin. (2003) Orienting and defensive behaviors elicited by superior colliculus stimulation in rats: effects of 5-HT depletion, uptake inhibition, and direct midbrain or frontal cortex application. Behavioural Brain Research 144:1-2, pages 95-103.
Crossref
J.R. Eckler, J. Chang-Fong, R.A. Rabin, C. Smith, M. Teitler, R.A. Glennon & J.C. Winter. (2003) Behavioral characterization of 2-O-desmethyl and 5-O-desmethyl metabolites of the phenylethylamine hallucinogen DOM. Pharmacology Biochemistry and Behavior 75:4, pages 845-852.
Crossref
Steven M Bromidge, Stephen E Clarke, Frank D King, Peter J Lovell, Helen Newman, Graham Riley, Carol Routledge, Halina T Serafinowska, Douglas R Smith & David R Thomas. (2002) Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 12:10, pages 1357-1360.
Crossref
Yuching Tsai, Malgorzata Dukat, Abdelmalik Slassi, Neil MacLean, Lidia Demchyshyn, Jason E. Savage, Bryan L. Roth, Sandy Hufesein, Mase Lee & Richard A. Glennon. (2000) N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. Bioorganic & Medicinal Chemistry Letters 10:20, pages 2295-2299.
Crossref
Richard A. Glennon, Mase Lee, Jagadeesh B. Rangisetty, Malgorzata Dukat, Bryan L. Roth, Jason E. Savage, Ace McBride, Laura Rauser, Sandy Hufeisen & David K. H. Lee. (2000) 2-Substituted Tryptamines:  Agents with Selectivity for 5-HT 6 Serotonin Receptors . Journal of Medicinal Chemistry 43:5, pages 1011-1018.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.