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N-type calcium channel blockers in pain and stroke

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Pages 1237-1250 | Published online: 25 Feb 2005

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Melika Zamani, Thomas Budde & Hooman Bozorgi. (2020) Intracerebroventricular administration of N-type calcium channel blocker ziconotide displays anticonvulsant, anxiolytic, and sedative effects in rats: A preclinical and pilot study. Epilepsy & Behavior 111, pages 107251.
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Hassan Pajouhesh, Zhong-Ping Feng, Lingyun Zhang, Hossein Pajouhesh, Xinpo Jiang, Adam Hendricson, Haiheng Dong, Elizabeth Tringham, Yanbing Ding, Todd W. Vanderah, Frank Porreca, Francesco Belardetti, Gerald W. Zamponi, Lester A. Mitscher & Terrance P. Snutch. (2012) Structure–activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters 22:12, pages 4153-4158.
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Dimitra Hadjipavlou-Litina. 2011. Ion Channels and Their Inhibitors. Ion Channels and Their Inhibitors 265 288 .
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Takashi Yamamoto, Seiji Niwa, Seiji Ohno, Munetaka Tokumasu, Yoko Masuzawa, Chika Nakanishi, Akira Nakajo, Tomoyuki Onishi, Hajime Koganei, Shin-ichi Fujita, Tomoko Takeda, Morikazu Kito, Yukitsugu Ono, Yuki Saitou, Akira Takahara, Seinosuke Iwata & Masataka Shoji. (2008) The structure–activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels. Bioorganic & Medicinal Chemistry Letters 18:17, pages 4813-4816.
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Lars J.S. Knutsen, Christopher J. Hobbs, Christopher G. Earnshaw, Andrea Fiumana, Jenny Gilbert, Sarah L. Mellor, Fleur Radford, Nichola J. Smith, Philip J. Birch, J. Russell Burley, Stuart D.C. Ward & Iain F. James. (2007) Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers. Bioorganic & Medicinal Chemistry Letters 17:3, pages 662-667.
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Il Whea Ku, Sangwon Cho, Munikumar Reddy Doddareddy, Min Seok Jang, Gyochang Keum, Jung-Ha Lee, Bong Young Chung, Youseung Kim, Hyewhon Rhim & Soon Bang Kang. (2006) Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers. Bioorganic & Medicinal Chemistry Letters 16:19, pages 5244-5248.
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Takashi Yamamoto, Seiji Niwa, Satoshi Iwayama, Hajime Koganei, Shin-ichi Fujita, Tomoko Takeda, Morikazu Kito, Yukitsugu Ono, Yuki Saitou, Akira Takahara, Seinosuke Iwata, Hiroshi Yamamoto & Masataka Shoji. (2006) Discovery, structure–activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorganic & Medicinal Chemistry 14:15, pages 5333-5339.
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Christina Schroeder & Richard Lewis. (2006) ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential. Marine Drugs 4:3, pages 193-214.
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Su Li, Anne Dodge, Chris Poll & Martin Gosling. 2005. Calcium Signaling, Second Edition. Calcium Signaling, Second Edition 455 485 .
Hyewhon Rhim, Yong Sup Lee, Seong Jun Park, Bong Young Chung & Jae Yeol Lee. (2005) Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers. Bioorganic & Medicinal Chemistry Letters 15:2, pages 283-286.
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Silvina M Tasso, Sung Ch Moon, Luis E Bruno-Blanch & Guillermina L Estiú. (2004) Characterization of the anticonvulsant profile of valpromide derivatives. Bioorganic & Medicinal Chemistry 12:14, pages 3857-3869.
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Takuya Seko, Masashi Kato, Hiroshi Kohno, Shizuka Ono, Kazuya Hashimura, Hideyuki Takimizu, Katsuhiko Nakai, Hitoshi Maegawa, Nobuo Katsube & Masaaki Toda. (2003) Structure–activity study of l-amino acid-based N-type calcium channel blockers. Bioorganic & Medicinal Chemistry 11:8, pages 1901-1913.
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Yuichi Suzuki, Noboru Yamamoto, Yoichi Iimura, Koki Kawano, Teiji Kimura, Satoshi Nagato, Koichi Ito, Makoto Komatsu, Yoshihiko Norimine, Manami Kimura, Tetsuyuki Teramoto, Yoshihisa Kaneda, Takeshi Hamano, Tetsuhiro Niidome & Masahiro Yonaga. (2003) Discovery of novel neuronal voltage-Dependent calcium channel blockers based on emopamil left hand as a bioactive template. Bioorganic & Medicinal Chemistry Letters 13:5, pages 919-922.
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Yoshihiko Norimine, Noboru Yamamoto, Yuichi Suzuki, Teiji Kimura, Koki Kawano, Koichi Ito, Satoshi Nagato, Yoichi Iimura & Masahiro Yonaga. (2002) Enantioselective synthesis of (2S)-5-{4-[2-(4-fluorophenoxy)ethyl]piperazin-1-yl}-2-isopropyl-2-phenyl-pentanenitrile dihydrochloride (E2050) using enzyme-catalyzed kinetic resolution. Tetrahedron: Asymmetry 13:14, pages 1493-1502.
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Takuya Seko, Masashi Kato, Hiroshi Kohno, Shizuka Ono, Kazuya Hashimura, Hideyuki Takimizu, Katsuhiko Nakai, Hitoshi Maegawa, Nobuo Katsube & Masaaki Toda. (2002) Structure–Activity Study of l -Cysteine-Based N-Type Calcium Channel Blockers: Optimization of N- and C-Terminal Substituents. Bioorganic & Medicinal Chemistry Letters 12:6, pages 915-918.
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C. P. Taylor. 2002. CNS Neuroprotection. CNS Neuroprotection 209 244 .
Takuya Seko, Masashi Kato, Hiroshi Kohno, Shizuka Ono, Kazuya Hashimura, Hideyuki Takimizu, Katsuhiko Nakai, Hitoshi Maegawa, Nobuo Katsube & Masaaki Toda. (2001) Structure–Activity Study and Analgesic Efficacy of Amino Acid Derivatives as N-Type Calcium Channel Blockers. Bioorganic & Medicinal Chemistry Letters 11:16, pages 2067-2070.
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Brian Cox. (2000) Calcium channel blockers and pain therapy. Current Review of Pain 4:6, pages 488-498.
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Zhao-Xia Guo, Andrew N Cammidge & David C Horwell. (2000) Dendroid Peptide Structural Mimetics of ω-Conotoxin MVIIA based on a 2(1H)-Quinolinone Core. Tetrahedron 56:29, pages 5169-5175.
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Lain-Yen Hu, Todd R. Ryder, Michael F. Rafferty, Charles P. Taylor, M.Rose Feng, Be-Sheng Kuo, Susan M. Lotarski, George P. Miljanich, Elizabeth Millerman, Krista M. Siebers & Balazs G. Szoke. (2000) The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phenyl]-(3-methyl-but-2-enyl)-amine, an N-type Ca +2 channel blocker with oral activity for analgesia. Bioorganic & Medicinal Chemistry 8:6, pages 1203-1212.
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M Duff Davis & Joann J Schmidt. (2000) In vivo spectrometric calcium flux recordings of intrinsic caudate-putamen cells and transplanted IMR-32 neuroblastoma cells using miniature fiber optrodes in anesthetized and awake rats and monkeys. Journal of Neuroscience Methods 99:1-2, pages 9-23.
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Stefan Menzler, Jack A Bikker, Nirmala Suman-Chauhan & David C Horwell. (2000) Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA. Bioorganic & Medicinal Chemistry Letters 10:4, pages 345-347.
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Todd R. Ryder, Lain-Yen Hu, Michael F. Rafferty, Susan M. Lotarski, David M. Rock, Sally J. Stoehr, Charles P. Taylor, Mark L. Weber, George P. Miljanich, Elizabeth Millerman & Balazs G. Szoke. (1999) Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists. Bioorganic & Medicinal Chemistry Letters 9:16, pages 2453-2458.
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Robert M. Schelkun, Po-wai Yuen, Thomas C. Malone, David M. Rock, Sally Stoehr, Balazs Szoke & Katalin Tarczy-Hornoch. (1999) Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorganic & Medicinal Chemistry Letters 9:16, pages 2447-2452.
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Raymond S. Norton, Paul K. Pallaghy, Jonathan B. Baell, Christine E. Wright, Michael J. Lew & James A. Angus. (1999) Polypeptide ?-conotoxin GVIA as a basis for new analgesic and neuroprotective agents. Drug Development Research 46:3-4, pages 206-218.
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