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Expert Opinion on Therapeutic Patents Volume 8, 1998 - Issue 11
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Review

Antimalarial peroxides in the qinghaosu (artemisinin) and yingzhaosu families

Gary H Posner Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA
Pages 1487-1493 | Published online: 25 Feb 2005

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Mosebolatan V. Fafowora, Francis O. Atanu, Olayinka Sanya, Olufunso O. Olorunsogo & Ochuko L. Erukainure. (2011) Effect of oral coadministration of artesunate with ferrous sulfate on rat liver mitochondrial membrane permeability transition. Drug and Chemical Toxicology 34:3, pages 318-323.
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Yuxiang Dong & Jonathan L Vennerstrom. (2001) Peroxidic antimalarials. Expert Opinion on Therapeutic Patents 11:11, pages 1753-1760.
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. (2001) Water-soluble trioxanes as potent and safe antimalarial agents. Expert Opinion on Therapeutic Patents 11:8, pages 1351-1354.
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Alan T Hudson. (2000) Patent focus on antiparasitic agents: May - October 1999. Expert Opinion on Therapeutic Patents 10:2, pages 153-163.
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W. Peters & B. L. Robinson. (1999) The chemotherapy of rodent malaria. LVI. Studies on the development of resistance to natural and synthetic endoperoxides. Annals of Tropical Medicine & Parasitology 93:4, pages 325-339.
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Articles from other publishers (20)

Christian Bailly & Jean-Pierre Hénichart. (2022) Advocacy for the Medicinal Plant Artabotrys hexapetalus (Yingzhao) and Antimalarial Yingzhaosu Endoperoxides. Molecules 27:19, pages 6192.
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Lars Herrmann, Ivan A. Yaremenko, Aysun Çapcı, Julia Struwe, Dhanir Tailor, Arpit Dheeraj, Jan Hodek, Yulia Yu. Belyakova, Peter S. Radulov, Jan Weber, Sanjay V. Malhotra, Alexander O. Terent'ev, Lutz Ackermann & Svetlana B. Tsogoeva. (2022) Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer. ChemMedChem 17:9.
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Christopher M. Woodley, Patrícia S. M. Amado, Maria L. S. Cristiano & Paul M. O'Neill. (2021) Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies. Medicinal Research Reviews 41:6, pages 3062-3095.
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Dung Tien Nguyen, Thuong Hanh Ngo, Hien Thu Tran, Thao Phuong Dinh, Phuong Thi Do, Hau Ba Nguyen, Linh Thi Phuong Tran & Hanh My Ta. (2021) Synthesis and Anticancer Activity of 11-azaartemisinin Derivatives Bearing 1,2,3-triazole Moiety. Chemistry of Heterocyclic Compounds 57:10, pages 1037-1044.
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Lorenzo Botta, Silvia Filippi, Bruno M. Bizzarri, Claudio Zippilli, Roberta Meschini, Rebecca Pogni, Maria Camilla Baratto, Luciano Villanova & Raffaele Saladino. (2019) Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents. ACS Omega 5:1, pages 243-251.
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Aysun Çapcı Karagöz, Maria Leidenberger, Friedrich Hahn, Frank Hampel, Oliver Friedrich, Manfred Marschall, Barbara Kappes & Svetlana B. Tsogoeva. (2019) Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities. Bioorganic & Medicinal Chemistry 27:1, pages 110-115.
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Tony Fröhlich, Aysun Çapcı Karagöz, Christoph Reiter & Svetlana B. Tsogoeva. (2016) Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents. Journal of Medicinal Chemistry 59:16, pages 7360-7388.
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Nelly L. Jorge, Alfonso Hernández-Laguna & Eduardo A. Castro. (2013) Some Recent Developments on the Synthesis, Chemical Reactivity, and Theoretical Studies of Tetroxanes. International Journal of Chemoinformatics and Chemical Engineering 3:1, pages 48-73.
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Edward E. Korshin & Mario D. Bachi. 2009. PATAI'S Chemistry of Functional Groups. PATAI'S Chemistry of Functional Groups.
J.M. Romero, N.L. Jorge, M.E. Gómez-Vara, A.H. Jubert & E.A. Castro. (2008) Spectroscopic study of the dispiro-1,2,4,5-tetroxane (cyclohexanone diperoxide). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 70:4, pages 775-779.
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Richard K. Haynes, Ho-Wai Chan, Wing-Yan Ho, Cliff Ki-Fung Ko, Lucia Gerena, Dennis E. Kyle, Wallace Peters & Brian L. Robinson. (2005) Convenient Access Both to Highly Antimalaria-Active 10-Arylaminoartemisinins, and to 10-Alkyl Ethers Including Artemether, Arteether, and Artelinate. ChemBioChem 6:4, pages 659-667.
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Yuanqing Tang, Yuxiang Dong & Jonathan L. Vennerstrom. (2004) Synthetic peroxides as antimalarials. Medicinal Research Reviews 24:4, pages 425-448.
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Gary H. Posner, Heung Bae Jeon, Poonsakdi Ploypradith, Ik-Hyeon Paik, Kristina Borstnik, Suji Xie & Theresa A. Shapiro. (2002) Orally Active, Water-Soluble Antimalarial 3-Aryltrioxanes:  Short Synthesis and Preclinical Efficacy Testing in Rodents. Journal of Medicinal Chemistry 45:18, pages 3824-3828.
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Robert G. Ridley. (2002) Medical need, scientific opportunity and the drive for antimalarial drugs. Nature 415:6872, pages 686-693.
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Gary H. Posner, Heung Bae Jeon, Michael H. Parker, Mikhail Krasavin, Ik-Hyeon Paik & Theresa A. Shapiro. (2001) Antimalarial Simplified 3-Aryltrioxanes:  Synthesis and Preclinical Efficacy/Toxicity Testing in Rodents. Journal of Medicinal Chemistry 44:19, pages 3054-3058.
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Jonathan L. VennerstromYuxiang DongSteven L. AndersenArba L. Ager,Hong-ning FuRobert E. MillerDavid L. WescheDennis E. KyleLucia GerenaSheri M. WaltersJames K. WoodGeoffrey EdwardsAlexandra D. HolmeW. Graham McLeanWilbur K. Milhous. (2000) Synthesis and Antimalarial Activity of Sixteen Dispiro-1,2,4,5-tetraoxanes:  Alkyl-Substituted 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes. Journal of Medicinal Chemistry 43:14, pages 2753-2758.
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Gary H. Posner, John P. Maxwell, Hardwin O'Dowd, Mikhail Krasavin, Suji Xie & Theresa A. Shapiro. (2000) Antimalarial sulfide, sulfone, and sulfonamide trioxanes. Bioorganic & Medicinal Chemistry 8:6, pages 1361-1370.
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Mario D. Bachi, Edward E. Korshin, Roland Hoos & Alex M. Szpilman. (2009) Synthesis and reactions of antimalarial bicyclic peroxides. Journal of Heterocyclic Chemistry 37:3, pages 639-646.
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Simon L. Croft. (1999) Antiparasitic agents: challenges of sleeping sickness, hopes for malaria. Current Opinion in Infectious Diseases 12:6, pages 557-558.
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Olivier Provot, Boris Camuzat-Dedenis, Mohamed Hamzaoui, Henri Moskowitz, Joëlle Mayrargue, Anne Robert, Jérôme Cazelles, Bernard Meunier, Fatima Zouhiri, Didier Desmaële, Jean d'Angelo, Jacqueline Mahuteau, Frédérick Gay & Liliane Cicéron. (1999) Structure–Activity Relationships of Synthetic Tricyclic Trioxanes Related to Artemisinin: The Unexpected Alkylative Property of a 3-(Methoxymethyl) Analog. European Journal of Organic Chemistry 1999:8, pages 1935-1938.
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