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Expert Opinion on Therapeutic Patents Volume 8, 1998 - Issue 6
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Review

Cathepsin B inhibitors as potential anti-metastatic agents

Stephanie Michaud Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec, H3A 2K6, Canada
&
Barbara J Gour Department of Medicine, McGill University, Royal Victoria Hospital, 687 Pine Ave., Montreal, Quebec, H3A 1A1, Canada
Pages 645-672 | Published online: 25 Feb 2005

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Ernesto Menta & Manlio Palumbo. (1998) Antineoplastic agents 1998. Expert Opinion on Therapeutic Patents 8:12, pages 1627-1672.
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Anthony Feral, Anthony R. Martin, Alexandre Desfoux, Muriel Amblard & Lubomir L. Vezenkov. (2023) Covalent-reversible peptide-based protease inhibitors. Design, synthesis, and clinical success stories. Amino Acids.
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C. Pitchumani Violet Mary, S. Vijayakumar & R. Shankar. (2019) Inhibition mechanism of cathepsin B by curcumin molecule: a DFT study. Theoretical Chemistry Accounts 138:2.
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Neera Raghav & Mamta Singh. (2014) Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H. European Journal of Medicinal Chemistry 77, pages 231-242.
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Luigino Troisi, Catia Granito & Emanuela Pindinelli. 2010. Heterocyclic Scaffolds I. Heterocyclic Scaffolds I 101 209 .
Patricia Schenker, Pietro Alfarano, Peter Kolb, Amedeo Caflisch & Antonio Baici. (2009) A double‐headed cathepsin B inhibitor devoid of warhead. Protein Science 17:12, pages 2145-2155.
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Nuzhat MotlekarScott L. DiamondAndrew D. Napper. (2008) Evaluation of an Orthogonal Pooling Strategy for Rapid High-Throughput Screening of Proteases. ASSAY and Drug Development Technologies 6:3, pages 395-405.
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Michael C. Myers, Andrew D. Napper, Nuzhat Motlekar, Parag P. Shah, Chun-Hao Chiu, Mary Pat Beavers, Scott L. Diamond, Donna M. Huryn & Amos B. SmithIIIIII. (2007) Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: The confounding effects of DTT and cysteine in biological assays. Bioorganic & Medicinal Chemistry Letters 17:17, pages 4761-4766.
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Cláudia Bincoletto, Ivarne L.S. Tersariol, Carlos R. Oliveira, Simone Dreher, Daniela M. Fausto, Marco Antonio Soufen, Fábio D. Nascimento & Antonio C.F. Caires. (2005) Chiral cyclopalladated complexes derived from N,N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents. Bioorganic & Medicinal Chemistry 13:8, pages 3047-3055.
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Rodrigo L.O.R. Cunha, Miriam E. Urano, Jair R. Chagas, Paulo C. Almeida, Cláudia Bincoletto, Ivarne L.S. Tersariol & João V. Comasseto. (2005) Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B. Bioorganic & Medicinal Chemistry Letters 15:3, pages 755-760.
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Donald J. AbrahamM. Angels Estiarte & Daniel H. Rich. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 633 685 .
Nian E. Zhou, Deqi Guo, George Thomas, Andhe V.N. Reddy, Jadwiga Kaleta, Enrico Purisima, Robert Menard, Ronald G. Micetich & Rajeshwar Singh. (2003) 3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors. Bioorganic & Medicinal Chemistry Letters 13:1, pages 139-141.
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Nian E Zhou, Jadwiga Kaleta, Enrico Purisima, Robert Menard, Ronald G Micetich & Rajeshwar Singh. (2002) 6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S. Bioorganic & Medicinal Chemistry Letters 12:23, pages 3417-3419.
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Nian E Zhou, Deqi Guo, Jadwiga Kaleta, Enrico Purisima, Robert Menard, Ronald G Micetich & Rajeshwar Singh. (2002) Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors. Bioorganic & Medicinal Chemistry Letters 12:23, pages 3413-3415.
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Brian E Cathers, Cynthia Barrett, James T Palmer & Robert M Rydzewski. (2002) pH Dependence of inhibitors targeting the occluding loop of cathepsin B. Bioorganic Chemistry 30:4, pages 264-275.
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Gregor Gunčar, Ivica Klemenčič, Boris Turk, Vito Turk, Adriana Karaoglanovic-Carmona, Luiz Juliano & Dušan Turk. (2000) Crystal structure of cathepsin X: a flip–flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. Structure 8:3, pages 305-313.
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Katia Sol-Church, Jennifer Frenck & Robert W. Mason. (2000) Cathepsin Q, a Novel Lysosomal Cysteine Protease Highly Expressed in Placenta. Biochemical and Biophysical Research Communications 267:3, pages 791-795.
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