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Cathepsin K inhibitors for osteoporosis and potential off-target effects

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Pages 585-600 | Published online: 24 Apr 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Priyanka Kannan, Hadeefa Begum A.Madhana Priya N.Thirumal Kumar D.Gnansambandan Ramanathan, Rajalakshmanan Eswaramoorthy & Magesh Ramasamy. (2023) Unravelling the Relacatib activity against the CTSK proteins causing pycnodysostosis: a molecular docking and dynamics approach. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
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Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow & Michael Mareš. (2022) Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 515-526.
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Fernanda R. Rocho, Vinícius Bonatto, Rafael F. Lameiro, Jerônimo Lameira, Andrei Leitão & Carlos A. Montanari. (2022) A patent review on cathepsin K inhibitors to treat osteoporosis (2011 – 2021). Expert Opinion on Therapeutic Patents 32:5, pages 561-573.
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Isaac O. Donkor. (2020) An update on the therapeutic potential of calpain inhibitors: a patent review. Expert Opinion on Therapeutic Patents 30:9, pages 659-675.
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C. Pitchumani Violet Mary, R. Shankar & S. Vijayakumar. (2018) Theoretical studies on the interaction between the nitrile-based inhibitors and the catalytic triad of Cathepsin K. Journal of Biomolecular Structure and Dynamics 36:3, pages 634-655.
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Melisa Bunderson-Schelvan, Andrij Holian & Raymond F. Hamilton$suffix/text()$suffix/text(). (2017) Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents. Journal of Toxicology and Environmental Health, Part B 20:4, pages 230-248.
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Dieter Brömme, Preety Panwar & Serap Turan. (2016) Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences. Expert Opinion on Drug Discovery 11:5, pages 457-472.
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Xianglian Yuan, Yonggang Liu, Xin Hua, Xiaoxia Deng, Peijiao Sun, Chunmei Yu, Liping Chen, Shenye Yu, Siguo Liu & Hai Pang. (2015) Myricetin ameliorates the symptoms of collagen-induced arthritis in mice by inhibiting cathepsin K activity. Immunopharmacology and Immunotoxicology 37:6, pages 513-519.
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Miranda K Boggild, Olga Gajic-Veljanoski, Heather McDonald-Blumer, Rowena Ridout, Lianne Tile, Robert Josse & Angela M Cheung. (2015) Odanacatib for the treatment of osteoporosis. Expert Opinion on Pharmacotherapy 16:11, pages 1717-1726.
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Kong Wah Ng. (2012) Potential role of odanacatib in the treatment of osteoporosis. Clinical Interventions in Aging 7, pages 235-247.
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Jac Wijkmans & Jan Gossen. (2011) Inhibitors of cathepsin K: a patent review (2004 – 2010). Expert Opinion on Therapeutic Patents 21:10, pages 1611-1629.
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Sheila Siqueira Andrade, Iuri Estrada Gouvea, Mariana Cristina C. Silva, Elo?sa Dognani Castro, Cl?udia A. A. de Paula, Debora Okamoto, Lilian Oliveira, Giovani Bravin Peres, Tatiana Ottaiano, Gil Facina, Afonso Celso Pinto Naz?rio, Antonio Hugo J. F. M. Campos, Edgar Julian Paredes-Gamero, Maria Juliano, Ismael D. C. G. da Silva, Maria Luiza V. Oliva & Manoel J. B. C. Gir?o. (2016) Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer. BMC Cancer 16:1.
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