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Drug Evaluations

Cladribine: not just another purine analogue?

, , & , MD PhD
Pages 1169-1181 | Published online: 15 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Prajwal Boddu, Hagop Kantarjian, Farhad Ravandi, Guillermo Garcia-Manero, Gautam Borthakur, Michael Andreeff, Elias J. Jabbour, Christopher B. Benton, Courtney D. DiNardo, Marina Konopleva, Naval Daver, Keyur Patel, Koichi Takahashi, Rashmi Kanagal-Shamanna, Jorge Cortes & Tapan Kadia. (2018) Outcomes with lower intensity therapy in TP53-mutated acute myeloid leukemia. Leukemia & Lymphoma 59:9, pages 2238-2241.
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Michael E. Williams, Joseph M. Connors, Martin H. Dreyling, Randy D. Gascoyne, Brad S. Kahl, John P. Leonard, Oliver W. Press & Wyndham H. Wilson. (2011) Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop. Leukemia & Lymphoma 52:1, pages 24-33.
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Jeffrey L Bennett & Augusto A Miravalle. (2010) Recent advances in the treatment of multiple sclerosis. Journal of Experimental Pharmacology 2, pages 155-161.
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John R Corboy & Augusto A Miravalle. (2010) Emerging therapies for treatment of multiple sclerosis. Journal of Inflammation Research 3, pages 53-59.
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Patricia Hentosh & Dennis M Peffley. (2010) The cladribine conundrum: deciphering the drug's mechanism of action. Expert Opinion on Drug Metabolism & Toxicology 6:1, pages 75-81.
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Dan-Xia Ying, Peng-Cheng Zhao, Wen Zhang & Guo-Wu Rao. (2023) Research Progress in Competitive Purine Antagonists. Current Medicinal Chemistry 30:34, pages 3880-3904.
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Guillermo Cruz, Laura Pilar Saiz, Muhammad Bilal, Lobna Eltoukhy, Christoph Loderer & Jesús Fernández-Lucas. (2022) Magnetic Multi-Enzymatic System for Cladribine Manufacturing. International Journal of Molecular Sciences 23:21, pages 13634.
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Katarzyna Rakoczy, Wojciech Szlasa, Natalia Sauer, Jolanta Saczko & Julita Kulbacka. (2022) Molecular relation between biological stress and carcinogenesis. Molecular Biology Reports 49:10, pages 9929-9945.
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Francis R. LeBlanc, Zainul S. Hasanali, August Stuart, Sara Shimko, Kamal Sharma, Violetta V. Leshchenko, Samir Parekh, Haiqing Fu, Ya Zhang, Melvenia M. Martin, Mark Kester, Todd Fox, Jiangang Liao, Thomas P. Loughran, Juanita Evans, Jeffrey J. Pu, Stephen E. Spurgeon, Mirit I. Aladjem & Elliot M. Epner. (2022) Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma. Oncotarget 13:1, pages 986-1002.
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Shuli Man, Yingying Lu, Lijuan Yin, Xinkuan Cheng & Long Ma. (2021) Potential and promising anticancer drugs from adenosine and its analogs. Drug Discovery Today 26:6, pages 1490-1500.
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Marta Libura, Emilia Bialopiotrowicz, Sebastian Giebel, Agnieszka Wierzbowska, Gail J. Roboz, Beata Piatkowska-Jakubas, Marta Pawelczyk, Patryk Gorniak, Katarzyna Borg, Magdalena Wojtas, Izabella Florek, Karolina Matiakowska, Bozena Jazwiec, Iwona Solarska, Monika Noyszewska-Kania, Karolina Piechna, Magdalena Zawada, Sylwia Czekalska, Zoriana Salamanczuk, Karolina Karabin, Katarzyna Wasilewska, Monika Paluszewska, Elzbieta Urbanowska, Justyna Gajkowska-Kulik, Grazyna Semenczuk, Justyna Rybka, Tomasz Wrobel, Anna Ejduk, Dariusz Kata, Sebastian Grosicki, Tadeusz Robak, Agnieszka Pluta, Agata Kominek, Katarzyna Piwocka, Karolina Pyziak, Agnieszka Sroka-Porada, Anna Wrobel, Agnieszka Przybylowicz, Marzena Wojtaszewska, Krzysztof Lewandowski, Lidia Gil, Agnieszka Piekarska, Wanda Knopinska, Lukasz Bolkun, Krzysztof Warzocha, Kazimierz Kuliczkowski, Tomasz Sacha, Grzegorz Basak, Wieslaw Wiktor Jedrzejczak, Jerzy Holowiecki, Przemysław Juszczynski & Olga Haus. (2021) IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen. Scientific Reports 11:1.
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Cintia Wanda Rivero, Natalia Soledad García, Jesús Fernández-Lucas, Lorena Betancor, Gustavo Pablo Romanelli & Jorge Abel Trelles. (2021) Green Production of Cladribine by Using Immobilized 2′-Deoxyribosyltransferase from Lactobacillus delbrueckii Stabilized through a Double Covalent/Entrapment Technology. Biomolecules 11:5, pages 657.
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Cintia W. Rivero, Eliana C. De Benedetti, Jorge Sambeth & Jorge A. Trelles. (2020) Biotransformation of cladribine by a nanostabilized extremophilic biocatalyst. Journal of Biotechnology 323, pages 166-173.
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Stephen E. Spurgeon, Kamal Sharma, David F. Claxton, Christopher Ehmann, Jeffrey Pu, Sara Shimko, August Stewart, Nan Subbiah, Gundula Palmbach, Francis LeBlanc, Emile Latour, YiYi Chen, Motomi Mori, Zainul Hasanali & Elliot M. Epner. (2019) Phase 1–2 study of vorinostat (SAHA), cladribine and rituximab (SCR) in relapsed B‐cell non‐Hodgkin lymphoma and previously untreated mantle cell lymphoma. British Journal of Haematology 186:6, pages 845-854.
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Jun Xu, Ting-Ting Lv, Xiao-Fen Zhou, Ying Huang, Dong-Dong Liu & Guo-Lin Yuan. (2018) Efficacy of common salvage chemotherapy regimens in patients with refractory or relapsed acute myeloid leukemia. Medicine 97:39, pages e12102.
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Mark S. Freedman, Daniel Selchen, Alexandre Prat & Paul S. Giacomini. (2018) Managing Multiple Sclerosis: Treatment Initiation, Modification, and Sequencing. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45:5, pages 489-503.
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Tapan M Kadia, Jorge Cortes, Farhad Ravandi, Elias Jabbour, Marina Konopleva, Christopher B Benton, Jan Burger, Koji Sasaki, Gautam Borthakur, Courtney D DiNardo, Naveen Pemmaraju, Naval Daver, Alessandra Ferrajoli, Xuemei Wang, Keyur Patel, Jeffrey L Jorgensen, Sa Wang, Susan O'Brien, Sherry Pierce, Carla Tuttle, Zeev Estrov, Srdan Verstovsek, Guillermo Garcia-Manero & Hagop Kantarjian. (2018) Cladribine and low-dose cytarabine alternating with decitabine as front-line therapy for elderly patients with acute myeloid leukaemia: a phase 2 single-arm trial. The Lancet Haematology 5:9, pages e411-e421.
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Y. Bao, J. Zhao & Z.-Z. Li. (2017) Comparison of clinical remission and survival between CLAG and FLAG induction chemotherapy in patients with refractory or relapsed acute myeloid leukemia: a prospective cohort study. Clinical and Translational Oncology 20:7, pages 870-880.
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S. Jayashree, K. Nirekshana, Gunjan Guha & Dipita Bhakta-Guha. (2018) Cancer chemotherapeutics in rheumatoid arthritis: A convoluted connection. Biomedicine & Pharmacotherapy 102, pages 894-911.
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V. Gupta, B.K. Khaitan, S. Patra & R. Yadav. (2016) Xanthoma disseminatum: improvement in disfiguring facial lesions with cladribine. Journal of the European Academy of Dermatology and Venereology 30:10, pages e43-e44.
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M. Nadeem, O. Mufti, I. Ahsan, R. Naheed & S. M. Faheem. (2016) Treatment of Multiple Sclerosis. Neuroscience and Medicine 07:02, pages 74-82.
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Benigno C. Valdez, Yang Li, David Murray, Jie Ji, Yan Liu, Uday Popat, Richard E. Champlin & Borje S. Andersson. (2015) Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators. Experimental Hematology 43:6, pages 448-461.e2.
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Karen Schreiber & Per Soelberg Sorensen. (2011) Cladribine in the treatment of multiple sclerosis. Clinical Investigation 1:2, pages 317-326.
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