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Drug Evaluations

AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies

, MD PhD, , MD & , PhD
Pages 571-578 | Published online: 31 Mar 2010

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Olga Scudiero, Ersilia Nigro, Maria Ludovica Monaco, Giorgia Oliviero, Rita Polito, Nicola Borbone, Stefano D'Errico, Luciano Mayol, Aurora Daniele & Gennaro Piccialli. (2016) New synthetic AICAR derivatives with enhanced AMPK and ACC activation. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 748-753.
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Piotr Smolewski & Tadeusz Robak. (2015) The preclinical discovery of rituximab for the treatment of non-Hodgkin’s lymphoma. Expert Opinion on Drug Discovery 10:7, pages 791-808.
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Shlomit Kfir-Erenfeld, Ronit Vogt Sionov, Rachel Spokoini, Orly Cohen & Eitan Yefenof. (2010) Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations. Leukemia & Lymphoma 51:11, pages 1968-2005.
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Articles from other publishers (20)

Yuyang Pang, Tingxun Lu, Zijun Y. Xu-Monette & Ken H. Young. (2023) Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma. International Journal of Molecular Sciences 24:6, pages 5493.
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Marçal Pastor-Anglada, Aida Mata-Ventosa & Sandra Pérez-Torras. (2022) Inborn Errors of Nucleoside Transporter (NT)-Encoding Genes (SLC28 and SLC29). International Journal of Molecular Sciences 23:15, pages 8770.
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Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong & Zhen-ling Li. (2021) HELQ and EGR3 expression correlate with IGHV mutation status and prognosis in chronic lymphocytic leukemia. Journal of Translational Medicine 19:1.
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Hyejin Lee, Dnyandev B. Jarhad, Ahrim Lee, Choongho Lee & Lak Shin Jeong. (2021) 4′‐Selenonucleosides: Regio‐ and Stereoselective Synthesis of Novel Ribavirin and Acadesine Analogs as Anti‐Hepatitis C Virus (HCV) Agents. Asian Journal of Organic Chemistry 10:11, pages 2993-2999.
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Dora Višnjić, Hrvoje Lalić, Vilma Dembitz, Barbara Tomić & Tomislav Smoljo. (2021) AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells 10:5, pages 1095.
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Dora Visnjic, Vilma Dembitz & Hrvoje Lalic. (2019) The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia. Current Medicinal Chemistry 26:12, pages 2208-2229.
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Li Jiang, Tingting Liu, Lijie Xie, Chen Ouyang, Jianping Ji & Ting Huang. (2019) AICAR prolongs corneal allograft survival via the AMPK-mTOR signaling pathway in mice. Biomedicine & Pharmacotherapy 113, pages 108558.
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Fatima Djouadi & Jean Bastin. (2019) Mitochondrial Genetic Disorders: Cell Signaling and Pharmacological Therapies. Cells 8:4, pages 289.
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Minjing Li, Changzhu Jin, Maolei Xu, Ling Zhou, Defang Li & Yancun Yin. (2017) Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling. Cell Communication and Signaling 15:1.
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Enyu Rao, Yuwen Zhang, Qiang Li, Jiaqing Hao, Nejat K. Egilmez, Jill Suttles & Bing Li. (2016) AMPK-dependent and independent effects of AICAR and compound C on T-cell responses. Oncotarget 7:23, pages 33783-33795.
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Arnau Montraveta, Sílvia Xargay-Torrent, Laia Rosich, Mònica López-Guerra, Jocabed Roldán, Vanina Rodríguez, Eriong Lee-Vergés, Mercè de Frías, Clara Campàs, Elias Campo, Gaël Roué & Dolors Colomer. (2015) Bcl-2 high mantle cell lymphoma cells are sensitized to acadesine with ABT-199 . Oncotarget 6:25, pages 21159-21172.
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Daniel?J. Asby, Francesco Cuda, Maxime Beyaert, Franchesca?D. Houghton, Felino?R. Cagampang & Ali Tavassoli. (2015) AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization. Chemistry & Biology 22:7, pages 838-848.
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Joanna Zeidler, Dagmara Baraniak & Tomasz Ostrowski. (2015) Bioactive nucleoside analogues possessing selected five-membered azaheterocyclic bases. European Journal of Medicinal Chemistry 97, pages 409-418.
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Arnau Montraveta, Sílvia Xargay-Torrent, Mónica López-Guerra, Laia Rosich, Patricia Pérez-Galán, Itziar Salaverria, Silvia Beà, Susana G. Kalko, Mercè de Frias, Clara Campàs, Gaël Roué & Dolors Colomer. (2014) Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma . Oncotarget 5:3, pages 726-739.
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Stefano D'Errico, Giorgia Oliviero, Nicola Borbone, Jussara Amato, Vincenzo Piccialli, Michela Varra, Luciano Mayol & Gennaro Piccialli. (2013) Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose. Molecules 18:8, pages 9420-9431.
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Santiago Diaz-Moralli, Míriam Tarrado-Castellarnau, Anibal Miranda & Marta Cascante. (2013) Targeting cell cycle regulation in cancer therapy. Pharmacology & Therapeutics 138:2, pages 255-271.
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Eric Van Den Neste, Bruno Cazin, Ann Janssens, Eva González-Barca, María José Terol, Vincent Levy, Jaime Pérez de Oteyza, Pierre Zachee, Andrew Saunders, Mercè de Frias & Clara Campàs. (2012) Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II study. Cancer Chemotherapy and Pharmacology 71:3, pages 581-591.
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Mohsine Driowya, Alexandre Puissant, Guillaume Robert, Patrick Auberger, Rachid Benhida & Khalid Bougrin. (2012) Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis. Ultrasonics Sonochemistry 19:6, pages 1132-1138.
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M. Visentin, R. Zhao & I. D. Goldman. (2012) Augmentation of Reduced Folate Carrier-Mediated Folate/Antifolate Transport through an Antiport Mechanism with 5-Aminoimidazole-4-Carboxamide Riboside Monophosphate. Molecular Pharmacology 82:2, pages 209-216.
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Antonio F. SantidriánDiana M. González-GironèsDaniel Iglesias-SerretLlorenç Coll-MuletAna M. CosiallsMercè de FriasClara CampàsEva González-BarcaEsther AlonsoVerena LabiBenoit Viollet, Adalberto Benito, Gabriel PonsAndreas VillungerJoan Gil. (2010) AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood 116:16, pages 3023-3032.
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