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Drug Evaluation

Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug

Pages 547-560 | Published online: 24 Feb 2005

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Read on this site (6)

Vanesa González-Núñez, Antonio Valero & Joaquim Mullol. (2013) Safety evaluation of desloratadine in allergic rhinitis. Expert Opinion on Drug Safety 12:3, pages 445-453.
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R. Ramanathan, L. Reyderman, A.-D. Su, N. Alvarez, S. K. Chowdhury, K. B. Alton, M. A. Wirth, R. P. Clement, P. Statkevich & J. E. Patrick. (2007) Disposition of desloratadine in healthy volunteers. Xenobiotica 37:7, pages 770-787.
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R. Ramanathan, L. Reyderman, K. Kulmatycki, A.-D. Su, N. Alvarez, S. K. Chowdhury, K. B. Alton, M. A. Wirth, R. P. Clement, P. Statkevich & J. E. Patrick. (2007) Disposition of loratadine in healthy volunteers. Xenobiotica 37:7, pages 753-769.
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Bruce Prenner, Kenneth Kim, Samir Gupta, Sauzanne Khalilieh, Bhavna Kantesaria, Prasarn Manitpisitkul, Richard Lorber, Zaiqi Wang & Barry Lutsky. (2006) Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety. Expert Opinion on Drug Safety 5:2, pages 211-223.
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Garry M Walsh. (2002) Emerging safety issues regarding long-term usage of H1-receptor antagonists. Expert Opinion on Drug Safety 1:3, pages 225-235.
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Luis M Salmun. (2002) Antihistamines in late-phase clinical development for allergic disease. Expert Opinion on Investigational Drugs 11:2, pages 259-273.
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Margot Morin-Dewaele, Sophie Bartier, François Berry, Rozenn Brillet, Dennis Salomón López-Molina, Công Trung Nguyễn, Pascale Maille, Kevin Sereno, Quentin Nevers, Laurent Softic, Jean-Marie Vaugeois, Bruno Louis, Emilie Bequignon, Patrice Bruscella, André Coste, Jean-Michel Pawlotsky, Stéphane Jamain & Abdelhakim Ahmed-Belkacem. (2022) Desloratadine, an FDA-approved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry. Scientific Reports 12:1.
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Yajing Hou, Shuai Ge, Xiaowei Li, Cheng Wang, Huaizhen He & Langchong He. (2021) Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis. Chemico-Biological Interactions 338, pages 109420.
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Selvakumar Kanthiah & Valliappan Kannappan. (2017) D-Optimal mixture design optimization of an HPLC method for simultaneous determination of commonly used antihistaminic parent molecules and their active metabolites in human serum and urine. Biomedical Chromatography 31:8, pages e3932.
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Piotr Kuna, Dariusz Jurkiewicz, Magdalena M. Czarnecka-Operacz, Rafał Pawliczak, Jarosław Woroń, Marcin Moniuszko & Andrzej Emeryk. (2017) The role and choice criteria of antihistamines in allergy management – Expert opinion. Alergologia Polska - Polish Journal of Allergology 4:1, pages 7-19.
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Ruben Vardanyan. 2017. Piperidine-Based Drug Discovery. Piperidine-Based Drug Discovery 223 239 .
Ting Wang, Kun Zhang, Tingting Li, Lin He, Huiru Xie, Xuehua Jiang & Ling Wang. (2015) Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers. Clinical Drug Investigation 35:12, pages 807-813.
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Rafał Pawliczak. (2015) Alergiczny nieżyt nosa – nowoczesne leczenie w świetle wytycznych. Alergologia Polska - Polish Journal of Allergology 2:3, pages 106-110.
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G. Walter Canonica & Michael Blaiss. (2011) Antihistaminic, Anti-Inflammatory, and Antiallergic Properties of the Nonsedating Second-Generation Antihistamine Desloratadine: a Review of the Evidence. World Allergy Organization Journal 4:2, pages 47-53.
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Evrim Alyamac Dizdar, Bulent Enis Sekerel & Ayfer Tuncer. (2008) Desloratadine: a review of pharmacology and clinical efficacy in allergic rhinitis and urticaria. Therapy 5:6, pages 817-828.
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Shigeru Hishinuma, Yuko Sato, Yusuke Kobayashi, Hiroshi Komazaki & Masaki Saito. (2008) Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H1–Receptor Antagonists Based on Receptor Internalization. Journal of Pharmacological Sciences 107:1, pages 66-79.
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A. M. Moustafa & A. S. Girgis. (2007) Synthesis and crystal structure determination of 6,7-dihydro-2-methoxy-4-(substituted)-5H -benzo[6,7]cyclohepta[1,2-b ]pyridine-3-carbonitrile. Crystal Research and Technology 42:4, pages 400-406.
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Ramón Pérez. (2005) Acute cholestasis related to desloratidine. World Journal of Gastroenterology 11:23, pages 3647.
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Glenis Scadding. (2005) Predicting and Establishing the Clinical Efficacy of a Histamine H1-Receptor Antagonist. Clinical Drug Investigation 25:3, pages 153-164.
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Michael M. Cyr, Lisa M. Hayes, Lynn Crawford, Adrian J. Baatjes, Paul K. Keith & Judah A. Denburg. (2005) The Effect of Desloratadine on Eosinophil/Basophil Progenitors and Other Inflammatory Markers in Seasonal Allergic Rhinitis: A Placebo-Controlled Randomized Study. International Archives of Allergy and Immunology 138:3, pages 209-216.
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D. K. Agrawal. (2004) Anti-inflammatory properties of desloratadine. Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy 34:9, pages 1342-1348.
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M. Molimard, B. Diquet & M. Strolin Benedetti. (2004) Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. Fundamental and Clinical Pharmacology 18:4, pages 399-411.
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Ashok Purohit, Michel Melac, Gabrielle Pauli & Nelly Frossard. (2004) Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours. Annals of Allergy, Asthma & Immunology 92:6, pages 635-640.
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U. Satish, S. Streufert, M. Dewan & S. Vande Voort. (2004) Improvements in simulated real-world relevant performance for patients with seasonal allergic rhinitis: impact of desloratadine. Allergy 59:4, pages 415-420.
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William E Berger. (2004) Allergic Rhinitis in Children. Pediatric Drugs 6:4, pages 233-250.
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Ashok Purohit, Michel Melac, Gabrielle Pauli & Nelly Frossard. (2003) Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin. British Journal of Clinical Pharmacology 56:4, pages 388-394.
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Jeffrey A. Wilken, Robert L. Kane, Anne K. Ellis, Elizabeth Rafeiro, Maureen P. Briscoe, Cynthia L. Sullivan & James H. Day. (2003) A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis. Annals of Allergy, Asthma & Immunology 91:4, pages 375-385.
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Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Kelly H. Jordan, Angela L. Mote, Jo A. Salisbury, Timothy K. Tippin & Cosette J. Serabjit‐Singh. (2003) P‐glycoprotein Influences the Brain Concentrations of Cetirizine (Zyrtec®), a Second‐Generation Non‐Sedating Antihistamine. Journal of Pharmaceutical Sciences 92:10, pages 2082-2089.
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Usha Satish & Siegfried Streufert. (2007) Treatment of Hay Fever With the Antihistamine Desloratadine: Impact on Performance of Simple, Intermediate, and Complex Task Requirements1. Journal of Applied Biobehavioral Research 8:2, pages 61-76.
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Daniel K. C. Lee, Kay Haggart, Graeme P. Currie, Sandra D. Anderson & Brian J. Lipworth. (2003) The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis. British Journal of Clinical Pharmacology 55:6, pages 639-642.
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Daniel K.C. Lee, Caroline E. Bates, Graeme P. Currie & Brian J. Lipworth. (2003) Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma. Journal of Allergy and Clinical Immunology 111:2, pages 337-341.
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William E. Berger, Eric J. Schenkel & Lyndon E. Mansfield. (2002) Safety and efficacy of desloratadine 5 mg in asthma patients with seasonal allergic rhinitis and nasal congestion. Annals of Allergy, Asthma & Immunology 89:5, pages 485-491.
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