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Tricyclic antidepressants and fibromyalgia: what is the mechanism of action?

Pages 1437-1445 | Published online: 24 Feb 2005

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Kim Lawson. (2008) Treatment options and patient perspectives in the management of fibromyalgia: future trends. Neuropsychiatric Disease and Treatment 4:6, pages 1059-1071.
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Sarah M. R. Wille, Sarah G. Cooreman, Hugo M. Neels & Willy E. E. Lambert. (2008) Relevant Issues in the Monitoring and the Toxicology of Antidepressants. Critical Reviews in Clinical Laboratory Sciences 45:1, pages 25-89.
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Samuel DeMaria, Afton L. Hassett & Leonard H. Sigal. (2007) N-Methyl-D-Aspartate Receptor-Mediated Chronic Pain: New Approaches to Fibromyalgia Syndrome Etiology and Therapy. Journal of Musculoskeletal Pain 15:2, pages 33-44.
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Kenneth R. Kaufman & Paul J. Goodnick. (2006) Depression, Chronic Fatigue Syndrome, and Fibromyalgia. Journal Of Chronic Fatigue Syndrome 13:4, pages 77-107.
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Hülya Gültekin & Murat Büyükşekerci. (2005) Magnesium increases the antinociceptive effect of amitriptyline. The Pain Clinic 17:2, pages 153-156.
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Articles from other publishers (22)

Nasser M. Alorfi. (2022) Pharmacological treatments of fibromyalgia in adults; overview of phase IV clinical trials. Frontiers in Pharmacology 13.
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Matteo Borgini, Pravat Mondal, Ruiting Liu & Peter Wipf. (2021) Chemical modulation of Kv7 potassium channels. RSC Medicinal Chemistry 12:4, pages 483-537.
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Kinga Sałat & Anna Furgała-Wojas. (2021) Serotonergic Neurotransmission System Modulator, Vortioxetine, and Dopaminergic D2/D3 Receptor Agonist, Ropinirole, Attenuate Fibromyalgia-Like Symptoms in Mice. Molecules 26:8, pages 2398.
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Zhuo-Ying Tao, Pei-Xing Wang, Si-Qi Wei, Richard J. Traub, Jin-Feng Li & Dong-Yuan Cao. (2019) The Role of Descending Pain Modulation in Chronic Primary Pain: Potential Application of Drugs Targeting Serotonergic System. Neural Plasticity 2019, pages 1-16.
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Zaher A. Radi, Zachary S. Stewart, Felicity A. Grzemski & Walter F. Bobrowski. (2012) Renal Pathophysiologic Role of Cortical Tubular Inclusion Bodies. Toxicologic Pathology 41:1, pages 32-37.
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Laura M. Traynor, Christopher N. Thiessen & Andrew P. Traynor. (2011) Pharmacotherapy of fibromyalgia. American Journal of Health-System Pharmacy 68:14, pages 1307-1319.
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Roberto Vlainich, Adriana M. Issy, Luis R. Gerola & Rioko K. Sakata. (2010) Effect of Intravenous Lidocaine on Manifestations of Fibromyalgia. Pain Practice 10:4, pages 301-305.
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Lesley M. Arnold. (2010) The Pathophysiology, Diagnosis and Treatment of Fibromyalgia. Psychiatric Clinics of North America 33:2, pages 375-408.
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Raphael J Leo. (2009) Milnacipran, a serotonin and norepinephrine reuptake inhibitor: a novel treatment for fibromyalgia. International Journal of Clinical Rheumatology 4:5, pages 507-517.
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Tomohiro Sato, Yo Matsuo, Teruki Honma & Shigeyuki Yokoyama. (2008) In Silico Functional Profiling of Small Molecules and Its Applications . Journal of Medicinal Chemistry 51:24, pages 7705-7716.
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Sami R. Achem. (2008) Treatment of Non-Cardiac Chest Pain. Disease-a-Month 54:9, pages 642-670.
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Kim Lawson. (2008) Pharmacological treatments of fibromyalgia: Do complex conditions need complex therapies?. Drug Discovery Today 13:7-8, pages 333-340.
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Lesley M. Arnold. (2007) Duloxetine and Other Antidepressants in the Treatment of Patients with Fibromyalgia. Pain Medicine 8:suppl 2, pages S63-S74.
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Zhong-Qiu Zhao, Santina Chiechio, Yan-Gang Sun, Kai-Hua Zhang, Cheng-Shui Zhao, Michael Scott, Randy L. Johnson, Evan S. Deneris, Kenneth J. Renner, Robert W. GereauIVIV & Zhou-Feng Chen. (2007) Mice Lacking Central Serotonergic Neurons Show Enhanced Inflammatory Pain and an Impaired Analgesic Response to Antidepressant Drugs. The Journal of Neuroscience 27:22, pages 6045-6053.
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Chris Dickens & Graham Ash. 2009. Handbook of Liaison Psychiatry. Handbook of Liaison Psychiatry 527 546 .
David L. Katz, Lindsey Greene, Ather Ali & Zubaida Faridi. (2007) The pain of fibromyalgia syndrome is due to muscle hypoperfusion induced by regional vasomotor dysregulation. Medical Hypotheses 69:3, pages 517-525.
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Serge Perrot. (2006) Rationalizing the use of antidepressants in painful rheumatic conditions. Future Rheumatology 1:4, pages 387-391.
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Serge Perrot, Emmanuel Maheu, Rose-Marie Javier, Alain Eschalier, Anne Coutaux, Manuela LeBars, Philippe Bertin, Bernard Bannwarth & Richard Trèves. (2006) Guidelines for the use of antidepressants in painful rheumatic conditions. European Journal of Pain 10:3, pages 185-185.
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Deborah Antai-Otong. (2005) The Art of Prescribing. Depression and Fibromyalgia Syndrome (FMS): Pharmacologic Considerations. Perspectives In Psychiatric Care 41:3, pages 146-148.
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Martti J Huuhka, Maija L Haanpää & Esa V.J Leinonen. (2004) Electroconvulsive therapy in patients with depression and fibromyalgia. European Journal of Pain 8:4, pages 371-376.
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For-Wey Lung, Yi-Lin Huang, Bih-Ching Shu & Fei-Yin Lee. (2004) Parental rearing style, premorbid personality, mental health, and quality of life in chronic regional pain: A causal analysis. Comprehensive Psychiatry 45:3, pages 206-212.
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