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Miscellaneous

Fondaparinux: a synthetic heparin pentasaccharide as a new antithrombotic agent

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Pages 397-407 | Published online: 24 Feb 2005

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Stephanie A. Smith, Richard J. Travers & James H. Morrissey. (2015) How it all starts: Initiation of the clotting cascade. Critical Reviews in Biochemistry and Molecular Biology 50:4, pages 326-336.
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Meyer-Michel Samama, Jean Amiral, Céline Guinet, Léna Le Flem & Jerard Seghatchian. (2013) Monitoring plasma levels of factor Xa inhibitors: how, why and when?. Expert Review of Hematology 6:2, pages 155-164.
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Peter P. Toth. (2012) Practical Management of Anticoagulants in Family Medicine after Orthopedic Surgery. Postgraduate Medicine 124:4, pages 206-214.
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Jeffrey I Weitz & Lori-Ann Linkins. (2007) Beyond heparin and warfarin: the new generation of anticoagulants. Expert Opinion on Investigational Drugs 16:3, pages 271-282.
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Peter A Kouides & William Fricke. (2005) Diagnosis and management of heparin-induced thrombocytopenia. Expert Review of Cardiovascular Therapy 3:2, pages 335-345.
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Johannes Ruef & Hugo A Katus. (2003) New antithrombotic drugs on the horizon. Expert Opinion on Investigational Drugs 12:5, pages 781-797.
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Sheila A Doggrell. (2003) Reviparin as prophylaxis for thromboembolism after leg injury and hip replacement. Expert Opinion on Pharmacotherapy 4:2, pages 285-288.
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Sheila A Doggrell. (2002) Fondaparinux versus enoxaparin for the prevention of venous thromboembolism. Expert Opinion on Pharmacotherapy 3:4, pages 455-457.
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Flávia S Frattani, Lidia M Lima, Eliezer J Barreiro & Russolina B Zingali. (2017) The antithrombotic and haemostatic effects of LASSBio-752: a synthetic, orally active compound in an arterial and venous thrombosis model in rats. Journal of Pharmacy and Pharmacology 69:10, pages 1374-1380.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 428 432 .
Mashio Nakamura, Norikazu Yamada & Masaaki Ito. (2015) Current management of venous thromboembolism in Japan: Current epidemiology and advances in anticoagulant therapy. Journal of Cardiology 66:6, pages 451-459.
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S. Peraramelli, S. Thomassen, A. Heinzmann, T. M. Hackeng, R. Hartmann, F. Scheiflinger, M. Dockal & J. Rosing. (2015) Role of exosite binding modulators in the inhibition of Fxa by TFPI. Thrombosis and Haemostasis 115:3, pages 580-590.
Crossref
Baolin Wu, Na Wei, Vireak Thon, Mohui Wei, Zaikuan Yu, Yongmei Xu, Xi Chen, Jian Liu, Peng George Wang & Tiehai Li. (2015) Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide. Organic & Biomolecular Chemistry 13:18, pages 5098-5101.
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Jawed Fareed, Evi Kalodiki & Debra Hoppensteadt. 2014. Urgent Interventional Therapies. Urgent Interventional Therapies 27 40 .
Martin KreimannSven BrandtKrystin KrauelStephan BlockChristiane A. Helm, Werner Weitschies, Andreas GreinacherMihaela Delcea. (2014) Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4. Blood 124:15, pages 2442-2449.
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Cheng‐Hsiu Chang, Larry S. Lico, Teng‐Yi Huang, Shu‐Yi Lin, Chi‐Liang Chang, Susan D. Arco & Shang‐Cheng Hung. (2014) Synthesis of the Heparin‐Based Anticoagulant Drug Fondaparinux. Angewandte Chemie International Edition 53:37, pages 9876-9879.
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Cheng-Hsiu Chang, Larry S. Lico, Teng-Yi Huang, Shu-Yi Lin, Chi-Liang Chang, Susan D. Arco & Shang-Cheng Hung. (2014) Synthesis of the Heparin-Based Anticoagulant Drug Fondaparinux. Angewandte Chemie 126:37, pages 10034-10037.
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Lauri Virtanen, Birgitta Salmela, Jari Leinonen, Marja Lemponen, Jukka Huhtala, Lotta Joutsi-Korhonen & Riitta Lassila. (2014) Laboratory-monitored fondaparinux and coagulation activity in association with total hip replacement. Blood Coagulation & Fibrinolysis 25:6, pages 597-603.
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Tiehai Li, Hui Ye, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen, Wei Zhao & Peng Wang. (2014) Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux. ChemMedChem 9:5, pages 1071-1080.
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Nick van Es, Suzanne M. Bleker, Harry R. Büller & Michiel Coppens. (2013) New developments in parenteral anticoagulation for arterial and venous thromboembolism. Best Practice & Research Clinical Haematology 26:2, pages 203-213.
Crossref
Sebastian Harder. (2013) Renal Profiles of Anticoagulants. The Journal of Clinical Pharmacology 52:7, pages 964-975.
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Stephanie Ann Smith. (2012) Antithrombotic Therapy. Topics in Companion Animal Medicine 27:2, pages 88-94.
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Meyer Michel Samama. (2011) The mechanism of action of rivaroxaban – an oral, direct Factor Xa inhibitor – compared with other anticoagulants. Thrombosis Research 127:6, pages 497-504.
Crossref
Hannes G. Wallnoefer, Klaus R. Liedl & Thomas Fox. (2011) A challenging system: Free energy prediction for factor Xa. Journal of Computational Chemistry 32:8, pages 1743-1752.
Crossref
M. Wolzt, M. M. Samama, S. Kapiotis, K. Ogata, J. Mendell & S. Kunitada. (2011) Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux. Thrombosis and Haemostasis 105:6, pages 1080-1090.
Crossref
Walter P Jeske, Jeanine M Walenga, Meyer M Samama, Debra Hoppensteadt, Myttle Mayuga & Jawed Fareed. (2011) Functionality of fondaparinux (pentasaccharide) depends on clinical antithrombin levels. Blood Coagulation & Fibrinolysis 22:3, pages 206-210.
Crossref
Meyer M. Samama & Céline Guinet. (2011) Laboratory assessment of new anticoagulants. Clinical Chemistry and Laboratory Medicine 49:5.
Crossref
Jawed Fareed, Cafer Adiguzel & Indermohan Thethi. (2011) Differentiation of parenteral anticoagulants in the prevention and treatment of venous thromboembolism. Thrombosis Journal 9:1, pages 5.
Crossref
Ali Zalpour, Michael H. Kroll, Vahid Afshar-Kharghan, Syed Wamique Yusuf & Carmen Escalante. (2011) Role of Factor Xa Inhibitors in Cancer-Associated Thrombosis: Any New Data?. Advances in Hematology 2011, pages 1-12.
Crossref
Sun Hee Park, Rui Jiang, Shunfu Piao, Bing Zhang, Eun-Hye Kim, Hyun-Mi Kwon, Xiao Ling Jin, Bok Luel Lee & Nam-Chul Ha. (2011) Structural and Functional Characterization of a Highly Specific Serpin in the Insect Innate Immunity. Journal of Biological Chemistry 286:2, pages 1567-1575.
Crossref
Richard Montagnac, Saïd Brahimi, Pascale Janian, Jean-Pierre Melin, Jean-Philippe Bertocchio & Alain Wynckel. (2010) Intérêt du fondaparinux (Arixtra®) en hémodialyse dans les thrombopénies induites par l’héparine de type II (TIH II). À propos d’une nouvelle observation. Néphrologie & Thérapeutique 6:7, pages 581-584.
Crossref
Sam Schulman. 2009. New Therapeutic Agents in Thrombosis and Thrombolysis. New Therapeutic Agents in Thrombosis and Thrombolysis 155 170 .
Leszek Czerchawski & Wojciech Witkiewicz. (2009) New Anticoagulants in Clinical Practice. Polish Journal of Surgery 81:6.
Crossref
. 2009. MeylerâÂÂs Side Effects of Cardiovascular Drugs. MeylerâÂÂs Side Effects of Cardiovascular Drugs 449 556 .
Martin de Kort, Bas Gianotten, Jeffry A. J. Wisse, Ebo S. Bos, Michel H. M. Eppink, Ellen Mattaar, Gerard M. T. Vogel, Wim H. A. Dokter, Maarten Honing, Stanislava Vonsovic, Martin-Jan Smit, Jac C. H. M. Wijkmans & Constant A. A. van Boeckel. (2008) Conjugation of ATIII-Binding Pentasaccharides to Extend the Half-Life of Proteins: Long-Acting Insulin. ChemMedChem 3:8, pages 1189-1193.
Crossref
Stephen P. O’Connor, Karnail Atwal, Chi Li, Eddie C.-K. Liu, Steven M. Seiler, Mengxiao Shi, Yan Shi, Philip D. Stein & Ying Wang. (2008) Synthesis and evaluation of acylguanidine FXa inhibitors. Bioorganic & Medicinal Chemistry Letters 18:16, pages 4696-4699.
Crossref
Job Harenberg, Ingrid Jörg, Yvonne Vukojevic, Gerd Mikus & Christel Weiss. (2008) Anticoagulant effects of Idraparinux after termination of therapy for prevention of recurrent venous thromboembolism: observations from the van Gogh trials. European Journal of Clinical Pharmacology 64:6, pages 555-563.
Crossref
P.C. WONG, E.J. CRAIN, B. XIN, R.R. WEXLER, P.Y.S. LAM, D.J. PINTO, J.M. LUETTGEN & R.M. KNABB. (2008) Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. Journal of Thrombosis and Haemostasis 6:5, pages 820-829.
Crossref
. 2006. Wiley Handbook of Current and Emerging Drug Therapies. Wiley Handbook of Current and Emerging Drug Therapies.
. 2006. Wiley Handbook of Current and Emerging Drug Therapies. Wiley Handbook of Current and Emerging Drug Therapies.
. 2006. Wiley Handbook of Current and Emerging Drug Therapies. Wiley Handbook of Current and Emerging Drug Therapies.
DAVID BERGQVIST. 2007. The Vein Book. The Vein Book 347 351 .
Don T Elmore, Imre Sovago, Etelka Farkas, Avril Higton, Weng Chan, Botond Penke, Gabor Toth & Gyorgyi VaradiBotond Penke, Gábor Tóth & Györgyi Váradi. 2006. Amino Acids, Peptides and Proteins. Amino Acids, Peptides and Proteins 129 271 .
Shannon M. Bates & Jeffrey I. Weitz. (2006) The status of new anticoagulants. British Journal of Haematology 134:1, pages 3-19.
Crossref
. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 1437 1439 .
J.I. WEITZ & S.M. BATES. (2005) New anticoagulants. Journal of Thrombosis and Haemostasis 3:8, pages 1843-1853.
Crossref
K. Olanders, A. Borjesson, X. Zhao & R. Andersson. (2005) Effects of anticoagulant treatment on intestinal ischaemia and reperfusion injury in rats. Acta Anaesthesiologica Scandinavica 49:4, pages 517-524.
Crossref
Shannon M Bates & Jeffrey I Weitz. (2005) New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin. British Journal of Pharmacology 144:8, pages 1017-1028.
Crossref
P. Bramlage, D. Pittrow & W. Kirch. (2005) Current concepts for the prevention of venous thromboembolism. European Journal of Clinical Investigation 35:s1, pages 4-11.
Crossref
Rodger L. Bick, Eugene P. Frenkel, Jeanine Walenga, Jawed Fareed & Deborah A. Hoppensteadt. (2005) Unfractionated Heparin, Low Molecular Weight Heparins, and Pentasaccharide: Basic Mechanism of Actions, Pharmacology, and Clinical Use. Hematology/Oncology Clinics of North America 19:1, pages 1-51.
Crossref
Eugene P. Frenkel, Yu-Min Shen & Barbara B. Haley. (2005) The Direct Thrombin Inhibitors: Their Role and Use for Rational Anticoagulation. Hematology/Oncology Clinics of North America 19:1, pages 119-145.
Crossref
M. Tobu, Q. Ma, O. Iqbal, C. Schultz, W. Jeske, D. A. Hoppensteadt & J. Fareed. (2016) Comparative Tissue Factor Pathway Inhibitor Release Potential of Heparins. Clinical and Applied Thrombosis/Hemostasis 11:1, pages 37-47.
Crossref
Jeffrey I. Weitz, Jack Hirsh & Meyer M. Samama. (2004) New Anticoagulant Drugs. Chest 126:3, pages 265S-286S.
Crossref
Nick R. Bijsterveld, Roel Vink, Benien E. Van Aken, Hein Fennema, Ron J. G. Peters, Joost C. M. Meijers, Harry R. Büller & Marcel Levi. (2004) Recombinant factor VIIa reverses the anticoagulant effect of the long-acting pentasaccharide idraparinux in healthy volunteers. British Journal of Haematology 124:5, pages 653-658.
Crossref
K. Peerlinck. 2004. 358 361 .
Grigoris T Gerotziafas, Ismail Elalamy, François Depasse, Tahar Chakroun, Lucienne Bara, Pantelis Arzoglou & Meyer M Samama. (2003) On the mechanism of inhibition of tissue factor pathway by the synthetic pentasaccharide during coagulation of human plasma. Blood Coagulation & Fibrinolysis 14:7, pages 633-638.
Crossref
Jeanine M. Walenga, Walter P. Jeske, Peter Bacher & Jawed Fareed. 2001. Kirk-Othmer Encyclopedia of Chemical Technology. Kirk-Othmer Encyclopedia of Chemical Technology.
Shaker A. Mousa, Jeffrey Bozarth & Jeffrey S. Barrett. (2003) Pharmacodynamic Properties of the Low Molecular Weight Heparin, Tinzaparin: Effect of Molecular Weight Distribution on Plasma Tissue Factor Pathway Inhibitor in Healthy Human Subjects. The Journal of Clinical Pharmacology 43:7, pages 727-734.
Crossref
L Lalourcey. (2003) THE DESIGN OF VENOUS THROMBOEMBOLISM PROPHYLAXIS TRIALS: IS ENOXAPARIN MORE EFFECTIVE THAN FONDAPARINUX?. International Journal of Clinical Practice 57:4, pages 289-294.
Crossref
Debra Hoppensteadt, Jeanine M. Walenga, Jawed Fareed & Rodger L. Bick. (2003) Heparin, low–molecular-weight heparins, and heparin pentasaccharide. Hematology/Oncology Clinics of North America 17:1, pages 313-341.
Crossref
Harry L Messmore, Walter P Jeske, William H Wehrmacher & Jeanine M Walenga. (2003) Benefit-Risk Assessment of Treatments for Heparin-Induced Thrombocytopenia. Drug Safety 26:9, pages 625-641.
Crossref
Cécile Boyer-Joubert, Edwige Lorthiois & François Moreau. 2003. 347 374 .
Monica S. Da Silva & Michael Sobel. (2002) Anticoagulants: To bleed or not to bleed, that is the question. Seminars in Vascular Surgery 15:4, pages 256-267.
Crossref
Nicola Volpi & Francesca Maccari. (2002) Detection of submicrogram quantities of glycosaminoglycans on agarose gels by sequential staining with toluidine blue and Stains‐All. ELECTROPHORESIS 23:24, pages 4060-4066.
Crossref

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