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Expert Opinion on Investigational Drugs Volume 12, 2003 - Issue 7
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Drug Evaluation

Thalidomide: a new anticancer drug?

Massimo Fanelli Division of Clinical Oncology, San Filippo Neri Hospital, Via C. Martinotti 20, 00135 Rome, Italy
,
Roberta Sarmiento Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, Policlinico, P.zza Giulio Cesare 11, 70124 Bari, Italy
,
Domenico Gattuso Division of Clinical Oncology, San Filippo Neri Hospital, Via C. Martinotti 20, 00135 Rome, Italy. [email protected]
,
Guido Carillio Division of Clinical Oncology, San Filippo Neri Hospital, Via C. Martinotti 20, 00135 Rome, Italy
,
Barbara Capaccetti Division of Clinical Oncology, San Filippo Neri Hospital, Via C. Martinotti 20, 00135 Rome, Italy
,
Angelo Vacca Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, Policlinico, P.zza Giulio Cesare 11, 70124 Bari, Italy
,
Aldo Maria Roccaro Division of Clinical Oncology, San Filippo Neri Hospital, Via C. Martinotti 20, 00135 Rome, Italy
&
Giampietro Gasparini Division of Clinical Oncology, San Filippo Neri Hospital, Via C. Martinotti 20, 00135 Rome, Italy. [email protected]
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Pages 1211-1225 | Published online: 02 Mar 2005

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Andreja Kovač, Rosalind A. Wilson, Gurdyal S. Besra, Metka Filipič, Danijel Kikelj & Stanislav Gobec. (2006) New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: Inhibition of antigen 85C mycolyltransferase activity and cytotoxicity. Journal of Enzyme Inhibition and Medicinal Chemistry 21:4, pages 391-397.
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Philip E Shaheen & Ronald M Bukowski. (2005) Emerging drugs for renal cell carcinoma. Expert Opinion on Emerging Drugs 10:4, pages 773-795.
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Mathias Kees, Markus Raderer, Sylvia Metz-Schimmerl, Andreas Chott & Heinz Gisslinger. (2005) Very good partial response in a patient with MALT-lymphoma of the lung after treatment with low-dose thalidomide. Leukemia & Lymphoma 46:9, pages 1379-1382.
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Verena Jendrossek, Claus Belka & Michael Bamberg. (2003) Novel chemotherapeutic agents for the treatment of glioblastoma multiforme. Expert Opinion on Investigational Drugs 12:12, pages 1899-1924.
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Articles from other publishers (25)

Sandra Domingo, Cristina Solé, Teresa Moliné, Berta Ferrer, Josep Ordi-Ros & Josefina Cortés-Hernández. (2020) Efficacy of Thalidomide in Discoid Lupus Erythematosus: Insights into the Molecular Mechanisms. Dermatology 236:5, pages 467-476.
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A. Ferrazzi, R. Zambello, I. Russo & M. Alaibac. (2014) Psoriasis induced by thalidomide in a patient with multiple myeloma. Case Reports 2014:jun27 1, pages bcr2014204469-bcr2014204469.
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Wen-wen Lv, Si-ning Qin, Cong-qin Chen, Jin-jie Zhang, Tian-shu Ren, Yong-nan Xu & Qing-chun Zhao. (2014) Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition. Acta Pharmacologica Sinica 35:5, pages 625-635.
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D. Nathan Kim, Taek-Keun Nam, Kevin S. Choe & Hak Choy. (2012) Personalized Combined Modality Therapy for Locally Advanced Non-small Cell Lung Cancer. Cancer Research and Treatment 44:2, pages 74-84.
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Joanne Reid, Moyra Mills, Marie M Cantwell, Chris R Cardwell, Liam J Murray & Michael Donnelly. (2012) Thalidomide for managing cancer cachexia. Cochrane Database of Systematic Reviews 2021:5.
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Shigeru Suzuki, Takeshi Yamamoto, Etsuko Tokunaga, Shuichi Nakamura, Motohiro Tanaka, Takuma Sasaki & Norio Shibata. (2009) Design and Synthesis of Thalidomide–Deoxyribonucleoside Chimeras. Chemistry Letters 38:11, pages 1046-1047.
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Iyad N Daher & Edward TH Yeh. (2008) Vascular complications of selected cancer therapies. Nature Clinical Practice Cardiovascular Medicine 5:12, pages 797-805.
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Wen-Jen Hwu, Ana E. Ayala & Ingrid M. Hernandez. (2008) Alternative temozolomide dosing regimens and novel combinations for the treatment of advanced metastatic melanoma. Oncology Reviews 2:3, pages 183-193.
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Lukas RadbruchFlorian Strasser, Frank Elsner, Jose Ferraz Gonçalves, Jon Løge, Stein Kaasa, Friedemann Nauck & Patrick Stone. (2008) Fatigue in palliative care patients — an EAPC approach. Palliative Medicine 22:1, pages 13-32.
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Christopher D. Turner, Susan Chi, Karen J. Marcus, Tobey MacDonald, Roger J. Packer, Tina Young Poussaint, Sridhar Vajapeyam, Nicole Ullrich, Liliana C. Goumnerova, R. Michael Scott, Caitlin Briody, Christine Chordas, Mary Ann Zimmerman & Mark W. Kieran. (2006) Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. Journal of Neuro-Oncology 82:1, pages 95-101.
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Carlos Camps, Vega Iranzo, Roy M. Bremnes & Rafael Sirera. (2006) Anorexia–Cachexia syndrome in cancer: implications of the ubiquitin–proteasome pathway. Supportive Care in Cancer 14:12, pages 1173-1183.
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Christian Zimmermann, Heike Gutmann & Juergen Drewe. (2005) Thalidomide does not interact with P-glycoprotein. Cancer Chemotherapy and Pharmacology 57:5, pages 599-606.
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Jan Komorowski, Hanna Jerczyńska, Agnieszka Siejka, Patrycja Barańska, Hanna Ławnicka, Zofia Pawłowska & Henryk Stępień. (2006) Effect of thalidomide affecting VEGF secretion, cell migration, adhesion and capillary tube formation of human endothelial EA.hy 926 cells. Life Sciences 78:22, pages 2558-2563.
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Edward T.H. Yeh. (2006) Cardiotoxicity Induced by Chemotherapy and Antibody Therapy. Annual Review of Medicine 57:1, pages 485-498.
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J. Ockenga & L. Valentini. (2006) Thalidomide: an effective anabolic agent in gastrointestinal cancer cachexia: authors' reply. Alimentary Pharmacology and Therapeutics 23:3, pages 446-447.
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Wen‐Jen Hwu, Eric Lis, Jennifer H. Menell, Katherine S. Panageas, Lynne A. Lamb, Janene Merrell, Linda J. Williams, Susan E. Krown, Paul B. Chapman, Philip O. Livingston, Jedd D. Wolchok & Alan N. Houghton. (2005) Temozolomide plus thalidomide in patients with brain metastases from melanoma. Cancer 103:12, pages 2590-2597.
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Roy S. Herbst, Pat LoRusso, Takeshi Isobe & Herbert I. Hurwitz. 2005. 225 245 .
Chuanhua Wang, Georgia B Schuller Levis, Eun Bang Lee, William R Levis, Da Wei Lee, Bo Sook Kim, Seung Yong Park & Eunkyue Park. (2004) Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells. International Immunopharmacology 4:8, pages 1039-1049.
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J. Blake Bartlett, Keith Dredge & Angus G. Dalgleish. (2004) The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nature Reviews Cancer 4:4, pages 314-322.
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