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Review

Novel peroxisome proliferator-activated receptor ligands for Type 2 diabetes and the metabolic syndrome

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Pages 1489-1500 | Published online: 02 Mar 2005

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Yasamin Davatgaran Taghipour, Marziyeh Hajialyani, Rozita Naseri, Mahvash Hesari, Pantea Mohammadi, Azzurra Stefanucci, Adriano Mollica, Mohammad Hosein Farzaei & Mohammad Abdollahi. (2019) Nanoformulations of natural products for management of metabolic syndrome. International Journal of Nanomedicine 14, pages 5303-5321.
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Lalit S Doshi, Manoja Kumar Brahma, Umakant A Bahirat, Amol V Dixit & Kumar VS Nemmani. (2010) Discovery and development of selective PPARγ modulators as safe and effective antidiabetic agents. Expert Opinion on Investigational Drugs 19:4, pages 489-512.
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Hiroyuki Miyachi. (2005) Analysis of patent applications relating to peroxisome proliferator-activated receptor (PPAR) ligands in 2004. Expert Opinion on Therapeutic Patents 15:11, pages 1521-1530.
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Harrihar A Pershadsingh. (2004) Peroxisome proliferator-activated receptor-γ: therapeutic target for diseases beyond diabetes: quo vadis?. Expert Opinion on Investigational Drugs 13:3, pages 215-228.
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Raman K. Verma, Vijay Kumar, Prithwish Ghosh & Lalit K. Wadhwa. (2012) 3D-QSAR study of tyrosine and propanoic acid derivatives as PPARα/γ dual agonists using CoMSIA. Medicinal Chemistry Research 22:1, pages 287-302.
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Paul S. Humphries, Quyen-Quyen T. Do & David M. Wilhite. (2009) Synthesis of 2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoic acid, a dual PPARα/γ agonist. Tetrahedron Letters 50:16, pages 1765-1767.
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Hiroyuki Kagechika & Aya Tanatani. 2008. Gene Family Targeted Molecular Design. Gene Family Targeted Molecular Design 275 316 .
Tatiana M. Garcia-Bates, Geniece M. Lehmann, Patricia J. Simpson-Haidaris, Steven H. Bernstein, Patricia J. Sime & Richard P. Phipps. (2008) Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies. PPAR Research 2008, pages 1-18.
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Rakesh Kumar, Amit Mittal & Uma Ramachandran. (2007) Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARγ activators. Bioorganic & Medicinal Chemistry Letters 17:16, pages 4613-4618.
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Ronda K. Rippley, Kerri X. Yan, Natalie D. Matthews, Howard E. Greenberg, Gary A. Herman & John A. Wagner. (2007) Human Pharmacokinetics and Interconversion of Enantiomers of MK-0767, a Dual PPARα/γ Agonist. The Journal of Clinical Pharmacology 47:3, pages 323-333.
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Fang Zhang, Brian E. Lavan & Francine M. Gregoire. (2007) Selective Modulators of PPAR- Activity: Molecular Aspects Related to Obesity and Side-Effects . PPAR Research 2007, pages 1-7.
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Harrihar A. Pershadsingh. (2006) New generation angiotensin II type 1 receptor antagonists that selectively modulate peroxisome proliferator-activated receptor-γ. Drug Development Research 67:8, pages 687-697.
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Paul S. Humphries, Simon Bailey, Quyen-Quyen T. Do, Jack H. Kellum, Guy A. McClellan & David M. Wilhite. (2006) Intermolecular palladium-catalyzed coupling of 2-halopyridines and alcohols for the preparation of pyridine ether PPAR agonists. Tetrahedron Letters 47:30, pages 5333-5336.
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Harrihar A. Pershadsingh. (2006) Treating the metabolic syndrome using angiotensin receptor antagonists that selectively modulate peroxisome proliferator-activated receptor-γ. The International Journal of Biochemistry & Cell Biology 38:5-6, pages 766-781.
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Harrihar A Pershadsingh. (2006) Dual Peroxisome Proliferator-Activated Receptor-??/?? Agonists. Treatments in Endocrinology 5:2, pages 89-99.
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Robert A. Hegele & Rebecca L. Pollex. (2005) Genetic and physiological insights into the metabolic syndrome. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 289:3, pages R663-R669.
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Tom Hsun-Wei Huang, Bhavani Prasad Kota, Valentina Razmovski & Basil D. Roufogalis. (2005) Herbal or Natural Medicines as Modulators of Peroxisome Proliferator-Activated Receptors and Related Nuclear Receptors for Therapy of Metabolic Syndrome. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 96:1, pages 3-14.
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Joseph L. Evans, Jack F. Youngren & Ira D. Goldfine. (2004) Effective treatments for insulin resistance: trim the fat and douse the fire. Trends in Endocrinology & Metabolism 15:9, pages 425-431.
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Robert A. Hegele. (2004) Treatment of partial lipodystrophy: can the zebra teach us about the horse?. Drug Discovery Today: Disease Mechanisms 1:2, pages 195-203.
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