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Review

The potential role of non-steroidal anti-inflammatory drugs in treating Alzheimer’s disease

Pages 1469-1481 | Published online: 24 Feb 2005

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Antoni Camins, Francesc Xavier Sureda, Felix Junyent, Ester Verdaguer, Jaume Folch, Carlos Beas-Zarate & Merce Pallas. (2010) An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders. Expert Opinion on Investigational Drugs 19:5, pages 587-604.
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Bruno P Imbimbo. (2009) An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease. Expert Opinion on Investigational Drugs 18:8, pages 1147-1168.
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David B Hogan. (2007) Progress update: Pharmacological treatment of Alzheimer’s disease. Neuropsychiatric Disease and Treatment 3:5, pages 569-578.
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Roberto Scatena, Giuseppe E Martorana, Patrizia Bottoni, Giorgia Botta, Paola Pastore & Bruno Giardina. (2007) An update on pharmacological approaches to neurodegenerative diseases. Expert Opinion on Investigational Drugs 16:1, pages 59-72.
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Gary R. M. Wong, Elina J. A. Lee, Qian Yan Liaw & Hrishikesh Rajaram. (2023) The role of oestrogen therapy in reducing risk of Alzheimer's disease: systematic review. BJPsych Open 9:6.
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Hamad Ghaleb Dailah. (2022) Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review. Molecules 27:21, pages 7207.
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Aparna Das & Bimal Krishna Banik. (2022) Versatile Synthesis of Organic Compounds Derived from Ascorbic Acid. Current Organocatalysis 9:1, pages 14-33.
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Raafat A. Abdel-Aal, Ola A. Hussein, Reham G. Elsaady & Lobna A. Abdelzaher. (2022) Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism. European Journal of Pharmacology 915, pages 174695.
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Makbule Dilara ODABAŞI & Zekiye Tuba TÜYLÜ KÜÇÜKKILINÇ. (2021) Alzheimer Hastalığı Tedavisindeki Güncel Yaklaşımlar. Hacettepe University Journal of the Faculty of Pharmacy.
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Ricardo B. Maccioni, Leonardo P. Navarrete, Andrea González, Alejandra González-Canacer, Leonardo Guzmán-Martínez & Nicole Cortés. (2020) Inflammation: A Major Target for Compounds to Control Alzheimer’s Disease. Journal of Alzheimer's Disease 76:4, pages 1199-1213.
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Pei-Pei Guan & Pu Wang. (2018) Integrated communications between cyclooxygenase‐2 and Alzheimer's disease. The FASEB Journal 33:1, pages 13-33.
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Manju Tiwari. (2017) The role of serratiopeptidase in the resolution of inflammation. Asian Journal of Pharmaceutical Sciences 12:3, pages 209-215.
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Jia-ying Xin, Li-rui Sun, Shu-ming Chen, Yan Wang & Chun-gu Xia. (2017) Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions. BioMed Research International 2017, pages 1-6.
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Pu Wang, Pei-Pei Guan, Xin Yu, Li-Chao Zhang, Ya-Nan Su & Zhan-You Wang. (2016) Prostaglandin I2 Attenuates Prostaglandin E2-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism. Scientific Reports 6:1.
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Boris Decourt, MiMi Macias, Marwan Sabbagh & Abdu Adem. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 518 546 .
Christopher Lockhart, Seongwon Kim & Dmitri K. Klimov. (2012) Explicit Solvent Molecular Dynamics Simulations of Aβ Peptide Interacting with Ibuprofen Ligands. The Journal of Physical Chemistry B 116:43, pages 12922-12932.
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Antje Hillmann, Stefanie Hahn, Stephan Schilling, Torsten Hoffmann, Hans-Ulrich Demuth, Bruno Bulic, Thomas Schneider-Axmann, Thomas A. Bayer, Sascha Weggen & Oliver Wirths. (2012) No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease. Neurobiology of Aging 33:4, pages 833.e39-833.e50.
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Seongwon Kim, Wenling E. Chang, Rashmi Kumar & Dmitri K. Klimov. (2011) Naproxen Interferes with the Assembly of Aβ Oligomers Implicated in Alzheimer's Disease. Biophysical Journal 100:8, pages 2024-2032.
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Alexandre E. Medina. (2010) Vinpocetine as a potent antiinflammatory agent. Proceedings of the National Academy of Sciences 107:22, pages 9921-9922.
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Francesco Panza, Vincenzo Solfrizzi, Vincenza Frisardi, Bruno P. Imbimbo, Cristiano Capurso, Alessia D’Introno, Anna M. Colacicco, Davide Seripa, Gianluigi Vendemiale, Antonio Capurso & Alberto Pilotto. (2013) Beyond the neurotransmitter-focused approach in treating Alzheimer’s Disease: drugs targeting β-amyloid and tau protein. Aging Clinical and Experimental Research 21:6, pages 386-406.
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E. Prabhu Raman, Takako Takeda & Dmitri K. Klimov. (2009) Molecular Dynamics Simulations of Ibuprofen Binding to Aβ Peptides. Biophysical Journal 97:7, pages 2070-2079.
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Francesco Panza, Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia DʼIntrono, Anna M. Colacicco, Gianluigi Vendemiale, Antonio Capurso & Bruno P. Imbimbo. (2009) Disease-Modifying Approach to the Treatment of Alzheimerʼs Disease. Drugs & Aging 26:7, pages 537-555.
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Lena N. Turner, Ramesh Balasubramaniam, Elliot V. Hersh & Eric T. Stoopler. (2008) Drug therapy in Alzheimer disease: an update for the oral health care provider. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 106:4, pages 467-476.
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Ann C. McKee, Isabel Carreras, Lokman Hossain, Hoon Ryu, William L. Klein, Salvatore Oddo, Frank M. LaFerla, Bruce G. Jenkins, Neil W. Kowall & Alpaslan Dedeoglu. (2008) Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Research 1207, pages 225-236.
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Rosario Pignatello, Valentina Pantò, Stefano Salmaso, Sara Bersani, Venerando Pistarà, Vladimir Kepe, Jorge R. Barrio & Giovanni Puglisi. (2007) Flurbiprofen Derivatives in Alzheimer’s Disease: Synthesis, Pharmacokinetic and Biological Assessment of Lipoamino Acid Prodrugs. Bioconjugate Chemistry 19:1, pages 349-357.
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Akhlaq A. Farooqui, Wei-Yi Ong & Lloyd A. Horrocks. 2008. Neurochemical Aspects of Excitotoxicity. Neurochemical Aspects of Excitotoxicity 261 279 .
Gemma Casadesus, Mark A Smith, Samar Basu, Jing Hua, Dae E Capobianco, Sandra L Siedlak, Xiongwei Zhu & George Perry. (2007) Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. Molecular Neurodegeneration 2:1.
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Zheng-hong QIN, Lu-yang TAO & Xin CHEN. (2007) Dual roles of NF-κB in cell survival and implications of NF-κB inhibitors in neuroprotective therapy. Acta Pharmacologica Sinica 28:12, pages 1859-1872.
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Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks, Peng Chen & Tahira Farooqui. (2007) Comparison of biochemical effects of statins and fish oil in brain: The battle of the titans. Brain Research Reviews 56:2, pages 443-471.
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Akhlaq A. Farooqui, Lloyd A. Horrocks & Tahira Farooqui. (2006) Modulation of inflammation in brain: a matter of fat. Journal of Neurochemistry 101:3, pages 577-599.
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Bruno P. Imbimbo, Elda Del Giudice, Valentina Cenacchi, Roberta Volta, Gino Villetti, Fabrizio Facchinetti, Benedetta Riccardi, Paola Puccini, Nadia Moretto, Francesca Grassi, Simone Ottonello & Alberta Leon. (2007) In vitro and in vivo profiling of CHF5022 and CHF5074. Pharmacological Research 55:4, pages 318-328.
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Alistair Burns & John O'Brien. (2006) Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology. Journal of Psychopharmacology 20:6, pages 732-755.
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Eva Czirr & Sascha Weggen. (2006) γ-Secretase Modulation with Aβ42-Lowering Nonsteroidal Anti-Inflammatory Drugs and Derived Compounds. Neurodegenerative Diseases 3:4-5, pages 298-304.
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Lap Ho, Weiping Qin, Breton S Stetka & Giulio M Pasinetti. (2006) Is there a Future for Cyclo-Oxygenase Inhibitors in Alzheimer???s Disease?. CNS Drugs 20:2, pages 85-98.
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Yvette Akwa, Hervé Allain, Danièle Bentue-Ferrer, Claudine Berr, Régis Bordet, Hugo Geerts, André Nieoullon, Brigitte Onteniente & Martine Vercelletto. (2005) Neuroprotection and Neurodegenerative Diseases. Alzheimer Disease & Associated Disorders 19:4, pages 226-239.
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Ilaria Peretto, Stefano Radaelli, Carlo Parini, Michele Zandi, Luca F. Raveglia, Giulio Dondio, Laura Fontanella, Paola Misiano, Chiara Bigogno, Andrea Rizzi, Benedetta Riccardi, Marcello Biscaioli, Silvia Marchetti, Paola Puccini, Silvia Catinella, Ivano Rondelli, Valentina Cenacchi, Pier Tonino Bolzoni, Paola Caruso, Gino Villetti, Fabrizio Facchinetti, Elda Del Giudice, Nadia Moretto & Bruno P. Imbimbo. (2005) Synthesis and Biological Activity of Flurbiprofen Analogues as Selective Inhibitors of β-Amyloid 1 - 42 Secretion . Journal of Medicinal Chemistry 48:18, pages 5705-5720.
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