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Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor

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Pages 1199-1212 | Published online: 27 Sep 2005

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I. Chandra, S.V. Prabhu, C. Nayak & S.K. Singh. (2021) E-pharmacophore based screening to identify potential HIV-1 gp120 and CD4 interaction blockers for wild and mutant types. SAR and QSAR in Environmental Research 32:5, pages 353-377.
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Kristin Kassler & Heinrich Sticht. (2014) Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity. Journal of Biomolecular Structure and Dynamics 32:1, pages 52-64.
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Articles from other publishers (20)

Radhika Vangala, Sree Kanth Sivan, Saikiran Reddy Peddi & Vijjulatha Manga. (2019) Computational design, synthesis and evaluation of new sulphonamide derivatives targeting HIV-1 gp120. Journal of Computer-Aided Molecular Design 34:1, pages 39-54.
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Apilak Worachartcheewan, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul, Chanin Nantasenamat & Virapong Prachayasittikul. (2019) Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking. Medicinal Chemistry 15:4, pages 328-340.
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Michelle L. Tonkin & Martin J. Boulanger. (2015) The Shear Stress of Host Cell Invasion: Exploring the Role of Biomolecular Complexes. PLOS Pathogens 11:1, pages e1004539.
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Ralf Dürr, Oliver Keppler, Frauke Christ, Emmanuele Crespan, Anna Garbelli, Giovanni Maga & Ursula Dietrich. 2015. Therapy of Viral Infections. Therapy of Viral Infections 183 222 .
Sree Kanth Sivan, Radhika Vangala & Vijjulatha Manga. (2013) Molecular docking guided structure based design of symmetrical N,N′-disubstituted urea/thiourea as HIV-1 gp120–CD4 binding inhibitors. Bioorganic & Medicinal Chemistry 21:15, pages 4591-4599.
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Laurence Morellato-Castillo, Priyamvada Acharya, Olivier Combes, Johan Michiels, Anne Descours, Oscar H. P. Ramos, Yongping Yang, Guido Vanham, Kevin K. Ariën, Peter D. Kwong, Loïc Martin & Pascal Kessler. (2013) Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein. Journal of Medicinal Chemistry 56:12, pages 5033-5047.
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Alicia Regueiro-Ren, Qiufen M. Xue, Jacob J. Swidorski, Yi-Fei Gong, Marina Mathew, Dawn D. Parker, Zheng Yang, Betsy Eggers, Celia D’Arienzo, Yongnian Sun, Jacek Malinowski, Qi Gao, Dedong Wu, David R. Langley, Richard J. Colonno, Caly Chien, Dennis M. Grasela, Ming Zheng, Pin-Fang Lin, Nicholas A. Meanwell & John F. Kadow. (2013) Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 12. Structure–Activity Relationships Associated with 4-Fluoro-6-azaindole Derivatives Leading to the Identification of 1-(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1 H -pyrrolo[2,3- c ]pyridin-3-yl)ethane-1,2-dione (BMS-585248) . Journal of Medicinal Chemistry 56:4, pages 1656-1669.
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Jiexia Wen, Sumin Pan, Shuang Liang, Zhenyu Zhong, Ying He, Hongyu Lin, Wenyan Li, Liyue Wang, Xiujin Li & Fei Zhong. (2013) Soluble Form of Canine Transferrin Receptor Inhibits Canine Parvovirus Infection In Vitro and In Vivo . BioMed Research International 2013, pages 1-8.
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Tao Wang, Zhong Yang, Zhongxing Zhang, Yi-Fei Gong, Keith A. Riccardi, Pin-Fang Lin, Dawn D. Parker, Sandhya Rahematpura, Marina Mathew, Ming Zheng, Nicholas A. Meanwell, John F. Kadow & John A. Bender. (2013) Inhibitors of HIV-1 attachment. Part 10. The discovery and structure–activity relationships of 4-azaindole cores. Bioorganic & Medicinal Chemistry Letters 23:1, pages 213-217.
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Erik De Clercq. 2011. HIV‐1 Integrase. HIV‐1 Integrase 1 14 .
Kristin Kassler, Julia Meier, Jutta Eichler & Heinrich Sticht. (2011) Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides. Advances in Bioinformatics 2011, pages 1-12.
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Erik De Clercq. (2009) Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes, and paraductions. Medicinal Research Reviews 30:4, pages 667-707.
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Tao Wang, Zhiwei Yin, Zhongxing Zhang, John A. Bender, Zhong Yang, Graham Johnson, Zheng Yang, Lisa M. Zadjura, Celia J. D’Arienzo, Dawn DiGiugno Parker, Christophe Gesenberg, Gregory A. Yamanaka, Yi-Fei Gong, Hsu-Tso Ho, Hua Fang, Nannan Zhou, Brian V. McAuliffe, Betsy J. Eggers, Li Fan, Beata Nowicka-Sans, Ira B. Dicker, Qi Gao, Richard J. Colonno, Pin-Fang Lin, Nicholas A. Meanwell & John F. Kadow. (2009) Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 5. An Evolution from Indole to Azaindoles Leading to the Discovery of 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1 H -pyrrolo[2,3- c ]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a Drug Candidate That Demonstrates Antiviral Activity in HIV-1-Infected Subjects . Journal of Medicinal Chemistry 52:23, pages 7778-7787.
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Fabiana Caporuscio, Andrea Tafi, Emmanuel González, Fabrizio Manetti, José A. Esté & Maurizio Botta. (2009) A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120–CD4 protein–protein interactions. Bioorganic & Medicinal Chemistry Letters 19:21, pages 6087-6091.
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C. Teixeira, N. Serradji, F. Maurel & F. Barbault. (2009) Docking and 3D-QSAR studies of BMS-806 analogs as HIV-1 gp120 entry inhibitors. European Journal of Medicinal Chemistry 44:9, pages 3524-3532.
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Ignacio J. Juncadella, Renu Garg, Tonya C. Bates, Elias R. Olivera & Juan Anguita. (2008) The Ixodes scapularis salivary protein, salp15, prevents the association of HIV-1 gp120 and CD4. Biochemical and Biophysical Research Communications 367:1, pages 41-46.
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Ren-rong Tian, Qing-jiao Liao & Xu-lin Chen. (2008) Current status of targets and assays for anti-HIV drug screening. Virologica Sinica 22:6, pages 476-485.
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Hui XieDanny NgSergey N. SavinovBarna DeyPeter D. KwongRichard WyattAmos B. SmithWayne A. Hendrickson. (2007) Structure−Activity Relationships in the Binding of Chemically Derivatized CD4 to gp120 from Human Immunodeficiency Virus. Journal of Medicinal Chemistry 50:20, pages 4898-4908.
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Kurt Vermeire, Andrea Lisco, Jean-Charles Grivel, Emily Scarbrough, Kaka Dey, Noah Duffy, Leonid Margolis, Thomas W. Bell & Dominique Schols. (2007) Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity. Biochemical Pharmacology 74:4, pages 566-578.
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Axel T. Neffe, Matthias Bilang, Ilona Grüneberg & Bernd Meyer. (2007) Rational Optimization of the Binding Affinity of CD4 Targeting Peptidomimetics with Potential Anti HIV Activity. Journal of Medicinal Chemistry 50:15, pages 3482-3488.
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