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The use of melanocortin antagonists in cachexia of chronic disease

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Pages 1233-1240 | Published online: 27 Sep 2005

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Josep M Argilés, Mireia Olivan, Sílvia Busquets & Francisco Javier López-Soriano. (2010) Optimal management of cancer anorexia–cachexia syndrome. Cancer Management and Research 2, pages 27-38.
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Josep M Argilés, Francisco J López-Soriano & Sílvia Busquets. (2007) Emerging drugs for cancer cachexia. Expert Opinion on Emerging Drugs 12:4, pages 555-570.
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Articles from other publishers (24)

Xinxia Zhu, Michael F. Callahan, Kenneth A. Gruber, Marek Szumowski & Daniel L. Marks. (2020) Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease–associated cachexia. Journal of Clinical Investigation 130:9, pages 4921-4934.
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Marco Koch. (2017) Cannabinoid Receptor Signaling in Central Regulation of Feeding Behavior: A Mini-Review. Frontiers in Neuroscience 11.
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J.M. Argilés, F.J. López-Soriano & S. Busquets. (2013) Mechanisms and treatment of cancer cachexia. Nutrition, Metabolism and Cardiovascular Diseases 23, pages S19-S24.
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Julie Bienertová-Vašků, Petr Bienert, Dalibor Valík & Anna Vašků. (2011) Melanocortin system in cancer-related cachexia. Open Medicine 6:5, pages 550-557.
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R. Dallmann, P. Weyermann, C. Anklin, M. Boroff, K. Bray-French, B. Cardel, I. Courdier-Fruh, H. Deppe, J. Dubach-Powell, M. Erb, R. H. Haefeli, M. Henneböhle, H. Herzner, M. Hufschmid, D. L. Marks, S. Nordhoff, M. Papp, C. Rummey, G. Santos, F. Schärer, H. Siendt, M. Soeberdt, L. T. Sumanovski, M. Terinek, C. Mondadori, N. Güven & A. Feurer. (2011) The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle 2:3, pages 163-174.
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Kathleen G. Mountjoy. (2010) Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes. Biochemical Journal 428:3, pages 305-324.
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J. C. Peter, A. C. Lecourt, M. Weckering, G. Zipfel, M. L. Niehoff, W. A. Banks & K. G. Hofbauer. (2010) A Pharmacologically Active Monoclonal Antibody against the Human Melanocortin-4 Receptor: Effectiveness After Peripheral and Central Administration. Journal of Pharmacology and Experimental Therapeutics 333:2, pages 478-490.
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B. E. Grayson, P. R. Levasseur, S. M. Williams, M. S. Smith, D. L. Marks & K. L. Grove. (2010) Changes in Melanocortin Expression and Inflammatory Pathways in Fetal Offspring of Nonhuman Primates Fed a High-Fat Diet. Endocrinology 151:4, pages 1622-1632.
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Eslam Pourbasheer, Siavash Riahi, Mohammad Reza Ganjali & Parviz Norouzi. (2010) QSAR study on melanocortin-4 receptors by support vector machine. European Journal of Medicinal Chemistry 45:3, pages 1087-1093.
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Olaf Hiort, Thomas Danne & Martin WabitschChristian L. Roth. 2010. Pädiatrische Endokrinologie und Diabetologie. Pädiatrische Endokrinologie und Diabetologie 215 227 .
Philipp Weyermann, Robert Dallmann, Josef Magyar, Corinne Anklin, Martina Hufschmid, Judith Dubach-Powell, Isabelle Courdier-Fruh, Marco Henneböhle, Sonja Nordhoff & Cesare Mondadori. (2009) Orally Available Selective Melanocortin-4 Receptor Antagonists Stimulate Food Intake and Reduce Cancer-Induced Cachexia in Mice. PLoS ONE 4:3, pages e4774.
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Kamyar Kalantar-Zadeh, Stefan D. Anker, Tamara B. Horwich & Gregg C. Fonarow. (2008) Nutritional and Anti-Inflammatory Interventions in Chronic Heart Failure. The American Journal of Cardiology 101:11, pages S89-S103.
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Jarl E. S. Wikberg & Felikss Mutulis. (2008) Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction. Nature Reviews Drug Discovery 7:4, pages 307-323.
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Joe A. Tran, Fabio C. Tucci, Melissa Arellano, Wanlong Jiang, Caroline W. Chen, Dragan Marinkovic, Beth A. Fleck, Jenny Wen, Alan C. Foster & Chen Chen. (2008) Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands. Bioorganic & Medicinal Chemistry Letters 18:6, pages 1931-1938.
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Joe A. Tran, Caroline W. Chen, Fabio C. Tucci, Wanlong Jiang, Beth A. Fleck & Chen Chen. (2008) Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands. Bioorganic & Medicinal Chemistry Letters 18:3, pages 1124-1130.
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Autumn L Fletcher & Daniel L Marks. (2007) Central mechanisms controlling appetite and food intake in a cancer setting: an update. Current Opinion in Supportive and Palliative Care 1:4, pages 306-311.
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Caroline W. Chen, Joe A. Tran, Beth A. Fleck, Fabio C. Tucci, Wanlong Jiang & Chen Chen. (2007) Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor. Bioorganic & Medicinal Chemistry Letters 17:24, pages 6825-6831.
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Wanlong Jiang, Fabio C. Tucci, Joe A. Tran, Beth A. Fleck, Jenny Wen, Stacy Markison, Dragan Marinkovic, Caroline W. Chen, Melissa Arellano, Sam R. Hoare, Michael Johns, Alan C. Foster, John Saunders & Chen Chen. (2007) Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor. Bioorganic & Medicinal Chemistry Letters 17:20, pages 5610-5613.
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Lydie Poitout, Valérie Brault, Carole Sackur, Sonia Bernetière, José Camara, Pascale Plas & Pierre Roubert. (2007) Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor. Bioorganic & Medicinal Chemistry Letters 17:16, pages 4464-4470.
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Joe A. Tran, Fabio C. Tucci, Wanlong Jiang, Dragan Marinkovic, Caroline W. Chen, Melissa Arellano, Stacy Markison, Beth A. Fleck, Jenny Wen, Nicole S. White, Joseph Pontillo, John Saunders, Daniel Marks, Sam R. Hoare, Ajay Madan, Alan C. Foster & Chen Chen. (2007) Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity. Bioorganic & Medicinal Chemistry 15:15, pages 5166-5176.
Crossref
Chen Chen. 2007. Progress in Medicinal Chemistry Volume 45. Progress in Medicinal Chemistry Volume 45 111 167 .
James P. Cain, Alexander V. Mayorov, Minying Cai, Hui Wang, Bahar Tan, Kevin Chandler, YeonSun Lee, Ravil R. Petrov, Dev Trivedi & Victor J. Hruby. (2006) Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters 16:20, pages 5462-5467.
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Wanlong Jiang, Fabio C. Tucci, Caroline W. Chen, Melissa Arellano, Joe A. Tran, Nicole S. White, Dragan Marinkovic, Joseph Pontillo, Beth A. Fleck, Jenny Wen, John Saunders, Ajay Madan, Alan C. Foster & Chen Chen. (2006) Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor. Bioorganic & Medicinal Chemistry Letters 16:17, pages 4674-4678.
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Lisa D Madison & Daniel L Marks. (2006) Anticatabolic properties of melanocortin-4 receptor antagonists. Current Opinion in Clinical Nutrition & Metabolic Care 9:3, pages 196-200.
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