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Expert Opinion on Investigational Drugs Volume 14, 2005 - Issue 10
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Drug Evaluation

Vinflunine: a novel antitubulin agent in solid malignancies

Jaafar Bennouna Centre René Gauducheau, Saint-Herblain, France. [email protected]
,
Mario Campone Centre René Gauducheau, Saint-Herblain, France. [email protected]
,
Jean Pierre Delord Institut Claudius regaud, Toulouse, France
&
Marie-Claire Pinel Institut de Recherche Pierre Fabre, Boulogne-Billancourt, France
Pages 1259-1267 | Published online: 27 Sep 2005

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Herbert H Loong & Winnie Yeo. (2014) Microtubule-targeting agents in oncology and therapeutic potential in hepatocellular carcinoma. OncoTargets and Therapy 7, pages 575-585.
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Armand Morel & Denis Talbot. (2010) Critical evaluation of vinflunine in the treatment of refractory metastatic urothelial carcinoma. Open Access Journal of Urology 2, pages 99-108.
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Robert O Carlson. (2008) New tubulin targeting agents currently in clinical development. Expert Opinion on Investigational Drugs 17:5, pages 707-722.
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Adrian Yun-San Yip, Eleanor Yuen-Yuen Ong & Louis Wing-Cheong Chow. (2008) Vinflunine: clinical perspectives of an emerging anticancer agent. Expert Opinion on Investigational Drugs 17:4, pages 583-591.
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Nadine Darwiche, Sara El-Banna & Hala Gali-Muhtasib. (2007) Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development. Expert Opinion on Drug Discovery 2:3, pages 361-379.
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Mark R Miglarese & Robert O Carlson. (2006) Development of new cancer therapeutic agents targeting mitosis. Expert Opinion on Investigational Drugs 15:11, pages 1411-1425.
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Syed Nasir Abbas Bukhari, Gajjela Bharath Kumar, Hrishikesh Mohan Revankar & Hua-Li Qin. (2017) Development of combretastatins as potent tubulin polymerization inhibitors. Bioorganic Chemistry 72, pages 130-147.
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Eric K. Rowinsky. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 41 .
Marc Perez, Tahar Ayad, Philippe Maillos, Valérie Poughon, Jacques Fahy & Virginie Ratovelomanana-Vidal. (2016) Synthesis and biological evaluation of new securinine analogues as potential anticancer agents. European Journal of Medicinal Chemistry 109, pages 287-293.
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P. Barbier, P. O. Tsvetkov, G. Breuzard & F. Devred. (2013) Deciphering the molecular mechanisms of anti-tubulin plant derived drugs. Phytochemistry Reviews 13:1, pages 157-169.
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J. P. Delord, J. M. Tourani, F. Lefresne, A. Pétain, J.-C. Pouget & A. Ravaud. (2013) Phase I dose-escalation study of oral vinflunine administered once daily for 6 weeks every 8 weeks in patients with advanced/metastatic solid tumours. Cancer Chemotherapy and Pharmacology 71:3, pages 647-656.
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Huang Pin, Lu Hong‐min, Ye Ming & Li Qin. (2011) A validated LC‐MS/MS method for the determination of vinflunine in plasma and its application to pharmacokinetic studies. Biomedical Chromatography 26:7, pages 797-801.
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Susana M. Campos & Don S. Dizon. (2012) Antimitotic Inhibitors. Hematology/Oncology Clinics of North America 26:3, pages 607-628.
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E. Calvo, J. B. Vermorken, S. Hiret, J. Rodon, J. Cortes, H. Senellart, J. Van den Brande, J. Dyck, A. Pétain, P. Ferre & J. Bennouna. (2012) Phase I dose-escalation study of vinflunine hard capsules administered twice a day for 2 consecutive days every week in patients with advanced/metastatic solid tumors. Cancer Chemotherapy and Pharmacology 69:6, pages 1467-1475.
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Javier Cortes, Alberto J. Montero & Stefan Glück. (2012) Eribulin mesylate, a novel microtubule inhibitor in the treatment of breast cancer. Cancer Treatment Reviews 38:2, pages 143-151.
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Bhuwan B. Mishra & Vinod K. Tiwari. (2011) Natural products: An evolving role in future drug discovery. European Journal of Medicinal Chemistry 46:10, pages 4769-4807.
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John S Ng. (2010) Vinflunine: review of a new vinca alkaloid and its potential role in oncology . Journal of Oncology Pharmacy Practice 17:3, pages 209-224.
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Holger Gerullis, Thorsten Ecke, Christoph Eimer, Mohamed Wishahi & Thomas Otto. (2011) Vinflunine as second-line treatment in platin-resistant metastatic urothelial carcinoma. Anti-Cancer Drugs 22:1, pages 9-17.
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Grégoire Zorza, Delphine Pellerin, Valérie Fortune & Christian Puozzo. (2010) A Simple and Sensitive High-Performance Liquid Chromatographic Method for the Determination of Vinflunine and 4-O-Deacetylvinflunine From Human Blood. Therapeutic Drug Monitoring 32:6, pages 734-740.
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David J. Vaughn, Sandy Srinivas, Walter M. Stadler, Roberto Pili, Daniel Petrylak, Cora N. Sternberg, David C. Smith, Sarah Ringuette, Edwin de Wit, Virginie Pautret & Claude George. (2009) Vinflunine in platinum‐pretreated patients with locally advanced or metastatic urothelial carcinoma. Cancer 115:18, pages 4110-4117.
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Edith A. Perez. (2009) Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Molecular Cancer Therapeutics 8:8, pages 2086-2095.
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David G. I. Kingston. (2009) Tubulin-Interactive Natural Products as Anticancer Agents. Journal of Natural Products 72:3, pages 507-515.
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Vivek Roy & Edith A. Perez. 2009. Pharmacology and Therapeutics. Pharmacology and Therapeutics 933 944 .
Cindy Simoens, Filip Lardon, Bea Pauwels, Christel MJ De Pooter, Hilde AJ Lambrechts, Greet GO Pattyn, Fabienne Breillout & Jan B Vermorken. (2008) Comparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in vitro. BMC Cancer 8:1.
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Cindy Simoens, Bea Pauwels, Jan B. Vermorken, Greet G. O. Pattyn, Hilde A. J. Lambrechts, Fabienne Breillout & Filip Lardon. (2007) Further mechanistic unravelling of the influence of the cell cycle effects on the radiosensitising mechanism of vinflunine, in vitro. Cancer Chemotherapy and Pharmacology 62:2, pages 183-193.
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Joaquim Bellmunt, Francois-Michel Delgado & Claude George. (2008) Clinical Activity of Vinflunine in Transitional Cell Carcinoma of the Urothelium and Other Solid Tumors. Seminars in Oncology 35, pages S34-S43.
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Jaafar Bennouna, Jean-Pierre Delord, Mario Campone & Laurent Nguyen. (2008) Vinflunine: A New Microtubule Inhibitor Agent. Clinical Cancer Research 14:6, pages 1625-1632.
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Gustavo F.V. Ismael, Daniela Dornelles Rosa, Max S. Mano & Ahmad Awada. (2008) Novel cytotoxic drugs: Old challenges, new solutions. Cancer Treatment Reviews 34:1, pages 81-91.
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Mark S. Butler. (2008) Natural products to drugs: natural product-derived compounds in clinical trials. Natural Product Reports 25:3, pages 475.
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Olivier Potterat & Matthias Hamburger. 2008. Natural Compounds as Drugs Volume I. Natural Compounds as Drugs Volume I 45 118 .
Mark S. Butler & David J. Newman. 2008. Natural Compounds as Drugs Volume I. Natural Compounds as Drugs Volume I 1 44 .
J. Robert. (2007) Les poisons du fuseauSpindle poisons. Oncologie 9:11, pages 766-772.
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Muriel Cuendet & John M. Pezzuto. 2007. Modern Alkaloids. Modern Alkaloids 25 52 .
Denis C. Talbot, Jacques Margery, Gérard Dabouis, Graham Dark, Henry Taylor, Hélène Boussemart, Véronique Cadic, Marie-Claire Pinel, Alain Rivière, Liliane Ollivier & Pierre Ruffié. (2007) Phase II Study of Vinflunine in Malignant Pleural Mesothelioma. Journal of Clinical Oncology 25:30, pages 4751-4756.
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I.N. Olver, M.J. Byrne, E. Walpole, D. Vorobiof, C. Jacobs, K. Maart, S. Hewitt, G. McAdam, J.C. Pouget & M.C. Pinel. (2007) Phase II study of IV vinflunine in patients with chemotherapy naive metastatic malignant melanoma. European Journal of Cancer 43:12, pages 1829-1832.
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G. Zorza, J.C. Van Heugen, J. De Graeve & C. Puozzo. (2007) Development of a sensitive liquid chromatography method coupled with a tandem mass spectrometric detection for the clinical analysis of vinflunine and 4-O-deacetyl vinflunine in blood, urine and faeces. Journal of Chromatography B 853:1-2, pages 294-302.
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Dominique Levêque & François Jehl. (2007) Molecular Pharmacokinetics of Catharanthus (Vinca) Alkaloids. The Journal of Clinical Pharmacology 47:5, pages 579-588.
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