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Review

Benign prostatic hyperplasia: an insight into current investigational medical therapies

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Pages 1359-1372 | Published online: 28 Oct 2005

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Read on this site (4)

Atul Tiwari. (2007) Advances in the development of hormonal modulators for the treatment of benign prostatic hyperplasia. Expert Opinion on Investigational Drugs 16:9, pages 1425-1439.
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Atul Tiwari & Krishna S Naruganahalli. (2006) Current and emerging investigational medical therapies for the treatment of overactive bladder. Expert Opinion on Investigational Drugs 15:9, pages 1017-1037.
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PKS Sarma, Atul Tiwari, Atul Kondaskar & Ian A Cliffe. (2006) Peptidomimetic GnRH receptor antagonists for the treatment of reproductive and proliferative diseases. Expert Opinion on Therapeutic Patents 16:6, pages 733-751.
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Articles from other publishers (38)

Deusdedit Tusubira, Jonasi Munezero, Peter Chinedu Agu, Clement Olusoji Ajayi, Joseph Oloro, Nathiim Namale, Frank Ssedyabane, Caroline Kiwanuka Nakiguli, Abayomi E. Adegboyega & Patrick Maduabuchi Aja. (2023) In-vivo and in-silico studies revealed the molecular mechanisms of Colocasia esculenta phenolics as novel chemotherapy against benign prostatic hyperplasia via inhibition of 5α-reductase and α1-adrenoceptor. In Silico Pharmacology 11:1.
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Akansha Sharma, Priyanka Rana, Poonam Arora, Tanzeer Kaur & Neelima Dhingra. (2022) Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors. Current Enzyme Inhibition 18:3, pages 180-193.
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Chu-Wen Fang, Chun-Hao Chen, Kun-Hung Shen, Wen-Chi Yang, Chih-Hsin Muo & Shih-Chi Wu. (2020) Increased risk of subsequent benign prostatic hyperplasia in non-Helicobacter pylori-infected peptic ulcer patients: a population-based cohort study. Scientific Reports 10:1.
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Ceyda Tuba Sengel-Turk, Mehmet Eray Alcigir, Okan Ekim, Filiz Bakar-Ates & Canan Hascicek. (2020) Clinicopathological and immunohistochemical evaluation of lonidamine-entrapped lipid–polymer hybrid nanoparticles in treatment of benign prostatic hyperplasia: An experimental rat model. European Journal of Pharmaceutics and Biopharmaceutics 157, pages 211-220.
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Wang Xi, Qiaogen Zou & Pingkai Ouyang. (2019) Pharmacokinetics of cligosiban in dog plasma after oral administration by liquid chromatography electrospray ionization tandem mass spectrometry. Biomedical Chromatography 33:10.
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Xueliang Yue, Lingpan Lu, Hongshan Liu & Huanzhou Xue. (2019) Pharmacokinetics, bioavailability and metabolism of cligosiban, an antagonist of oxytocin receptor, in rat by liquid chromatography hyphenated with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 164, pages 725-733.
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Neelima Dhingra. (2018) In silico Identification of potential 5α‒reductase inhibitors for prostatic diseases: QSAR modelling, molecular docking, and pre ADME predictions. MOJ Drug Design Development & Therapy 2:3.
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William B. Coleman. 2018. Molecular Pathology. Molecular Pathology 71 97 .
Kejing Lao, Jie Sun, Chong Wang, Weiting Lyu, Boshen Zhou, Ruheng Zhao, Qian Xu, Qidong You & Hua Xiang. (2017) Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2. Steroids 124, pages 29-34.
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Caroline M. Moore & Mark Emberton. 2017. Imaging and Focal Therapy of Early Prostate Cancer. Imaging and Focal Therapy of Early Prostate Cancer 293 306 .
Eunjin JeonKyung-Sook ChungHyo-Jin An. (2016) Anti-proliferation effects of Cistanches salsa on the progression of benign prostatic hyperplasia . Canadian Journal of Physiology and Pharmacology 94:1, pages 104-111.
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Liya Liu, Yun Wan, Aling Shen, Jinyan Zhao, Jiumao Lin, Xiaoyong Zhong, Yuchen Zhang & Zhenfeng Hong. (2015) miRNA Regulation Network Analysis in Qianliening Capsule Treatment of Benign Prostatic Hyperplasia. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-9.
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Simone Chevalier, Fabio L. Cury, Eleonora Scarlata, Ehab El-Zayat, Lucie Hamel, Joice Rocha, Fatima Z. Zouanat, Sabri Moussa, Avigdor Scherz, Mostafa Elhilali & Maurice Anidjar. (2013) Endoscopic Vascular Targeted Photodynamic Therapy with the Photosensitizer WST11 for Benign Prostatic Hyperplasia in the Preclinical Dog Model. The Journal of Urology 190:5, pages 1946-1953.
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Hui-Wen Chiu, Mei-Huei Chen, Wen-Hung Fang, Ching-Ming Hung, Yen-Lin Chen, Ming-Der Wu, Gwo-Fang Yuan, Ming-Jiuan Wu & Ying-Jan Wang. (2013) Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer. Journal of Agricultural and Food Chemistry 61:18, pages 4379-4386.
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Alan D. Borthwick & John Liddle. 2013. Protein-Protein Interactions in Drug Discovery. Protein-Protein Interactions in Drug Discovery 225 256 .
Caroline M. Moore & Mark Emberton. 2013. Imaging and Focal Therapy of Early Prostate Cancer. Imaging and Focal Therapy of Early Prostate Cancer 283 295 .
Saurabh Aggarwal, Suresh Thareja, T.R. Bhardwaj, J?rg Haupenthal, R.W. Hartmann & Manoj Kumar. (2012) Synthesis and biological evaluation of novel unsaturated carboxysteroids as?human 5?-reductase inhibitors: A legitimate approach. European Journal of Medicinal Chemistry 54, pages 728-739.
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Liang-Ming Lee, Chih-Cheng Lu, Hsien-Hui Chung & Juei-Tang Cheng. (2012) Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats. The Scientific World Journal 2012, pages 1-7.
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Jeroen C. Verheijen, David J. Richard & Arie Zask. 2011. Kinase Drug Discovery. Kinase Drug Discovery 161 217 .
Lucas P. Nacusi & Donald J. Tindall. (2011) Targeting 5α-reductase for prostate cancer prevention and treatment. Nature Reviews Urology 8:7, pages 378-384.
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Pedro A.V. Reis de Souza, Antonio PalumboJrJr, Leandro M. Alves, Valéria Pereira de Souza, Lúcio M. Cabral, Patrícia D. Fernandes, Christina M. Takiya, Fábio S. Menezes & Luiz E. Nasciutti. (2011) Effects of a nanocomposite containing Orbignya speciosa lipophilic extract on Benign Prostatic Hyperplasia. Journal of Ethnopharmacology 135:1, pages 135-146.
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CHIH-CHENG LU, HSIEN-HUI CHUNG & JUEI-TANG CHENG. (2011) Prostatic relaxation induced by loperamide is mediated through activation of opioid μ-2 receptors in vitro. Experimental and Therapeutic Medicine 2:2, pages 281-285.
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Alan D. Borthwick. (2010) Oral Oxytocin Antagonists. Journal of Medicinal Chemistry 53:18, pages 6525-6538.
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Xin Zhao, Mu Yuan, Biyun Huang, Hong Ji & Liu Zhu. (2010) Ligand-based pharmacophore model of N-Aryl and N-Heteroaryl piperazine ?1A-adrenoceptors antagonists using GALAHAD. Journal of Molecular Graphics and Modelling 29:2, pages 126-136.
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Alan Brown, Dave Ellis, Olga Wallace & Michael Ralph. (2010) Identification of amide bioisosteres of triazole Oxytocin antagonists. Bioorganic & Medicinal Chemistry Letters 20:7, pages 2224-2228.
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Alan Brown, Dave Ellis, Olga Wallace & Michael Ralph. (2010) Identification of a urea bioisostere of a triazole oxytocin antagonist. Bioorganic & Medicinal Chemistry Letters 20:6, pages 1851-1853.
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Alan Brown, T. Bruce Brown, Andrew Calabrese, Dave Ellis, Nicholas Puhalo, Michael Ralph & Lesa Watson. (2010) Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituent. Bioorganic & Medicinal Chemistry Letters 20:2, pages 516-520.
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Osamu Yamaguchi, Ken Aikawa, Keiichi Shishido & Masanori Nomiya. (2009) Place of overactive bladder in male lower urinary tract symptoms. World Journal of Urology 27:6, pages 723-728.
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Alexander Roosen, Ben T. Blake‐James, Daniel Wood & Christopher H. Fry. (2009) Clinical and experimental aspects of Adreno‐muscarinic synergy in the bladder base and prostate. Neurourology and Urodynamics 28:8, pages 938-943.
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Alan Brown, Dave Ellis, David Pearce, Michael Ralph & Nunzio Sciammetta. (2009) Aryloxypyrazines as highly selective antagonists of Oxytocin. Bioorganic & Medicinal Chemistry Letters 19:10, pages 2634-2636.
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Kamna Nanda, Krishna S. Naruganahalli, Suman Gupta, Shivani Malhotra, Atul Tiwari, Laxminarayan G. Hegde, Sanjay Jain, Neelima Sinha, Jung B. Gupta, Anita Chugh, Nitya Anand & Abhijit Ray. (2009) RBx 6198: A novel α1-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia. European Journal of Pharmacology 607:1-3, pages 213-219.
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Paloma Alonso-MagdalenaClemens BrössnerAngelika Reiner, Guojun Cheng, Nobuhiro Sugiyama, Margaret Warner & Jan-Åke Gustafsson. (2009) A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia. Proceedings of the National Academy of Sciences 106:8, pages 2859-2863.
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William B. Coleman & Tara C. Rubinas. 2009. Molecular Pathology. Molecular Pathology 63 86 .
Craig V. Comiter. 2009. Continence. Continence 393 409 .
Alan Brown, Lindsay Brown, T. Bruce Brown, Andrew Calabrese, Dave Ellis, Nicholas Puhalo, Chris R. Smith, Olga Wallace & Lesa Watson. (2008) Triazole oxytocin antagonists: Identification of aryl ether replacements for a biaryl substituent. Bioorganic & Medicinal Chemistry Letters 18:19, pages 5242-5244.
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Alan Brown, Lindsay Brown, Dave Ellis, Nicholas Puhalo, Chris R. Smith, Olga Wallace & Lesa Watson. (2008) Design and optimization of potent, selective antagonists of Oxytocin. Bioorganic & Medicinal Chemistry Letters 18:15, pages 4278-4281.
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W.M. Kwiatek, A. Banaś, K. Banaś, G. Cinque, G. Dyduch, G. Falkenberg, A. Kisiel, A. Marcelli & M. Podgórczyk. (2007) Micro and bulk analysis of prostate tissues classified as hyperplasia. Spectrochimica Acta Part B: Atomic Spectroscopy 62:6-7, pages 707-710.
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Christopher R. Chapple & Claus G. Roehrborn. (2006) A Shifted Paradigm for the Further Understanding, Evaluation, and Treatment of Lower Urinary Tract Symptoms in Men: Focus on the Bladder. European Urology 49:4, pages 651-659.
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