97
Views
35
CrossRef citations to date
0
Altmetric
Review

Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants

&
Pages 1373-1383 | Published online: 28 Oct 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Articles from other publishers (34)

Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska & Mark T. Quinn. (2023) Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors. Molecules 28:12, pages 4806.
Crossref
Serhii A. Liakhov, Igor A. Schepetkin, Olexander S. Karpenko, Hanna I. Duma, Nadiia M. Haidarzhy, Liliya N. Kirpotina, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Irina Y. Bagryanskaya & Mark T. Quinn. (2021) Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11H-Indeno[1,2-b]quinoxalin-11-one Scaffold. Molecules 26:18, pages 5688.
Crossref
Min Wang, Hideki Hayashi, Ichiro Horinokita, Mayumi Asada, Yui Iwatani, Jian-xun Liu & Norio Takagi. (2021) Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis. Biomedicine & Pharmacotherapy 140, pages 111696.
Crossref
Yanna Mao, Kunjal Soni, Chetan Sangani & Yongfang Yao. (2020) An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents. Current Topics in Medicinal Chemistry 20:28, pages 2599-2633.
Crossref
Elina Kibler, Anastasia Lavrinenko, Ilya Kolesnik, Ksenia Stankevich, Evgeny Bolbasov, Valeriya Kudryavtseva, Andrey Leonov, Igor Schepetkin, Andrei Khlebnikov, Mark T. Quinn & Sergei Tverdokhlebov. (2020) Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1. European Polymer Journal 127, pages 109598.
Crossref
Shweta Jain, Vikash Chandra, Pankaj Kumar Jain, Kamla Pathak, Devendra Pathak & Ankur Vaidya. (2019) Comprehensive review on current developments of quinoline-based anticancer agents. Arabian Journal of Chemistry 12:8, pages 4920-4946.
Crossref
Ksenia S. Stankevich, Igor A. Schepetkin, Semen I. Goreninskii, Anastasia K. Lavrinenko, Evgeniy N. Bolbasov, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Victor D. Filimonov, Andrei I. Khlebnikov, Sergei I. Tverdokhlebov & Mark T. Quinn. (2019) Poly(ε-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation. ACS Biomaterials Science & Engineering 5:11, pages 5990-5999.
Crossref
Xiaodong Dou, Huixia Huang, Yibo Li, Lan Jiang, Yanxing Wang, Hongwei Jin, Ning Jiao, Lihe Zhang, Liangren Zhang & Zhenming Liu. (2019) Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. Journal of Medicinal Chemistry 62:14, pages 6645-6664.
Crossref
Igor A. Schepetkin, Andrei I. Khlebnikov, Andrei S. Potapov, Anastasia R. Kovrizhina, Vladislava V. Matveevskaya, Maxim L. Belyanin, Dmitriy N. Atochin, Svitlana O. Zanoza, Nadiya M. Gaidarzhy, Sergiy A. Lyakhov, Liliya N. Kirpotina & Mark T. Quinn. (2019) Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors. European Journal of Medicinal Chemistry 161, pages 179-191.
Crossref
Peter Schröder, Tim Förster, Stefan Kleine, Christian Becker, André Richters, Slava Ziegler, Daniel Rauh, Kamal Kumar & Herbert Waldmann. (2015) Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4. Angewandte Chemie International Edition 54:42, pages 12398-12403.
Crossref
Peter Schröder, Tim Förster, Stefan Kleine, Christian Becker, André Richters, Slava Ziegler, Daniel Rauh, Kamal Kumar & Herbert Waldmann. (2015) Neuritogenic Militarinone-Inspired 4-Hydroxypyridones Target the Stress Pathway Kinase MAP4K4. Angewandte Chemie 127:42, pages 12575-12580.
Crossref
Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso & Yangbo Feng. (2014) Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives. Journal of Medicinal Chemistry 57:23, pages 10013-10030.
Crossref
Igor A. Schepetkin, Liliya N. Kirpotina, Andrei I. Khlebnikov, Tracey S. Hanks, Irina Kochetkova, David W. Pascual, Mark A. Jutila & Mark T. Quinn. (2012) Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors. Molecular Pharmacology 81:6, pages 832-845.
Crossref
Thirumurthy Madhavan. (2012) Design of Novel JNK3 Inhibitors Based on 3D-QSAR In Silico Model. Journal of the Chosun Natural Science 5:1, pages 6-12.
Crossref
Tinghu Zhang, Francisco Inesta-Vaquera, Mario Niepel, Jianming Zhang, Scott?B. Ficarro, Thomas Machleidt, Ting Xie, Jarrod?A. Marto, NamDoo Kim, Taebo Sim, John?D. Laughlin, Hajeung Park, Philip?V. LoGrasso, Matt Patricelli, Tyzoon?K. Nomanbhoy, Peter?K. Sorger, Dario?R. Alessi & Nathanael?S. Gray. (2012) Discovery of Potent and Selective Covalent Inhibitors of JNK. Chemistry & Biology 19:1, pages 140-154.
Crossref
Monica Sanchez Contreras & Fernando Cardozo-Pelaez. 2011. Extracellular and Intracellular Signaling. Extracellular and Intracellular Signaling 247 282 .
Gary D. Probst, Simeon Bowers, Jennifer M. Sealy, Anh P. Truong, Roy K. Hom, Robert A. GalemmoJr.Jr., Andrei W. Konradi, Hing L. Sham, David A. Quincy, Hu Pan, Nanhua Yao, May Lin, Gergley Tóth, Dean R. Artis, Wes Zmolek, Karina Wong, Ann Qin, Colin Lorentzen, David F. Nakamura, Kevin P. Quinn, John-Michael Sauer, Kyle Powell, Lany Ruslim, Sarah Wright, David Chereau, Zhao Ren, John P. Anderson, Frédérique Bard, Ted A. Yednock & Irene Griswold-Prenner. (2011) Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorganic & Medicinal Chemistry Letters 21:1, pages 315-319.
Crossref
B. V. S. Suneel Kumar, Rohith Kotla, Revanth Buddiga, Jyoti Roy, Sardar Shamshair Singh, Rambabu Gundla, Muttineni Ravikumar & Jagarlapudi A. R. P. Sarma. (2010) Ligand-based and structure-based approaches in identifying ideal pharmacophore against c-Jun N-terminal kinase-3. Journal of Molecular Modeling 17:1, pages 151-163.
Crossref
Xiang Li, Ruth MacLeod, Allan J. Dunlop, Helen V. Edwards, Noopur Advant, Lucien C.D. Gibson, Nicola M. Devine, Kim M. Brown, David R. Adams, Miles D. Houslay & George S. Baillie. (2009) A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex. FEBS Letters 583:20, pages 3310-3316.
Crossref
Nanako Hamada, Yasunori Fujita, Arisa Tanaka, Makoto Naoi, Yoshinori Nozawa, Yoshiko Ono, Yoshinori Kitagawa, Namino Tomimori, Yoshinobu Kiso & Masafumi Ito. (2009) Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway. Journal of Neural Transmission 116:7, pages 841-852.
Crossref
Youseung Shin, Weiming Chen, Jeff Habel, Derek Duckett, Yuan Yuan Ling, Marcel Koenig, Yuanjun He, Tomas Vojkovsky, Philip LoGrasso & Theodore M. Kamenecka. (2009) Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors. Bioorganic & Medicinal Chemistry Letters 19:12, pages 3344-3347.
Crossref
Douglas L. Sheridan, Yong Kong, Sirlester A. Parker, Kevin N. Dalby & Benjamin E. Turk. (2008) Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs. Journal of Biological Chemistry 283:28, pages 19511-19520.
Crossref
Raghu R. KrishnamoorthyVidhya R. RaoRachel DauphinGanesh PrasannaChristina JohnsonThomas Yorio. (2008) Role of the ET B receptor in retinal ganglion cell death in glaucomaThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin. . Canadian Journal of Physiology and Pharmacology 86:6, pages 380-393.
Crossref
S Carboni, U Boschert, P Gaillard, J-P Gotteland, J-Y Gillon & P-A Vitte. (2008) AS601245, a c-Jun NH 2 -terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils . British Journal of Pharmacology 153:1, pages 157-163.
Crossref
Jing Pan, Gang Wang, Hong-Qi Yang, Zhen Hong, Qin Xiao, Ru-Jing Ren, Hai-Yan Zhou, Li Bai & Sheng-Di Chen. (2007) K252a Prevents Nigral Dopaminergic Cell Death Induced by 6-Hydroxydopamine through Inhibition of Both Mixed-Lineage Kinase 3/c-Jun NH 2 -Terminal Kinase 3 (JNK3) and Apoptosis-Inducing Kinase 1/JNK3 Signaling Pathways . Molecular Pharmacology 72:6, pages 1607-1618.
Crossref
Rong Jiang, Derek Duckett, Weiming Chen, Jeff Habel, Yuan Yuan Ling, Philip LoGrasso & Theodore M. Kamenecka. (2007) 3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 17:22, pages 6378-6382.
Crossref
Albert Y Hung & Michael A Schwarzschild. (2007) Clinical trials for neuroprotection in Parkinson??s disease: overcoming angst and futility?. Current Opinion in Neurology 20:4, pages 477-483.
Crossref
Ismail Ijjaali, François Petitet, Elodie Dubus, Olivier Barberan & André Michel. (2007) Assessing potency of c-Jun N-terminal kinase 3 (JNK3) inhibitors using 2D molecular descriptors and binary QSAR methodology. Bioorganic & Medicinal Chemistry 15:12, pages 4256-4264.
Crossref
P.J. Brooks. (2007) The case for 8,5?-cyclopurine-2?-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum. Neuroscience 145:4, pages 1407-1417.
Crossref
Jie Zhao, Dong-Sheng Pei, Quan-Guang Zhang & Guang-Yi Zhang. (2007) Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Cellular Signalling 19:4, pages 831-843.
Crossref
Quan-Guang Zhang, Dong-Na Wu, Dong Han & Guang-Yi Zhang. (2007) Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury. FEBS Letters 581:3, pages 495-505.
Crossref
Q.-G. Zhang, D. Han, J. Xu, Q. Lv, R. Wang, X.-H. Yin, T.-L. Xu & G.-Y. Zhang. (2006) Ischemic preconditioning negatively regulates plenty of SH3s–mixed lineage kinase 3–Rac1 complex and c-Jun N-terminal kinase 3 signaling via activation of Akt. Neuroscience 143:2, pages 431-444.
Crossref
Quan-Guang Zhang, Xiao-Tian Wang, Dong Han, Xiao-Hui Yin, Guang-Yi Zhang & Tian-Le Xu. (2006) Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury. Journal of Neurochemistry 98:6, pages 1886-1898.
Crossref
Quan-Guang Zhang, Yong-Ling Xu, Hong-Chun Li, Dong Han & Guang-Yi Zhang. (2006) NMDA receptor/L-VGCC-dependent expression and AMPA/KA receptor-dependent activation of c-Jun induced by cerebral ischemia in rat hippocampus. Neuroscience Letters 398:3, pages 268-273.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.