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Expert Opinion on Investigational Drugs Volume 14, 2005 - Issue 11
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Drug Evaluation

MC-1 (pyridoxal 5′-phosphate): novel therapeutic applications to reduce ischaemic injury

David E Kandzari Duke Clinical Research Institute, Room 7063, Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA. [email protected]
,
Jean-Pierre Dery Duke Clinical Research Institute, Room 7063, Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA. [email protected]
,
Paul W Armstrong Department of Medicine, Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
,
Deborah A Douglas Medicure, Inc., Winnipeg, Manitoba, Canada
,
Marjorie E Zettler Medicure, Inc., Winnipeg, Manitoba, Canada
,
G Karl-Gunnar Hidinger Medicure, Inc., Winnipeg, Manitoba, Canada
,
Albert D Friesen Medicure, Inc., Winnipeg, Manitoba, Canada
&
Robert A Harrington Duke Clinical Research Institute, Room 7063, Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA. [email protected]
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Pages 1435-1442 | Published online: 28 Oct 2005

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Stefan M Gehrig & Gordon S Lynch. (2011) Emerging drugs for treating skeletal muscle injury and promoting muscle repair. Expert Opinion on Emerging Drugs 16:1, pages 163-182.
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Shubham J. Khairnar, Eknath D. Ahire, Madhuri D. Deshmukh, Raj K. Keservani, Sanjay J. Kshirsagar, Amit Kumar Rajora & Manju Amit Kumar Rajora. 2023. Vitamins as Nutraceuticals. Vitamins as Nutraceuticals 61 85 .
Meirong Shan, Xujie Yu, Yajie Li, Changning Fu & Cheng Zhang. (2021) Vitamin B6 Alleviates Lipopolysaccharide-induced Myocardial Injury by Ferroptosis and Apoptosis Regulation. Frontiers in Pharmacology 12.
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Anureet K. Shah & Naranjan S. Dhalla. (2021) Effectiveness of Some Vitamins in the Prevention of Cardiovascular Disease: A Narrative Review. Frontiers in Physiology 12.
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Dorien Deluyker, Vesselina Ferferieva, Ronald B. Driesen, Maxim Verboven, Ivo Lambrichts & Virginie Bito. (2017) Pyridoxamine improves survival and limits cardiac dysfunction after MI. Scientific Reports 7:1.
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Fatemeh Sharifpanah & Heinrich Sauer. 2016. Oxidative Stress and Antioxidant Protection. Oxidative Stress and Antioxidant Protection 281 306 .
Soonmi Won, Iqbal Sayeed, Bethany L. Peterson, Bushra Wali, Jared S. Kahn & Donald G. Stein. (2015) Vitamin D Prevents Hypoxia/Reoxygenation-Induced Blood-Brain Barrier Disruption via Vitamin D Receptor-Mediated NF-kB Signaling Pathways. PLOS ONE 10:3, pages e0122821.
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Naranjan S. Dhalla, Satoshi Takeda & Vijayan Elimban. (2013) Mechanisms of the beneficial effects of vitamin B6 and pyridoxal 5-phosphate on cardiac performance in ischemic heart disease. Clinical Chemistry and Laboratory Medicine 51:3.
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Bhuwan B. Mishra & Vinod K. Tiwari. (2011) Natural products: An evolving role in future drug discovery. European Journal of Medicinal Chemistry 46:10, pages 4769-4807.
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Aslan T. Turer & Joseph A. Hill. (2010) Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy. The American Journal of Cardiology 106:3, pages 360-368.
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Hervé Millart, Loubna Alouane, Floriane Oszust, Stephane Chevallier & Arnaud Robinet. (2009) Involvement of P2Y receptors in pyridoxal-5′-phosphate-induced cardiac preconditioning. Fundamental & Clinical Pharmacology 23:3, pages 279-292.
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Naranjan S DhallaHarjot K Saini-ChohanTodd A Duhamel. (2008) Strategies for the regulation of intracellular calcium in ischemic heart disease. Future Cardiology 4:4, pages 339-345.
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In Koo Hwang, Ki-Yeon Yoo, Dae Won Kim, Oh-Shin Kwon, Soon Sung Lim, Il-Jun Kang, Soo Young Choi & Moo-Ho Won. (2008) Differential Changes in Pyridoxine 5′-Phosphate Oxidase Immunoreactivity and Protein Levels in the Somatosensory Cortex and Striatum of the Ischemic Gerbil Brain. Neurochemical Research 33:7, pages 1356-1364.
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Rajendra H. Mehta, John H. Alexander, Robert Emery, Stephen J. Ellis, Vic Hasselblad, Ahmad Khalil, Michel Carrier, Robert A. Harrington & Jean-Claude Tardif. (2008) A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery Trial (MEND-CABG) II?study design and rationale. American Heart Journal 155:4, pages 600-608.
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Mark S. Butler. (2008) Natural products to drugs: natural product-derived compounds in clinical trials. Natural Product Reports 25:3, pages 475.
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In Koo Hwang, Ki-Yeon Yoo, Do Hoon Kim, Bong-Hee Lee, Young-Guen Kwon & Moo Ho Won. (2007) Time course of changes in pyridoxal 5?-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage. Experimental Neurology 206:1, pages 114-125.
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Jean-Claude Tardif, Michel Carrier, David E. Kandzari, Robert Emery, Robert Cote, Therese Heinonen, Marjorie Zettler, Vic Hasselblad, Marie-Claude Guertin & Robert A. Harrington. (2007) Effects of pyridoxal-5?-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: Results of the MEND-CABG randomized study. The Journal of Thoracic and Cardiovascular Surgery 133:6, pages 1604-1611.e1.
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C.A. Briggs & M. Gopalakrishnan. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 877 918 .
Deepak L. Bhatt. (2006) Shifting the Diagnosis of Periprocedural Myocardial Infarction Upstream. Circulation 114:18, pages 1898-1900.
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L.J. Hoffer. (2006) Testing the homocysteine hypothesis in end-stage renal disease: Problems and a possible solution. Kidney International 69:9, pages 1507-1510.
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