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Review

Agents and strategies in development for improved management of herpes simplex virus infection and disease

Pages 135-161 | Published online: 22 Apr 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Sandra K Weller & Robert D Kuchta. (2013) The DNA helicase–primase complex as a target for herpes viral infection. Expert Opinion on Therapeutic Targets 17:10, pages 1119-1132.
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Suzanne Luck, Mike Sharland, Paul Griffiths & Sian M Jenkins. (2006) Advances in the antiviral therapy of herpes virus infection in children. Expert Review of Anti-infective Therapy 4:6, pages 1005-1020.
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Sreeman K Mamidyala & Steven M Firestine. (2006) Advances in herpes simplex virus antiviral therapies. Expert Opinion on Therapeutic Patents 16:11, pages 1463-1480.
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David I. Bernstein, Nancy M. Sawtell, Fernando J. Bravo, David A. Dixon, Christian Gege & Gerald Kleymann. (2023) Intermittent therapy with helicase-primase inhibitor IM-250 efficiently controls recurrent herpes disease and reduces reactivation of latent HSV. Antiviral Research 219, pages 105733.
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Xuanhe Pan, Yapeng Zhang, Yiming Zhao, Siqi Yao, Chaxiang Guan, Linqian Wang & Liyu Chen. (2022) Inhibitory activity and mechanism of silver nanoparticles against herpes simplex virus type 1. Archives of Virology 167:8, pages 1619-1636.
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Chandi Charan Kandar. 2022. Anti-Viral Metabolites from Medicinal Plants. Anti-Viral Metabolites from Medicinal Plants 1 40 .
Qunshuo Zhang, Yang Li, Xuanlei Zhong, Wenwei Fu, Xiaomei Luo, Jiling Feng, Man Yuan, Lianbo Xiao & Hongxi Xu. (2021) Polyphenolic-protein-polysaccharide conjugates from Spica of Prunella vulgaris: Chemical profile and anti-herpes simplex virus activities. International Journal of Biological Macromolecules.
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Nadja Uhlig, Anne-Kathrin Donner, Christian Gege, Franziska Lange, Gerald Kleymann & Thomas Grunwald. (2021) Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model. Antiviral Research 195, pages 105190.
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Subrata Jana, Shuvam Mukherjee, Elisa Vicente Ribelato, Maria Laura Darido, Ligia Carla Faccin-Galhardi, Bimalendu Ray & Sayani Ray. (2021) The heparin-mimicking arabinogalactan sulfates from Anogeissus latifolia gum: Production, structures, and anti-herpes simplex virus activity. International Journal of Biological Macromolecules 183, pages 1419-1426.
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Shuvam Mukherjee, Carlos A. Pujol, Subrata Jana, Elsa B. Damonte, Bimalendu Ray & Sayani Ray. (2021) Chemically sulfated arabinoxylans from Plantago ovata seed husk: Synthesis, characterization and antiviral activity. Carbohydrate Polymers 256, pages 117555.
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Woo Jung Kim, Ji Won Choi, Won Jong Jang, Young-Sun Kang, Chang Won Lee, Andriy Synytsya & Yong Il Park. (2017) Low-molecular weight mannogalactofucans prevent herpes simplex virus type 1 infection via activation of Toll-like receptor 2. International Journal of Biological Macromolecules 103, pages 286-293.
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Romain Boulho, Christel Marty, Yolanda Freile-Pelegrín, Daniel Robledo, Nathalie Bourgougnon & Gilles Bedoux. (2017) Antiherpetic (HSV-1) activity of carrageenans from the red seaweed Solieria chordalis (Rhodophyta, Gigartinales) extracted by microwave-assisted extraction (MAE). Journal of Applied Phycology 29:5, pages 2219-2228.
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Aurélia Galus, Jean-Maurice Mallet, David Lembo, Valeria Cagno, Madeleine Djabourov, Hugues Lortat-Jacob & Kawthar Bouchemal. (2016) Hexagonal-shaped chondroitin sulfate self-assemblies have exalted anti-HSV-2 activity. Carbohydrate Polymers 136, pages 113-120.
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L. M. Alimbarova, A. V. Kharlamov, N. A. Bondarenko & I. F. Barinskii. (2015) Composition on the basis of phosphonoacetic acid. Synthesis and antiviral activity. Russian Journal of General Chemistry 85:10, pages 2441-2448.
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Sherif T S Hassan, Radka Masarčíková & Kateřina Berchová. (2015) Bioactive natural products with anti-herpes simplex virus properties. Journal of Pharmacy and Pharmacology 67:10, pages 1325-1336.
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Shinji Nakama, Kazumi Tamaki, Chie Ishikawa, Masayuki Tadano & Naoki Mori. (2012) Efficacy of Bidens pilosa Extract against Herpes Simplex Virus Infection In Vitro and In Vivo . Evidence-Based Complementary and Alternative Medicine 2012, pages 1-10.
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Paula Faral-Tello, Santiago Mirazo, Carmelo Dutra, Andr?s P?rez, Luc?a Geis-Asteggiante, Sandra Frabasile, Elina Koncke, Danilo Davyt, Luc?a Cavallaro, Horacio Heinzen & Juan Arbiza. (2012) Cytotoxic, Virucidal, and Antiviral Activity of South American Plant and Algae Extracts. The Scientific World Journal 2012, pages 1-5.
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Sudipta Saha, Mojdeh Heidary Navid, Shruti S. Bandyopadhyay, Paul Schnitzler & Bimalendu Ray. (2012) Sulfated polysaccharides from Laminaria angustata: Structural features and in vitro antiviral activities. Carbohydrate Polymers 87:1, pages 123-130.
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Nathan B Price & Mark N Prichard. (2011) Progress in the development of new therapies for herpesvirus infections. Current Opinion in Virology 1:6, pages 548-554.
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Hai-Rong Xiong, Jun Luo, Wei Hou, Hong Xiao & Zhan-Qiu Yang. (2011) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo. Journal of Ethnopharmacology 133:2, pages 718-723.
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Xiao-xiao Liu, Zhen-jiang Wan, Lin Shi & Xiao-xia Lu. (2011) Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua. Carbohydrate Polymers 83:2, pages 737-742.
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Soumi Sukla, Subhajit Biswas, Alexander Birkmann, Peter Lischka, Helga Ruebsamen-Schaeff, Holger Zimmermann & Hugh J. Field. (2010) Effects of therapy using a helicase–primase inhibitor (HPI) in mice infected with deliberate mixtures of wild-type HSV-1 and an HPI-resistant UL5 mutant. Antiviral Research 87:1, pages 67-73.
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Paramita Karmakar, Carlos Alberto Pujol, Elsa Beatriz Damonte, Tuhin Ghosh & Bimalendu Ray. (2010) Polysaccharides from Padina tetrastromatica: Structural features, chemical modification and antiviral activity. Carbohydrate Polymers 80:2, pages 513-520.
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S. M. Breathnach. 2010. Rook's Textbook of Dermatology. Rook's Textbook of Dermatology 1 177 .
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Sharmistha Sinha, Akram Astani, Tuhin Ghosh, Paul Schnitzler & Bimalendu Ray. (2010) Polysaccharides from Sargassum tenerrimum: Structural features, chemical modification and anti-viral activity. Phytochemistry 71:2-3, pages 235-242.
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Graciela Andrei, Erik De Clercq & Robert Snoeck. 2009. Viral Genome Replication. Viral Genome Replication 481 526 .
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Pinaki Mandal, Carlos A. Pujol, María J. Carlucci, Kausik Chattopadhyay, Elsa B. Damonte & Bimalendu Ray. (2008) Anti-herpetic activity of a sulfated xylomannan from Scinaia hatei. Phytochemistry 69:11, pages 2193-2199.
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Subhajit Biswas, Gerald Kleymann, Mihaiela Swift, Laurence S. Tiley, Jonathan Lyall, Jesús Aguirre-Hernández & Hugh J. Field. (2008) A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase–primase inhibitors in their mode of interaction with the antiviral target. Journal of Antimicrobial Chemotherapy 61:5, pages 1044-1047.
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Subhajit Biswas & Hugh J Field. (2008) Herpes Simplex Virus Helicase—Primase Inhibitors: Recent Findings from the Study of Drug Resistance Mutations. Antiviral Chemistry and Chemotherapy 19:1, pages 1-6.
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Judith Baumeister, Ruediger Fischer, Peter Eckenberg, Kerstin Henninger, Helga Ruebsamen-Waigmann & Gerald Kleymann. (2016) Superior Efficacy of Helicase-Primase Inhibitor BAY 57–1293 for Herpes Infection and Latency in the Guinea Pig Model of Human Genital Herpes Disease. Antiviral Chemistry and Chemotherapy 18:1, pages 35-48.
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Julliane Diniz Yoneda, Magaly Girão Albuquerque, Kátia Zaccur Leal, Peter R. Seidl, Ralph A. Wheeler, Scott E. Boesch, Ricardo Bicca de Alencastro, Maria Cecília B.V. de Souza & Vitor F. Ferreira. (2006) Molecular dynamics simulations of a nucleoside analogue of 1,4-dihydro-4-oxoquinoline-3-carboxylic acid synthesized as a potential antiviral agent: Conformational studies in vacuum and in water. Journal of Molecular Structure: THEOCHEM 778:1-3, pages 97-103.
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Catalena Birek & Giuseppe Ficarra. (2006) The diagnosis and management of oral herpes simplex infection. Current Infectious Disease Reports 8:3, pages 181-188.
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