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Berberine – a novel approach to cholesterol lowering

KONG W, WEI J, ABIDI P et al.: Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med. (2005) 12:1344-1351.

Pages 683-685 | Published online: 31 May 2005

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Limiao Shi, Jianhao Hu, Kailong Zhu, Yongping Fu, Ruiming Xia & Xuejian Hu. (2014) Changes of prevalence of dyslipidemia among adults: a cross‑sectional study with a 2‑year follow‑up in urban southeast China. Clinical Lipidology 9:1, pages 33-47.
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Cong Li, Shuang Jiang, Hengfei Wang, Yuhong Wang, Yanxing Han & Jiandong Jiang. (2022) Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway. Biomedicine & Pharmacotherapy 151, pages 113097.
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Thirunavukkarasu Palaniyandi, Asha Sivaji, Rajeswari Hari, Sudhakar Natrajan, Yuvaraj Srinivasan, Sandhiya Vishwanathan, Mohan Ranganathan, Priya Durairaj & Rohith Kumar Reddy. (2021) Isolation and Characterization of Berberine from Ceriops decandra Mangrove Plant Species. Pharmaceutical Chemistry Journal 55:7, pages 691-697.
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Rasool Soltani, Syed Mustafa Ghanadian, Bijan Iraj, Alireza Homayouni, Tanin Shahmiveh Esfahani & Mojtaba Akbari. (2021) The Effects of Berberis integerrima Fruit Extract on Glycemic Control Parameters in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-7.
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Roberta D’Assante, Mariarosaria De Luca, Sergio Ferraro, Andrea Ferraro, Antonio Ruvolo, Francesco Natale, Pietro Sotgiu, Maurizio Petitto, Romolo Rizzo, Umberto De Maria, Luigi Liguori, Gianluigi Gentile, Paola Ragucci, Vittorio Donadio, Valeria Valente & Antonio Cittadini. (2021) Beneficial Metabolic Effect of a Nutraceuticals Combination (Monacolin K, Yeasted Red Rice, Polyphenolic Extract of Annurca Apple and Berberine) on Acquired Hypercholesterolemia: A Prospective Analysis. Metabolites 11:4, pages 223.
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Lyudmila O. Kostjukova & Victor V. Kostjukov. (2020) The electronic states and vibronic absorption spectrum of berberine in aqueous solution. International Journal of Quantum Chemistry 121:6.
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Atena Mahdavi, Mohammad Bagherniya, Omid Fakheran, Željko Reiner, Suowen Xu & Amirhossein Sahebkar. (2020) Medicinal plants and bioactive natural compounds as inhibitors of HMG‐CoA reductase: A literature review . BioFactors 46:6, pages 906-926.
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Tayyebeh Kermani, Toba Kazemi, Somayye Molki, Khadije Ilkhani & Gholam Reza Sharifzadeh. (2020) The Effect of Berberis vulgaris (Barberry Fruit) on a Component of Metabolic Syndrome: A Randomized Clinical Trial. Modern Care Journal 17:2.
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Sant Kumar Verma & Suresh Thareja. 2020. Bioactive Natural Products. Bioactive Natural Products 381 429 .
Bikarma Singh & Anil Kumar Katare. 2020. Botanical Leads for Drug Discovery. Botanical Leads for Drug Discovery 421 462 .
Alireza Fatahian, Saeed Mohammadian Haftcheshmeh, Sara Azhdari, Helaleh Kaboli Farshchi, Banafsheh Nikfar & Amir Abbas Momtazi-Borojeni. 2020. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 83 110 .
Sarfraz Ahmad, Amina Hussain, Aroosha Hussain, Iskandar Abdullah, Muhammad Sajjad Ali, Matheus Froeyen & Muhammad Usman Mirza. (2019) Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity. Antioxidants 8:6, pages 185.
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Peng Xu, Chen Xu, Xiaoxia Li, Dan Li, Yan Li, Jiebing Jiang, Ping Yang & Gengli Duan. (2019) Rapid Identification of Berberine Metabolites in Rat Plasma by UHPLC-Q-TOF-MS. Molecules 24:10, pages 1994.
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Shijie Cao, Peixiang Xu, Jiankun Yan, Hui Liu, Lu Liu, Lina Cheng, Feng Qiu & Ning Kang. (2018) Berberrubine and its analog, hydroxypropyl‐berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol‐lowering effects in human hepatoma HepG2 cells. Journal of Cellular Biochemistry 120:2, pages 1340-1349.
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Giuseppe Marazzi, Giuseppe Campolongo, Francesco Pelliccia, Paolo Calabrò, MD, Luca Cacciotti, Cristiana Vitale, Rosalba Massaro, Maurizio Volterrani & Giuseppe Rosano. (2019) Usefulness of Low-Dose Statin Plus Ezetimibe and/or Nutraceuticals in Patients With Coronary Artery Disease Intolerant to High-Dose Statin Treatment. The American Journal of Cardiology 123:2, pages 233-238.
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Josélia A. Lima & Lidilhone Hamerski. 2019. 301 334 .
Ying Liao, Kaihong Chen, Xingmo Dong, Weiguo Li, Ganyang Li, Guoyong Huang, Wei Song, Liling Chen & Yong Fang. (2018) Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats. Experimental and Therapeutic Medicine.
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Johnna Francis Varghese, Rohit Patel, Mohit Singh & Umesh C. S. Yadav. 2018. Functional Food and Human Health. Functional Food and Human Health 277 296 .
Suriya P. Singh & Koneni V. Sashidhara. (2017) Lipid lowering agents of natural origin: An account of some promising chemotypes. European Journal of Medicinal Chemistry 140, pages 331-348.
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Han-bin Chen, Chao-dan Luo, Jia-li Liang, Zhen-biao Zhang, Guo-sheng Lin, Jia-zhen Wu, Cai-lan Li, Li-hua Tan, Xiao-bo Yang, Zi-ren Su, Jian-hui Xie & Hui-fang Zeng. (2017) Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways. European Journal of Pharmacology 811, pages 222-231.
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T.P. Johnston, T.A. Korolenko, M. Pirro & A. Sahebkar. (2017) Preventing cardiovascular heart disease: Promising nutraceutical and non-nutraceutical treatments for cholesterol management. Pharmacological Research 120, pages 219-225.
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Muhammad Abdul Aziz, Amir Hasan Khan, Muhammad Adnan & Izatullah Izatullah. (2017) Traditional uses of medicinal plants reported by the indigenous communities and local herbal practitioners of Bajaur Agency, Federally Administrated Tribal Areas, Pakistan. Journal of Ethnopharmacology 198, pages 268-281.
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Vivencio Barrios, Carlos Escobar, Arrigo Francesco Giuseppe Cicero, David Burke, Peter Fasching, Maciej Banach & Eric Bruckert. (2017) A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: Review of the clinical evidence. Atherosclerosis Supplements 24, pages 1-15.
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Ming Zhang, Linjing Feng, Junnan Li & Li Chen. (2016) Therapeutic Potential and Mechanisms of Berberine in Cardiovascular Disease. Current Pharmacology Reports 2:6, pages 281-292.
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Mokhles M. Abd-Elzaher, Ammar A. Labib, Hanan A. Mousa, Samia A. Moustafa, Mamdouh M. Ali & Ahmed A. El-Rashedy. (2016) Synthesis, anticancer activity and molecular docking study of Schiff base complexes containing thiazole moiety. Beni-Suef University Journal of Basic and Applied Sciences 5:1, pages 85-96.
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Fereshteh Rafiee, Vahid Nejati, Reza Heidari & Hossein Ashraf. (2016) Protective effect of methanolic extract of Berberis integerrima Bunge. root on carbon tetrachloride-induced testicular injury in Wistar rats. International Journal of Reproductive BioMedicine 14:2, pages 133-140.
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Jae Sue Choi, Ji-Hye Kim, Md. Yousof Ali, Hee Jin Jung, Byung-Sun Min, Ran Joo Choi, Gun-Do Kim & Hyun Ah Jung. (2015) Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Archives of Pharmacal Research 38:12, pages 2153-2162.
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Jae Sue Choi, Md. Yousof Ali, Hyun Ah Jung, Sang Ho Oh, Ran Joo Choi & Eon Ji Kim. (2015) Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies. Journal of Ethnopharmacology 171, pages 28-36.
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WEI LU, SHANSHAN DU & JIAQIANG WANG. (2015) Berberine inhibits the proliferation of prostate cancer cells and induces G0/G1 or G2/M phase arrest at different concentrations. Molecular Medicine Reports 11:5, pages 3920-3924.
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Jae Sue Choi, Ji-Hye Kim, Md. Yousof Ali, Byung-Sun Min, Gun-Do Kim & Hyun Ah Jung. (2014) Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ. Fitoterapia 98, pages 199-208.
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Marzie Zilaee, Tayyebeh Kermany, Shima Tavalaee, Maryam Salehi, Majid Ghayour-Mobarhan & Gordon A. A. Ferns. (2014) Barberry Treatment Reduces Serum Anti-Heat Shock Protein 27 and 60 Antibody Titres and High-sensitivity C-reactive Protein in Patients with Metabolic Syndrome: A Double-blind, Randomized Placebo-controlled Trial. Phytotherapy Research 28:8, pages 1211-1215.
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Zhenhai Zhang, Yan Chen, Jin Deng, Xiaobin Jia, Jianping Zhou & Huixia Lv. (2014) Solid dispersion of berberine–phospholipid complex/TPGS 1000/SiO2: preparation, characterization and in vivo studies. International Journal of Pharmaceutics 465:1-2, pages 306-316.
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Shijie Cao, Yan Zhou, Peixiang Xu, Ying Wang, Jiankun Yan, Wen Bin, Feng Qiu & Ning Kang. (2013) Berberine metabolites exhibit triglyceride-lowering effects via activation of AMP-activated protein kinase in Hep G2 cells. Journal of Ethnopharmacology 149:2, pages 576-582.
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Eva M. Galvez, M. Perez, P. Domingo, D. Nuñez, V. L. Cebolla, M. Matt & J. Pardo. 2013. Natural Products. Natural Products 1301 1329 .
Kotamballi N. Chidambara Murthy, Guddadarangavvanahally K. Jayaprakasha & Bhimanagouda S. Patil. (2012) The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. European Journal of Pharmacology 688:1-3, pages 14-21.
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Shu Meng, Lian-Sheng Wang, Zhou-Qing Huang, Qing Zhou, Ying-Gang Sun, Jia-Tian Cao, Yi-Gang Li & Chang-Qian Wang. (2012) Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. Clinical and Experimental Pharmacology and Physiology 39:5, pages 406-411.
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Zhouqing Huang, Shu Meng, Liansheng Wang, Yue Wang, Ting Chen & Changqian Wang. (2012) Suppression of oxLDL-Induced MMP-9 and EMMPRIN Expression by Berberine via Inhibition of NF-κB Activation in Human THP-1 Macrophages. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 295:1, pages 78-86.
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Qian Zhang, Xinhua Xiao, Kai Feng, Tong Wang, Wenhui Li, Tao Yuan, Xiaofang Sun, Qi Sun, Hongding Xiang & Heng Wang. (2011) Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism. Evidence-Based Complementary and Alternative Medicine 2011, pages 1-10.
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Zhouqing Huang, Liansheng Wang, Shu Meng, Yue Wang, Ting Chen & Changqian Wang. (2011) Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages. International Journal of Cardiology 146:2, pages 153-158.
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Faqing Tang, Wenhua Mei, Daofa Tian & Damao Huang. 2011. Evidence-based Anticancer Materia Medica. Evidence-based Anticancer Materia Medica 111 130 .
Sunil Kumar Battu, Michael A. Repka, Sindhuri Maddineni, Amar G. Chittiboyina, Mitchell A. Avery & Soumyajit Majumdar. (2010) Physicochemical Characterization of Berberine Chloride: A Perspective in the Development of a Solution Dosage Form for Oral Delivery. AAPS PharmSciTech 11:3, pages 1466-1475.
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S. K. Kulkarni & Ashish Dhir. (2009) Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytotherapy Research 24:3, pages 317-324.
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Li-Shuang Yu, Xue-Qin Xu, Lu Huang, Jin-Ming Lin & Guo-Nan Chen. (2009) Separation and detection of isoquinoline alkaloids using MEEKC coupled with field-amplified sample injection induced by ACN. ELECTROPHORESIS 30:4, pages 661-667.
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Hyun Ah Jung, Byung-Sun Min, Takako Yokozawa, Je-Hyun Lee, Yeong Shik Kim & Jae Sue Choi. (2009) Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids. Biological and Pharmaceutical Bulletin 32:8, pages 1433-1438.
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Feng Qiu, Zhiyong Zhu, Ning Kang, Shujuan Piao, Gengyao Qin & Xinsheng Yao. (2008) Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans. Drug Metabolism and Disposition 36:11, pages 2159-2165.
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Hyun Ah Jung, Na Young Yoon, Hyun Ju Bae, Byung-Sun Min & Jae Sue Choi. (2008) Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Archives of Pharmacal Research 31:11, pages 1405-1412.
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Arrigo F. G. Cicero & Sibel Ertek. (2008) Natural sources of antidyslipidaemic agents: is there an evidence-based approach for their prescription?. Mediterranean Journal of Nutrition and Metabolism 1:2, pages 85-93.
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Weihua Liu, Peiqinq Liu, Sha Tao, Yanhui Deng, Xuejuan Li, Tian Lan, Xiaoyan Zhang, Fenfen Guo, Wenge Huang, Fengying Chen, Heqing Huang & Shu-Feng Zhou. (2008) Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose. Archives of Biochemistry and Biophysics 475:2, pages 128-134.
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Jun Yin, Huili Xing & Jianping Ye. (2008) Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 57:5, pages 712-717.
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Yih-Shou HsiehWu-Hsien KuoTa-Wei LinHorng-Rong ChangTeseng-His LinPei-Ni ChenShu-Chen Chu. (2007) Protective Effects of Berberine against Low-Density Lipoprotein (LDL) Oxidation and Oxidized LDL-Induced Cytotoxicity on Endothelial Cells. Journal of Agricultural and Food Chemistry 55:25, pages 10437-10445.
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Amira N. Kassis, Christopher P.F. Marinangeli, Deepak Jain, Naoyuki Ebine & Peter J.H. Jones. (2007) Lack of effect of sugar cane policosanol on plasma cholesterol in golden syrian hamsters. Atherosclerosis 194:1, pages 153-158.
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Shrinivas K. Kulkarni & Ashish Dhir. (2007) Possible involvement of l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. European Journal of Pharmacology 569:1-2, pages 77-83.
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Marc Issandou. (2006) Pharmacological regulation of low density lipoprotein receptor expression: Current status and future developments. Pharmacology & Therapeutics 111:2, pages 424-433.
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