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Therapeutic potential of peptide deformylase inhibitors

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Pages 1107-1116 | Published online: 22 Aug 2005

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Yun-Ju KWON, Chang-Ji ZHENG & Won-Gon KIM. (2010) Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, from Aspergillus flavipes as an Inhibitor of Peptide Deformylase. Bioscience, Biotechnology, and Biochemistry 74:2, pages 390-393.
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Anshika Sharma, Gopal K Khuller & Sadhna Sharma. (2009) Peptide deformylase – a promising therapeutic target for tuberculosis and antibacterial drug discovery. Expert Opinion on Therapeutic Targets 13:7, pages 753-765.
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Garyphallia Poulakou & Helen Giamarellou. (2007) Investigational treatments for postoperative surgical site infections. Expert Opinion on Investigational Drugs 16:2, pages 137-155.
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Articles from other publishers (34)

Kajal Chakraborty, Vinaya Kizhakkepatt Kizhakkekalam & Minju Joy. (2022) Polyketide-derived macrobrevins from marine macroalga-associated Bacillus amyloliquefaciens as promising antibacterial agents against pathogens causing nosocomial infections. Phytochemistry 193, pages 112983.
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Kajal Chakraborty, Vinaya Kizhakkepatt Kizhakkekalam, Minju Joy & Shubhajit Dhara. (2021) Difficidin class of polyketide antibiotics from marine macroalga-associated Bacillus as promising antibacterial agents. Applied Microbiology and Biotechnology 105:16-17, pages 6395-6408.
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John BremnerJohn Bremner. 2021. Multiple Action-Based Design Approaches to Antibacterials. Multiple Action-Based Design Approaches to Antibacterials 121 158 .
Kajal Chakraborty, Vinaya Kizhakkepatt Kizhakkekalam, Minju Joy & Rekha Devi Chakraborty. (2020) Moving away from traditional antibiotic treatment: can macrocyclic lactones from marine macroalga-associated heterotroph be the alternatives?. Applied Microbiology and Biotechnology 104:16, pages 7117-7130.
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Vinaya Kizhakkepatt Kizhakkekalam, Kajal Chakraborty & Minju Joy. (2020) Oxygenated elansolid-type of polyketide spanned macrolides from a marine heterotrophic Bacillus as prospective antimicrobial agents against multidrug-resistant pathogens. International Journal of Antimicrobial Agents 55:3, pages 105892.
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Raivis Žalubovskis & Jean-Yves Winum. (2019) Inhibitors of Selected Bacterial Metalloenzymes. Current Medicinal Chemistry 26:15, pages 2690-2714.
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Madhu Yadav, Ritika Srivastava, Farha Naaz & Ramendra K. Singh. (2018) Synthesis, docking, ADMET prediction, cytotoxicity and antimicrobial activity of oxathiadiazole derivatives. Computational Biology and Chemistry 77, pages 226-239.
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Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 435 480 .
Fengping Lv, Chen Chen, Yang Tang, Jianhai Wei, Tong Zhu & Wenhao Hu. (2016) New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment. Bioorganic & Medicinal Chemistry Letters 26:15, pages 3714-3718.
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Xiaofeng Bao, Bryce E. Nickels & Huizhou Fan. (2012) Chlamydia trachomatis protein GrgA activates transcription by contacting the nonconserved region of σ 66 . Proceedings of the National Academy of Sciences 109:42, pages 16870-16875.
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Yun-Ju Kwon, Mi-Jin Sohn, Chang-Jin Kim, Hiroyuki Koshino & Won-Gon Kim. (2012) Flavimycins A and B, Dimeric 1,3-Dihydroisobenzofurans with Peptide Deformylase Inhibitory Activity from Aspergillus flavipes . Journal of Natural Products 75:2, pages 271-274.
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P Rolan, H Sun, C MacLeod, K Bracken & T G Evans. (2011) Pharmacokinetics and Unexpected Safety Issues of LBM415, a Novel Oral Peptide Deformylase Inhibitor. Clinical Pharmacology & Therapeutics 90:2, pages 256-262.
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Christopher B Oey. (2011) High tolerance to mutations in a Chlamydia trachomatis peptide deformylase loop. World Journal of Biological Chemistry 2:5, pages 90.
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Patrick J. Gross & Stefan Bräse. (2010) The Total Synthesis of (±)‐Fumimycin. Chemistry – A European Journal 16:42, pages 12660-12667.
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Seung Kyu Lee, Kwang Hyun Choi, Sang Jae Lee, Se Won Suh, B. Moon Kim & Bong Jin Lee. (2010) Peptide deformylase inhibitors with retro-amide scaffold: Synthesis and structure–activity relationships. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4317-4319.
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Anshika Sharma, G.K. Khuller, A.J. Kanwar & Sadhna Sharma. (2010) Therapeutic potential of peptide deformylase inhibitors against experimental tuberculosis. Journal of Infection 60:6, pages 498-501.
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Patrick J. Gross, Caroline E. Hartmann, Martin Nieger & Stefan Bräse. (2009) Synthesis of Methoxyfumimycin with 1,2-Addition to Ketimines. The Journal of Organic Chemistry 75:1, pages 229-232.
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Shannon B Falconer & Eric D Brown. (2009) New screens and targets in antibacterial drug discovery. Current Opinion in Microbiology 12:5, pages 497-504.
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Anshika Sharma, Sadhna Sharma, G.K. Khuller & A.J. Kanwar. (2009) In vitro and ex vivo activity of peptide deformylase inhibitors against Mycobacterium tuberculosis H37Rv. International Journal of Antimicrobial Agents 34:3, pages 226-230.
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Knut Ohlsen, Martin Eckart, Ulrich Dobrindt, Heike Bruhn & Jörg Hacker. 2009. Antiparasitic and Antibacterial Drug Discovery. Antiparasitic and Antibacterial Drug Discovery 373 413 .
Alexander K. Berg & D. K. Srivastava. (2009) Delineation of Alternative Conformational States in Escherichia coli Peptide Deformylase via Thermodynamic Studies for the Binding of Actinonin . Biochemistry 48:7, pages 1584-1594.
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Caroline E. Hartmann, Patrick J. Gross, Martin Nieger & Stefan Bräse. (2009) Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin. Organic & Biomolecular Chemistry 7:24, pages 5059.
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Amit Balakrishnan, Lingling Wang, Xiaojin Li, Pamela Ohman-Strickland, Paul Malatesta & Huizhou Fan. (2009) Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitor. Microbiological Research 164:3, pages 338-346.
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Arkadius Pichota, Jeyaraj Duraiswamy, Zheng Yin, Thomas H. Keller, Jenefer Alam, Sarah Liung, Gladys Lee, Mei Ding, Gang Wang, Wai Ling Chan, Mark Schreiber, Ida Ma, David Beer, Xinyi Ngew, Kakoli Mukherjee, Mahesh Nanjundappa, Jeanette W.P. Teo, Pamela Thayalan, Amelia Yap, Thomas Dick, Wuyi Meng, Mei Xu, James Koehn, Shi-Hao Pan, Kirk Clark, Xiaoling Xie, Carolyn Shoen & Michael Cynamon. (2008) Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results. Bioorganic & Medicinal Chemistry Letters 18:24, pages 6568-6572.
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Gang Shen, Jinge Zhu, Anthony M. Simpson & Dehua Pei. (2008) Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors. Bioorganic & Medicinal Chemistry Letters 18:10, pages 3060-3063.
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Knut OhlsenUdo Lorenz. (2007) Novel targets for antibiotics in Staphylococcus aureus . Future Microbiology 2:6, pages 655-666.
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Chang-Ji Zheng, Sangku Lee, Choong-Hwan Lee & Won-Gon Kim. (2007) Macrolactins O–R, Glycosylated 24-Membered Lactones from Bacillus sp. AH159-1 . Journal of Natural Products 70:10, pages 1632-1635.
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Yun-Ju Kwon, Mi-Jin Sohn, Chang-Ji Zheng & Won-Gon Kim. (2007) Fumimycin:  A Peptide Deformylase Inhibitor with an Unusual Skeleton Produced by Aspergillus fumisynnematus . Organic Letters 9:13, pages 2449-2451.
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Michael J Pucci. (2007) Novel Genetic Techniques and Approaches in the Microbial Genomics Era. Drugs in R & D 8:4, pages 201-212.
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Jung-Sung Yoo, Chang-Ji Zheng, Sangku Lee, Jin-Hwan Kwak & Won-Gon Kim. (2006) Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis. Bioorganic & Medicinal Chemistry Letters 16:18, pages 4889-4892.
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Franz von Nussbaum, Michael Brands, Berthold Hinzen, Stefan Weigand & Dieter Häbich. (2006) Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?. Angewandte Chemie International Edition 45:31, pages 5072-5129.
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Franz von Nussbaum, Michael Brands, Berthold Hinzen, Stefan Weigand & Dieter Häbich. (2006) Antibakterielle Naturstoffe in der medizinischen Chemie – Exodus oder Renaissance?. Angewandte Chemie 118:31, pages 5194-5254.
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Amit Balakrishnan, Bhairavi Patel, Stephan A. Sieber, Ding Chen, Niseema Pachikara, Guangming Zhong, Benjamin F. Cravatt & Huizhou Fan. (2006) Metalloprotease Inhibitors GM6001 and TAPI-0 Inhibit the Obligate Intracellular Human Pathogen Chlamydia trachomatis by Targeting Peptide Deformylase of the Bacterium. Journal of Biological Chemistry 281:24, pages 16691-16699.
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Zhengyu Yuan & Richard J. White. (2006) The evolution of peptide deformylase as a target: Contribution of biochemistry, genetics and genomics. Biochemical Pharmacology 71:7, pages 1042-1047.
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