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Review

Recent developments in antibacterial drug discovery: microbe-derived natural products – from collection to the clinic

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Pages 211-226 | Published online: 27 Feb 2006

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Navid J. Ayon. (2023) High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery. Metabolites 13:5, pages 625.
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Antonio Hernandez, Linh T. Nguyen, Radhika Dhakal & Brian T. Murphy. (2021) The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia. Natural Product Reports 38:2, pages 292-300.
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Ling Ye, Jiaxing Zhang, Wei Xiao & Shuwen Liu. (2020) Efficacy and mechanism of actions of natural antimicrobial drugs. Pharmacology & Therapeutics 216, pages 107671.
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Pengcheng Zhu, Huimin Bu, Shirui Tan, Jinjuan Liu, Bo Yuan, Guokai Dong, Meng Wang, Yuji Jiang, Hong Zhu, Hui Li, Zhenjun Li, Jihong Jiang, Min Wu & Rongpeng Li. (2020) A Novel Cochlioquinone Derivative, CoB1, Regulates Autophagy in Pseudomonas aeruginosa Infection through the PAK1/Akt1/mTOR Signaling Pathway . The Journal of Immunology 205:5, pages 1293-1305.
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Ramaswamy Rajendran, Mariappan Abirami, Elango Santhini, Selvaraj Dinesh Kirupha & Ketankumar Vadodaria. (2020) Evaluation of the bioactive properties of Alternanthera sessilis extract and development of sodium alginate – Alternanthera sessilis membrane for wound management . Journal of Polymer Engineering 40:6, pages 507-518.
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Jack G. Ganley & Emily R. Derbyshire. (2020) Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire. Molecules 25:3, pages 625.
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Maria S. Costa, Chase M. Clark, Sesselja Ómarsdóttir, Laura M. Sanchez & Brian T. Murphy. (2019) Minimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac. Journal of Natural Products 82:8, pages 2167-2173.
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Mona Dehhaghi, Fatemeh Mohammadipanah & Gilles J. Guillemin. (2018) Myxobacterial natural products: An under-valued source of products for drug discovery for neurological disorders. NeuroToxicology 66, pages 195-203.
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Miaomiao Liu, Tanja Grkovic, Xueting Liu, Jianying Han, Lixin Zhang & Ronald J. Quinn. (2017) A systems approach using OSMAC, Log P and NMR fingerprinting: An approach to novelty. Synthetic and Systems Biotechnology 2:4, pages 276-286.
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Jane Hubert, Jean-Marc Nuzillard & Jean-Hugues Renault. (2015) Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?. Phytochemistry Reviews 16:1, pages 55-95.
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Ana Martins, Helena Vieira, Helena Gaspar & Susana Santos. (2014) Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success. Marine Drugs 12:2, pages 1066-1101.
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Shahul H. Nilar, Ngai Ling Ma & Thomas H. Keller. (2013) The importance of molecular complexity in the design of screening libraries. Journal of Computer-Aided Molecular Design 27:9, pages 783-792.
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Marta Pelay-Gimeno, Judit Tulla-Puche & Fernando Albericio. (2013) “Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin. Marine Drugs 11:5, pages 1693-1717.
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Laura Freire-Moran, Bo Aronsson, Chris Manz, Inge C. Gyssens, Anthony D. So, Dominique L. Monnet & Otto Cars. (2011) Critical shortage of new antibiotics in development against multidrug-resistant bacteria—Time to react is now. Drug Resistance Updates 14:2, pages 118-124.
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Lisa S. McCoy, Yun Xie & Yitzhak Tor. (2011) Antibiotics that target protein synthesis. Wiley Interdisciplinary Reviews: RNA 2:2, pages 209-232.
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Lynn L. Silver. (2011) Challenges of Antibacterial Discovery. Clinical Microbiology Reviews 24:1, pages 71-109.
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Savvas N. Georgiades & Jon Clardy. (2008) Synthetic libraries of tyrosine-derived bacterial metabolites. Bioorganic & Medicinal Chemistry Letters 18:10, pages 3117-3121.
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Mark S. Butler. (2008) Natural products to drugs: natural product-derived compounds in clinical trials. Natural Product Reports 25:3, pages 475.
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Michael J Pucci. (2007) Novel Genetic Techniques and Approaches in the Microbial Genomics Era. Drugs in R & D 8:4, pages 201-212.
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Dwight D. Baker, Min Chu, Uma Oza & Vineet Rajgarhia. (2007) The value of natural products to future pharmaceutical discovery. Natural Product Reports 24:6, pages 1225.
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