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Expert Opinion on Investigational Drugs Volume 16, 2007 - Issue 4
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Drug Evaluation

Current perspectives on FTY720

Sebastian Martini Charité, Universitätsmedizin Berlin, Department of Nephrology, Charitéplatz 1, 10117 Berlin, Germany. [email protected]
,
Harm Peters Charité, Universitätsmedizin Berlin, Department of Nephrology, Charitéplatz 1, 10117 Berlin, Germany. [email protected]
,
Torsten Böhler INSERM U466, Institut Louis Bugnard, CHU Rangueil, Toulouse, France
&
Klemens Budde Charité, Universitätsmedizin Berlin, Department of Nephrology, Charitéplatz 1, 10117 Berlin, Germany. [email protected]
Pages 505-518 | Published online: 20 Mar 2007

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Qingyuan Li & Feng Li. (2010) Effects of different dose of FTY720 on lymphocyte cell cycle arrest in cardiac transplantation model of rats. Immunopharmacology and Immunotoxicology 32:4, pages 680-687.
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Alejandro Horga & Xavier Montalban. (2008) FTY720 (fingolimod) for relapsing multiple sclerosis. Expert Review of Neurotherapeutics 8:5, pages 699-714.
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Hiroki Torikai & Laurence JN Cooper. (2016) Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors. Molecular Therapy 24:7, pages 1178-1186.
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Zahra Tolou-Ghamari & Hamid Mazdak. (2016) Fingolimod for Multiple Sclerosis; Mechanism of Action, Safety and Toxicity. Archives of Neuroscience 3:3.
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Iryna V. Samarska, Hjalmar R. Bouma, Hendrik Buikema, Hubert E. Mungroop, Martin C. Houwertjes, Anthony R. Absalom, Anne H. Epema & Robert H. Henning. (2014) S1P1 Receptor Modulation Preserves Vascular Function in Mesenteric and Coronary Arteries after CPB in the Rat Independent of Depletion of Lymphocytes. PLoS ONE 9:5, pages e97196.
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Kirill Lukin, Vimal Kishore & Thomas Gordon. (2013) Development of a Scalable Synthesis of Oxadiazole Based S1P 1 Receptor Agonists . Organic Process Research & Development 17:4, pages 666-671.
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Emmanuel H. Demont, Sandra Arpino, Rino A. Bit, Colin A. Campbell, Nigel Deeks, Sapna Desai, Simon J. Dowell, Pam Gaskin, James R. J. Gray, Lee A. Harrison, Andrea Haynes, Tom D. Heightman, Duncan S. Holmes, Philip G. Humphreys, Umesh Kumar, Mary A. Morse, Greg J. Osborne, Terry Panchal, Karen L. Philpott, Simon Taylor, Robert Watson, Robert Willis & Jason Witherington. (2011) Discovery of a Brain-Penetrant S1P 3 -Sparing Direct Agonist of the S1P 1 and S1P 5 Receptors Efficacious at Low Oral Dose . Journal of Medicinal Chemistry 54:19, pages 6724-6733.
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Emmanuel H. Demont, Benjamin I. Andrews, Rino A. Bit, Colin A. Campbell, Jason W. B. Cooke, Nigel Deeks, Sapna Desai, Simon J. Dowell, Pam Gaskin, James R. J. Gray, Andrea Haynes, Duncan S. Holmes, Umesh Kumar, Mary A. Morse, Greg J. Osborne, Terry Panchal, Bela Patel, Alcide Perboni, Simon Taylor, Robert Watson, Jason Witherington & Robert Willis. (2011) Discovery of a Selective S1P 1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate . ACS Medicinal Chemistry Letters 2:6, pages 444-449.
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Henk-Jan Schuurman. 2011. Principles of Immunopharmacology. Principles of Immunopharmacology 525 556 .
Rosa López Almagro, Gema Tarrasón & Nuria Godessart. 2012. G Protein-Coupled Receptors. G Protein-Coupled Receptors 380 397 .
Anne Jörns, Klaus Jan Rath, Taivankhuu Terbish, Tanja Arndt, Andreas Meyer zu Vilsendorf, Dirk Wedekind, Hans-Jürgen Hedrich & Sigurd Lenzen. (2010) Diabetes Prevention by Immunomodulatory FTY720 Treatment in the LEW.1AR1-iddm Rat Despite Immune Cell Activation. Endocrinology 151:8, pages 3555-3565.
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Stephanie Krämer, Eva Binder, Tanja Loof, Yingrui Wang-Rosenke, Sebastian Martini, Dmytro Khadzhynov, Klemens Budde, Hans-H. Neumayer & Harm Peters. (2009) The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy. American Journal of Physiology-Renal Physiology 297:1, pages F218-F227.
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Xuequan Lu, Chaode Sun, William J. Valentine, Shuyu E, Jianxiong Liu, Gabor Tigyi & Robert Bittman. (2009) Chiral Vinylphosphonate and Phosphonate Analogues of the Immunosuppressive Agent FTY720. The Journal of Organic Chemistry 74:8, pages 3192-3195.
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Claudine S. Bonder, Wai Y. SunTyson MatthewsCarlos CassanoXiaochun LiHayley S. RamshawStuart M. PitsonAngel F. LopezP. Toby CoatesRichard L. Proia, Mathew A. VadasJennifer R. Gamble. (2009) Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood 113:9, pages 2108-2117.
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C. K. Means & J. H. Brown. (2008) Sphingosine-1-phosphate receptor signalling in the heart. Cardiovascular Research 82:2, pages 193-200.
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Zhiren Zhang, Zhi-Yuan Zhang, Uwe Fauser & Hermann J. Schluesener. (2008) FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves. Experimental Neurology 210:2, pages 681-690.
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Yutaka Yatomi. 2008. Recent Advances in Thrombosis and Hemostasis 2008. Recent Advances in Thrombosis and Hemostasis 2008 265 276 .
T. B?hler, J. Guillebaud, L. Etienne, C. Canivet, N. Kamar, L. Rostaing, J.C. Thiers, S. Galvani, N. Aug?R. Salvayre, A. N?gre-Salvayre & M. Thomsen. (2007) Effect of FTY720 on Apoptosis of Smooth Muscle Cells. Transplantation Proceedings 39:8, pages 2624-2626.
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Nigel Cooke & Frédéric Zécri. 2007. Annual Reports in Medicinal Chemistry Volume 42. Annual Reports in Medicinal Chemistry Volume 42 245 263 .

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