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Drug Evaluation

Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent

Pages 519-532 | Published online: 20 Mar 2007

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Lingyue Zhao, Qian Yang, Yiqun Tang, Qidong You & Xiaoke Guo. (2022) Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 462-471.
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Alessandro Capucci, Laura Cipolletta, Federico Guerra & Irene Giannini. (2018) Emerging pharmacotherapies for the treatment of atrial fibrillation. Expert Opinion on Emerging Drugs 23:1, pages 25-36.
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Jules C. Hancox, Andrew F. James, Neil V. Marrion, Henggui Zhang & Dierk Thomas. (2016) Novel ion channel targets in atrial fibrillation. Expert Opinion on Therapeutic Targets 20:8, pages 947-958.
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Federico Guerra, Maria Vittoria Matassini, Lorena Scappini, Alessia Urbinati & Alessandro Capucci. (2014) Intravenous vernakalant for the rapid conversion of recent onset atrial fibrillation: systematic review and meta-analysis. Expert Review of Cardiovascular Therapy 12:9, pages 1067-1075.
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Yukiomi Tsuji & Dobromir Dobrev. (2013) Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update. Vascular Health and Risk Management 9, pages 165-175.
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Neil A Castle. (2010) Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy. Expert Opinion on Therapeutic Patents 20:11, pages 1471-1503.
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Andrew Tinker & Stephen C Harmer. (2010) K+ channels in the heart: new insights and therapeutic implications. Expert Review of Clinical Pharmacology 3:3, pages 305-319.
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Dariusz Kozlowski, Szymon Budrejko, Gregory YH Lip, Dimitri P Mikhailidis, Jacek Rysz, Grzegorz Raczak & Maciej Banach. (2009) Vernakalant hydrochloride for the treatment of atrial fibrillation. Expert Opinion on Investigational Drugs 18:12, pages 1929-1937.
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Alexander Burashnikov & Charles Antzelevitch. (2009) Atrial-selective sodium channel block for the treatment of atrial fibrillation. Expert Opinion on Emerging Drugs 14:2, pages 233-249.
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Juan Tamargo, Ricardo Caballero, Ricardo Gómez & Eva Delpón. (2009) IKur/Kv1.5 channel blockers for the treatment of atrial fibrillation. Expert Opinion on Investigational Drugs 18:4, pages 399-416.
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Gerald V Naccarelli, Deborah L Wolbrette, Soraya Samii, Javier E Banchs, Erica Penny-Peterson, Robert Stevenson & Mario D Gonzalez. (2008) Vernakalant – a promising therapy for conversion of recent-onset atrial fibrillation. Expert Opinion on Investigational Drugs 17:5, pages 805-810.
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Qian Yang, Xiaojian Wang, Lupei Du, Minyong Li & Qidong You. (2007) Strategies for atrial fibrillation therapy: focusing on IKur potassium channel. Expert Opinion on Therapeutic Patents 17:12, pages 1443-1456.
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Assad Shiti, Gil Arbil, Naim Shaheen, Irit Huber, Noga Setter & Lior Gepstein. (2023) Utilizing human induced pluripotent stem cells to study atrial arrhythmias in the short QT syndrome. Journal of Molecular and Cellular Cardiology.
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Andrew Allan, Jeffery Creech, Christian Hausner, Peyton Krajcarski, Bianca Gunawan, Noah Poulin, Paul Kozlowski, Christopher Wayne Clark, Rachel Dow, Prakaimuk Saraithong, Devin B. Mair, Travis Block, Andre Monteiro da Rocha, Deok-Ho Kim & Todd J. Herron. (2023) High-throughput longitudinal electrophysiology screening of mature chamber-specific hiPSC-CMs using optical mapping. iScience 26:7, pages 107142.
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Hindol Mazumdar, Rudranil Bhowmik, Md. Adil Shaharyar, Avishek Mandal, Kumar Anand, Susmita Patra, Reshma Kumari, Sandipan Jana, Pallab Kanti Haldar & Sanmoy Karmakar. 2023. How Synthetic Drugs Work. How Synthetic Drugs Work 289 327 .
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Manuel Kraft, Antonius Büscher, Felix Wiedmann, Yannick L’hoste, Walter E. Haefeli, Norbert Frey, Hugo A. Katus & Constanze Schmidt. (2021) Current Drug Treatment Strategies for Atrial Fibrillation and TASK-1 Inhibition as an Emerging Novel Therapy Option. Frontiers in Pharmacology 12.
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Leona A Ritchie, Shuguang Qin, Peter E Penson, Neil C Henney & Gregory YH Lip. (2020) Vernakalant hydrochloride for the treatment of atrial fibrillation: evaluation of its place in clinical practice. Future Cardiology 16:6, pages 585-595.
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Juan Tamargo. 2020. Antiarrhythmic Drugs. Antiarrhythmic Drugs 265 306 .
Antoine Kossaify. (2019) Vernakalant in Atrial Fibrillation: A Relatively New Weapon in the Armamentarium Against an Old Enemy. Drug Target Insights 13, pages 117739281986111.
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Ingo Staudacher, Claudius Illg, Sam Chai, Isabelle Deschenes, Sebastian Seehausen, Dominik Gramlich, Mara Elena Müller, Teresa Wieder, Ann-Kathrin Rahm, Christina Mayer, Patrick A. Schweizer, Hugo A. Katus & Dierk Thomas. (2018) Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels. Naunyn-Schmiedeberg's Archives of Pharmacology 391:10, pages 1119-1131.
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Márcia Vagos, Ilsbeth G. M. van Herck, Joakim Sundnes, Hermenegild J. Arevalo, Andrew G. Edwards & Jussi T. Koivumäki. (2018) Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges. Frontiers in Physiology 9.
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Tamer Akel & James Lafferty. (2018) Efficacy and safety of intravenous vernakalant for the rapid conversion of recent-onset atrial fibrillation: A meta-analysis. Annals of Noninvasive Electrocardiology 23:3, pages e12508.
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Alexander Burashnikov. (2017) Late INa Inhibition as an Antiarrhythmic Strategy. Journal of Cardiovascular Pharmacology 70:3, pages 159-167.
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Nipavan Chiamvimonvat, Ye Chen-Izu, Colleen E. Clancy, Isabelle Deschenes, Dobromir Dobrev, Jordi Heijman, Leighton Izu, Zhilin Qu, Crystal M. Ripplinger, Jamie I. Vandenberg, James N. Weiss, Gideon Koren, Tamas Banyasz, Eleonora Grandi, Michael C. Sanguinetti, Donald M. Bers & Jeanne M. Nerbonne. (2017) Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. The Journal of Physiology 595:7, pages 2229-2252.
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Andreas M?ssigbrodt, Silke John, Jedrzej Kosiuk, Sergio Richter, Gerhard Hindricks & Andreas Bollmann. (2016) Vernakalant-facilitated electrical cardioversion: comparison of intravenous vernakalant and amiodarone for drug-enhanced electrical cardioversion of atrial fibrillation after failed electrical cardioversion. Europace 18:1, pages 51-56.
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Maria Vittoria Matassini, Federico Guerra, Lorena Scappini, Alessia Urbinati & Alessandro Capucci. (2015) New anthyarrhythmic drugs for atrial fibrillation. Future Cardiology 11:6, pages 705-717.
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E. B. Maykov, Yu. A. Yuricheva, N. Yu. Mironov, S. F. Sokolov, S. P. Golitsyn, L. V. Rozenshtraukh & E. I. Chazov. (2015) Refralon (niferidil) is a new class III antiarrhythmic agent for pharmacological cardioversion for persistent atrial fibrillation and atrial flutter. Terapevticheskii arkhiv 87:1, pages 38.
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Evgeny B. Maykov, Yulia A. Yuricheva, Nikolay Yu. Mironov, Sergey F. Sokolov, Sergey P. Golitsyn, Leonid V. Rosenshtraukh & Evgeny I. Chazov. (2014) Efficacy of a New Class III Drug Niferidil in Cardioversion of Persistent Atrial Fibrillation and Flutter. Journal of Cardiovascular Pharmacology 64:3, pages 247-255.
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Constanze Schmidt, Felix Wiedmann, Patrick A. Schweizer, Hugo A. Katus & Dierk Thomas. (2014) Inhibition of cardiac two-pore-domain K+ (K2P) channels – an emerging antiarrhythmic concept. European Journal of Pharmacology 738, pages 250-255.
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Diego Conde & Adrian Baranchuk. (2014) Vernakalant for the Conversion of Atrial Fibrillation: The New Kid On the Block?. Annals of Noninvasive Electrocardiology 19:4, pages 299-302.
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Nicole Schmitt, Morten Grunnet & Søren-Peter Olesen. (2014) Cardiac Potassium Channel Subtypes: New Roles in Repolarization and Arrhythmia. Physiological Reviews 94:2, pages 609-653.
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Ursula Ravens. (2014) Neue Entwicklungen in der antiarrhythmischen Therapie des VorhofflimmernsNew developments in the antiarrhythmic therapy of atrial fibrillation. Herzschrittmachertherapie + Elektrophysiologie 25:1, pages 41-46.
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Claudia Seyler, Jin Li, Patrick A. Schweizer, Hugo A. Katus & Dierk Thomas. (2014) Inhibition of cardiac two-pore-domain K+ (K2P) channels by the antiarrhythmic drug vernakalant – Comparison with flecainide. European Journal of Pharmacology 724, pages 51-57.
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Alain Rudiger, Alexander Breitenstein, Mattia Arrigo, Sacha P. Salzberg & Dominique Bettex. (2014) Suitability, Efficacy, and Safety of Vernakalant for New Onset Atrial Fibrillation in Critically Ill Patients. Critical Care Research and Practice 2014, pages 1-7.
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Torsten Christ. (2014) Atrial-selective Antiarrhythmic Activity by Vernakalant Fact or Fiction?. Journal of Cardiovascular Pharmacology 63:1, pages 23-24.
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Charles Antzelevitch, Vladislav Nesterenko, John C. Shryock, Sridharan Rajamani, Yejia Song & Luiz Belardinelli. 2014. Voltage Gated Sodium Channels. Voltage Gated Sodium Channels 137 168 .
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Rosanne Varkevisser, Marcel A.G. van der Heyden, Ralph G. Tieland, Jet D.M. Beekman & Marc A. Vos. (2013) Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model. European Journal of Pharmacology 720:1-3, pages 49-54.
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Ingemar Jacobson, Göran Duker, Malin Florentzson, Gunilla Linhardt, Emma Lindhardt, Ann-Kristin Nordkam, Annika Åstrand & Leif Carlsson. (2013) Electrophysiological Characterization and Antiarrhythmic Efficacy of the Mixed Potassium Channel-Blocking Antiarrhythmic Agent AZ13395438 In Vitro and In Vivo. Journal of Cardiovascular Pharmacology and Therapeutics 18:3, pages 290-300.
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Erich Wettwer, Torsten Christ, Sebastian Endig, Nadiia Rozmaritsa, Klaus Matschke, Joseph J. Lynch, Marc Pourrier, John K. Gibson, David Fedida, Michael Knaut & Ursula Ravens. (2013) The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation. Cardiovascular Research 98:1, pages 145-154.
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Joseph J. LynchJrJr, Christopher P. Regan, Gregory N. Beatch, Gilbert W. Gleim & Christopher J. Morabito. (2013) Comparison of the Intrinsic Vasorelaxant and Inotropic Effects of the Antiarrhythmic Agents Vernakalant and Flecainide in Human Isolated Vascular and Cardiac Tissues. Journal of Cardiovascular Pharmacology 61:3, pages 226-232.
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David Filgueiras-RamaRaphael P. MartinsSergey MironovMasatoshi YamazakiConrado J. CalvoSteve R. EnnisKrishna BandaruSami F. NoujaimJérôme KalifaOmer BerenfeldJosé Jalife. (2012) Chloroquine Terminates Stretch-Induced Atrial Fibrillation More Effectively Than Flecainide in the Sheep Heart. Circulation: Arrhythmia and Electrophysiology 5:3, pages 561-570.
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Alexander Burashnikov, Hector Barajas-Martinez, Dan Hu, Eyal Nof, Jonathan Blazek & Charles Antzelevitch. (2012) Atrial-selective Prolongation of Refractory Period With AVE0118 is Due Principally to Inhibition of Sodium Channel Activity. Journal of Cardiovascular Pharmacology 59:6, pages 539-546.
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Alexander BurashnikovMarc PourrierJohn K. GibsonJoseph J. LynchCharles Antzelevitch. (2012) Rate-Dependent Effects of Vernakalant in the Isolated Non-Remodeled Canine Left Atria Are Primarily Due to Block of the Sodium Channel. Circulation: Arrhythmia and Electrophysiology 5:2, pages 400-408.
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Lori D. Bash, Jessica L. Buono, Glenn M. Davies, Amber Martin, Kyle Fahrbach, Hemant Phatak, Ruzan Avetisyan & Mkaya Mwamburi. (2012) Systematic Review and Meta-analysis of the Efficacy of Cardioversion by Vernakalant and Comparators in Patients with Atrial Fibrillation. Cardiovascular Drugs and Therapy 26:2, pages 167-179.
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Serge Sicouri, Marc Pourrier, John K. Gibson, Joseph J. Lynch & Charles Antzelevitch. (2012) Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations. Heart Rhythm 9:3, pages 422-429.
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