863
Views
111
CrossRef citations to date
0
Altmetric
Review

Ibudilast (AV-411)

a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes

, , &
Pages 935-950 | Published online: 26 Jun 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Shanshan Zhong, Zhike Zhou, Yifan Liang, Xi Cheng, Yong Li, Weiyu Teng, Mei Zhao, Chang Liu, Meiting Guan & Chuansheng Zhao. (2019) Targeting strategies for chemotherapy-induced peripheral neuropathy: does gut microbiota play a role?. Critical Reviews in Microbiology 45:4, pages 369-393.
Read now
Nicole E. Burma, Heather Leduc-Pessah & Tuan Trang. (2017) Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice. Channels 11:5, pages 487-494.
Read now
Laura Poupon, Nicolas Kerckhove, Julie Vein, Sylvain Lamoine, Nicolas Authier, Jérôme Busserolles & David Balayssac. (2015) Minimizing chemotherapy-induced peripheral neuropathy: preclinical and clinical development of new perspectives. Expert Opinion on Drug Safety 14:8, pages 1269-1282.
Read now
Sarah Vollbracht & Alan M Rapoport. (2012) New and emerging treatments for headache. Expert Review of Neurotherapeutics 12:11, pages 1271-1273.
Read now
Lorenzo Galluzzi, Erika Vacchelli, Alexander Eggermont, Wolf Hervé Fridman, Jérôme Galon, Catherine Sautès-Fridman, Eric Tartour, Laurence Zitvogel & Guido Kroemer. (2012) Trial Watch. OncoImmunology 1:5, pages 699-739.
Read now
Ziva D Cooper, Jermaine D Jones & Sandra D Comer. (2012) Glial modulators: a novel pharmacological approach to altering the behavioral effects of abused substances. Expert Opinion on Investigational Drugs 21:2, pages 169-178.
Read now
Shaherin Basith, Balachandran Manavalan, Gwang Lee, Sang Geon Kim & Sangdun Choi. (2011) Toll-like receptor modulators: a patent review (2006 – 2010). Expert Opinion on Therapeutic Patents 21:6, pages 927-944.
Read now
Karsten Ahlbeck. (2011) Opioids: a two-faced Janus. Current Medical Research and Opinion 27:2, pages 439-448.
Read now
L. M. Sanftner, J. A. Gibbons, M. I. Gross, B. M. Suzuki, F. C. A. Gaeta & K. W. Johnson. (2009) Cross-species comparisons of the pharmacokinetics of ibudilast. Xenobiotica 39:12, pages 964-977.
Read now
P Rolan, MR Hutchinson & KW Johnson. (2009) Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy 10:17, pages 2897-2904.
Read now
Maria Schäfers & Claudia Sommer. (2007) Anticytokine therapy in neuropathic pain management. Expert Review of Neurotherapeutics 7:11, pages 1613-1627.
Read now

Articles from other publishers (100)

Xinzhu Wang, Yansheng Wang, Ning Yu, Hui Xu & Zeming Lei. (2023) Observational study of ropivacaine and compound betamethasone mixture for analgesia after triangular fibrocartilage complex repair under wrist arthroscopy: A single-center randomized double-blind controlled trial. Journal of Orthopaedic Science.
Crossref
Arushi Sandhu, Kajal Rawat, Vipasha Gautam, Antika Sharma, Anil Kumar & Lekha Saha. (2023) Phosphodiesterase inhibitor, ibudilast alleviates core behavioral and biochemical deficits in the prenatal valproic acid exposure model of autism spectrum disorder. Brain Research 1815, pages 148443.
Crossref
Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira & Peter A Serrano. (2023) Repurposing ibudilast to mitigate Alzheimer’s disease by targeting inflammation. Brain 146:3, pages 898-911.
Crossref
Megan M. St. Peters, Chun Hui J. Park, Alyna Turner, Alexandre A. Guerin & Jee Hyun Kim. (2023) Past and current drug repurposing clinical trials to treat cognition in methamphetamine use: a scoping review of pharmacotherapy candidates. Addiction Neuroscience 5, pages 100064.
Crossref
Efthalia Angelopoulou, Efstratios-Stylianos Pyrgelis & Christina Piperi. (2022) Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence. Molecules 27:23, pages 8448.
Crossref
Hongjin Zhai, Shuo Zhang, Maxwell Ampomah-Wireko, Huanhuan Wang, Yaquan Cao, Pu Yang, Yingxue Yang, Firas Obald Arhema Frejat, Lihong Wang, Bingbing Zhao, Changzhong Ren & Chunli Wu. (2022) Pyrazole: An Important Core in Many Marketed and Clinical Drugs. Russian Journal of Bioorganic Chemistry 48:6, pages 1175-1189.
Crossref
Igor Philippov, Yuriy Gatilov, Alina Sonina & Aleksey Vorob’ev. (2022) Oxidative [3+2]Cycloaddition of Alkynylphosphonates with Heterocyclic N-Imines: Synthesis of Pyrazolo[1,5-a]Pyridine-3-phosphonates. Molecules 27:22, pages 7913.
Crossref
Cora E. Smiley & Susan K. Wood. (2022) Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders. Pharmacology & Therapeutics 239, pages 108212.
Crossref
Shibam Das & Rohit Bhatia. (2022) Liquid extraction surface analysis‐mass spectrometry: An advanced and environment‐friendly analytical tool in modern analysis. Journal of Separation Science 45:14, pages 2746-2765.
Crossref
Aref-Ali Gharooni, Brian K. Kwon, Michael G. Fehlings, Timothy F. Boerger, Ricardo Rodrigues-Pinto, Paul Aarne Koljonen, Shekar N. Kurpad, James S. Harrop, Bizhan Aarabi, Vafa Rahimi-Movaghar, Jefferson R. Wilson, Benjamin M. Davies, Mark R. N. Kotter & James D. Guest. (2022) Developing Novel Therapies for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 7]: Opportunities From Restorative Neurobiology. Global Spine Journal 12:1_suppl, pages 109S-121S.
Crossref
Shan Liu, Jiguo Gao, Kangding Liu & Hong-Liang Zhang. (2021) Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target. Mechanisms of Ageing and Development 199, pages 111560.
Crossref
David Baker, Charalambos Hadjicharalambous, Sharmilee Gnanapavan & Gavin Giovannoni. (2021) Can rheumatologists stop causing demyelinating disease?. Multiple Sclerosis and Related Disorders 53, pages 103057.
Crossref
Tao Wang, Xun Zhu, Hyun Yi, Jun Gu, Shue Liu, Sari Izenwasser, Vance P Lemmon, Sabita Roy & Shuanglin Hao. (2021) Viral vector-mediated gene therapy for opioid use disorders. Experimental Neurology 341, pages 113710.
Crossref
Qiaofeng Liu, Ting Min, Jun Dong & Xin Wang. (2021) Minocycline alleviates the symptoms of morphine withdrawal via the CaMKII-Ras-ERK signaling pathway. Neuroscience Letters 752, pages 135825.
Crossref
Qiaofeng Liu, Shan Tang, Xiaoyu Du, Yuzhu Sun, Jialing Lai & Xin Wang. (2020) Injection of minocycline into the periaqueductal gray attenuates morphine withdrawal signs. Neuroscience Letters 736, pages 135283.
Crossref
Jermaine D. Jones. (2020) Potential of Glial Cell Modulators in the Management of Substance Use Disorders. CNS Drugs 34:7, pages 697-722.
Crossref
Christopher R. Donnelly, Amanda S. Andriessen, Gang Chen, Kaiyuan Wang, Changyu Jiang, William Maixner & Ru-Rong Ji. (2020) Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain. Neurotherapeutics 17:3, pages 846-860.
Crossref
Sabina V. Alieva & Aleksey Yu. Vorob’ev. (2020) Synthesis of 3-Fluoropyrazolo[1,5-A]Pyridines by Fluorination of Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylates. Chemistry of Heterocyclic Compounds 56:7, pages 957-960.
Crossref
George S. Baillie, Gonzalo S. Tejeda & Michy P. Kelly. (2019) Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nature Reviews Drug Discovery 18:10, pages 770-796.
Crossref
Prabarna Ganguly, Jennifer A. Honeycutt, June R. Rowe, Camila Demaestri & Heather C. Brenhouse. (2019) Effects of early life stress on cocaine conditioning and AMPA receptor composition are sex-specific and driven by TNF. Brain, Behavior, and Immunity 78, pages 41-51.
Crossref
Felix I. L. Clanchy & Richard O. Williams. (2019) Ibudilast Inhibits Chemokine Expression in Rheumatoid Arthritis Synovial Fibroblasts and Exhibits Immunomodulatory Activity in Experimental Arthritis. Arthritis & Rheumatology 71:5, pages 703-711.
Crossref
Vinita Mishra & Chandramani Pathak. (2019) Human Toll-Like Receptor 4 (hTLR4): Structural and functional dynamics in cancer. International Journal of Biological Macromolecules 122, pages 425-451.
Crossref
Eric A. Woodcock, Ansel T. Hillmer, Graeme F. Mason & Kelly P. Cosgrove. (2019) Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review. Complex Psychiatry 5:3, pages 125-146.
Crossref
Esther Blessing, Sanya Virani & John Rotrosen. 2020. Substance Use Disorders. Substance Use Disorders 167 202 .
Kelly Bruno, Sarah A. Woller, Yury I. Miller, Tony L. Yaksh, Mark Wallace, Graham Beaton & Krishnan Chakravarthy. (2018) Targeting toll-like receptor-4 (TLR4)—an emerging therapeutic target for persistent pain states. Pain 159:10, pages 1908-1915.
Crossref
Nicole E Burma, Charlie HT Kwok & Tuan Trang. (2017) Therapies and mechanisms of opioid withdrawal. Pain Management 7:6, pages 455-459.
Crossref
Ian N. Johnston, Manuela Tan, Jacob Cao, Antigone Matsos, Daniel R.L. Forrest, Emily Si, Joanna E. Fardell & Mark R. Hutchinson. (2017) Ibudilast reduces oxaliplatin-induced tactile allodynia and cognitive impairments in rats. Behavioural Brain Research 334, pages 109-118.
Crossref
Verena E Metz, Jermaine D Jones, Jeanne Manubay, Maria A Sullivan, Shanthi Mogali, Andrew Segoshi, Gabriela Madera, Kirk W Johnson & Sandra D Comer. (2017) Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence. Neuropsychopharmacology 42:9, pages 1825-1832.
Crossref
Lara A Ray, Spencer Bujarski, Steve Shoptaw, Daniel JO Roche, Keith Heinzerling & Karen Miotto. (2017) Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial. Neuropsychopharmacology 42:9, pages 1776-1788.
Crossref
Joanna Schwenkgrub, Malgorzata Zaremba, Ilona Joniec-Maciejak, Agnieszka Cudna, Dagmara Mirowska-Guzel & Iwona Kurkowska-Jastrzębska. (2017) The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson’s disease. PLOS ONE 12:7, pages e0182019.
Crossref
Julie Wieseler, Amanda Ellis, Andrew McFadden, Kendra Stone, Kimberley Brown, Sara Cady, Leandro F. Bastos, David Sprunger, Niloofar Rezvani, Kirk Johnson, Kenner C. Rice, Steven F. Maier & Linda R. Watkins. (2017) Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators. Brain Research 1664, pages 87-94.
Crossref
H Yi, T Iida, S Liu, D Ikegami, Q Liu, A Iida, D A Lubarsky & S Hao. (2017) IL-4 mediated by HSV vector suppresses morphine withdrawal response and decreases TNFα, NR2B, and pC/EBPβ in the periaqueductal gray in rats. Gene Therapy 24:4, pages 224-233.
Crossref
El-Hadi Zerdazi, Jos? Oliveira, Florence Vorspan, Meriem Bennabi, St?phane Jamain, Bruno Etain, Marion Leboyer, Ryad Tamouza & Frank Bellivier. (2017) TLR4 gene polymorphism associated with lifetime cigarette smoking in bipolar disorder. Journal of Neuroimmunology 305, pages 96-101.
Crossref
Raye Z. Litten, Daniel E. Falk, Megan L. Ryan, Joanne Fertig & Lorenzo Leggio. 2018. The Neuropharmacology of Alcohol. The Neuropharmacology of Alcohol 579 613 .
Jorge Montesinos, Silvia Alfonso-Loeches & Consuelo Guerri. (2016) Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System. Alcoholism: Clinical and Experimental Research 40:11, pages 2260-2270.
Crossref
Robert J. Fox, Christopher S. Coffey, Merit E. Cudkowicz, Trevis Gleason, Andrew Goodman, Eric C. Klawiter, Kazuko Matsuda, Michelle McGovern, Robin Conwit, Robert Naismith, Akshata Ashokkumar, Robert Bermel, Dixie Ecklund, Maxine Koepp, Jeffrey Long, Sneha Natarajan, Srividya Ramachandran, Thomai Skaramagas, Brenda Thornell, Jon Yankey, Mark Agius, Khurram Bashir, Bruce Cohen, Patricia Coyle, Silvia Delgado, Dana Dewitt, Angela Flores, Barbara Giesser, Myla Goldman, Burk Jubelt, Neil Lava, Sharon Lynch, Augusto Miravalle, Harold Moses, Daniel Ontaneda, Jai Perumal, Michael Racke, Pavle Repovic, Claire Riley, Christopher Severson, Shlomo Shinnar, Valerie Suski, Bianca Weinstock-Gutman, Vijayshree Yadav & Aram Zabeti. (2016) Design, rationale, and baseline characteristics of the randomized double-blind phase II clinical trial of ibudilast in progressive multiple sclerosis. Contemporary Clinical Trials 50, pages 166-177.
Crossref
Daniel Ruiz-PérezJavier BenitoGonzalo PoloCarlota LargoDelia AguadoLuis SanzIgnacio A. Gómez de Segura. (2016) The Effects of the Toll-Like Receptor 4 Antagonist, Ibudilast, on Sevoflurane’s Minimum Alveolar Concentration and the Delayed Remifentanil-Induced Increase in the Minimum Alveolar Concentration in Rats. Anesthesia & Analgesia 122:5, pages 1370-1376.
Crossref
M. Akhtar Anwar, Tuqa S. Al Shehabi & Ali H. Eid. (2016) Inflammogenesis of Secondary Spinal Cord Injury. Frontiers in Cellular Neuroscience 10.
Crossref
Martin F. Bjurstrom, Sarah E. Giron & Charles A. Griffis. (2016) Cerebrospinal Fluid Cytokines and Neurotrophic Factors in Human Chronic Pain Populations: A Comprehensive Review. Pain Practice 16:2, pages 183-203.
Crossref
Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 15 64 .
John G. SwalesJames W. TuckerMichael J. SpreadboroughSuzanne L. IversonMalcolm R. ClenchPeter J. H. WebbornRichard J. A. Goodwin. (2015) Mapping Drug Distribution in Brain Tissue Using Liquid Extraction Surface Analysis Mass Spectrometry Imaging. Analytical Chemistry 87:19, pages 10146-10152.
Crossref
Jacinta L. Johnson, Yuen H. Kwok, Nicole M. Sumracki, James E. Swift, Mark R. Hutchinson, Kirk Johnson, Desmond B. Williams, Jonathon Tuke & Paul E. Rolan. (2015) Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety. Headache: The Journal of Head and Face Pain 55:9, pages 1192-1208.
Crossref
Sarah E. Giron, Charles A. Griffis & Joseph F. Burkard. (2015) Chronic Pain and Decreased Opioid Efficacy: An Inflammatory Link. Pain Management Nursing 16:5, pages 819-831.
Crossref
Sergios Charntikov, Steven T. Pittenger, Ishwor Thapa, Dhundy R. Bastola, Rick A. Bevins & Gurudutt Pendyala. (2015) Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats. Drug and Alcohol Dependence 152, pages 15-23.
Crossref
Todd V. Brennan, Victoria R. Rendell & Yiping Yang. (2015) Innate Immune Activation by Tissue Injury and Cell Death in the Setting of Hematopoietic Stem Cell Transplantation. Frontiers in Immunology 6.
Crossref
Richard L. Bell, Marcelo F. Lopez, Changhai Cui, Mark Egli, Kirk W. Johnson, Kelle M. Franklin & Howard C. Becker. (2015) Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence. Addiction Biology 20:1, pages 38-42.
Crossref
E. Alfonso Romero-Sandoval & Sarah Sweitzer. 2015. Molecular and Cell Biology of Pain. Molecular and Cell Biology of Pain 325 358 .
Marco Sisignano, Ralf Baron, Klaus Scholich & Gerd Geisslinger. (2014) Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain. Nature Reviews Neurology 10:12, pages 694-707.
Crossref
Hao Wang, Zhen lin Mei, Kai Long Zhong, Mei Hu, Yan Long, Ming Xing Miao, Ning Li, Tian Hua Yan & Hao Hong. (2014) Pretreatment with antiasthmatic drug ibudilast ameliorates Aβ1–42-induced memory impairment and neurotoxicity in mice. Pharmacology Biochemistry and Behavior 124, pages 373-379.
Crossref
Vinod Tiwari, Yun Guan & Srinivasa N. Raja. (2014) Modulating the delicate glial–neuronal interactions in neuropathic pain: Promises and potential caveats. Neuroscience & Biobehavioral Reviews 45, pages 19-27.
Crossref
Cleverton K. F. Lima, Rafael M. Silva, Renata B. Lacerda, Bruna L. R. Santos, Rafaela V. Silva, Luciana S. Amaral, Lu?s E. M. Quintas, Carlos A. M. Fraga, Eliezer J. Barreiro, Mar?lia Z. P. Guimaraes & Ana L. P. Miranda. (2014) LASSBio-1135: A Dual TRPV1 Antagonist and Anti-TNF-Alpha Compound Orally Effective in Models of Inflammatory and Neuropathic Pain. PLoS ONE 9:6, pages e99510.
Crossref
Sarah Vollbracht & Alan M. Rapoport. (2014) New treatments for headache. Neurological Sciences 35:S1, pages 89-97.
Crossref
Amanda Ellis, Julie Wieseler, Jacob Favret, Kirk W. Johnson, Kenner C. Rice, Steven F. Maier, Scott Falci & Linda R. Watkins. (2014) Systemic Administration of Propentofylline, Ibudilast, and (+)-Naltrexone Each Reverses Mechanical Allodynia in a Novel Rat Model of Central Neuropathic Pain. The Journal of Pain 15:4, pages 407-421.
Crossref
Kirk W Johnson, Kazuko Matsuda & Yuichi Iwaki. (2014) Ibudilast for the treatment of drug addiction and other neurological conditions. Clinical Investigation 4:3, pages 269-279.
Crossref
Xiaohui Wang, Thomas A. Cochran, Mark R. Hutchinson, Hang Yin & Linda R. Watkins. 2014. Microglia in Health and Disease. Microglia in Health and Disease 299 317 .
Manuel Diezi, Thierry Buclin & Thierry Kuntzer. (2013) Toxic and drug-induced peripheral neuropathies. Current Opinion in Neurology 26:5, pages 481-488.
Crossref
Joanna Mika, Magdalena Zychowska, Katarzyna Popiolek-Barczyk, Ewelina Rojewska & Barbara Przewlocka. (2013) Importance of glial activation in neuropathic pain. European Journal of Pharmacology 716:1-3, pages 106-119.
Crossref
Sarah Vollbracht & Alan M. Rapoport. (2013) The Pipeline in Headache Therapy. CNS Drugs 27:9, pages 717-729.
Crossref
Giulio Podda, Mukanthu Nyirenda, James Crooks & Bruno Gran. (2013) Innate Immune Responses in the CNS: Role of Toll-Like Receptors, Mechanisms, and Therapeutic Opportunities in Multiple Sclerosis. Journal of Neuroimmune Pharmacology 8:4, pages 791-806.
Crossref
Sarah E. Snider, Elizabeth S. Hendrick & Patrick M. Beardsley. (2013) Glial cell modulators attenuate methamphetamine self-administration in therat. European Journal of Pharmacology 701:1-3, pages 124-130.
Crossref
Yue Wu & Mark R. Hutchinson. 2013. Neural-Immune Interactions in Brain Function and Alcohol Related Disorders. Neural-Immune Interactions in Brain Function and Alcohol Related Disorders 535 559 .
Jennifer H. Benbow, Taylor Mann, Camille Keeler, Chengpeng Fan, Michael E. Hodsdon, Elias Lolis, Brenda DeGray & Barbara E. Ehrlich. (2012) Inhibition of Paclitaxel-induced Decreases in Calcium Signaling. Journal of Biological Chemistry 287:45, pages 37907-37916.
Crossref
Janelle Drouin-Ouellet & Francesca Cicchetti. (2012) Inflammation and neurodegeneration: the story ‘retolled’. Trends in Pharmacological Sciences 33:10, pages 542-551.
Crossref
Takeshi Kondo, Taro Kawai & Shizuo Akira. (2012) Dissecting negative regulation of Toll-like receptor signaling. Trends in Immunology 33:9, pages 449-458.
Crossref
Yuqiang Shi, Benjamin B. Gelman, Joshua G. Lisinicchia & Shao-Jun Tang. (2012) Chronic-Pain-Associated Astrocytic Reaction in the Spinal Cord Dorsal Horn of Human Immunodeficiency Virus-Infected Patients. The Journal of Neuroscience 32:32, pages 10833-10840.
Crossref
Krista M. RodgersFlorencia M. BercumDanielle L. McCallumJerry W. RudyLauren C. FreyKirk W. JohnsonLinda R. WatkinsDaniel S. Barth. (2012) Acute Neuroimmune Modulation Attenuates the Development of Anxiety-Like Freezing Behavior in an Animal Model of Traumatic Brain Injury. Journal of Neurotrauma 29:10, pages 1886-1897.
Crossref
Xiao-Min Wang, Tanya J. Lehky, Joanna M. Brell & Susan G. Dorsey. (2012) Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy. Cytokine 59:1, pages 3-9.
Crossref
Handong Ouyang, Shue Liu, Weian Zeng, Roy C. Levitt, Keith A. Candiotti & Shuanglin Hao. (2012) An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray. The Scientific World Journal 2012, pages 1-9.
Crossref
Sudipta Roy, Sujata Roy & Gordon W. Gribble. 2012. Metalation of Azoles and Related Five-Membered Ring Heterocycles. Metalation of Azoles and Related Five-Membered Ring Heterocycles 155 260 .
M. Gambuzza, N. Licata, E. Palella, D. Celi, V. Foti Cuzzola, D. Italiano, S. Marino & P. Bramanti. (2011) Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management. Journal of Neuroimmunology 239:1-2, pages 1-12.
Crossref
Jamil Ahsan Kazi & Mohamed Ibrahim Abu-Hassan. (2010) Gabapentin Completely Attenuated the Acute Morphine-Induced c-Fos Expression in the Rat Nucleus Accumbens. Journal of Molecular Neuroscience 45:2, pages 101-109.
Crossref
Aisling Dunne, Neil A Marshall & Kingston HG Mills. (2011) TLR based therapeutics. Current Opinion in Pharmacology 11:4, pages 404-411.
Crossref
Brian W. LeBlanc, Michele L. Zerah, Laith M. Kadasi, Noori Chai & Carl Y. Saab. (2011) Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy. Neuroscience Letters 498:2, pages 138-142.
Crossref
Michelle Kiebala & Sanjay B. Maggirwar. (2011) Ibudilast, a Pharmacologic Phosphodiesterase Inhibitor, Prevents Human Immunodeficiency Virus-1 Tat-Mediated Activation of Microglial Cells. PLoS ONE 6:4, pages e18633.
Crossref
Serena Stopponi, Lorenzo Somaini, Andrea Cippitelli, Nazzareno Cannella, Simone Braconi, Marsida Kallupi, Barbara Ruggeri, Markus Heilig, Gregory Demopulos, George Gaitanaris, Maurizio Massi & Roberto Ciccocioppo. (2011) Activation of Nuclear PPARγ Receptors by the Antidiabetic Agent Pioglitazone Suppresses Alcohol Drinking and Relapse to Alcohol Seeking. Biological Psychiatry 69:7, pages 642-649.
Crossref
Shuanglin Hao, Shue Liu, Xuexing Zheng, Wenwen Zheng, Handong Ouyang, Marina Mata & David J Fink. (2010) The Role of TNFα in the Periaqueductal Gray During Naloxone-Precipitated Morphine Withdrawal in Rats. Neuropsychopharmacology 36:3, pages 664-676.
Crossref
Charles Feldman & Ronald Anderson. (2011) Bacteraemic Pneumococcal Pneumonia. Drugs 71:2, pages 131-153.
Crossref
Aldric Hama, Shyam Gajavelli & Jacqueline Sagen. 2011. Rothman Simeone The Spine. Rothman Simeone The Spine 1872 1885 .
Eduardo E. Benarroch. (2010) Central neuron-glia interactions and neuropathic pain. Neurology 75:3, pages 273-278.
Crossref
Patrick M. Beardsley, Keith L. Shelton, Elizabeth Hendrick & Kirk W. Johnson. (2010) The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse. European Journal of Pharmacology 637:1-3, pages 102-108.
Crossref
Yoonsang ChoGregg V. CrichlowJon J. VermeireLin Leng, Xin Du, Michael E. HodsdonRichard Bucala, Michael CappelloMatt GrossFederico GaetaKirk Johnson & Elias J. Lolis. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proceedings of the National Academy of Sciences 107:25, pages 11313-11318.
Crossref
Elizabeth J. Hennessy, Andrew E. Parker & Luke A. J. O'Neill. (2010) Targeting Toll-like receptors: emerging therapeutics?. Nature Reviews Drug Discovery 9:4, pages 293-307.
Crossref
Haroon Hameed, Mariam Hameed & Paul J. Christo. (2010) The Effect of Morphine on Glial Cells as a Potential Therapeutic Target for Pharmacological Development of Analgesic Drugs. Current Pain and Headache Reports 14:2, pages 96-104.
Crossref
Daan Crommelin, Pieter Stolk, Luc Besançon, Vinod Shah, Kamal Midha & Hubert Leufkens. (2010) Pharmaceutical sciences in 2020. Nature Reviews Drug Discovery 9:2, pages 99-100.
Crossref
Bianca Jupp & Andrew J. Lawrence. (2010) New horizons for therapeutics in drug and alcohol abuse. Pharmacology & Therapeutics 125:1, pages 138-168.
Crossref
Tuomas O. Lilius, Pekka V. Rauhala, Oleg Kambur & Eija A. Kalso. (2009) Modulation of Morphine-induced Antinociception in Acute and Chronic Opioid Treatment by Ibudilast. Anesthesiology 111:6, pages 1356-1364.
Crossref
José M. SantiagoOdrick RosasAranza I. TorradoMaría M. GonzálezPriya O. Kalyan-MasihJorge D. Miranda. (2009) Molecular, Anatomical, Physiological, and Behavioral Studies of Rats Treated with Buprenorphine after Spinal Cord Injury. Journal of Neurotrauma 26:10, pages 1783-1793.
Crossref
Howard S Smith. (2009) Future of minimizing opioid adverse effects while maintaining or improving opioid-related analgesia. Therapy 6:5, pages 667-683.
Crossref
Sondra T. Bland, Mark R. Hutchinson, Steven F. Maier, Linda R. Watkins & Kirk W. Johnson. (2009) The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, Behavior, and Immunity 23:4, pages 492-497.
Crossref
Jim Bartley. (2009) Could glial activation be a factor in migraine?. Medical Hypotheses 72:3, pages 255-257.
Crossref
Mark R. Hutchinson, Susannah S. Lewis, Benjamen D. Coats, David A. Skyba, Nicole Y. Crysdale, Debra L. Berkelhammer, Anita Brzeski, Alexis Northcutt, Christine M. Vietz, Charles M. Judd, Steven F. Maier, Linda R. Watkins & Kirk W. Johnson. (2009) Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain, Behavior, and Immunity 23:2, pages 240-250.
Crossref
Paul Rolan, Jacqueline A. Gibbons, Lin He, Eppie Chang, Drew Jones, Matthew I. Gross, Jennifer Bahr Davidson, Laura M. Sanftner & Kirk W. Johnson. (2008) Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses. British Journal of Clinical Pharmacology 66:6, pages 792-801.
Crossref
. (2008) Discovery of the Role Glia Plays in Pathogenic Pain Paves Way For Revolutionary Therapies. Topics in Pain Management 24:4, pages 7-9.
Crossref
Mark R. Hutchinson, Alexis L. Northcutt, Lindsey W. Chao, Jeffrey J. Kearney, Yingning Zhang, Debra L. Berkelhammer, Lisa C. Loram, Robert R. Rozeske, Sondra T. Bland, Steven F. Maier, Todd T. Gleeson & Linda R. Watkins. (2008) Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain, Behavior, and Immunity 22:8, pages 1248-1256.
Crossref
. (2008) Current World Literature. Current Opinion in Anaesthesiology 21:5, pages 684-693.
Crossref
Ke Ren & Ronald Dubner. (2008) Neuron–glia crosstalk gets serious: role in pain hypersensitivity. Current Opinion in Anaesthesiology 21:5, pages 570-579.
Crossref
Mark R. Hutchinson, Yingning Zhang, Kimberley Brown, Benjamen D. Coats, Mitesh Shridhar, Paige W. Sholar, Sonica J. Patel, Nicole Y. Crysdale, Jacqueline A. Harrison, Steven F. Maier, Kenner C. Rice & Linda R. Watkins. (2008) Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). European Journal of Neuroscience 28:1, pages 20-29.
Crossref
Carl Y. Saab, Stephen G. Waxman & Bryan C. Hains. (2008) Alarm or curse? The pain of neuroinflammation. Brain Research Reviews 58:1, pages 226-235.
Crossref
Gary McCleane & Howard S. Smith. (2007) Opioids for Persistent Noncancer Pain. Anesthesiology Clinics 25:4, pages 787-807.
Crossref
Linda R. Watkins, Mark R. Hutchinson, Erin D. Milligan & Steven F. Maier. (2007) “Listening” and “talking” to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids. Brain Research Reviews 56:1, pages 148-169.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.