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Expert Opinion on Investigational Drugs Volume 16, 2007 - Issue 9
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Drug Evaluation

Phosphodiesterase 4 inhibitors and inflammatory bowel disease: emerging therapies in inflammatory bowel disease

Ali Keshavarzian Rush University Medical Center, Department of Internal Medicine (Division of Digestive Disease), Pharmacology, Physiology and Molecular Biophysics, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA +1 312 942 5861; +1 312 563 3883; [email protected]
, MD,
Ece Mutlu Rush University Medical Center, Department of Internal Medicine (Division of Digestive Disease), Pharmacology, Physiology and Molecular Biophysics, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA +1 312 942 5861; +1 312 563 3883; [email protected]; Otsuka Pharmaceutucal Development and Commercialization, 2440 Research Boulevard, Rockville, MD 20850, USA
, MD,
Juan P Guzman Rush University Medical Center, Department of Internal Medicine (Division of Digestive Disease), Pharmacology, Physiology and Molecular Biophysics, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA +1 312 942 5861; +1 312 563 3883; [email protected]; Otsuka Pharmaceutucal Development and Commercialization, 2440 Research Boulevard, Rockville, MD 20850, USA
, MD MSc,
Christopher Forsyth Rush University Medical Center, Department of Internal Medicine (Division of Digestive Disease), Pharmacology, Physiology and Molecular Biophysics, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA +1 312 942 5861; +1 312 563 3883; [email protected]; Otsuka Pharmaceutucal Development and Commercialization, 2440 Research Boulevard, Rockville, MD 20850, USA
, PhD &
Ali Banan Rush University Medical Center, Department of Internal Medicine (Division of Digestive Disease), Pharmacology, Physiology and Molecular Biophysics, 1725 W. Harrison, Suite 206, Chicago, IL 60612, USA +1 312 942 5861; +1 312 563 3883; [email protected]; Otsuka Pharmaceutucal Development and Commercialization, 2440 Research Boulevard, Rockville, MD 20850, USA
, PhD
Pages 1489-1506 | Published online: 22 Aug 2007

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Ana Martinez & Carmen Gil. (2014) cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opinion on Therapeutic Patents 24:12, pages 1311-1321.
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Stephen J Bickston, Kenneth R Snider & Matthew R Kappus. (2012) Tetomilast: new promise for phosphodiesterase-4 inhibitors?. Expert Opinion on Investigational Drugs 21:12, pages 1845-1849.
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Pooneh Salari & Mohammad Abdollahi. (2012) Phosphodiesterase inhibitors in inflammatory bowel disease. Expert Opinion on Investigational Drugs 21:3, pages 261-264.
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Articles from other publishers (25)

Feng Zhou, Nan-Zhen Wu, Yong Xie & Xiao-Jiang Zhou. (2023) Intestinal barrier in inflammatory bowel disease: A bibliometric and knowledge-map analysis. World Journal of Gastroenterology 29:36, pages 5254-5267.
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Naif O. Al-Harbi, Faisal Imam, Mohammad Matar Al-Harbi, Khaldoon Aljeryan, Othman A. Al-Shabanah, Khaled A. Alhosaini, Lamya Saif Alqahtani, Muhammad Afzal, M.D. Khalid Anwer, Abdullah A. Aldossari, Mohammed M. Alanazi, Sary Alsanea & Mohammed A. Assiri. (2022) Protective effect of Apremilast against LPS-induced acute lung injury via modulation of oxidative stress and inflammation. Saudi Journal of Biological Sciences 29:5, pages 3414-3424.
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Irene Marafini, Edoardo Troncone, Silvia Salvatori & Giovanni Monteleone. (2020) TGF-β activity restoration and phosphodiesterase 4 inhibition as therapeutic options for inflammatory bowel diseases. Pharmacological Research 155, pages 104757.
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Peter H. Schafer, Mary Adams, Gerald Horan, Francesca Truzzi, Alessandra Marconi & Carlo Pincelli. (2019) Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice. Drugs in R&D 19:4, pages 329-338.
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Marco Spadaccini, Silvia D’Alessio, Laurent Peyrin-Biroulet & Silvio Danese. (2017) PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue. International Journal of Molecular Sciences 18:6, pages 1276.
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Naiem T. Issa, Jordan Kruger, Henri Wathieu, Rajarajan Raja, Stephen W. Byers & Sivanesan Dakshanamurthy. (2016) DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing. BMC Bioinformatics 17:1.
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Peter H. Schafer, Francesca Truzzi, Anastasia Parton, Lei Wu, Jolanta Kosek, Ling-Hua Zhang, Gerald Horan, Annalisa Saltari, Marika Quadri, Roberta Lotti, Alessandra Marconi & Carlo Pincelli. (2016) Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex. Cellular Signalling 28:7, pages 753-763.
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So Motoyoshi, Yasuhiko Yamamoto, Seiichi Munesue, Hirobumi Igawa, Ai Harashima, Hidehito Saito, Dong Han, Takuo Watanabe, Hiroshi Sato & Hiroshi Yamamoto. (2014) cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products. Biochemical Journal 463:1, pages 75-82.
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Monalisa F. AzevedoFabio R. FauczEirini BimpakiAnelia HorvathIsaac LevyRodrigo B. de AlexandreFaiyaz AhmadVincent ManganielloConstantine A. Stratakis. (2014) Clinical and Molecular Genetics of the Phosphodiesterases (PDEs). Endocrine Reviews 35:2, pages 195-233.
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Huey-Yi Chen, Wen-Chi Chen, Yu-Ning Lin & Yung-Hsiang Chen. (2014) Synergistic Effect of Vaginal Trauma and Ovariectomy in a Murine Model of Stress Urinary Incontinence: Upregulation of Urethral Nitric Oxide Synthases and Estrogen Receptors. Mediators of Inflammation 2014, pages 1-8.
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Pascal Juillerat & Joshua R. Korzenik. 2014. Medical Therapy of Ulcerative Colitis. Medical Therapy of Ulcerative Colitis 221 235 .
Neal Kumar, Ari M Goldminz, Noori Kim & Alice B Gottlieb. (2013) Phosphodiesterase 4-targeted treatments for autoimmune diseases. BMC Medicine 11:1.
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Peter Schafer. (2012) Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochemical Pharmacology 83:12, pages 1583-1590.
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Dalip Kumar, Gautam Patel, Lalitha Vijayakrishnan, Sunanda G. Dastidar & Abhijit Ray. (2012) Design and Synthesis of 3,5-Disubstituted-1,2,4-Oxadiazoles as Potent Inhibitors of Phosphodiesterase4B2. Chemical Biology & Drug Design 79:5, pages 810-818.
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Klaus F. Rabe. (2011) Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. British Journal of Pharmacology 163:1, pages 53-67.
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Hermann Tenor, Armin Hatzelmann, Rolf Beume, Gezim Lahu, Karl Zech & Thomas D. Bethke. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 85 119 .
C. P. Page & D. Spina. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 391 414 .
Mohammad Ali Rezvanfar, Mohammad Amin Rezvanfar, Akram Ranjbar, Maryam Baeeri, Azadeh Mohammadirad & Mohammad Abdollahi. (2010) Biochemical evidence on positive effects of rolipram a phosphodiesterase-4 inhibitor in malathion-induced toxic stress in rat blood and brain mitochondria. Pesticide Biochemistry and Physiology 98:1, pages 135-143.
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Jieru E. Lin, Michael Valentino, Glen Marszalowicz, Michael S. Magee, Peng Li, Adam E. Snook, Brian A. Stoecker, Chang Chang & Scott A. Waldman. (2010) Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics. Toxins 2:8, pages 2028-2054.
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Miles Houslay & Marco Conti. (2010) Phosphodiesterase 4D, cAMP specific. AfCS-Nature Molecule Pages.
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PH Schafer, A Parton, AK Gandhi, L Capone, M Adams, L Wu, JB Bartlett, MA Loveland, A Gilhar, Y-F Cheung, GS Baillie, MD Houslay, H-W Man, GW Muller & DI Stirling. (2010) Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. British Journal of Pharmacology 159:4, pages 842-855.
Crossref
Sevgin Ozlem Iseri, Yasemin Ersoy, Feriha Ercan, Meral Yuksel, Pinar Atukeren, Koray Gumustas & Inci Alican. (2009) The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat. Journal of Gastroenterology and Hepatology 24:6, pages 1142-1148.
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John A. Meyers, Derrick W. Su & Adam Lerner. (2009) Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors. The Journal of Immunology 182:9, pages 5400-5411.
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Neil J. Press & Katharine H. Banner. 2009. Progress in Medicinal Chemistry Volume 47. Progress in Medicinal Chemistry Volume 47 37 74 .
Amanda P. Skoumbourdis, Ruili Huang, Noel Southall, William Leister, Vicky Guo, Ming-Hsuang Cho, James Inglese, Marshall Nirenberg, Christopher P. Austin, Menghang Xia & Craig J. Thomas. (2008) Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorganic & Medicinal Chemistry Letters 18:4, pages 1297-1303.
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