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Review

Therapeutic applications of aptamers

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Pages 43-60 | Published online: 20 Dec 2007

Keep up to date with the latest research on this topic with citation updates for this article.

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Wei Fan, Xiang Wang, Baoyue Ding, Haimin Cai, Xudong Wang, Yueqi Fan, Yong Li, Shenghui Liu, Suifeng Nie & Qiping Lu. (2016) Thioaptamer-conjugated CD44-targeted delivery system for the treatment of breast cancer in vitro and in vivo. Journal of Drug Targeting 24:4, pages 359-371.
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Yoshimasa Takafuji, Jun-ichiro Jo & Yasuhiko Tabata. (2011) Simple PEG Modification of DNA Aptamer Based on Copper Ion Coordination for Tumor Targeting. Journal of Biomaterials Science, Polymer Edition 22:9, pages 1179-1195.
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Ravinder Malik & Ipsita Roy. (2008) Design and development of antisense drugs. Expert Opinion on Drug Discovery 3:10, pages 1189-1207.
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Ala’a S. Shraim, Bayan A. Abdel Majeed, Maysaa’ Adnan Al-Binni & Abdelrahim Hunaiti. (2022) Therapeutic Potential of Aptamer–Protein Interactions. ACS Pharmacology & Translational Science 5:12, pages 1211-1227.
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Suliman Khan, Arif Hussain, Hossein Fahimi, Fakhteh Aliakbari, Samir Haj Bloukh, Zehra Edis, Mohammad Mahdi Nejadi Babadaei, Zhila Izadi, Behrang Shiri Varnamkhasti, Fatemeh Jahanshahi, Yueting Lin, Xiao Hao, Rizwan Hasan Khan, Behnam Rasti, Gholamreza Vaghar-Lahijani, Linlin Hua, Hossein Derakhshankhah, Majid Sharifi & Mojtaba Falahati. (2022) A review on the therapeutic applications of aptamers and aptamer-conjugated nanoparticles in cancer, inflammatory and viral diseases. Arabian Journal of Chemistry 15:2, pages 103626.
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Mohamad Zulkeflee Sabri, Azzmer Azzar Abdul Hamid, Sharifah Mariam Sayed Hitam & Mohd. Zulkhairi Abdul Rahim. (2020) The assessment of three dimensional modelling design for single strand DNA aptamers for computational chemistry application. Biophysical Chemistry 267, pages 106492.
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Ka-To Shum & John J. Rossi. 2013. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases 395 423 .
Ka-To Shum & John J. Rossi. 2013. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases 395 423 .
David H. J. Bunka & Peter G. Stockley. 2012. DNA Conjugates and Sensors. DNA Conjugates and Sensors 140 165 .
Young Ju Lee, Seung Ryul Han, Nam Yeon Kim, Soo–Han Lee, Jin–Sook Jeong & Seong–Wook Lee. (2012) An RNA Aptamer That Binds Carcinoembryonic Antigen Inhibits Hepatic Metastasis of Colon Cancer Cells in Mice. Gastroenterology 143:1, pages 155-165.e8.
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Saraswat Pushpendra, Pareek Arvind & Bhandari Anil. 2012. From Nucleic Acids Sequences to Molecular Medicine. From Nucleic Acids Sequences to Molecular Medicine 19 45 .
Davoud Ahmadvand, Fatemeh Rahbarizadeh & Seyed Moein Moghimi. (2011) Biological targeting and innovative therapeutic interventions with phage-displayed peptides and structured nucleic acids (aptamers). Current Opinion in Biotechnology 22:6, pages 832-838.
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Andrew Prussia, Pahk Thepchatri, James P. Snyder & Richard Plemper. (2011) Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics. International Journal of Molecular Sciences 12:6, pages 4027-4052.
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Achim Boltz, Birgit Piater, Lars Toleikis, Ralf Guenther, Harald Kolmar & Bjoern Hock. (2011) Bi-specific Aptamers Mediating Tumor Cell Lysis. Journal of Biological Chemistry 286:24, pages 21896-21905.
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Crossref
Meng Jing & Michael T. Bowser. (2011) Isolation of DNA aptamers using micro free flow electrophoresis. Lab on a Chip 11:21, pages 3703.
Crossref
L. Bildstein, C. Dubernet & P. Couvreur. (2011) Prodrug-based intracellular delivery of anticancer agents. Advanced Drug Delivery Reviews 63:1-2, pages 3-23.
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Katarzyna Piekielska, Magdalena Gębala, Sławomir Gwiazda, Sabine Müller & Wolfgang Schuhmann. (2010) Impedimetric Detection of Hairpin Ribozyme Activity. Electroanalysis 23:1, pages 37-42.
Crossref
Yamei Liu, Victor G Stepanov, Ulrich Strych, Richard C Willson, George W Jackson & George E Fox. (2010) DNAzyme-mediated recovery of small recombinant RNAs from a 5S rRNA-derived chimera expressed in Escherichia coli. BMC Biotechnology 10:1.
Crossref
Bieke Van Dorst, Jaytry Mehta, Karen Bekaert, Elsa Rouah-Martin, Wim De Coen, Peter Dubruel, Ronny Blust & Johan Robbens. (2010) Recent advances in recognition elements of food and environmental biosensors: A review. Biosensors and Bioelectronics 26:4, pages 1178-1194.
Crossref
Jagat R Kanwar, Rajiv R Mohan, Rupinder K Kanwar, Kislay Roy & Raj Bawa. (2010) Applications of aptamers in nanodelivery systems in cancer, eye and inflammatory diseases. Nanomedicine 5:9, pages 1435-1445.
Crossref
Sujin JeongSeung Ryul HanYoung Ju LeeJu Hyun KimSeong-Wook Lee. (2010) Identification of RNA Aptamer Specific to Mutant KRAS Protein. Oligonucleotides 20:3, pages 155-161.
Crossref
Britta Hoehn & John J. Rossi. 2010. The Chemical Biology of Nucleic Acids. The Chemical Biology of Nucleic Acids 233 260 .
P.R. BouchardR.M. HutabaratK.M. Thompson. (2010) Discovery and Development of Therapeutic Aptamers. Annual Review of Pharmacology and Toxicology 50:1, pages 237-257.
Crossref
Peng Zhang, Nianxi Zhao, Zihua Zeng, Yongdong Feng, Ching-Hsuan Tung, Chung-Che Chang & Youli Zu. (2009) Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells. Laboratory Investigation 89:12, pages 1423-1432.
Crossref
Changfeng Zhu, Yanqin Wen, Di Li, Lihua Wang, Shiping Song, Chunhai Fan & Itamar Willner. (2009) Inhibition of the In Vitro Replication of DNA by an Aptamer–Protein Complex in an Autonomous DNA Machine. Chemistry – A European Journal 15:44, pages 11898-11903.
Crossref
Huifen F. Wang & John W. A. Findlay. 2009. Ligand‐Binding Assays. Ligand‐Binding Assays 343 380 .
Guy A TremblayPhilip R Oldfield. (2009) Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues. Bioanalysis 1:3, pages 595-609.
Crossref
Eric Peyrin. (2009) Nucleic acid aptamer molecular recognition principles and application in liquid chromatography and capillary electrophoresis. Journal of Separation Science 32:10, pages 1531-1536.
Crossref
Yevgeny Brudno & David R. Liu. (2009) Recent Progress Toward the Templated Synthesis and Directed Evolution of Sequence-Defined Synthetic Polymers. Chemistry & Biology 16:3, pages 265-276.
Crossref
Zhiguo WangZhiguo Wang. 2009. MicroRNA Interference Technologies. MicroRNA Interference Technologies 59 73 .
Anita SchwegmannFrank Brombacher. (2008) Host-Directed Drug Targeting of Factors Hijacked by Pathogens. Science Signaling 1:29.
Crossref
William Garland, Amy Cavalli & Geneviève Hansen. 2008. 203 226 .

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