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Review

Nicotinic receptor partial agonists as novel compounds for the treatment of smoking cessation

, MD PhD
Pages 1473-1485 | Published online: 22 Sep 2008

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Jon O Ebbert. (2009) Emerging drugs for the treatment of tobacco dependence. Expert Opinion on Emerging Drugs 14:1, pages 23-32.
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Jonathan Livingstone-Banks, Thomas R Fanshawe, Kyla H Thomas, Annika Theodoulou, Anisa Hajizadeh, Lilian Hartman & Nicola Lindson. (2023) Nicotine receptor partial agonists for smoking cessation. Cochrane Database of Systematic Reviews 2023:6.
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Jonathan Livingstone-Banks, Thomas R Fanshawe, Kyla H Thomas, Annika Theodoulou, Anisa Hajizadeh, Lilian Hartman & Nicola Lindson. (2023) Nicotine receptor partial agonists for smoking cessation. Cochrane Database of Systematic Reviews 2023:5.
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Piotr Bernat, Patrycjusz Kołodziejczyk, Jarogniew J. Łuszczki, Mirosław Zagaja & Piotr Tutka. (2023) Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model. International Journal of Molecular Sciences 24:3, pages 2616.
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Piotr Tutka, Denis Vinnikov, Ryan J. Courtney & Neal L. Benowitz. (2019) Cytisine for nicotine addiction treatment: a review of pharmacology, therapeutics and an update of clinical trial evidence for smoking cessation. Addiction 114:11, pages 1951-1969.
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Juan Pablo Gonzalez-Gutierrez, Martin Hodar, Franco Viscarra, Pablo Paillali, Nicolás Guerra-Díaz, Hernán Pessoa-Mahana, Juan José Hernández-Morantes, Horacio Pérez-Sánchez, Isabel Bermúdez, Miguel Reyes-Parada & Patricio Iturriaga-Vásquez. (2019) Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues. Molecules 24:15, pages 2684.
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Anna K. Przybył, Ewa Maj, Joanna Wietrzyk & Maciej Kubicki. (2019) Spectroscopic, structural and anticancer activity studies of (−)-cytisine halogenated N-benzyl derivatives. Journal of Molecular Structure 1176, pages 871-880.
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Ewa Krystkowiak, Anna K. Przybył, Małgorzata Bayda-Smykaj, Jacek Koput & Andrzej Maciejewski. (2018) Spectral and photophysical properties of cytisine in acetonitrile – Theory and experiment. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 203, pages 375-382.
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Nieves Gómez-Coronado, Adam J. Walker, Michael Berk & Seetal Dodd. (2018) Current and Emerging Pharmacotherapies for Cessation of Tobacco Smoking. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 38:2, pages 235-258.
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Piotr Tutka, Maria W. Kondrat-Wróbel, Katarzyna Zaluska, Dorota Żółkowska, Magdalena Florek-Łuszczki & Jarogniew J. Łuszczki. (2016) Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. Psychopharmacology 234:2, pages 281-291.
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Kate Cahill, Nicola Lindson-Hawley, Kyla H Thomas, Thomas R Fanshawe & Tim Lancaster. (2016) Nicotine receptor partial agonists for smoking cessation. Cochrane Database of Systematic Reviews.
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Soo Hee Jeong, David Newcombe, Janie Sheridan & Malcolm Tingle. (2014) Pharmacokinetics of cytisine, an α 4 β 2 nicotinic receptor partial agonist, in healthy smokers following a single dose . Drug Testing and Analysis 7:6, pages 475-482.
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Antoni R. Blaazer & Iwan J. P. de Esch. 2015. Thermodynamics and Kinetics of Drug Binding. Thermodynamics and Kinetics of Drug Binding 81 105 .
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Brian Rinker. (2013) The Evils of Nicotine. Annals of Plastic Surgery 70:5, pages 599-605.
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Mariaelvina Sala, Daniela Braida, Luca Pucci, Irene Manfredi, Michael J Marks, Charles R Wageman, Sharon R Grady, Barbara Loi, Sergio Fucile, Francesca Fasoli, Michele Zoli, Bruno Tasso, Fabio Sparatore, Francesco Clementi & Cecilia Gotti. (2013) CC4, a dimer of cytisine, is a selective partial agonist at ?4?2/?6?2 nAChR with improved selectivity for tobacco smoking cessation. British Journal of Pharmacology 168:4, pages 835-849.
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Piotr Tutka, Tomasz Mróz, Jerzy Bednarski, Andrzej Styk, Jaromir Ognik, Jerzy Mosiewicz & Jarogniew Łuszczki. (2013) Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice. Pharmacological Reports 65:1, pages 195-200.
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Robert West, Witold Zatonski, Magdalena Cedzynska, Dorota Lewandowska, Joanna Pazik, Paul Aveyard & John Stapleton. (2011) Placebo-Controlled Trial of Cytisine for Smoking Cessation. New England Journal of Medicine 365:13, pages 1193-1200.
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F. Ivy Carroll, Ana Z. Muresan, Bruce E. Blough, Hernán A. Navarro, S. Wayne Mascarella, J. Brek Eaton, Xiaodong Huang, M. Imad Damaj & Ronald J. Lukas. (2011) Synthesis of 2-(Substituted Phenyl)-3,5,5-trimethylmorpholine Analogues and Their Effects on Monoamine Uptake, Nicotinic Acetylcholine Receptor Function, and Behavioral Effects of Nicotine. Journal of Medicinal Chemistry 54:5, pages 1441-1448.
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F. Ivy Carroll, Bruce E. Blough, S. Wayne Mascarella, Hernán A. Navarro, J. Brek Eaton, Ronald, J. Lukas & M. Imad Damaj. (2010) Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2β-substituted Tropanes. Journal of Medicinal Chemistry 53:23, pages 8345-8353.
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Juan Andrés Abin-Carriquiry, Margot Paulino Zunini, Bruce K. Cassels, Susan Wonnacott & Federico Dajas. (2010) In silico characterization of cytisinoids docked into an acetylcholine binding protein. Bioorganic & Medicinal Chemistry Letters 20:12, pages 3683-3687.
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Juan Andrés Abin-Carriquiry, Jessika Urbanavicius, Cecilia Scorza, Marcos Rebolledo-Fuentes, Susan Wonnacott, Bruce K. Cassels & Federico Dajas. (2010) Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats. European Journal of Pharmacology 634:1-3, pages 89-94.
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Pitchai Balakumar & Jagdeep Kaur. (2009) Is nicotine a key player or spectator in the induction and progression of cardiovascular disorders?. Pharmacological Research 60:5, pages 361-368.
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Hugo R. Arias. (2009) Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions?. The International Journal of Biochemistry & Cell Biology 41:11, pages 2098-2108.
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Fang Zheng, Linda P. Dwoskin, Peter A. Crooks & Chang-Guo Zhan. (2009) First-principles determination of molecular conformations of indolizidine (−)-235B′ in solution. Theoretical Chemistry Accounts 124:3-4, pages 269-278.
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Krista Spiller, Zheng-Xiong Xi, Xia Li, Charles R. AshbyJr.Jr., Patrick M. Callahan, Ashok Tehim & Eliot L. Gardner. (2009) Varenicline attenuates nicotine-enhanced brain-stimulation reward by activation of α4β2 nicotinic receptors in rats. Neuropharmacology 57:1, pages 60-66.
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Zheng-xiong Xi, Krista Spiller & Eliot L Gardner. (2009) Mechanism-based medication development for the treatment of nicotine dependence. Acta Pharmacologica Sinica 30:6, pages 723-739.
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